Article
Environmental Sciences
Ping-Kun Tsai, Shih-Pin Chen, Rosa Huang-Liu, Chun-Jung Chen, Wen-Ying Chen, Yan-Yan Ng, Yu-Hsiang Kuan
Summary: The study revealed that 1-NP induces a proinflammatory response through activation of the NF-kappa B pathway via Akt phosphorylation. This suggests that 1-NP triggers inflammation via the NF-kappa B pathway.
Article
Immunology
Miguel A. Zarate, Robyn K. De Dios, Durganili Balasubramaniyan, Lijun Zheng, Laura G. Sherlock, Paul J. Rozance, Clyde J. Wright
Summary: The study shows that intrauterine growth restriction (IUGR) has a negative impact on neonatal immunity, leading to a weakened acute inflammatory response to inflammatory stimuli.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Baojiang Wang, Yueyuan Qin, Qunyan Wu, Xi Li, Dongying Xie, Zhongying Zhao, Shan Duan
Summary: This study reports elevated levels of the proinflammatory chemokine CCL5 in children with Autism Spectrum Disorder (ASD), suggesting an abnormal inflammatory response in the development of ASD. The study also reveals that the mTOR signaling pathway is aberrantly activated in ASD patients and that suppression of mTOR reduces the expression of CCL5. Further analysis shows that NF-kappa B plays a determining role in upregulating CCL5 expression, but there is no direct regulatory relationship between NF-kappa B and the mTOR signaling pathway. The study suggests that the activation of mTOR signaling in ASD may induce the suppression of phosphorylation of CREB, leading to increased binding of CREBBP to NF-kappa B and thus driving the expression of CCL5.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sabrina Giantulli, Elisabetta Tortorella, Francesco Brasili, Susanna Scarpa, Barbara Cerroni, Gaio Paradossi, Angelico Bedini, Stefania Morrone, Ida Silvestri, Fabio Domenici
Summary: Keratinocytes, the main cell type of the skin, are highly exposed to environmental factors and play a crucial role in immune response by releasing inflammatory cytokines such as IL-6. Research suggests that low intensity ultrasound can induce the release of IL-6 while also impacting cell viability and membrane permeability.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Keyvan Amirshahrokhi, Mahsa Imani
Summary: This study aimed to investigate the potential protective effect of the antiepileptic drug levetiracetam against ulcerative colitis (UC) in mice. The results showed that levetiracetam can alleviate colonic mucosal injury in UC mice, promote antioxidant responses, reduce lipid peroxidation and myeloperoxidase activity, decrease inflammatory mediator expression, and increase anti-inflammatory cytokine levels.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Rajendra Sangaraju, Sateesh Alavala, Nasiruddin Nalban, Mahesh Kumar Jerald, Ramakrishna Sistla
Summary: The study demonstrated that galangin (GAL) has a significant protective effect on skin inflammation induced by psoriasis-like symptoms, possibly through modulation of inflammatory pathways and oxidative stress. Galangin also regulated protein levels and antioxidant markers, showing potential for treating psoriasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Theodomir Dusabimana, Jihyun Je, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: This study revealed the crucial role of GOLPH3 in the development and progression of acute liver and kidney injury induced by endotoxemia. Upregulation of GOLPH3 was associated with high morbidity and mortality. Knockdown of GOLPH3 alleviated cellular stress response and inflammatory reaction, leading to the recovery of Golgi morphology and function. These findings suggest GOLPH3 as a potential therapeutic target for endotoxemia-induced tissue injury.
CELL DEATH & DISEASE
(2023)
Article
Integrative & Complementary Medicine
Xiaojuan Yang, Yun Liu, Chao Zhong, Jia Hu, Song Xu, Ping Zhang, Ling He
Summary: Total flavonoids of Chrysanthemum indicum L (TFC) can suppress the development of acute pancreatitis by inhibiting inflammation and apoptosis. The study demonstrated that TFC can inhibit acute pancreatitis by restraining serum amylase, myeloperoxidase, water content of pancreatic tissue, inflammation levels, apoptosis, and NF-kappa B signaling pathway activation. This research provides insight into the potential inhibition mechanism of TFC in acute pancreatitis development.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Immunology
Justyna Smialek, Monika Bzowska, Alicja Hinz, Renata Mezyk-Kopec, Kamilla Soltys, Pawel Mak
Summary: The study shows that BacSp222 and its succinylated forms can effectively induce nitric oxide production and iNOS expression in macrophage-like cells, while promoting the secretion of certain cytokines in neutrophils. However, these bacteriocin forms do not induce reactive oxygen species production or NETs formation in neutrophils.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Environmental Sciences
Hao-Min Wu, Chen-Yu Chiang, Wen-Ying Chen, Chun-Jung Chen, Ching-Chi Tseng, Yu-Chi Chang, Wen-Min Cheng, Yu-Hsiang Kuan
Summary: Cyclizine exhibits sedation and treatment of nausea, vomiting, and motion sickness due to its antihistaminic and antimuscarinic effects. However, it has the potential for abuse due to its hallucinogenic and euphoric effects. Overdose and illegal abuse of Cyclizine can result in confusion, tremors, chest pain, ataxia, seizures, and even suicide.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bingyu Shen, Haoqing Zhang, Zhengjin Zhu, Zixi Ling, Fangyuan Zeng, Yazhou Wang, Jianguo Wang
Summary: Baicalin, extracted from Scutellaria, has anti-inflammatory effects and can reduce pulmonary edema caused by ALI. It inhibits the expression of TLR4 and MyD88, leading to a decrease in inflammatory molecules. Baicalin also promotes an increase in white blood cells and improves lung pathology, indicating its potential as a treatment for ALI.
Article
Biochemistry & Molecular Biology
Zeming Chen, Runzhui Lin, Hua Zhuo, Fengjie Xu, Xingmu Liu
Summary: This study investigated the role of IVIG in hepatic I/R in a rat model, showing that IVIG can alleviate hepatic I/R injury by inhibiting the classical NF-kappa B signaling pathway, reducing inflammatory cytokines release and cell apoptosis.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Monia Porpora, Mariangela Conte, Giuliana Lania, Claudia Bellomo, Luciano Rapacciuolo, Fernando Gabriel Chirdo, Renata Auricchio, Riccardo Troncone, Salvatore Auricchio, Maria Vittoria Barone, Merlin Nanayakkara
Summary: Celiac disease (CD) is a chronic inflammatory disease caused by a genetic predisposition to an abnormal T cell-mediated immune response to gluten in the diet. This study aimed to investigate the role of enterocytes in CD intestinal inflammation and their response to proinflammatory factors such as gliadin and viruses. The findings suggest that CD enterocytes have constitutive inflammation and are more sensitive to inflammatory stimuli.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Wen-Ching Shen, Yu-Hsiang Chou, Li-Shian Shi, Zhi-wei Chen, Hai-Jian Tu, Xin-yi Lin, Guei-Jane Wang
Summary: The study demonstrates that AST-120 treatment can alleviate kidney and heart damage in AKI patients by reducing harmful substance levels in plasma, improving inflammatory responses, and significantly reducing cardiac burden.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wuquan Li, Wentao Zhang, Jun Liu, Yalong Han, He Jiang, Gang Ji, Wenjun Liu
Summary: The study identified that down-regulation of miRNA let-7e attenuated LPS-induced acute lung injury in mice, improved survival rate, and reduced proinflammatory cytokines levels in bronchoalveolar lavage fluid. Let-7e exerts its protective effects through regulation of SOCS1/NF-kappa B pathway, suggesting it as a potential therapeutic target for ALI.
BIOSCIENCE REPORTS
(2021)
Article
Cell Biology
Irene Paterniti, Alessia Filippone, Irina Naletova, Valentina Greco, Sebastiano Sciuto, Emanuela Esposito, Salvatore Cuzzocrea, Enrico Rizzarelli
Summary: Spinal cord injury (SCI) can cause severe motor dysfunction and nervous system abnormalities. The conjugation of trehalose with l-carnosine (Tre-car) has been found to reduce inflammation in vitro and in vivo models of SCI. Tre-car decreased early inflammatory effects, oxidative stress, and apoptosis, and stimulated the release of neurotrophic factors and influenced Zn2+ homeostasis. Tre-car may be a promising therapeutic agent for treating SCI.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Andrea Duranti, Francesco Monaco, Rosalba Siracusa, Roberta Fusco, Daniela Impellizzeri, Ramona D'Amico, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Idiopathic pulmonary fibrosis (IPF), a deadly lung condition, worsens over time and has no known cause. Traditional treatments for IPF, such as corticosteroids and immunomodulatory drugs, often have noticeable side effects and are not very effective. By inhibiting the fatty acid amide hydrolase (FAAH) enzyme, which breaks down endocannabinoids, it is possible to increase the levels of these natural pain-relieving compounds and reduce inflammation. In our study, we used a bleomycin-induced IPF model and found that administering URB878, an FAAH inhibitor, reduced histological changes, cell infiltration, pro-inflammatory cytokine production, inflammation, and nitrosative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Ylenia Marino, Roberta Fusco, Rosalba Siracusa, Marika Cordaro, Ramona D'Amico, Francesco Macri, Emanuela Raffone, Daniela Impellizzeri, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The study investigated the beneficial effects of fisetin, a naturally occurring polyphenol, on endometriosis. Fisetin treatment reduced the size and volume of endometriotic implants, as well as histological alterations and inflammatory responses. It also decreased markers of oxidative stress and increased apoptosis in endometrial lesions. Fisetin may represent a potential therapeutic strategy for endometriosis by targeting inflammatory pathways and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alessia Arangia, Ylenia Marino, Daniela Impellizzeri, Ramona D'Amico, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: The phytoconstituents in the Mediterranean diet (MD) have been extensively studied for their beneficial effects on human health. Olive oil, a key component of the MD, has been particularly investigated due to its high content of hydroxytyrosol (HT), which possesses protective properties in various chronic disorders, including intestinal and gastrointestinal diseases. However, there is currently no comprehensive review summarizing the role of HT in these disorders. This review provides an overview of the anti-inflammatory and antioxidant properties of HT against intestinal and gastrointestinal diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Gianluca Antonio Franco, Livia Interdonato, Marika Cordaro, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: Neurodegenerative disorders are characterized by neuroinflammation, oxidative stress, and neuronal depletion, and there is currently no cure for these diseases. The Mediterranean diet, rich in antioxidants and omega-3 fatty acids, may have a protective effect on neurodegeneration. This review focuses on the therapeutic potential of natural products and the associations between the Mediterranean-style diet, neurodegenerative diseases, and markers and mechanisms of neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Alessio Ardizzone, Valentina Bova, Giovanna Casili, Alberto Repici, Marika Lanza, Raffaella Giuffrida, Cristina Colarossi, Marzia Mare, Salvatore Cuzzocrea, Emanuela Esposito, Irene Paterniti
Summary: Cancer, the leading cause of death worldwide, requires successful strategies for treatment. Growth factors like VEGF, bFGF, and TGF-beta play significant roles in tumor growth, activating essential signaling pathways and promoting cell proliferation, angiogenesis, and metastasis. Specifically, bFGF is secreted by tumor cells and interacts with its receptors (FGFRs), leading to tumor cell proliferation, invasion, and upregulation of pro-inflammatory and anti-apoptotic proteins. Studies have focused on developing therapeutic strategies targeting the bFGF/FGFR axis, considering its involvement in oncogenesis. This review comprehensively examines the biological mechanisms of bFGF in the tumor microenvironment, available anticancer therapies targeting FGFRs, and the prognostic value of bFGF.
Article
Cell Biology
Alessia Filippone, Laura Cucinotta, Valentina Bova, Marika Lanza, Giovanna Casili, Irene Paterniti, Michela Campolo, Salvatore Cuzzocrea, Emanuela Esposito
Summary: Moderate traumatic brain injury (mTBI) is associated with emotional dysregulation. This study investigates the role of LRRK2 in reducing depression-related symptoms after mTBI and tests the antidepressant effects of LRRK2 inhibition by PF-06447475. The results show that mTBI promotes the development of depression-like behavior, but LRRK2 inhibition reduces histological damage and behavioral disturbances, suggesting an antidepressant effect.
Article
Biochemistry & Molecular Biology
Marco Calapai, Luisa Puzzo, Giuseppe Bova, Daniele Alfio Vecchio, Rosario Blandino, Alessia Barbagallo, Ilaria Ammendolia, Luigi Cardia, Maria De Pasquale, Fabrizio Calapai, Emanuela Esposito, Fabio Trimarchi, Debora Di Mauro, Gioacchino Calapai, Carmen Mannucci
Summary: The aim of this study was to evaluate the effects of physical activity on chronic pain in post-mastectomy women. The results showed that adequate physical activity can reduce pain intensity and interference, and is associated with a reduction in blood biomarkers of inflammation.
Article
Biochemistry & Molecular Biology
Alessio Ardizzone, Alberto Repici, Anna Paola Capra, Federica De Gaetano, Valentina Bova, Giovanna Casili, Michela Campolo, Emanuela Esposito
Summary: Atopic dermatitis (AD) is a common inflammatory skin disease that mainly affects children. This study evaluated the effects of a cream formulation containing tempol in a murine model of AD. The results demonstrated that tempol reduced histological damage, mast cell infiltration, and improved skin barrier function by restoring tight junctions and filaggrin. Furthermore, tempol modulated inflammation and oxidative stress through the NF-κB/Nrf2 signaling pathways.
Article
Biochemistry & Molecular Biology
Kristian Riolo, Archimede Rotondo, Giovanna Loredana La Torre, Ylenia Marino, Gianluca Antonio Franco, Rosalia Crupi, Roberta Fusco, Rosanna Di Paola, Sabrina Oliva, Giuseppe De Marco, Domenico Savastano, Salvatore Cuzzocrea, Enrico Gugliandolo, Alessia Giannetto
Summary: In this study, protein hydrolysates (BPHs) produced from black soldier fly larvae were characterized and evaluated for their potential biological activity. The BPHs showed antioxidant activity and could protect cells from oxidative stress. These findings suggest that BPHs could be used as ingredients to promote animal health in feed formulations.
Review
Biochemistry & Molecular Biology
Federica Rey, Clarissa Berardo, Erika Maghraby, Alessia Mauri, Letizia Messa, Letizia Esposito, Giovanna Casili, Sara Ottolenghi, Eleonora Bonaventura, Salvatore Cuzzocrea, Gianvincenzo Zuccotti, Davide Tonduti, Emanuela Esposito, Irene Paterniti, Cristina Cereda, Stephana Carelli
Summary: Oxygen imbalance can have detrimental effects on the brain, leading to various neurological disorders. The dysfunctions caused by oxygen imbalance in neurodegenerative and pediatric neurological disorders result from redox imbalance. This review focuses on the underlying dysfunction in redox and potential therapeutic strategies for these conditions.
Article
Biochemistry & Molecular Biology
Marika Lanza, Laura Cucinotta, Giovanna Casili, Alessia Filippone, Rossella Basilotta, Anna Paola Capra, Michela Campolo, Irene Paterniti, Salvatore Cuzzocrea, Emanuela Esposito
Summary: This study aimed to evaluate the inhibitory effect of Antrodia camphorata (AC) administration on neuroinflammation and oxidative stress in a murine model of Parkinson's disease (PD). The results showed that AC treatment significantly reduced PD-related pathological changes, increased tyrosine hydroxylase expression, reduced alpha-synuclein-positive neurons, restored the myelination process of neurons associated with PD, and attenuated neuroinflammation. Furthermore, AC was able to reduce oxidative stress induced by MPTP injection. This study highlights AC as a potential therapeutic agent for neurodegenerative disorders such as PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ylenia Marino, Ramona D'Amico, Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Francesco Macri, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: This study investigates the molecular mechanisms underlying endometriosis and how they can be modulated by Actaea racemosa (AR). The findings show that AR can reduce the size and histological morphology of the lesions and suppress the disease development through regulating multiple pathways, including cell proliferation, apoptosis, antioxidant, and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Arangia, Agnese Ragno, Marika Cordaro, Ramona D'Amico, Rosalba Siracusa, Roberta Fusco, Francesca Marino Merlo, Antonella Smeriglio, Daniela Impellizzeri, Salvatore Cuzzocrea, Giuseppina Mandalari, Rosanna Di Paola
Summary: The study evaluated the antioxidant and anti-inflammatory effects of almond skin extract (ASE) and found that it inhibited the formation of ROS and apoptosis in vitro, and restored tissue changes and decreased inflammation in an in vivo model. The mechanisms of action could be related to the inhibition of the pro-inflammatory nuclear factor NF-κB and activation of the Nrf2 antioxidant pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Alberto Repici, Alessio Ardizzone, Alessia Filippone, Cristina Colarossi, Marzia Mare, Gabriele Raciti, Deborah Mannino, Salvatore Cuzzocrea, Irene Paterniti, Emanuela Esposito
Summary: Brain tumors are a heterogeneous group of neoplasms affecting populations of all ages. Glioblastoma (GB), the most common primary brain tumor, often leads to death within a few months after diagnosis. Immunotherapy, particularly targeting interleukin 21 (IL-21), appears to be a promising approach to improve the survival rate of GB patients. The review evaluates the potential use of IL-21 and its mechanisms in the progression of GB.