Article
Cell Biology
Jing Chen, Esther A. Zaal, Celia R. Berkers, Rob Ruijtenbeek, Johan Garssen, Frank A. Redegeld
Summary: The study demonstrates that pretreating MM cells with DHA/EPA before bortezomib significantly enhances chemosensitivity by decreasing GSH levels and altering metabolism, highlighting the role of GSH degradation in overcoming drug resistance. RNA-seq results suggest the NRF2-ATF3/4-CHAC1 signaling pathway as central in GSH degradation and indicate potential connections to various pathways contributing to the tumor suppressive effect. The findings implicate GSH degradation as a promising therapeutic target in MM and provide new insights into combating bortezomib resistance.
Review
Nutrition & Dietetics
A. Lehner, K. Staub, L. Aldakak, P. Eppenberger, F. Ruehli, Robert D. Martin, N. Bender
Summary: The study found no significant association between DHA/EPA supplementation and cognitive performance of children born to pregnant and/or breastfeeding women who consumed fish oil supplements.
Article
Medicine, General & Internal
Marina Ivanisevic, Marina Horvaticek, Karlo Delmis, Josip Delmis
Summary: This study found that supplementation with DHA and EPA in pregnant women with type 1 diabetes can increase the concentration and proportions of n-3 PUFAs in maternal and fetal blood, while decreasing the proportion of n-6 PUFAs.
ANNALS OF MEDICINE
(2021)
Review
Food Science & Technology
Arti Kumari, Sunil Pabbi, Aruna Tyagi
Summary: Omega-3 fatty acids, particularly EPA and DHA, are essential for human health and must be obtained through diet or supplementation. Traditional sources include vegetable oils and fish, but concerns about sustainability and contamination have led to the exploration of alternative sources, such as microalgae. This review discusses strategies for enhancing EPA and DHA production in microalgae, including strain selection, cultivation optimization, and genetic engineering. These approaches pave the way for large-scale production of EPA and DHA to promote human health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Emanuela Talamonti, Anders Jacobsson, Valerio Chiurchiu
Summary: Omega-3 polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), play important roles in various biological processes and have numerous health benefits. Deficiency in Elovl2, a key enzyme involved in DHA synthesis, leads to decreased DHA levels, increased brain inflammation, and heightened pro-inflammatory responses in T lymphocytes. Additionally, DHA deficiency affects the interaction between dendritic cells (DC) and T cells. Therefore, DHA plays a crucial role in regulating adaptive immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Alejandra Valencia-Naranjo, Luz M. Manjarres-Correa, Juliana Bermudez-Cardona
Summary: This study aimed to evaluate the changes in the concentrations of EPA and DHA in the erythrocytes and breast milk of lactating women after three months of supplementation. The study found low consumption of omega-3 food sources and low EPA and DHA content initially. After supplementation, there was a significant increase in DHA levels in both erythrocytes and breast milk, while EPA levels did not change significantly.
CURRENT RESEARCH IN FOOD SCIENCE
(2022)
Article
Nutrition & Dietetics
Gemma Chiva-Blanch, Vibeke Bratseth, Kristian Laake, Harald Arnesen, Svein Solheim, Erik Berg Schmidt, Lina Badimon, Ingebjorg Seljeflot
Summary: This study aimed to investigate the effects of long-term n3 PUFA supplementation on the release of cMV in elderly patients at very high risk of CVD, and found that supplementation with 1.8 g/day n3 PUFA for two years did not significantly modulate the release of prothrombotic MV from blood and vascular cells in elderly Norwegians who had suffered a recent acute myocardial infarction and were treated as per guidelines.
CLINICAL NUTRITION
(2021)
Review
Agriculture, Dairy & Animal Science
Tomas R. Magalhaes, Ronald J. Corbee, Felisbina L. Queiroga, Ana L. Lourenco
Summary: Periodontal disease is a common oral disorder in cats, caused by inflammation in response to bacterial plaque. Treatment options vary depending on the stage of the disease and can include dental scaling, localized application of perioceutics, tissue regeneration, tooth extraction, and periodontal surgery. As multimodal therapy is often necessary, new approaches are being developed to enhance treatment response. The use of omega-3 fatty acids as an adjuvant therapy has shown potential in humans with periodontal disease, although its efficacy in cats and other companion animals is still uncertain and contradictory. This review aims to assess the potential impact of omega-3 fatty acids on the clinical management of feline periodontal disease based on available evidence.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2023)
Article
Nutrition & Dietetics
Teresa Padro, Anallely Lopez-Yerena, Antonio Perez, Gemma Vilahur, Lina Badimon
Summary: High-density lipoproteins (HDLs) are complex particles that have multiple cardiovascular protective properties. Diet, specifically supplementation with ?3 and phytosterols, has been shown to improve the lipid profile of HDL. This study found that ?3 supplementation had greater effects on HDL lipidome compared to phytosterols, particularly in cholesteryl esters (CEs). Furthermore, the HDL lipidome was found to be sex-dependent. Overall, this study highlights the importance of diet and sex in modulating the HDL lipid profile.
Article
Pharmacology & Pharmacy
Lorena Ortega, Lorena Lobos-Gonzalez, Mauricio Reyna-Jeldes, Daniela Cerda, Erwin De la Fuente-Ortega, Patricio Castro, Giuliano Bernal, Claudio Coddou
Summary: This study demonstrated that docosahexaenoic acid (DHA) has a selective antiproliferative effect on gastric cancer (GC), primarily driven by apoptosis induction. DHA treatment consistently reduced tumor size, ascitic fluid volume, and liver metastasis in an in vivo mouse model. These findings provide promising potential for DHA as a therapeutic agent in GC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Agricultural Engineering
Ajeet Singh Chauhan, Anil Kumar Patel, Chiu-Wen Chen, Jo-Shu Chang, Philippe Michaud, Cheng-Di Dong, Reeta Rani Singhania
Summary: Considering the increasing health concerns, urban population tends to adopt a healthy lifestyle and incorporate nutritional food supplements to mitigate common health risks. The consumption of omega-3 and omega-6 PUFAs is on the rise, thus alternative commercial production methods are being developed. Microbial sources are emerging platforms to meet the global demand for omega PUFAs. Marine oleaginous protist Aurantiochytrium sp. has been identified as a potential source for substantial production of DHA and SFA. The objective of this research was to enhance PUFA yield by optimizing glucose concentration and nitrogen ratio. The maximum lipid and DHA yield and content were achieved at 30 g/L glucose, while the relative PUFA content was highest at 10 g/L glucose, with remaining SFA potentially usable for biodiesel.
BIORESOURCE TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Lidia Ciccone, Susanna Nencetti, Armando Rossello, Lucia Barlettani, Nicolo Tonali, Paola Nieri, Elisabetta Orlandini
Summary: EPA and DHA, two omega-3 polyunsaturated fatty acids, are safe dietary supplements derived from fish oil that contribute to human health. Studies show that these fatty acids have a role in counteracting neurodegenerative processes related to amyloidogenic proteins. The research found that EPA and DHA can directly interact with TTR and contribute to stabilizing the TTR tetramer.
Article
Biotechnology & Applied Microbiology
Wenjia Gu, John M. M. Kavanagh, Dale D. D. McClure
Summary: There is an increasing demand for sustainable sources of omega-3 fatty acids, and microalgae can be used to produce eicosapentaenoic acid (EPA) on a large scale. The choice of suitable strains is crucial for successful production. However, findings from small-scale systems do not always translate to larger photobioreactors. In this study, the productivity and fatty acid composition of eleven microalgal strains were examined in both flask and photobioreactor cultures. The results showed that predictions based on flask screening were not accurate for photobioreactors, highlighting the need for improved screening tools. Among the species tested, Phaeodactylum tricornutum showed the most potential when grown in photobioreactors. The study also investigated the impact of environmental conditions (temperature and salinity) on EPA production and found that EPA content remained relatively constant within the tested temperature and salinity ranges. Finally, nutritional information about the biomass was provided, which can be used as a starting point for formulating food products.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Nutrition & Dietetics
Martin E. Reiner, Philipp Baumgartner, Andrea Wiencierz, Michael Coslovsky, Nicole R. Bonetti, Mark G. Filipovic, Giulia Montrasio, Stefanie Aeschbacher, Nicolas Rodondi, Oliver Baretella, Michael Kuehne, Giorgio Moschovitis, Pascal Meyre, Leo H. Bonati, Thomas F. Luescher, Giovanni G. Camici, Stefan Osswald, David Conen, Juerg H. Beer
Summary: The study showed that EPA and DPA were associated with large noncortical or cortical infarcts (LNCCIs) in patients with atrial fibrillation, with EPA negatively correlated and DPA positively correlated with LNCCIs. However, there was no significant correlation between EPA and DPA with markers of small vessel disease in atrial fibrillation patients.
Article
Plant Sciences
Yi Cui, Skye R. Thomas-Hall, Elvis T. Chua, Peer M. Schenk
Summary: This study successfully achieved efficient large-scale cultivation of Phaeodactylum tricornutum by establishing a new culture medium and adjusting conditions such as nitrogen source and salinity levels.
JOURNAL OF PHYCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Edwin C. K. Tan, Duangjai Lexomboon, Henrike Habel, Johan Fastbom, Maria Eriksdotter, Kristina Johnell, Gunilla Sandborgh-Englund
Summary: This study externally validated a model for medication-related dental outcomes in older adults with and without dementia using population-based data from Swedish national registers. The results showed that certain medication types were associated with tooth extraction and restorative procedures in both dementia and non-dementia cohorts, indicating consistent performance of the model across different groups.
Article
Clinical Neurology
Olin Janssen, Willemijn J. Jansen, Stephanie J. B. Vos, Merce Boada, Lucilla Parnetti, Tomasz Gabryelewicz, Tormod Fladby, Jose Luis Molinuevo, Sylvia Villeneuve, Jakub Hort, Stephane Epelbaum, Alberto Lleo, Sebastiaan Engelborghs, Wiesje M. van der Flier, Susan Landau, Julius Popp, Anders Wallin, Philip Scheltens, Marcel Olde Rikkert, Peter J. Snyder, Chris Rowe, Gael Chetelat, Agustin Ruiz, Marta Marquie, Elena Chipi, Steffen Wolfsgruber, Michael Heneka, Henning Boecker, Oliver Peters, Jonas Jarholm, Lorena Rami, Adria Tort-Merino, Alexa Pichet Binette, Judes Poirier, Pedro Rosa-Neto, Jiri Cerman, Bruno Dubois, Marc Teichmann, Daniel Alcolea, Juan Fortea, M. Belen Sanchez-Saudinos, Jarith Ebenau, Cornelia Pocnet, Marie Eckerstrom, Louisa Thompson, Victor Villemagne, Rachel Buckley, Samantha Burnham, Marion Delarue, Yvonne Freund-Levi, Asa K. Wallin, Inez Ramakers, Magda Tsolaki, Hilkka Soininen, Harald Hampel, Luiza Spiru, Betty Tijms, Rik Ossenkoppele, Frans R. J. Verhey, Frank Jessen, Pieter Jelle Visser
Summary: In addition to age, setting, and APOE ε4 carriership, specific characteristics of subjective cognitive decline may aid in identifying individuals with amyloid positivity.
ALZHEIMERS & DEMENTIA
(2022)
Article
Biochemistry & Molecular Biology
Alexander Neumann, Fahri Kucukali, Isabelle Bos, Stephanie J. B. Vos, Sebastiaan Engelborghs, Tim De Pooter, Geert Joris, Peter De Rijk, Ellen De Roeck, Magda Tsolaki, Frans Verhey, Pablo Martinez-Lage, Mikel Tainta, Giovanni Frisoni, Oliver Blin, Jill Richardson, Regis Bordet, Philip Scheltens, Julius Popp, Gwendoline Peyratout, Peter Johannsen, Lutz Froelich, Rik Vandenberghe, Yvonne Freund-Levi, Johannes Streffer, Simon Lovestone, Cristina Legido-Quigley, Mara ten Kate, Frederik Barkhof, Mojca Strazisar, Henrik Zetterberg, Lars Bertram, Pieter Jelle Visser, Christine van Broeckhoven, Kristel Sleegers
Summary: In this study, rare variants in certain genes were found to be associated with Alzheimer's disease biomarkers. Four genes were associated with neuronal injury and inflammation, potentially increasing the risk of dementia by altering cytoskeleton structure and immune activity disinhibition. Two genes were associated with synaptic functioning, but had no consequential effect on AD development.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
Willemijn J. Jansen, Olin Janssen, Betty M. Tijms, Stephanie J. B. Vos, Rik Ossenkoppele, Pieter Jelle Visser
Summary: This study aims to estimate the prevalence of amyloid abnormality in individuals with different cognitive statuses and examine the factors that may affect these estimates. The results show that CSF-based estimates using adjusted data-driven cutoffs were higher than PET-based estimates in individuals without dementia, suggesting that preclinical and prodromal AD may be more prevalent than previously estimated. This finding has important implications for clinical trial recruitment strategies and healthcare planning policies.
Article
Clinical Neurology
Aurore Delvenne, Johan Gobom, Betty Tijms, Isabelle Bos, Lianne M. Reus, Valerija Dobricic, Mara Ten Kate, Frans Verhey, Inez Ramakers, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Jolien Schaeverbeke, Silvy Gabel, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos
Summary: The pathophysiology of MCI-SNAP is distinct from that of MCI-AD, highlighting the need for different treatment approaches.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Anders Wimo, Ron Handels, Riitta Antikainen, Maria Eriksdotter, Linus Jonsson, Martin Knapp, Jenni Kulmala, Tiina Laatikainen, Jenni Lehtisalo, Markku Peltonen, Anders Skoldunger, Hilkka Soininen, Alina Solomon, Timo Strandberg, Jaakko Tuomilehto, Tiia Ngandu, Miia Kivipelto
Summary: This study estimated the potential cost-effectiveness of the FINGER program in Finland. The results showed that the FINGER program could save costs and improve quality-adjusted life years, supporting its effectiveness in preventing cognitive impairment and disability.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Milan Nemy, Martin Dyrba, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, Doreen Goerss, Michael T. Heneka, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Renat Yakupov, Maria Eriksdotter, Eric Westman, Olga Stepankova, Lenka Vyslouzilova, Emrah Duezel, Frank Jessen, Stefan J. Teipel, Daniel Ferreira
Summary: Nemy et al. investigate cholinergic white matter projections along the Alzheimer's disease continuum, finding that alterations in these pathways are present in individuals with subjective cognitive decline. These alterations precede the more widespread changes seen in mild cognitive impairment and Alzheimer's disease dementia. The study highlights the potential of using cholinergic white matter pathways as markers for the early stages of Alzheimer's disease.
Review
Geriatrics & Gerontology
Ali Vahedi, Maria Eriksdotter, Hege Ihle-Hansen, Torgeir Bruun Wyller, Anne Rita Oksengard, Brynjar Fure
Summary: This study conducted a systematic review and meta-analysis to examine the relationship between cognitive functioning and phenotypic frailty status. The results showed that individuals in a frail state had poorer cognitive functioning, particularly in the domain of memory. These findings highlight the importance of incorporating cognitive function in assessments of frailty.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Urology & Nephrology
Hong Xu, Sara Garcia-Ptacek, Annette Bruchfeld, Edouard L. Fu, Taher Darreh Shori, Bengt Lindholm, Maria Eriksdotter, Juan Jesus Carrero
Summary: Preclinical evidence suggests that the use of Cholinesterase inhibitors (ChEIs) may have beneficial effects on the kidney. This study examined the risk of chronic kidney disease (CKD) progression among newly diagnosed Alzheimer's disease (AD) patients who either used or did not use ChEIs. The results showed that ChEI use was associated with a lower risk of CKD progression.
KIDNEY INTERNATIONAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Anton Jonsson, Jacob Holmer, Leif Kullman, Maria Eriksdotter, Jan Ahlqvist, Eva Levring Jaeghagen, Kare Buhlin
Summary: In this middle-aged and older Swedish population, CCAA was found to be common (40%). There were no differences in the prevalence of CCAA between cases with cognitive impairment and controls without cognitive impairment.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Article
Geriatrics & Gerontology
Jonathan K. L. Mak, Maria Eriksdotter, Martin Annetorp, Ralf Kuja-Halkola, Laura Kananen, Anne-Marie Bostrom, Miia Kivipelto, Carina Metzner, Viktoria Back Jerlardtz, Malin Engstrom, Peter Johnson, Lars Goran Lundberg, Elisabet Akesson, Carina Suhl Oberg, Maria Olsson, Tommy Cederholm, Sara Hagg, Dorota Religa, Juulia Jylhava
Summary: This retrospective cohort study used electronic health records to investigate the association between frailty and outcomes in older COVID-19 patients. The results showed that a medical record-based electronic frailty index (eFI) was effective for risk stratification in hospitalized COVID-19 patients. Frailty was significantly associated with higher mortality, readmission, and longer hospital stays, and the eFI had the best predictive accuracy among all measures.
Article
Clinical Neurology
Juraj Secnik, Maria Eriksdotter, Hong Xu, Martin Annetorp, Aleksander Rytarowski, Kristina Johnell, Sara Haegg, Dorota Religa
Summary: This study investigates the associations between dementia, medication use, and mortality in patients with COVID-19. The study finds that dementia is independently associated with higher in-hospital and overall mortality among COVID-19 patients. Furthermore, the use of antipsychotic medication is associated with an increased risk of mortality.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Microbiology
Nele Fogelholm, Jaakko Leskela, Muhammed Manzoor, Jacob Holmer, Susanna Paju, Kaija Hiltunen, Hanna-Maria Roitto, Riitta Kt Saarela, Kaisu Pitkala, Maria Eriksdotter, Kare Buhlin, Pirkko J. Pussinen, Paivi Mantyla
Summary: Oral health and declining cognition may have a bi-directional association. The composition of the subgingival microbiota was analyzed in subjects with normal cognition to severe cognitive decline. The study found that certain taxa of oral bacteria were associated with the MMSE score, and Lachnospiraceae [XIV] increased with decreasing MMSE. Impaired cognition is accompanied by changes in the composition of the oral microbiota, highlighting the importance of oral health-care practices among older adults.
JOURNAL OF ORAL MICROBIOLOGY
(2023)
Article
Clinical Neurology
Kirsten E. J. Wesenhagen, Johan Gobom, Isabelle Bos, Stephanie J. B. Vos, Pablo Martinez-Lage, Julius Popp, Magda Tsolaki, Rik Vandenberghe, Yvonne Freund-Levi, Frans Verhey, Simon Lovestone, Johannes Streffer, Valerija Dobricic, Lars Bertram, Kaj Blennow, Maria Pikkarainen, Merja Hallikainen, Johanna Kuusisto, Markku Laakso, Hilkka Soininen, Philip Scheltens, Henrik Zetterberg, Charlotte E. Teunissen, Pieter Jelle Visser, Betty M. Tijms
Summary: This study aimed to understand the changes in cerebrospinal fluid proteomics with aging and their associations with Alzheimer's disease risk. The results showed that while some proteins decreased with age in individuals with amyloid abnormalities, others increased independently of amyloid status, and were associated with immune and signaling processes.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)
Article
Geriatrics & Gerontology
Ulla L. Aalto, Kaisu H. Pitkala, Karen Andersen-Ranberg, Sylvie Bonin-Guillaume, Alfonso Jose Cruz-Jentoft, Maria Eriksdotter, Adam L. Gordon, Markus Gosch, Iva Holmerova, Hannu Kautiainen, Miia Kivipelto, Jurate Macijauskiene, Desmond O'Neill, Nele van den Noortgate, Anette H. Ranhoff, Jos M. G. A. Schols, Katrin Singler, Mindaugas Stankunas, Joseph G. Ouslander
Summary: There is significant variation in the prevalence and mortality of COVID-19 in nursing homes among different countries. We found a significant correlation between COVID-19 deaths in nursing homes and the total population's COVID-19 deaths, as well as the average size of nursing homes.
EUROPEAN GERIATRIC MEDICINE
(2022)
