期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 87, 期 2, 页码 237-243出版社
WILEY
DOI: 10.1189/jlb.0909608
关键词
cytotoxic lymphocyte; natural killer cell; familial hemophagocytic lymphohistiocytosis
A pore-forming protein, PRF, and serine proteases, Grz, are key effector molecules of CL. These toxins are stored within secretory granules, which exocytose their contents in response to immune synapse formation between the CL and virus-infected or transformed target cell. There, PRF and Grz synergize to induce various apoptotic death pathways and to maintain immune homeostasis. Mechanistic aspects of the synergy and apoptotic mechanisms are still not fully understood, and the current review will address some of the hotly debated controversies in the field. J. Leukoc. Biol. 87: 237-243; 2010.
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