Review
Biotechnology & Applied Microbiology
Helena H. W. B. Hansen, Haotian Cha, Lingxi Ouyang, Jun Zhang, Bo Jin, Helen Stratton, Nam-Trung Nguyen, Hongjie An
Summary: Nanobubbles, suspended gaseous entities in liquids, have versatile biomedical applications such as aiding in drug delivery, serving as imaging agents, and allowing controlled and targeted delivery. This review provides an overview of their preparation, characterization, current research focuses, and their potential impact on the future of biomedicine.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Microbiology
Anne-Grete Maertson, Jan-Willem C. Alffenaar, Roger J. Brueggemann, William Hope
Summary: Invasive fungal infections are a common cause of death in immunocompromised patients, and current strategies for antifungal therapy do not cater to individual patient's needs. More research is needed to maximize the effectiveness of antifungal therapy at an individual level.
Article
Multidisciplinary Sciences
Dhiraj Kumar, Akhilesh Mishra, Ala Lisok, Rakeeb Kureshi, Sagar Shelake, Donika Plyku, Rupashree Sen, Michele Doucet, Ravindra A. De Silva, Ronnie C. Mease, Patrick M. Forde, Elizabeth M. Jaffee, Prashant Desai, Sudipto Ganguly, Edward Gabrielson, Dhananjay Vaidya, Jamie B. Spangler, Sridhar Nimmagadda
Summary: Measuring accessible PD-L1 levels in tumors using PET imaging can elucidate the pharmacologic activity of mAbs and compare the activity of different mAbs. The study reveals subtle differences in the pharmacodynamic effects of anti-PD-1 mAbs, while starkly divergent target engagement is observed with anti-PD-L1 mAbs, correlating with differential effects on tumor growth.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Sergio Vencio, Rafael Caiado-Vencio, Leonardo Ferreira Caixeta, Malgorzata Masierek, Wojciech Mlynarski, Jozef Drzewoski, Justin M. Gregory
Summary: This study compared the pharmacokinetic and pharmacodynamic effects of a new insulin produced by Bioton S.A. with Humulin R produced by Eli Lilly. The results showed that both insulins are bioequivalent for treating type 1 diabetes patients.
DIABETES OBESITY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Chao Hu, Xiaofeng Ou, Yi Teng, Shiqing Shu, Ying Wang, Xiaohong Zhu, Yan Kang, Jia Miao
Summary: A study on healthy Chinese subjects showed that continuous infusions of ciprofol demonstrated pharmacodynamic and pharmacokinetic properties similar to propofol, with comparable safety and tolerability.
ADVANCES IN THERAPY
(2021)
Article
Infectious Diseases
Kasper Norskov Kragh, Desiree Gijon, Ainhize Maruri, Alberto Antonelli, Marco Coppi, Mette Kolpen, Stephanie Crone, Chaitanya Tellapragada, Badrul Hasan, Stine Radmer, Corne de Vogel, Willem van Wamel, Annelies Verbon, Christian G. Giske, Gian Maria Rossolini, Rafael Canton, Niels Frimodt-Moller
Summary: The study demonstrates the efficacy of using microcalorimetry screening to predict additive or synergistic effects of combination treatment for MDR infections. Several antibiotic combinations showed synergistic or additive effects in vitro testing.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Tingting Ma, Yanli Dong, Lei Huang, Yuanxun Yang, Yan Geng, Fei Fei, Pinhao Xie, Yu Zhao, Hui Lin, Zeyu Yang, Yun Jin, Xitong Ju, Runbin Sun, Juan Li
Summary: This study evaluated the safety and pharmacodynamics of SHR2285, the first oral coagulation factor XIa (FXIa) inhibitor developed in China, in combination with aspirin, clopidogrel or ticagrelor in healthy subjects. Results showed that SHR2285 was well tolerated, with no increased risk of bleeding, and effectively inhibited FXI activity and prolonged APTT when combined with these antiplatelet agents.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Infectious Diseases
Alberto Corona, Dario Cattaneo, Nicola Latronico
Summary: Critically ill patients with sepsis or septic shock have a worse prognosis due to a higher mortality rate and longer hospital stay. The proper use of antibiotics is crucial as it can affect the pharmacokinetics and pharmacodynamics in these patients. About 50% of septic patients develop acute renal failure, requiring continuous renal replacement therapy, which greatly affects the elimination rate of antibiotics. Adjustments in antibiotic doses are necessary in patients with acute renal failure based on glomerular filtration rate, while dosages should be increased in those undergoing continuous renal replacement therapy.
Article
Pharmacology & Pharmacy
Michael Nikolaou, Vincent H. Tam
Summary: This paper presents a novel integrated methodology for rapid assessment of antimicrobial drug efficacy under clinically relevant pharmacokinetic conditions. The methodology involves automated collection of time-kill data, processing of the data using a mathematical model to determine optimal dosing regimens, and in vitro validation in a hollow fiber system. Proof-of-concept is provided through several in vitro studies, and future directions for refinement are discussed.
Article
Ophthalmology
Jillian F. Ziemanski, Landon Wilson, Stephen Barnes, Kelly K. Nichols
Summary: The study aimed to compare CE profiles from HMGECs in response to rosiglitazone-induced differentiation with normal human meibum. Results showed differences between the two profiles, but rosiglitazone promoted upregulation of highly expressed meibum-relevant CEs and shifted the saturation level towards a more meibum-like profile.
Article
Hematology
Joanne L. Dunster, Alexander P. Bye, Neline Kriek, Tanya Sage, Joanne L. Mitchell, Carly Kempster, Joana Batista, Harriet McKinney, Patrick Thomas, Chris Jones, Kate Downes, Amanda J. Unsworth, Jonathan M. Gibbins
Summary: The PPAnalysis assay provides a detailed characterization of platelet function and identifies distinct subpopulations of donors based on their platelet reactivity metrics. It shows that platelet reactivity is not simply categorized as high or low responders, but exists in 6 subgroups with distinct platelet phenotypes within healthy cohorts. These platelet phenotypes are stable and can be used for stratification of cohorts to investigate the causes and consequences of differences in platelet function.
Article
Critical Care Medicine
Renata Cerna Parizkova, Jirina Martinkova, Eduard Havel, Petr Safranek, Milan Kaska, David Astapenko, Jan Bezouska, Jaroslav Chladek, Vladimir Cerny
Summary: This study showed that fluid overload in infected patients can significantly affect the pharmacokinetic/pharmacodynamic parameters of meropenem, but these effects can be mitigated over time with appropriate monitoring and dosing adjustments.
Review
Pharmacology & Pharmacy
Amir Hossein Miri, Mojtaba Kamankesh, Antoni Llopis-Lorente, Chenguang Liu, Matthias G. Wacker, Ismaeil Haririan, Hamid Asadzadeh Aghdaei, Michael R. Hamblin, Abbas Yadegar, Mazda Rad-Malekshahi, Mohammad Reza Zali
Summary: In this review, the colonization and invasion mechanisms of H. pylori infection are discussed, and a comprehensive survey of current curative options based on polypharmacy is provided.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Soo-Min Jang, Alex R. Shaw, Bruce A. Mueller
Summary: The study found that patients in lower weight quartiles tended to achieve higher antibiotic pharmacodynamic target attainment compared to heavier patients.
Article
Ophthalmology
Jillian F. Ziemanski, Landon Wilson, Stephen Barnes, Kelly K. Nichols
Summary: The study evaluated the physiological effects of PGF(2 alpha) and PGE(2) on immortalized human meibomian gland epithelial cells. The results showed that PGF(2 alpha) had a greater impact on lipid expression and may interfere with meibocyte differentiation. This has important implications for understanding the mechanism of MGD development in patients with glaucoma treated with PGF(2 alpha) analogs.
Article
Plant Sciences
Carmen Mansilla, Flora Sanchez, Hal S. Padgett, Gregory P. Pogue, Fernando Ponz
MOLECULAR PLANT PATHOLOGY
(2009)
Review
Biotechnology & Applied Microbiology
Gregory P. Pogue, Fakhrieh Vojdani, Kenneth E. Palmer, Ernie Hiatt, Steve Hume, Jim Phelps, Lori Long, Natasha Bohorova, Do Kim, Michael Pauly, Jesus Velasco, Kevin Whaley, Larry Zeitlin, Stephen J. Garger, Earl White, Yun Bai, Hugh Haydon, Barry Bratcher
PLANT BIOTECHNOLOGY JOURNAL
(2010)
Article
Multidisciplinary Sciences
Barry R. O'Keefe, Fakhrieh Vojdani, Viviana Buffa, Robin J. Shattock, David C. Montefiori, James Bakke, Jon Mirsalis, Anna-Lisa d'Andrea, Steven D. Hume, Barry Bratcher, Carrie J. Saucedo, James B. McMahon, Gregory P. Pogue, Kenneth E. Palmer
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Biotechnology & Applied Microbiology
Jyothi K. Mallajosyula, Ernie Hiatt, Steve Hume, Ashley Johnson, Trushar Jeevan, Rachel Chikwamba, Gregory P. Pogue, Barry Bratcher, Hugh Haydon, Richard J. Webby, Alison A. McCormick
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2014)
Article
Communication
Clay Spinuzzi, David Altounian, Gregory P. Pogue
IEEE TRANSACTIONS ON PROFESSIONAL COMMUNICATION
(2020)
Article
Communication
Clay Spinuzzi, David Altounian, Gregory Pogue, Robert Cochran, Lily Zhu
WRITTEN COMMUNICATION
(2018)
Article
Communication
Clay Spinuzzi, Scott Nelson, Keela S. Thomson, Francesca Lorenzini, Rosemary A. French, Gregory Pogue, Noelle London
WRITTEN COMMUNICATION
(2016)
Proceedings Paper
Computer Science, Theory & Methods
Clay Spinuzzi, Gregory Pogue, R. Scott Nelson, Keela S. Thomson, Francesca Lorenzini, Rosemary A. French, Sidney D. Burback, Joel Momberger
SIGDOC2015: PROCEEDINGS OF THE 33RD ANNUAL INTERNATIONAL CONFERENCE ON THE DESIGN OF COMMUNICATION
(2015)
Review
Medicine, General & Internal
Rafael Baltazar Reyes Leon-Cachon, Jorge Angel Isidro Ascacio-Martinez, Magdalena Gomez-Silva, Everardo Pineyro-Garza, Jose Gerardo Gonzalez-Gonzalez, Gregory Pogues, Laureano Simon-Buela, Hugo Alberto Barrera-Saldana
REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION
(2015)
Article
Communication
Clay Spinuzzi, Scott Nelson, Keela S. Thomson, Francesca Lorenzini, Rosemary A. French, Gregory Pogue, Sidney D. Burback, Joel Momberger
IEEE TRANSACTIONS ON PROFESSIONAL COMMUNICATION
(2014)
Article
Virology
Mark L. Smith, Tina Corbo, Jacqueline Bernales, John A. Lindbo, Gregory P. Pogue, Kenneth E. Palmer., Alison A. McCormick
Article
Immunology
Alison A. McCormick, Tina A. Corbo, Sherri Wykoff-Clary, Long V. Nguyen, Mark L. Smith, Kenneth E. Palmer, Gregory P. Pogue
Article
Biochemical Research Methods
Alison A. McCormick, Tina A. Corbo, Sherri Wykoff-Clary, Kenneth E. Palmer, Gregory P. Pogue
BIOCONJUGATE CHEMISTRY
(2006)
Article
Immunology
Kenneth E. Palmer, Ann Benko, Sarah A. Doucette, Terri I. Cameron, Tiffany Foster, Kathleen M. Hanley, Alison A. McCormick, Michael McCulloch, Gregory P. Pogue, Mark L. Smith, Neil D. Christensen