Review
Pharmacology & Pharmacy
Miguel Camba-Gomez, Laura Arosa, Oreste Gualillo, Javier Conde-Aranda
Summary: Despite the benefits of current therapeutic options, there is a need for novel pharmacological targets to improve the treatment of inflammatory bowel disease (IBD). Chemokine and chemokine receptors have emerged as appealing options, as they regulate leukocyte trafficking and other processes related to intestinal inflammation development.
DRUG DISCOVERY TODAY
(2022)
Article
Immunology
Monika Okuliarova, Nikoleta Mazgutova, Miroslava Majzunova, Valentina Sophia Rumanova, Michal Zeman
Summary: Research on the effects of exposure to dim light at night on immune cells and renal immune-related markers in rats reveals that dLAN disrupts the daily variations of circulating immune cells and disturbs renal immune and redox balance. These findings suggest a weakened circadian control and highlight the need for further studies on the impact of dLAN-disturbed immune balance on the immune system's response to other challenges.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Stav Kozlovski, Ofer Regev, Anita Sapoznikov, Marina Kizner, Hagit Achdout, Ekaterina Petrovich-Kopitman, Jacob Elkahal, Yoseph Addadi, Fernanda Vargas E. Silva Castanheira, Sara W. Feigelson, Paul Kubes, Noam Erez, Natalio Garbi, Ronen Alon
Summary: In this study, the role of ICAM-1 and ICAM-2 in immune responses to influenza infection was investigated in mice. The results showed that lung capillary ICAMs were not essential for the entry of NK and neutrophils into virus-infected lungs. Additionally, ICAM-1 and ICAM-2 had little effect on the recruitment of naive T cells and B lymphocytes in mediastinal lymph nodes, but were critical for humoral immunity and the differentiation of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Thomas Bromberger, Sarah Klapproth, Ina Rohwedder, Jasmin Weber, Robert Pick, Laura Mittmann, Soo Jin Min-Weissenhorn, Christoph A. Reichel, Christoph Scheiermann, Markus Sperandio, Markus Moser
Summary: Beta 2 integrins play a crucial role in leukocyte trafficking by mediating the processes of slow rolling and firm arrest through conformational changes, which are regulated by interactions with Rap1 and Riam. The loss of both pathways simultaneously results in a rolling phenotype similar to talin1 deficient neutrophils, suggesting that these two pathways primarily regulate beta 2 integrin.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Laleh Pezhman, Abd Tahrani, Myriam Chimen
Summary: Type 2 Diabetes Mellitus is a chronic inflammatory disorder associated with obesity, insulin resistance, and hyperglycemia, with white blood cell accumulation in adipose tissue playing a key role in insulin resistance and beta-cell dysfunction. Therapeutic targeting of leukocyte trafficking may be an effective way to control inflammation, diabetes, and its vascular complications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Egle Katkeviciute, Larissa Hering, Ana Montalban-Arques, Philipp Busenhart, Marlene Schwarzfischer, Roberto Manzini, Javier Conde, Kirstin Atrott, Silvia Lang, Gerhard Rogler, Elisabeth Naschberger, Vera S. Schellerer, Michael Stuerzl, Andreas Rickenbacher, Matthias Turina, Achim Weber, Sebastian Leibl, Gabriel E. Leventhal, Mitchell Levesque, Onur Boyman, Michael Scharl, Marianne R. Spalinger
Summary: PTPN2 has emerged as a potential target for cancer immunotherapy, with increased expression correlating with disease progression and decreased immune responses in human colorectal carcinoma. Deletion of T cell-specific PTPN2 reduces tumor burden and enhances antitumor immunity in CRC models, suggesting it could be exploited for cancer immunotherapy.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Immunology
Noor Bala, Alexander I. McGurk, Tiago Zilch, Anastasia N. Rup, Evan M. Carter, Scott A. Leddon, Deborah J. Fowell
Summary: Successful immunity relies on the coordinated recruitment of diverse immune cell subsets to target tissues, with effector T cells navigating through tissues based on chemotactic and structural cues. Spatial preference in T cell activation has been uncovered by tissue-wide visualization, with activation niches regulated by site-specific chemokines for optimized effector function.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Immunology
Anna Barkaway, Loic Rolas, Regis Joulia, Jennifer Bodkin, Tchern Lenn, Charlotte Owen-Woods, Natalia Reglero-Real, Monja Stein, Laura Vazquez-Martinez, Tamara Girbl, Robin N. Poston, Matthew Golding, Rebecca S. Saleeb, Aude Thiriot, Ulrich H. von Andrian, Johan Duchene, Mathieu-Benoit Voisin, Cleo L. Bishop, David Voehringer, Axel Roers, Antal Rot, Tim Laemmermann, Sussan Nourshargh
Summary: Aging is associated with dysregulated immune functions, affecting neutrophil diapedesis. In aged mice, neutrophils exhibit reverse transendothelial migration, causing remote organ damage.
Article
Cell Biology
Sophie J. Hopkin, Laleh Pezhman, Jenefa Begum, Dean Kavanagh, Helen M. Mcgettrick, Asif J. Iqbal, Myriam Chimen
Summary: Aging is associated with increased systemic inflammation and loss of immune system function. Leukocyte trafficking is affected by aging, particularly in the peritoneal cavity. In aged female mice, there is an increase in leukocyte population within the peritoneal cavity, accompanied by an increase in inflammatory environment and changes in vascular structure, which may contribute to increased leukocyte migration to the cavity. These findings indicate that aging and sex influence leukocyte trafficking in a unique manner.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Adel Abo Mansour, Federica Raucci, Mustafa Sevim, Anella Saviano, Jenefa Begum, Zhaogong Zhi, Laleh Pezhman, Samantha Tull, Francesco Maione, Asif Jilani Iqbal
Summary: This study investigates the role of Gal-9 in the migration and adhesion of CD4+ and CD8+ T cells and reveals its potential therapeutic significance in inflammatory-based diseases. The findings suggest that Gal-9 supports T cell adhesion and transmigration in a glycan dependent manner and inhibits the chemotactic function of CXCL12 through direct binding.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Rodrigo J. Gonzalez, Ulrich H. von Andrian
Summary: The interaction between GPR35 receptor and 5-HIAA serotonin metabolite promotes the recruitment of neutrophils from blood into inflamed tissues, which is significant for inflammation and anti-microbial host defense.
Article
Biochemistry & Molecular Biology
Asif J. Iqbal, Franziska Krautter, Isobel A. Blacksell, Rachael D. Wright, Shani N. Austin-Williams, Mathieu-Benoit Voisin, Mohammed T. Hussain, Hannah L. Law, Toshiro Niki, Mitsuomi Hirashima, Michele Bombardieri, Costantino Pitzalis, Alok Tiwari, Gerard B. Nash, Lucy Norling, Dianne Cooper
Summary: This study investigates the role of immunomodulatory lectin Galectin-9 (Gal-9) in neutrophil recruitment. The results show that Gal-9 is upregulated in inflamed blood vessels and released by activated endothelial cells. Gal-9 binding induces neutrophil activation and can enhance their interaction with endothelial cells. Both soluble and immobilized Gal-9 function as adhesion molecules and can capture neutrophils. These findings provide insights into the importance of Gal-9 in leukocyte recruitment during inflammation.
Article
Immunology
Bernd Uhl, Constanze Braun, Julian Dominik, Joshua Luft, Martin Canis, Christoph A. Reichel
Summary: Microvascular dysfunction plays a crucial role in the pathogenesis of salivary gland disorders, and restoring and preserving microvascular integrity could be a promising strategy for their treatment. The authors introduced a novel experimental approach for comprehensive in vivo analysis of the salivary gland microvasculature in mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sreelakshmi N. Menon, Farzana Zerin, Emmanuella Ezewudo, Nimi P. Simon, Sreeranjini N. Menon, Morgan L. Daniel, Andrea J. Green, Ajay Pandey, Charles E. Mackay, Sherif Hafez, Nader H. Moniri, Raquibul Hasan
Summary: Neflamapimod effectively inhibits endothelial cell activation, adhesion molecule expression, and leukocyte attachment, thereby reducing vascular inflammation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Surgery
Johan Linders, Raed Madhi, Matthias Morgelin, Ben C. King, Anna M. Blom, Milladur Rahman
Summary: The study revealed that C3 plays a crucial role in the recruitment of neutrophils and the formation of NETs in acute pancreatitis. Lack of C3 resulted in reduced NETs in pancreatic tissue, along with decreased levels of MPO in the lung, and plasma IL-6, MMP-9, and CXCL2. Targeting C3 could be a potential strategy to alleviate local damage and remote organ dysfunction in AP.
EUROPEAN SURGICAL RESEARCH
(2021)
Article
Immunology
Jessica K. Fiege, Brandon J. Burbach, Yoji Shimizu
JOURNAL OF IMMUNOLOGY
(2015)
Article
Peripheral Vascular Disease
Ninitha Asirvatham-Jeyaraj, Jessica K. Fiege, Ruijun Han, Jason Foss, Christopher T. Banek, Brandon J. Burbach, Maria Razzoli, Alessandro Bartolomucci, Yoji Shimizu, Angela Panoskaltsis-Mortari, John W. Osborn
Article
Peripheral Vascular Disease
Christopher T. Banek, Mark M. Knuepfer, Jason D. Foss, Jessica K. Fiege, Ninitha Asirvatham-Jeyaraj, Dusty Van Helden, Yoji Shimizu, John W. Osborn
Article
Peripheral Vascular Disease
Huan Wang, Dongmin Kwak, John Fassett, Lei Hou, Xin Xu, Brandon J. Burbach, Thenappan Thenappan, Yawei Xu, Jun-bo Ge, Yoji Shimizu, Robert J. Bache, Yingjie Chen
Article
Immunology
Jessica K. Fiege, Lalit K. Beura, Brandon J. Burbach, Yoji Shimizu
JOURNAL OF IMMUNOLOGY
(2016)
Article
Oncology
Eisuke Domae, Yuya Hirai, Takashi Ikeo, Seiji Goda, Yoji Shimizu
Article
Immunology
Christopher C. DeNucci, Yoji Shimizu
JOURNAL OF IMMUNOLOGY
(2011)
Article
Immunology
Brandon J. Burbach, Rupa Srivastava, Melissa A. Ingram, Jason S. Mitchell, Yoji Shimizu
JOURNAL OF IMMUNOLOGY
(2011)
Article
Immunology
Jason S. Mitchell, Brandon J. Burbach, Rupa Srivastava, Brian T. Fife, Yoji Shimizu
JOURNAL OF IMMUNOLOGY
(2013)
Article
Immunology
Nicholas A. Zumwalde, Eisuke Domae, Matthew F. Mescher, Yoji Shimizu
JOURNAL OF IMMUNOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Rupa Srivastava, Brandon J. Burbach, Jason S. Mitchell, Antonio J. Pagan, Yoji Shimizu
MOLECULAR AND CELLULAR BIOLOGY
(2012)
Article
Oncology
Qi Shao, Stephen O'Flanagan, Tiffany Lam, Priyatanu Roy, Francisco Pelaez, Brandon J. Burbach, Samira M. Azarin, Yoji Shimizu, John C. Bischof
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2019)
Article
Oncology
Katie L. Anderson, Kristin M. Snyder, Daisuke Ito, Debra C. Lins, Lauren J. Mills, Kipp Weiskopf, Nan G. Ring, Aaron M. Ring, Yoji Shimizu, Matthew F. Mescher, Irving L. Weissman, Jaime F. Modiano
Article
Multidisciplinary Sciences
Brandon J. Burbach, Stephen D. O'Flanagan, Qi Shao, Katharine M. Young, Joseph R. Slaughter, Meagan R. Rollins, Tami Jo L. Street, Victoria E. Granger, Lalit. K. Beura, Samira M. Azarin, Satish Ramadhyani, Bruce R. Forsyth, John C. Bischof, Yoji Shimizu
Summary: This study demonstrates that the combination of irreversible electroporation (IRE) and anti-CTLA-4 treatment can promote expansion of tumor-specific CD8+ T cells, leading to the establishment of tissue-resident memory cells and improved anti-tumor immune response in a preclinical model of prostate cancer.
NATURE COMMUNICATIONS
(2021)
Article
Physiology
Jason D. Foss, Jessica Fiege, Yoji Shimizu, John P. Collister, Tim Mayerhofer, Laurel Wood, John W. Osborn
PHYSIOLOGICAL REPORTS
(2018)