CHRFAM7A, a human-specific and partially duplicated α 7-nicotinic acetylcholine receptor gene with the potential to specify a human-specific inflammatory response to injury

Merging old and new perspectives on nicotinic acetylcholine receptors

(2014) Roger L. Papke   BIOCHEMICAL PHARMACOLOGY

The Duplicated α7 Subunits Assemble and Form Functional Nicotinic Receptors with the Full-length α7

(2014) Ying Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abandon the Mouse Research Ship? Not Just Yet!

(2014) Marcin F. Osuchowski et al.   SHOCK

Are nicotinic acetylcholine receptors coupled to G proteins?

(2013) Nadine Kabbani et al.   BIOESSAYS

?7 nAChR in Airway Respiratory Epithelial Cells

(2013)   CURRENT DRUG TARGETS

?7 Nicotinic Acetylcholine Receptor Subunit in Angiogenesis and Epithelial to Mesenchymal Transition

(2013)   CURRENT DRUG TARGETS

Association Study of the 2-bp Deletion Polymorphism in Exon 6 of the CHRFAM7A Gene with Idiopathic Generalized Epilepsy

(2013) Agata Rozycka et al.   DNA AND CELL BIOLOGY

Original article A transcript coding for a partially duplicated form of α7 nicotinic acetylcholine receptor is absent from the CD4 + T-lymphocytes of patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)

(2013) Agata Rozycka et al.   FOLIA NEUROPATHOLOGICA

A distinct vagal anti-inflammatory pathway modulates intestinal muscularis resident macrophages independent of the spleen

(2013) Gianluca Matteoli et al.   GUT

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting α-7 Nicotinic Acetylcholine Receptor in the Enteric Nervous System

(2012) Todd W. Costantini et al.   AMERICAN JOURNAL OF PATHOLOGY

Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function

(2012) Koichiro Kawashima et al.   Annals of the New York Academy of Sciences

Analysis of Copy Number Variation in Alzheimer’s Disease: The NIALOAD/ NCRAD Family Study

(2012) Shanker Swaminathan et al.   Current Alzheimer Research

Rethinking inflammation: neural circuits in the regulation of immunity

(2012) Peder S. Olofsson et al.   IMMUNOLOGICAL REVIEWS

Neural reflexes in inflammation and immunity

(2012) Ulf Andersson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The vagus nerve and the inflammatory reflex—linking immunity and metabolism

(2012) Valentin A. Pavlov et al.   Nature Reviews Endocrinology

Nicotinic Acetylcholine Receptor Expression and Susceptibility to Cholinergic Immunomodulation in Human Monocytes of Smoking Individuals

(2012) Esmerij P. van der Zanden et al.   NEUROIMMUNOMODULATION

Analysis of Copy Number Variation in Alzheimer’s Disease in a Cohort of Clinically Characterized and Neuropathologically Verified Individuals

(2012) Shanker Swaminathan et al.   PLoS One

The chimeric gene CHRFAM7A, a partial duplication of the CHRNA7 gene, is a dominant negative regulator of α7*nAChR function

(2011) Tanguy Araud et al.   BIOCHEMICAL PHARMACOLOGY

Nicotine: specific role in angiogenesis, proliferation and apoptosis

(2011) Alessio Cardinale et al.   CRITICAL REVIEWS IN TOXICOLOGY

A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder

(2011) Jillian P. Casey et al.   HUMAN GENETICS

15q11.2–13.3 chromatin analysis reveals epigenetic regulation of CHRNA7 with deficiencies in Rett and autism brain

(2011) Dag H. Yasui et al.   HUMAN MOLECULAR GENETICS

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Investigation of the Molecular Mechanism of the  7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator PNU-120596 Provides Evidence for Two Distinct Desensitized States

(2011) D. K. Williams et al.   MOLECULAR PHARMACOLOGY

Acetylcholine-Synthesizing T Cells Relay Neural Signals in a Vagus Nerve Circuit

(2011) M. Rosas-Ballina et al.   SCIENCE

De Novo Origin of Human Protein-Coding Genes

(2011) Dong-Dong Wu et al.   PLoS Genetics

Vagal nerve stimulation protects against burn-induced intestinal injury through activation of enteric glia cells

(2010) Todd W. Costantini et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Origins, evolution, and phenotypic impact of new genes

(2010) H. Kaessmann   GENOME RESEARCH

Function of Partially Duplicated Human α7 Nicotinic Receptor SubunitCHRFAM7AGene

(2010) Ana M. de Lucas-Cerrillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of the α7 nAChR subunit duplicate form (CHRFAM7A) is down-regulated in the monocytic cell line THP-1 on treatment with LPS

(2010) Roberta Benfante et al.   JOURNAL OF NEUROIMMUNOLOGY

Smoking in adult attention-deficit/hyperactivity disorder: Interaction between 15q13 nicotinic genes and Temperament Character Inventory scores

(2010) Mirko Manchia et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions

(2010) Chuan-Yun Li et al.   PLoS Computational Biology

Efferent Vagal Nerve Stimulation Attenuates Gut Barrier Injury After Burn: Modulation of Intestinal Occludin Expression

(2010) Todd W. Costantini et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

A 2-base pair deletion polymorphism in the partial duplication of the α7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia

(2009) Melissa L. Sinkus et al.   BRAIN RESEARCH

Association between a Genetic Variant of the Alpha-7 Nicotinic Acetylcholine Receptor Subunit and Four Types of Dementia

(2009) Ágnes Fehér et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

CHRFAM7A copy number and 2-bp deletion polymorphisms and antisaccade performance

(2009) Nadine Petrovsky et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Human-Specific Genes May Offer a Unique Window into Human Cell Signaling

(2009) P. D. Stahl et al.   Science Signaling

BURN-INDUCED GUT BARRIER INJURY IS ATTENUATED BY PHOSPHODIESTERASE INHIBITION

(2009) Todd W. Costantini et al.   SHOCK

Targeting the gut barrier: Identification of a homing peptide sequence for delivery into the injured intestinal epithelial cell

(2009) Todd W. Costantini et al.   SURGERY

Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway

(2008) Valentin A. Pavlov et al.   BRAIN BEHAVIOR AND IMMUNITY

Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans

(2008) I Wessler et al.   BRITISH JOURNAL OF PHARMACOLOGY

The copy number variant involving part of the α7 nicotinic receptor gene contains a polymorphic inversion

(2008) Rachel H Flomen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Differentiating nicotine- versus schizophrenia-associated decreases of the α7 nicotinic acetylcholine receptor transcript, CHRFAM7A, in peripheral blood lymphocytes

(2008) Emily G. Severance et al.   JOURNAL OF NEURAL TRANSMISSION

Basic and Clinical Aspects of Non-neuronal Acetylcholine: Biological and Clinical Significance of Non-canonical Ligands of Epithelial Nicotinic Acetylcholine Receptors

(2008) Sergei A. Grando   JOURNAL OF PHARMACOLOGICAL SCIENCES

Origin of Primate Orphan Genes: A Comparative Genomics Approach

(2008) M. Toll-Riera et al.   MOLECULAR BIOLOGY AND EVOLUTION

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(2008) William Parrish et al.   MOLECULAR MEDICINE

Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia

(2008) M. Rosas-Ballina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The alpha7 nicotinic acetylcholine receptor as a pharmacological target for inflammation

(2007) W J Jonge et al.   BRITISH JOURNAL OF PHARMACOLOGY