Article
Biochemistry & Molecular Biology
David a. Karadi, Anna Rita Galambos, Peter P. Lakatos, Joost Apenberg, Sarah K. Abbood, Mihaly Balogh, Kornel Kiraly, Pal Riba, Nariman Essmat, Edina Szucs, Sandor Benyhe, Zoltan V. Varga, Eva Szoko, Tamas Tabi, Mahmoud Al-Khrasani
Summary: The study investigates the antiallodynic effect of telmisartan and losartan, two AT1 blockers, in combination with morphine for neuropathic pain management. The combination therapy shows promising results in improving pain and delaying morphine tolerance development. Further studies are needed to analyze the effect of each component in the combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Anesthesiology
Andrew S. C. Rice, Robert H. Dworkin, Nanna B. Finnerup, Nadine Attal, Praveen Anand, Roy Freeman, Alessandro Piaia, Francesca Callegari, Christie Doerr, Subhayan Mondal, Nisha Narayanan, Laurent Ecochard, Yanina Flossbach, Shaloo Pandhi
Summary: The analgesic efficacy and safety of EMA401 in patients with postherpetic neuralgia and painful diabetic neuropathy were assessed in two phase 2b studies, showing consistent clinical improvement in pain intensity reduction. However, premature termination of the studies prevented definitive conclusions from being drawn.
Article
Neurosciences
Huan Wang, Yuzhong Hu, Jiayi Deng, Yang Ye, Manli Huang, Xianwei Che, Liang Yu
Summary: This study investigated the efficacy of repetitive transcranial magnetic stimulation (rTMS) on postherpetic neuralgia (PHN) by stimulating the motor cortex (M1) and the dorsolateral prefrontal cortex (DLPFC). The results showed that M1 stimulation was superior to DLPFC stimulation in reducing pain and improving sleep quality in PHN patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Guangda Zheng, Juanxia Ren, Lu Shang, Yanju Bao
Summary: Pain is a common clinical symptom caused by nerve injury, tissue damage, or diseases. It affects daily physical function and quality of life, resulting in physiological and psychological torture. The underlying molecular mechanisms and signaling pathways of pain are not fully understood, making pain management challenging. Autophagy, an intracellular process, plays a vital role in maintaining neural function and has been linked to neuropathic pain. Traditional Chinese medicine monomers have also been found to involve autophagy in pain relief, suggesting autophagy as a potential target for pain management.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Anesthesiology
Michael Fetell, Manon Sendel, Thomas Li, Leslie Marinelli, Jan Vollert, Elizaeth Ruggerio, George Houk, Marilyn Dockum, Phillip J. Albrecht, Frank L. Rice, Ralf Baron
Summary: Skin biopsies from patients with postherpetic neuralgia (PHN) showed no correlation between nerve fiber density and baseline pain, and concurrent loss of nerve fibers on the affected side was common. The role of Nav1.7 in PHN pain is still unclear.
Article
Anesthesiology
Kyung Ah Han, Yong-Ho Lee, Hyun-Shik Son, Ki-Ho Song, Sang Yong Kim, Choon Hee Chung, Hak Chul Jang, Kwan-Woo Lee, Bong Yun Cha, Kee-Ho Song, Young Kwon Ko, Pyung-Bok Lee, Beom Joon Kim, Sohee Kim, Taewon An, Yong-Chul Kim
Summary: This study demonstrates that a new sustained-release pregabalin formulation is noninferior to immediate-release pregabalin in reducing peripheral neuropathic pain in Korean patients with diabetic peripheral neuropathy or postherpetic neuralgia. The new formulation is well-tolerated after 12 weeks of treatment.
CLINICAL JOURNAL OF PAIN
(2022)
Article
Pharmacology & Pharmacy
Yiping Sun, Jiayi Shen, Guang Hei, Ji Yun, Bingjie Ma, Xuehua Huang, Zhiyuan Yu, Pingchuan Ma, Ma Ke
Summary: The study investigated the safety and effectiveness of epidural morphine or hydromorphone in treating refractory postherpetic neuralgia (PHN). The results showed that short-term application of these two medications can alleviate pain, improve quality of life, and have no obvious side effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Licet Caridad Mena-Valdes, Yisel Blanco-Hernandez, Josue Vidal Espinosa-Juarez, Francisco Javier Lopez-Munoz
Summary: The study demonstrated that in a neuropathic pain model, haloperidol enhanced the analgesic effect of morphine, delayed the development of morphine tolerance, and did not show significant adverse effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Cheolhwan Park, Hyunji John, Jaemoon Lee, Seungwan Hong, Minjung Kim, Sangtae Park, Jae Hun Kim
Summary: Postherpetic pruritus (PHP) is a rare complication of herpes zoster, and this study found that approximately 28% of patients with postherpetic neuralgia (PHN) developed PHP. Patients with PHN in the trigeminal nerve had a higher incidence of PHP, and those with PHP experienced greater pain improvement after 3 and 4 months.
Article
Economics
Amelia Smith, Stephen Doran, Maria Daly, Cormac Kennedy, Michael Barry
Summary: The introduction of a reimbursement application system significantly reduced the dispensing rate of Versatis(R), mainly through reducing expenditure under the GMS scheme. It is recommended to restrict the prescription of Versatis(R) to patients with PHN to ensure evidence-based use of the medication.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY
(2021)
Article
Multidisciplinary Sciences
Yiwen Hou, Guichang Zou, Xianglian Wang, Hui Guo, Xiao Ma, Xingyu Cheng, Zhiyong Xie, Xin Zuo, Jing Xia, Huanhuan Mao, Man Yuan, Qi Chen, Peng Cao, Yupeng Yang, Li Zhang, Wei Xiong
Summary: Using a combination of chemo/optogenetic manipulation with calcium imaging and slice physiology, this study identifies neuronal ensembles in a hierarchically organized pathway essential for associative opioid analgesic tolerance. The signaling from the ventral hippocampus to dorsomedial prefrontal cortex cholecystokininergic neurons, and subsequently to baso-lateral amygdala glutamatergic neurons, relays the tolerance signal and leads to the loss of morphine analgesic efficacy.
Review
Clinical Neurology
Alberto Corriero, Mariateresa Giglio, Francesco Inchingolo, Antonio Moschetta, Giustino Varrassi, Filomena Puntillo
Summary: This literature review investigates the role of modulating the gut microbiota (GM) in the treatment of neuropathic pain (NP). The interaction between the nervous system and GM occurs through immune mediators, metabolites, and nervous structures. The review explores therapeutic approaches such as probiotics, faecal microbiota transplantation, dietary supplements, and emotional support for various types of NP.
Article
Clinical Neurology
Lu Chen, Ailing Qing, Tao Zhu, Pingliang Yang, Ling Ye
Summary: This study evaluated the efficacy and safety of extracorporeal shockwave therapy (ESWT) for postherpetic neuralgia. The results showed that ESWT combined with conventional treatment could relieve pain and improve the psychological state in patients without serious adverse effects.
FRONTIERS IN NEUROLOGY
(2022)
Article
Anesthesiology
Ekim Can Ozturk, Savas Sencan, Osman Hakan Gunduz
Summary: Lumbar sympathetic block is effective in treating lower-limb PHN, as demonstrated by two cases with relief of symptoms, suggesting its potential role in the treatment of this neuropathic pain syndrome. Additional reports and controlled trials are necessary for further understanding its effectiveness.
Article
Clinical Neurology
Qianyan Liu, Xiaoliang Wu, Jing Guo, Jie Gao, Bingyang Liu, Yuhang Wang, Minghui Xia, Lixia Pei, Jianhua Sun
Summary: This study aims to evaluate the efficacy and safety of electroacupuncture in the treatment of postherpetic neuralgia, providing evidence-based medical evidence for its use. A randomized controlled trial will be conducted in multiple clinical centers, recruiting 448 patients to assess the treatment outcomes.
Review
Clinical Neurology
Frederick A. Zeiler, Alan C. Jackson
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2016)
Editorial Material
Neurosciences
Alan C. Jackson
JOURNAL OF NEUROVIROLOGY
(2016)
Review
Neurosciences
Alan C. Jackson
JOURNAL OF NEUROVIROLOGY
(2016)
Article
Clinical Neurology
Alan C. Jackson, Luiz C. Mostaco-Guidolin, Hasantha Sinnock, Songul Bozat-Emre, Michael Routledge, Salaheddin M. Mahmud
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2016)
Meeting Abstract
Infectious Diseases
A. Jackson
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Neurosciences
Wafa Kammouni, Heidi Wood, Alan C. Jackson
JOURNAL OF NEUROVIROLOGY
(2017)
Article
Neurosciences
Wafa Kammouni, Heidi Wood, Alan C. Jackson
JOURNAL OF NEUROVIROLOGY
(2017)
Editorial Material
Clinical Neurology
Alan C. Jackson
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2018)
Article
Immunology
Leonard J. Hoenig, Alan C. Jackson, Gordon M. Dickinson
Review
Clinical Neurology
Alan C. Jackson
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2018)
Article
Multidisciplinary Sciences
M. Brock Fenton, Alan C. Jackson, Paul A. Faure
Article
Veterinary Sciences
A. C. Jackson
REVUE SCIENTIFIQUE ET TECHNIQUE-OFFICE INTERNATIONAL DES EPIZOOTIES
(2018)
Meeting Abstract
Clinical Neurology
Alan Jackson, Wafa Kammouni, Heidi Wood, Paul Fernyhough
Article
Clinical Neurology
Carly Scramstad, Alan C. Jackson
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2017)
Article
Health Care Sciences & Services
Ian Gilron, Dongsheng Tu, Ronald Holden, Alan C. Jackson, Nader Ghasemlou, Scott Duggan, Elizabeth Vandenkerkhof, Roumen Milev
JMIR RESEARCH PROTOCOLS
(2017)