Article
Medicine, General & Internal
Keiko Tanaka, Hitoshi Sugiyama, Hiroshi Morinaga, Masashi Kitagawa, Yuzuki Kano, Yasuhiro Onishi, Koki Mise, Katsuyuki Tanabe, Haruhito A. Uchida, Jun Wada
Summary: This study found that levels of soluble CD40L and IL-31 were higher in patients with IgA nephropathy, and were significantly associated with higher estimated glomerular filtration rate, lower urinary protein to creatinine ratio, and milder tubulointerstitial lesions (i.e., the early phase of IgA nephropathy). Multivariate analysis showed that serum sCD40L was an independent determinant of a lower urinary protein to creatinine ratio after adjusting for age, estimated glomerular filtration rate, and mean blood pressure. This study demonstrated the significance of serum sCD40L and IL-31 in the early phase of IgA nephropathy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Wenjing Wu, Xiaoqin Wang, Xueqing Yu, Hui-Yao Lan
Summary: Renal inflammation and fibrosis are important pathological features of kidney diseases. Smad3 is a critical mediator in TGF-beta signaling and plays a role in the development of inflammation and fibrosis in the kidney. Smad3 can be activated by various stress molecules and interact with other signaling pathways to mediate these processes. Targeting Smad3 and its downstream genes may provide a new therapeutic strategy for kidney diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fabian Bohlaender, Sabrina Weissmueller, Dennis Riehl, Marcus Gutscher, Joerg Schuettrumpf, Stefanie Faust
Summary: The study aims to investigate the functional aspects of the IgA component in trimodulin, a new plasma-derived polyvalent immunoglobulin preparation, and demonstrates its potent immunomodulatory and anti-pathogenic effects, especially on neutrophil function.
Article
Immunology
Paolo Casali, Shili Li, Grecia Morales, Cassidy C. Daw, Daniel P. Chupp, Amanda D. Fisher, Hong Zan
Summary: IgA is the dominant antibody isotype in intestinal mucosae and dysregulation of its production can lead to diseases. MiR-146a plays a role in modulating CSR to IgA by targeting Smad2, Smad3, and Smad4 in B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Melissa S. Cobb, Shixin Tao, Katherine Shortt, Magdy Girgis, Jeryl Hauptman, Jill Schriewer, Zaphrirah Chin, Edward Dorfman, Kyle Campbell, Daniel P. Heruth, Ralph V. Shohet, Buddhadeb Dawn, Eugene A. Konorev
Summary: Many anticancer therapies cause cardiovascular complications, especially doxorubicin which leads to cardiomyopathy. This study shows that endothelial cells accumulate more doxorubicin than other cardiac cell types and that the TGF-beta/Smad3 pathway plays a critical role in cardiac damage caused by doxorubicin.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Plant Sciences
Xiao-Zhou Zou, Yi-Wen Zhang, Zong-Fu Pan, Xiao-Ping Hu, Yin-Ning Xu, Zhong-Jie Huang, Zhi-Yong Sun, Meng-Nan Yuan, Jia-Na Shi, Ping Huang, Ting Liu
Summary: This study investigated the cardioprotective role of Gentiopicroside (GPS) in rats with type 2 diabetes mellitus (T2DM) and its underlying mechanism. The results showed that GPS improved cardiac function in T2DM rats and attenuated inflammation and fibrosis by inhibiting the phosphorylation of Smad3.
Article
Immunology
Sonia Kiran, Mousumi Mandal, Ahmed Rakib, Amandeep Bajwa, Udai P. Singh
Summary: This study investigates the role and mechanism of miR-10a-3p in adipose inflammation and adipogenesis using ex vivo and in vitro approaches. The findings suggest that miR-10a-3p mimic reduces the expression of inflammatory cells and cytokines, and induces the expression of FoxP3 in adipose tissue. In vitro experiments also show that miR-10a-3p mimic reduces the expression of inflammatory genes and lipid accumulation. This study provides a new opportunity for the development of miR-10a-3p as a novel therapeutic for adipose inflammation and its associated metabolic disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Yanlin Zou, Cao Yu, Qian Huang, Xiaorong Tan, Xiaoyan Tan, Xiaolong Zhu, Dongyang Yi, Jingxin Mao
Summary: This study aimed to identify the most effective fraction of Nanocnide lobata in the treatment of burn and scald injuries and determine its bioactive constituents. Chemical identification methods were used to analyze the chemical constituents of Nanocnide lobata extracts, and UPLC-MS analysis revealed the presence of 39 main compounds. The results showed that the petroleum ether extract and volatile oil compounds of Nanocnide lobata might be effective drugs in the treatment of burn and scald injuries by reducing inflammation, promoting wound healing, and reducing scar tissue proliferation.
Article
Environmental Sciences
Naresh Singh, Naveen Arora
Summary: The study found that exposure to diesel exhaust in mice led to lung injury and pulmonary fibrosis, as evidenced by impaired lung function, cellular infiltration, inflammation, thickening of the alveolar wall, and tissue remodeling. The involvement of the TGF-beta/SMAD3 pathway and activation of EMT in diesel exhaust-exposed mice was demonstrated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Food Science & Technology
Hrvoje Urlic, Marko Kumric, Goran Dujic, Josip Vrdoljak, Daniela Supe-Domic, Zeljko Dujic, Josko Bozic
Summary: This study investigated the anti-inflammatory effects of CBD in hypertensive patients and found that oral CBD administration significantly reduced serum concentrations of IL-8, IL-10, and IL-18. Higher baseline levels of IL-8 and IL-10 predicted greater reduction in diastolic blood pressure, and the extent of reduction in IL-8 and IL-10 serum levels correlated with the extent of reduction in diastolic blood pressure.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Cell Biology
Lisa Perruzza, Francesco Strati, Matteo Raneri, Hai Li, Giorgio Gargari, Tanja Rezzonico-Jost, Martina Palatella, Ivo Kwee, Diego Morone, Frauke Seehusen, Paolo Sonego, Claudio Donati, Pietro Franceschi, Andrew J. Macpherson, Simone Guglielmetti, Victor Greiff, Fabio Grassi
Summary: This study demonstrates that hydrolysis of extracellular ATP by apyrase results in amplification of the SIgA repertoire, influencing the distribution of bacteria and gene expression in the intestinal epithelium in mice. Apyrase-induced SIgA improves intestinal homeostasis, attenuating barrier impairment and susceptibility to infection.
Article
Biochemistry & Molecular Biology
Asmaa Oun, Emmy Hoeksema, Ahmed Soliman, Famke Brouwer, Fabiola Garcia-Reyes, Henderikus Pots, Marina Trombetta-Lima, Arjan Kortholt, Amalia M. Dolga
Summary: Dysfunction of the immune system and mitochondrial metabolism is associated with Parkinson's disease (PD) pathology. Mutations and increased kinase activity of leucine-rich repeat kinase 2 (LRRK2) are linked to both idiopathic and familial PD. However, the function of LRRK2 in immune cells under inflammatory conditions is contradictory.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Richard A. Strugnell
Summary: IgA deficiency is a common immunodeficiency disease that affects a significant number of individuals. Recent studies have shown that the removal of secretory IgA can have subtle inflammatory consequences, suggesting a potential role for the excretory immune system in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychiatry
Yiyue Yang, Kaiqi Gu, Changyang Meng, Jia Li, Qiao Lu, Xiaobo Zhou, Deping Yan, Dongxiao Li, Changzhen Pei, Yue Lu, Shenglan Ran, Jing Li
Summary: There is a relationship between sleep and inflammatory factors, and the quality of sleep in MDD patients is associated with specific inflammatory factors. Poor sleep quality is negatively correlated with IL-2 and IL-8 levels, and positively correlated with IL-6, IL-10, CRP, TNF-alpha, CXCL-1, CXCL-2, and IFN-gamma levels.
PSYCHIATRY RESEARCH
(2023)
Article
Rheumatology
Liliana F. Mellor, Nuria Gago-Lopez, Latifa Bakiri, Felix N. Schmidt, Bjorn Busse, Simon Rauber, Maria Jimenez, Diego Megias, Sergio Oterino-Soto, Ricardo Sanchez-Prieto, Sergei Grivennikov, Xinzhu Pu, Julia Oxford, Andreas Ramming, Georg Schett, Erwin F. Wagner
Summary: Keratinocyte-derived S100A9 plays a regulatory role in psoriatic skin and joint disease. In addition, S100A9 and CP have the potential to serve as biomarkers for identifying Ps patients at risk of developing PsA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Nutrition & Dietetics
Abrar E. Al-Shaer, Jennifer Regan, Nicole Buddenbaum, Sonum Tharwani, Catie Drawdy, Madeline Behee, Selin Sergin, Jenifer Fenton, Krishna Rao Maddipati, Shawn Kane, Erik Butler, Saame Raza Shaikh
Summary: A marine oil supplement can increase the concentrations of specific specialized pro-resolving mediators (SPMs) and their metabolic intermediates in adults with obesity, which may be beneficial for controlling inflammation in obesity. However, further studies are needed to determine if increased concentrations of specific SPMs can control the resolution of inflammation in humans with obesity.
JOURNAL OF NUTRITION
(2022)
Article
Public, Environmental & Occupational Health
Ruth A. Pobee, Jenifer Fenton, Alla Sikorskii, Sarah K. Zalwango, Isabella Felzer-Kim, Ilce M. Medina, Bruno Giordani, Amara E. Ezeamama
Summary: This study aimed to quantify the relationship between PUFA (polyunsaturated fatty acids) and linear growth in children aged 6-10 years. The results showed that low levels of SFA (saturated fatty acids), Mead acid, total n-9, and the triene-to-tetraene ratio predicted better growth over 12 months. On the other hand, low levels of LA (linoleic acid) and total PUFA (the sum of total n-3, total n-6, and Mead acid) predicted growth deficits over the 12-month follow-up, regardless of HIV status.
PUBLIC HEALTH NUTRITION
(2022)
Article
Nutrition & Dietetics
Chen Du, Mary Adjepong, Megan Chong Hueh Zan, Min Jung Cho, Jenifer Fenton, Pao Ying Hsiao, Laura Keaver, Heesoon Lee, Mary-Jon Ludy, Wan Shen, Winnie Chee Siew Swee, Jyothi Thrivikraman, Felicity Amoah-Agyei, Emilie de Kanter, Wenyan Wang, Robin M. Tucker
Summary: The study explores the complex relationships among perceived stress, maladaptive eating behaviors, sleep quality, dietary risk, and BMI among university students. The findings suggest that interventions targeting uncontrolled and emotional eating, as well as improving sleep quality, may be beneficial for reducing obesity among students in higher education.
Article
Education, Scientific Disciplines
Tyler B. Becker, Jenifer I. Fenton, Michele Nikolai, Sarah S. Comstock, Jeffrey G. Swada, Lorraine J. Weatherspoon, Robin M. Tucker
Summary: The COVID-19 pandemic has disrupted higher education institutions and caused changes in student academic-related behaviors. Issues in problem-solving skills, grades, time management, attendance, and interpersonal communication have been observed. HEIs should make modifications to course content and delivery to address these deficiencies and improve student success.
ADVANCES IN PHYSIOLOGY EDUCATION
(2022)
Article
Biochemistry & Molecular Biology
Rafia Virk, Nicole Buddenbaum, Abrar Al-Shaer, Michael Armstrong, Jonathan Manke, Nichole Reisdorph, Selin Sergin, Jenifer I. Fenton, E. Diane Wallace, Brandie M. Ehrmann, Hannah B. Lovins, Kymberly M. Gowdy, M. Ryan Smith, Gregory J. Smith, Samir N. P. Kelada, Saame Raza Shaikh
Summary: Obesity dysregulates pulmonary PUFA metabolism, leading to increased inflammation in the lungs. High-fat diet and genetic model of obesity experiments support this finding. The dysregulation of pathways related to glycerophospholipid metabolism and immunity, including B cell differentiation and signaling, were observed. Computational integration of lipidomic and transcriptomic data identified novel networks between glycerophospholipid metabolism and B cell receptor signaling with specific PUFA-derived pulmonary oxylipins.
JOURNAL OF LIPID RESEARCH
(2022)
Editorial Material
Nutrition & Dietetics
Chen Du, Mary Adjepong, Megan Chong Hueh Zan, Min Jung Cho, Jenifer Fenton, Pao Ying Hsiao, Laura Keaver, Heesoon Lee, Mary-Jon Ludy, Wan Shen, Winnie Chee Siew Swee, Jyothi Thrivikraman, Felicity Amoah-Agyei, Emilie de Kanter, Wenyan Wang, Robin M. Tucker
Article
Food Science & Technology
Lucas Krusinski, Isabella C. F. Maciel, Selin Sergin, Travis Goeden, Jeannine P. Schweihofer, Sukhdeep Singh, Jason E. Rowntree, Jenifer I. Fenton
Summary: This study compared the effects of different diets and breeds on the nutritional profile of beef. The results showed that grass-fed beef had higher levels of certain fatty acids, iron, and vitamin E, while breed had an influence on specific acids and micronutrients. However, there was no interaction between diet and breed.
Article
Food Science & Technology
Selin Sergin, Vijayashree Jambunathan, Esha Garg, Jason E. Rowntree, Jenifer I. Fenton
Summary: The study demonstrated that using GFB by-products to feed pasture-raised hens in the US can significantly improve the nutrient profile and antioxidant properties of eggs. Eggs from hens supplemented with GFB by-products had higher levels of beneficial fatty acids and reduced agricultural waste.
Article
Food Science & Technology
Lucas Krusinski, Isabella C. F. Maciel, Selin Sergin, Vijayashree Jambunathan, Esha Garg, Andrea J. Garmyn, Sukhdeep Singh, Chad A. Bitler, Jason E. Rowntree, Jenifer I. Fenton
Summary: The study investigated the effects of supplemental feeds on the nutritional profile of grass-finished beef and found that different feeds had different impacts on the beef’s nutritional characteristics. Beef from cows fed with grass and hay had the most beneficial nutritional profile, while soybean hulls increased the n-6:n-3 ratio of the beef.
Article
Biochemistry & Molecular Biology
Christine E. Psaltis Matthews, Lynn A. Fussner, Michael Yaeger, Jim J. Aloor, Sky W. Reece, Brita J. Kilburg-Basnyat, Sanjay Varikuti, Bin Luo, Morgan Inks, Selin Sergin, Cameron A. Schmidt, P. Darrell Neufer, Edward Ross Pennington, Kelsey H. Fisher-Wellman, Saiful M. Chowdhury, Michael B. Fessler, Jenifer I. Fenton, Ethan J. Anderson, Saame Raza Shaikh, Kymberly M. Gowdy
Summary: Prohibitins are proteins that play important roles in signaling, transcription, and multiple other cell functions. The specific role of prohibitins in macrophage lipid rafts and associated inflammation signaling is unknown. In this study, prohibitin knockdown macrophages were generated and analyzed to evaluate their responses to lipopolysaccharide and tumor necrosis factor-alpha. The results indicate a novel role of prohibitins in macrophage inflammatory signaling through regulation of fatty acid composition and lipid raft formation.
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2023)
Article
Nutrition & Dietetics
Jorem E. Awadu, Bruno Giordani, Alla Sikorskii, Catherine Abbo, Jenifer I. Fenton, Sarah Zalwango, Amara Esther Ezeamama
Summary: The study tested the hypothesis that vitamin D deficiency is associated with a higher probability of developmental disorders in children with perinatal HIV infection. The results showed that vitamin D deficiency was positively associated with the probability scores of autism, ADHD, emotional behavioral disorder, and functional impairment, and this relationship was dependent on developmental stage.
Review
Nutrition & Dietetics
Vanessa N. Cardino, Travis Goeden, William Yakah, Amara E. Ezeamama, Jenifer I. Fenton
Summary: Malnutrition is commonly diagnosed based on abnormal anthropometric parameters related to protein energy malnutrition (PEM), but other contributors such as essential fatty acid deficiency (EFAD) are often overlooked. Previous studies in high-income countries (HICs) have shown that EFAD, characterized by deficiencies in essential fatty acids and their byproducts (HUFAs), can lead to abnormal growth and impaired cognitive development. This review emphasizes the importance of measuring endogenous fatty acid levels to assess fatty acid intake and highlights the potential of EFAD and HUFA scores as biomarkers for overall health and normal development in low-middle-income countries (LMICs).
Article
Nutrition & Dietetics
Mary Amoako, Felicity Amoah-Agyei, Chen Du, Jenifer I. Fenton, Robin M. Tucker
Summary: This cross-sectional study examined emotional eating, uncontrolled eating, and restrained eating behaviors in a population of Ghanaian university students. The study found that emotional eating was associated with BMI in males and anxiety and sleep quality in females. Overweight and obese females had higher emotional eating scores compared to healthy weight females.
Article
Food Science & Technology
Lucas Krusinski, Isabella C. F. Maciel, Stephan van Vliet, Muhammad Ahsin, Guanqi Lu, Jason E. Rowntree, Jenifer I. Fenton
Summary: Grass-finished beef contains higher levels of beneficial bioactive compounds, such as n-3 polyunsaturated fatty acids, micronutrients, and phytochemicals, compared to grain-finished beef. The composition of phytochemicals and fatty acids in meat can predict the feeding methods of cattle.
Article
Environmental Sciences
Mary Amoako, Felicity Amoah-Agyei, Gideon Okyere Mensah, Chen Du, Selin Sergin, Jenifer I. Fenton, Robin M. Tucker
Summary: This study aimed to assess the effects of the COVID-19 pandemic on the health behaviors of Ghanaian tertiary students. The findings showed that the pandemic had a negative impact on students' health behaviors, including dietary intake, sleep quality and duration, alcohol consumption, and exercise frequency. Additionally, shorter sleep duration was associated with higher scores of alcohol misuse.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)