Article
Multidisciplinary Sciences
Yangli Pei, Yuxin Song, Bingyuan Wang, Chenghong Lin, Ying Yang, Hua Li, Zheng Feng
Summary: By analyzing lipidomics and RNA sequencing data of 3T3-L1 cells, we observed significant changes in lipid composition and gene expression patterns during adipogenesis. Several genes were up-regulated, potentially enhancing glucose transport and increasing intracellular triacylglycerol accumulation. Other genes were also up-regulated, likely leading to elevated levels of intracellular free fatty acids and synthesis of various lipids. These findings provide important insights into the pathophysiology of obesity.
Article
Biochemistry & Molecular Biology
Elisabeth M. Haberl, Thomas S. Weiss, Georg Peschel, Kilian Weigand, Nikolai Koehler, Josch K. Pauling, Juergen J. Wenzel, Marcus Hoering, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler
Summary: The study revealed differences in lipid metabolism between liver cancer tissues and non-tumor liver tissues, as well as in the impact of HBV and HCV infections on hepatic lipid concentrations. The tumor suppressor protein p53 showed a negative correlation with free cholesterol in tumors, indicating its role in cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yali Zhou, Xusheng Huang, Ting Hu, Shuwei Chen, Yao Wang, Xianfei Shi, Miao Yin, Runzhi Li, Jiping Wang, Xiaoyun Jia
Summary: This study identified PfGPAT9 as a key player in the biosynthesis and accumulation of seed oil and PUFAs in Perilla frutescens. Heterogeneous expression of PfGPAT9 in tobacco plants significantly increased total oil and unsaturated fatty acid levels without negative effects on other agronomic traits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Chuanzeng Lan, Sen Wang, Huidan Zhang, Zhuojun Wang, Weijian Wan, Huan Liu, Yang Hu, Qiu Cui, Xiaojin Song
Summary: The study analyzed the functions of four DGAT2s in industrial oleaginous thraustochytrid Aurantiochytrium, with results indicating that DGAT2C mainly connects PUFA to TAG molecules, while DGAT2A and DGAT2D target SFA and/or MUFA. This research demonstrates the specific TAG assembly routes in Aurantiochytrium, providing insights for designing TAG molecules with desired characteristics.
BIOTECHNOLOGY FOR BIOFUELS
(2021)
Review
Chemistry, Organic
Mutay Aslan
Summary: This review highlights the essential roles of omega-3 and omega-6 fatty acids in metabolic homeostasis, as well as the functions of sphingolipids in cell growth and apoptosis. Tandem mass spectrometric analyses can directly measure quantitative changes in lipids across different matrices.
MINI-REVIEWS IN ORGANIC CHEMISTRY
(2021)
Review
Oncology
Jan Korbecki, Mateusz Bosiacki, Izabela Gutowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This review discusses the synthesis and significance of fatty acids, glycerophospholipids, and triacylglycerol in glioblastoma. The focus is on all enzymes involved in the synthesis of these lipids, highlighting their roles in the tumorigenesis of glioblastoma. Due to the fact that the role of many of these enzymes in glioblastoma tumorigenesis remains unexplored, we conducted a bioinformatic analysis based on the GEPIA database to indicate their possible functions and significance.
Editorial Material
Biochemistry & Molecular Biology
Etsuo Niki
Summary: This commentary describes a highly cited paper by Dahle, Hill, and Holman, which showed that the oxidation products of polyunsaturated fatty acids reacted with thiobarbituric acid to give a colored product, which might be used to assess lipid oxidation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Plant Sciences
James G. Wallis, Jesse D. Bengtsson, John Browse
Summary: Vegetable oils are a major source of calories in human diets but their fatty acid compositions are not ideal. Strategies such as transgenic expression of desaturases and downregulation of FatB thioesterase have been developed to lower oil saturates and improve nutrition.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Medicinal
Omri Avidan, Sergey Malitsky, Uri Pick
Summary: This study aimed to evaluate the contribution of the free fatty acid (FA) pool to triacylglyceride (TAG) biosynthesis and characterize the mechanism by which FA are assimilated into TAG in the green alga Dunaliella tertiolecta. The results suggest that FA biosynthesis is a major rate-controlling stage in TAG biosynthesis in D. tertiolecta under nitrogen deprivation conditions.
Article
Plant Sciences
Brice A. Jarvis, Trevor B. Romsdahl, Michaela G. McGinn, Tara J. Nazarenus, Edgar B. Cahoon, Kent D. Chapman, John C. Sedbrook
Summary: Pennycress is being domesticated as an oilseed cash cover crop, with CRISPR/Cas9 technology used to create gene mutations for increased oleic acid content. High oleic acid oil is valued for its oxidative stability over polyunsaturated fatty acids, making it a versatile option.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Food Science & Technology
Parisa Hajihashemi, Awat Feizi, Zahra Heidari, Fahimeh Haghighatdoost
Summary: This systematic review and meta-analysis summarizes previous findings on the association between n-6 PUFA levels in diets or blood and blood pressure. The results suggest that higher circulatory/dietary n-6 PUFAs tend to be associated with lower odds of hypertension, specifically total n-6 PUFAs and linoleic acid.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Sara C. Di Rienzi, Elizabeth L. Johnson, Jillian L. Waters, Elizabeth A. Kennedy, Juliet Jacobson, Peter Lawrence, Dong Hao Wang, Tilla S. Worgall, J. Thomas Brenna, Ruth E. Ley
Summary: Studies using germfree animals as controls have shown that the gut microbiome mediates diet-induced obesity. The microbial colonization status affects fatty acid levels and liver sphingolipid pools, regardless of the diet.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Physiology
Lin Zhu, Julia An, Sivaprakasam Chinnarasu, Thao Luu, Yasminye D. Pettway, Kelly Fahey, Bridget Litts, Hye-Young H. Kim, Charles R. Flynn, MacRae F. Linton, John M. Stafford
Summary: Mounting evidence suggests that CETP plays important physiological roles in adapting to chronic nutrient excess and protecting against diet-induced insulin resistance. The study shows that female mice with huCETP have higher insulin sensitivity and improved fatty liver and liver insulin action, possibly due to the upregulated fatty acid beta-oxidation and improved suppression of hepatic glucose production. These findings further support the beneficial physiological roles of CETP in metabolic adaptation to nutrient excess.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Ecology
Christian Werner, Kathrin A. Otte, Eric von Elert
Summary: The study found that D. magna populations have changes in fatty acid tissue concentrations at lower temperatures (15 degrees C), with significant differences in relative FA content and growth rates between genotypes at 15 degrees C and 20 degrees C. Genotype-specific changes in FA profiles between temperatures suggest different coping strategies. The clustering of genotypes into three clusters based on changes in FA composition implies different physiological solutions to temperature changes.
ECOLOGY AND EVOLUTION
(2021)
Article
Genetics & Heredity
Pranesha Prabhakaran, Nachon Raethong, Yusuf Nazir, Hafiy Halim, Wu Yang, Wanwipa Vongsangnak, Aidil Abdul Hamid, Yuanda Song
Summary: In this study, genomic characterization of Aurantiochytrium sp. SW1, a potential producer of docosahexaenoic acid (DHA), was carried out. The results reveal the genome information and metabolic pathways related to DHA synthesis in this strain. It is found that Aurantiochytrium sp. SW1 has the potential for high DHA production, and several key genes and enzymes involved in lipid metabolism and fatty acid biosynthesis pathways are identified.