Review
Immunology
Naomi Benne, Danielle ter Braake, Arie Jan Stoppelenburg, Femke Broere
Summary: This article discusses the strategy of using nanoparticles to deliver antigens and restore immune tolerance. It highlights potential cell targets and application methods for nanoparticles, as well as how nanoparticles carrying immunomodulators can activate tolerance in other antigen-presenting cell types. It also emphasizes the importance of considering relevant factors when translating animal studies to clinical applications.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jeffrey A. Bluestone, Brent S. McKenzie, Joshua Beilke, Fred Ramsdell
Summary: Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and preventing various immune-related diseases. They are able to develop in both the thymus and peripheral tissues through the expression of a transcription factor called FOXP3. Treg cells exert their tolerogenic effects by using multiple mechanisms, such as producing inhibitory cytokines, suppressing T effector cells, and modulating antigen-presenting cell function. Recently, there has been a focus on genetically engineering Treg cells to enhance their therapeutic potential, leading to ongoing clinical trials. This review highlights the advancements and challenges in harnessing Treg cells as a new approach for treating diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ting-Ting Sheu, Bor-Luen Chiang
Summary: This review discusses the critical role of immune homeostasis in defending against pathogens and preventing self-reactivity, as well as how defects in this system can lead to autoimmune diseases. It emphasizes the significance of lymphopenia and lymphopenia-induced proliferation in normal and autoimmune conditions, highlighting their importance in autoimmune diseases. The review also underscores the crucial role of regulatory T cells in autoimmune conditions, positioning them as key therapeutic targets for autoimmunity treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Andres Paris-Munoz, Gonzalo Aizpurua, Domingo F. Barber
Summary: This study revealed the absence of CD8(+) regulatory T cells in two lupus-prone mouse models, MRL/MPJ and MRL/lpr, compared to a non-prone mouse strain, C57BL/6. The findings suggest that Helios plays a regulatory role in the pathogenesis of lupus and its expression profile is altered in other relevant T cell populations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Achia Khatun, Xiaopeng Wu, Fu Qi, Kexin Gai, Arjun Kharel, Matthew R. Kudek, Lisa Fraser, Ashley Ceicko, Moujtaba Y. Kasmani, Amber Majnik, Robert Burns, Yi-Guang Chen, Nita Salzman, Elizabeth J. Taparowsky, Dayu Fang, Calvin B. Williams, Weiguo Cui
Summary: Regulatory T cells (Tregs) are crucial in preventing harmful immune responses. The transcription factor FOXP3 is essential for Treg function, which is divided into resting (rTregs) and activated (aTregs) subsets. The differentiation and homeostasis of aTregs rely on continuous T cell receptor (TCR) signaling. This study investigates the role of BATF in Treg stability and reveals that BATF is necessary for Treg differentiation, homeostasis, and stabilization of FOXP3 expression. BATF directly regulates Treg-specific genes and epigenetically controls the Foxp3 locus. It highlights BATF as a potential therapeutic target for autoimmune diseases.
Review
Immunology
Erin Strachan, Xavier Clemente-Casares, Sue Tsai
Summary: Maternal influences on the immune health and development of an infant begin in utero and continue after birth, shaping and educating the child's immune system. Two important provisions from the mother include early microbial colonizers and the transfer of antibodies. These provisions help educate the developing neonatal immune system, connecting with the microbiota and influencing disease development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kai Yang
Summary: Regulatory T cells (Tregs) play important roles in immune regulation, and cellular metabolism is crucial for their function. Tregs reprogram cellular metabolic programs to sustain their suppressive function, and altered metabolism also influences Treg activation and function. Manipulation of systemic metabolites has emerged as an attractive strategy to modulate tissue Treg metabolism and improve treatment of immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ranjeny Thomas, Jose M. Carballido, Johnna D. Wesley, Simi T. Ahmed
Summary: Antigen-specific immunotherapy shows promise for treating type 1 diabetes, but faces obstacles in clinical translation. The key to overcoming these challenges lies in collaboration and cooperation among various stakeholders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Antoine Freuchet, Apolline Salama, Severine Bezie, Laurent Tesson, Severine Remy, Romain Humeau, Hadrien Regue, Celine Serazin, Lea Flippe, Part Peterson, Nadege Vimond, Claire Usal, Severine Menoret, Jean-Marie Heslan, Franck Duteille, Frederic Blanchard, Magali Giral, Marco Colonna, Ignacio Anegon, Carole Guillonneau
Summary: This study highlights the crucial role of IL-34 in immune homeostasis and CD4(+) Treg suppressive function. The study also demonstrates the therapeutic potential of IL-34 in human transplantation and autoimmunity.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Elena Gianchecchi, Domenico V. Delfino, Alessandra Fierabracci
Summary: Autoimmune diseases have a multifactorial pathogenesis and the involvement of natural killer (NK) cells has been highlighted in shaping immune responses. Aberrant number and functionality of NK cells have been reported in various autoimmune disorders, indicating their potential as markers for disease activity and therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Igor Kudryavtsev, Yulia Zinchenko, Anna Starshinova, Maria Serebriakova, Anna Malkova, Tatiana Akisheva, Dmitriy Kudlay, Anzhela Glushkova, Piotr Yablonskiy, Yehuda Shoenfeld
Summary: This study aimed to evaluate the distribution and disturbance of circulating Treg cell subsets in patients with sarcoidosis. The results showed a decrease in the absolute numbers of Treg cells and several alterations in Treg cell subsets in patients with sarcoidosis. These findings suggest that the balance of Treg cell populations could be used for the diagnosis and prognosis of sarcoidosis.
Review
Cell Biology
Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Summary: T regulatory cell therapy offers a new approach for treating autoimmune diseases and transplantation. CD8(+) Treg cells, particularly the CD8(+)CD28(-) subset, have been shown to be effective in preclinical models, although their impaired functionality in disease limits their effectiveness in immunosuppression. The review focuses on harnessing CD8(+) Treg cell therapy in clinical settings to aid current treatments for autoimmune and inflammatory conditions.
Review
Immunology
Nick Giannoukakis
Summary: Tolerogenic dendritic cells (tDC) have the potential to prevent the progression of autoimmune-driven dysglycemia into insulin-requiring type 1 diabetes (T1D) and preserve β cells. tDC act via multiple layers of immune regulation to suppress effector lymphocytes targeting β cells. It is now appropriate to conduct phase II clinical trials for T1D using well-characterized tDC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Kathrin L. L. Braband, Tamara Kaufmann, Stefan Floess, Mangge Zou, Jochen Huehn, Michael Delacher
Summary: Regulatory T cells in non-lymphoid tissues play a critical role in maintaining self-tolerance, promoting organ homeostasis, and tissue repair. This review summarizes recent research on the differentiation of tissue Treg cells and highlights the importance of epigenetic remodeling in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Takashi Sekiya
Summary: This review investigates the role of Nr4a factors in regulating Treg cell activities in both lymphoid organs and tumor environments, highlighting the commonalities and differences in their behaviors between Treg cells in these two different environments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Scott Best, Vi Lam, Tingting Liu, Nur Bruss, Adam Kittai, Olga V. Danilova, Susan Murray, Allison Berger, Nathan D. Pennock, Evan F. Lind, Alexey V. Danilov
Summary: Novel targeted agents in lymphoid malignancies therapy have complex immune effects, particularly through modulation of NF-kappa B signaling and T-cell function by targeting NEDD8-activating enzyme. This approach may offer potential therapeutic benefits by altering the immune response and tumor microenvironment.
Article
Oncology
Alexandra Q. Bartlett, Nathan D. Pennock, Alex Klug, Pepper Schedin
Summary: This study discusses the mechanisms of breast cancer cells invading the liver and forming metastatic niches. The research found that the process of liver involution increases liver metastasis, which is associated with unique immunological properties in the involuting liver.
Article
Biochemistry & Molecular Biology
Qiuchen Guo, Duanchen Sun, Alexander S. Barrett, Sonali Jindal, Nathan D. Pennock, Matthew W. Conklin, Zheng Xia, Elizabeth Mitchell, Ravikant Samatham, Naomi Mirza, Steven Jacques, Sheila Weinmann, Virginia F. Borges, Kirk C. Hansen, Pepper J. Schedin
Summary: Mammographically-detected breast density has an impact on breast cancer risk and progression, and the presence of fibrillar collagen plays a crucial role in breast density. This study investigated the physiological factors influencing collagen production in the breast. Through the analysis of gene expression in female rats, the study revealed a triphasic pattern of collagen gene regulation and reproductive state-dependent composition. The findings were confirmed in human breast tissue from premenopausal women. The study also found a correlation between the collagen gene signature and poor progression-free survival in breast cancer patients. These findings contribute to a better understanding of normal breast function, the etiology of breast density, and breast cancer risk and outcomes.
Meeting Abstract
Endocrinology & Metabolism
Alyssa J. Shepherd, Martin Yussman, David H. Wagner, Gisela M. Vaitaitis
Meeting Abstract
Endocrinology & Metabolism
David H. Wagner, Gisela M. Vaitaitis
Article
Immunology
Ying Lu, Max Xu, Cayce E. Dorrier, Ray Zhang, Christian T. Mayer, David Wagner, Dorian B. McGavern, Richard J. Hodes
Summary: CD40 plays an essential role in driving autoimmune diseases in the central nervous system (CNS). It orchestrates distinct effector programs in dendritic cells (DCs) and B cells, leading to the activation of pathogenic T cells and the production of disease-causing antibodies, respectively.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Christian Curran, Gisela Vaitaitis, Dan Waid, Timothy Volmer, Enrique Alverez, David H. Wagner
Summary: Treating multiple sclerosis has been challenging, but Ocrelizumab has shown success in treating both chronic relapsing and progressive forms of the disease. In a study, it was found that TH40 cells, which are pathogenic effector T cells, increased in number during the earliest stage of multiple sclerosis (clinically isolated syndrome) and remained expanded in progressive forms of the disease. However, treatment with Ocrelizumab reduced TH40 cell numbers to healthy levels and decreased the production of inflammatory cytokines.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Eunseo Choi, Madeleine Landry, Nathan Pennock, Megan Neufeld, Katherine Weinfurter, Andrea Goforth, Joshua Walker, Conroy Sun
Summary: Recent studies have shown that combination radiotherapy and immunotherapy can improve outcomes. This study explores the use of folate-modified hafnium-based metal-organic frameworks as enhancers for radiotherapy and immune activation. The combination of HfMOF-PEG-FA with imiquimod effectively stimulates the immune response and enhances the antitumor effects of radiotherapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Gisela M. Vaitaitis, David H. Wagner Jr
Summary: CD40 signaling is an important target in autoimmunity. Blocking the CD40-CD154 pathway using monoclonal antibodies during clinical trials led to severe adverse events. A peptide called KGYY15 has shown promise in preventing type 1 diabetes and reversing hyperglycemia by normalizing effector T-cell levels. The peptide also interacts with integrins CD11a/CD18 and CD11b/CD18, complicating our understanding of the inflammatory nexus and how to prevent autoinflammation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Oncology
Xiaoguang Wang, Canping Chen, Dan Vuong, Sonia Rodriguez-Rodriguez, Vi Lam, Carly Roleder, Jing H. Wang, Swetha Kambhampati, Allison Berger, Nathan Pennock, Pallawi Torka, Francisco Hernandez-Ilizaliturri, Tanya Siddiqi, Lili Wang, Zheng Xia, Alexey V. Danilov
Summary: This study demonstrates that the drug pevonedistat, which targets Neddylation, directly affects CD8(+) T cells and enhances their cytotoxicity and anti-tumor activity. It also stimulates an inflammatory response in the T cells, leading to inhibited tumor growth.
Article
Oncology
Sarah M. M. Bernhardt, Elizabeth Mitchell, Stephanie Stamnes, Reuben J. Hoffmann, Andrea Calhoun, Alex Klug, Tanya D. Russell, Nathan D. Pennock, Joshua M. M. Walker, Pepper Schedin
Summary: In breast cancer, tumor cells can rapidly progress to invasive ductal carcinoma (IDC) without going through a non-invasive stage called ductal carcinoma in situ (DCIS). These mouse models that bypass the DCIS stage can aid in the study of IDC without DCIS and the development of immune therapies.
Article
Immunology
Fernanda M. Frank, David H. Wagner Jr, Miriam Postan, Patricia B. Petray
Summary: The CD40/CD40L interaction plays a dual role in Trypanosoma cruzi infection, depending on the timing of treatment initiation. Early treatment with CD40-targeted peptide leads to uncontrolled acute infection and marked tissue damage, while late treatment improves myocardial and skeletal muscle damage.
MICROBIAL PATHOGENESIS
(2023)
Article
Oncology
Vi Lam, Carly Roleder, Tingting Liu, Nur Bruss, Scott Best, Xiaoguang Wang, Tycel Phillips, Geoffrey Shouse, Allison J. Berger, Lapo Alinari, Lili Wang, Tanya Siddiqi, Nathan D. Pennock, Alexey V. Danilov
Summary: This study found that targeting SUMOylation can activate immune response in T cells and enhance the cytotoxic function of CD8 T cells, providing potential for immune therapy targeting SUMOylation in lymphoid malignancies.
MOLECULAR CANCER THERAPEUTICS
(2023)
Meeting Abstract
Oncology
K. C. Ohaegbulam, N. D. Pennock, J. Walker
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
N. D. Pennock, J. Walker
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)