Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity

Summary: This study investigates the role of PLIN5 in cellular energy metabolism and finds that it preserves mitochondrial function by regulating TG hydrolysis to adjust FA supply. Additionally, it demonstrates that LDMC plays a vital role in mitochondrial respiratory capacity and metabolic flexibility.