期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 86, 期 3, 页码 617-623出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.0908581
关键词
chemokines; DAMP; danger signals; stem cells; tissue repair
资金
- Associazione Italiana Ricerca sul Cancro
- Ministero dell'Universita e Ricerca
- Association for International Cancer Research
HMGB1 is a nuclear protein that signals tissue damage, as it is released by cells dying traumatically or secreted by activated innate immunity cells. Extracellular HMGB1 elicits the migration to the site of tissue damage of several cell types, including inflammatory cells and stem cells. The identity of the signaling pathways activated by extracellular HMGB1 is not known completely: We reported previously that ERK and NF-kappa B pathways are involved, and we report here that Src is also activated. The ablation of Src or inhibition with the kinase inhibitor PP2 blocks migration toward HMGB1. Src associates to and mediates the phosphorylation of FAK and the formation of focal adhesions. J. Leukoc. Biol. 86: 617-623; 2009.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据