Article
Biochemistry & Molecular Biology
Xiang Zhang, Falguni Basuli, Zhen-Dan Shi, Swati Shah, Jianfeng Shi, Amelia Mitchell, Jianhao Lai, Zeping Wang, Dima A. Hammoud, Rolf E. Swenson
Summary: In this study, a series of fluorine-18-labeled L-rhamnose derivatives were developed as potential PET tracers for various fungal and bacterial strains. The tracer showed good stability and renal clearance in mice, with minimal tissue and skeletal uptake and a low background signal in healthy mice.
Article
Chemistry, Multidisciplinary
Jay S. Wright, Richard Ma, E. William Webb, Wade P. Winton, Jenelle Stauff, Kevin Cheng, Allen F. Brooks, Melanie S. Sanford, Peter J. H. Scott
Summary: This report presents the development of a Zn(OTf)(2)-mediated method for converting alpha-tertiary haloamides to the corresponding alpha-tertiary fluoroamides. Under optimized conditions, high radiochemical conversion can be achieved. This method has been successfully applied to prepare various model radiofluorides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Thu Hang Lai, Magali Toussaint, Rodrigo Teodoro, Sladjana Dukic-Stefanovic, Mathias Kranz, Winnie Deuther-Conrad, Rares-Petru Moldovan, Peter Brust
Summary: The research focuses on developing a PET radiotracer for monitoring the expression and occupancy of the non-dopaminergic target A(2A) receptor in Parkinson's disease therapy. Novel fluorinated analogs are designed and evaluated in preclinical studies, showing specific in vitro binding to A(2A)R but no specific in vivo binding in dynamic PET/MRI studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Melissa Chasse, Anna Pees, Anton Lindberg, Steven H. H. Liang, Neil Vasdev
Summary: Positron emission tomography (PET) is a powerful imaging tool used for drug discovery, clinical diagnosis, and disease monitoring. However, the lack of compatible methods and precursors for radiolabeling with fluorine-18 has limited the development of radiotracers. The radiolabeling of electron-rich (hetero)aromatic rings has been a long-standing challenge in producing PET radiopharmaceuticals. In this personal account, the history and applications of spirocyclic iodonium ylide precursors are discussed for the incorporation of fluorine-18 into complex non-activated (hetero)aromatic rings.
Article
Engineering, Biomedical
Michael Barnes, Daryl John O'Connor, Martin Ebert
Summary: A novel method utilizing the He-3(d,p)He-4 nuclear reaction to produce fluorine-18 for PET scans was theoretically evaluated. The theoretical designs involve utilizing helium-3 beams on deuterated plastic targets backed with oxygen-18 heavy-water or super-heavy-water targets. However, practical challenges such as thermal and target degradation effects make the current systems technically infeasible despite the potential advantages over cyclotron-based production.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2021)
Article
Medicine, Research & Experimental
Hongzhang Yang, Lei Zhang, Huanhuan Liu, Yunming Zhang, Zhaobiao Mou, Xueyuan Chen, Jingchao Li, Fengming He, Zijing Li
Summary: 18F-labeled fluorothiophosphate (FTP) synthons with high radiochemical yields can be rapidly generated in reaction solutions using wet [18F]F- without the need for substrate pre-modification or lengthy radiosynthesis procedures. This simplified one-pot 18F-labeling method allows for the visualization and translation of a variety of biomolecules, making it valuable for modern positron emission tomography techniques.
Article
Chemistry, Multidisciplinary
Chris Hoffmann, Niklas Kolks, Daniel Smets, Alexander Haseloer, Benedikt Groener, Elizaveta A. Urusova, Heike Endepols, Felix Neumaier, Uwe Ruschewitz, Axel Klein, Bernd Neumaier, Boris D. Zlatopolskiy
Summary: In this study, a series of complexes were systematically evaluated and several generally applicable mediators were identified for highly efficient radiofluorination. The utilization of these mediators significantly improved the labeling yields, even with lower precursor amounts. The practicality of the novel mediators was demonstrated by the efficient production of five PET tracers and transfer of the method to an automated radiosynthesis module.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Chao Wang, Rong Lin, Shaobo Yao
Summary: This review focuses on recent advances in the synthesis, radiolabeling, and application of a series of F-18-labeled amino acid analogs using new F-18-labeling strategies.
Article
Radiology, Nuclear Medicine & Medical Imaging
R. Gallicchio, A. Nardelli, G. Calice, A. Guarini, G. Guglielmi, G. Storto
Summary: This study evaluated the prognostic significance of combined use of FDG and FLT PET/CT in MM patients, showing that PET/CT can predict patient prognosis and that FDG+; FLT- patients have better EFS compared to other groups.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Li Wang, Yubai Zhou, Xuedan Wu, Xinrui Ma, Bing Li, Ransheng Ding, Michael A. Stashko, Zhanhong Wu, Xiaodong Wang, Zibo Li
Summary: MerTK is abnormally expressed in various cancers, but the sensitivity of tumors to MerTK suppression may vary. In this study, a radiolabeled agent [F-18]-MerTK-6 was developed and showed prominent uptake in tumors in initial evaluation, suggesting it as a promising PET agent for MerTK imaging.
Review
Biochemistry & Molecular Biology
Felix Francis, Frank Wuest
Summary: Positron emission tomography (PET) is a vital imaging technique used for studying biological and physiological processes, with fluorine-18 (F-18) being a commonly used positron emitter in PET imaging. The presence of fluorine atoms in many drugs opens up possibilities for developing radioligands labeled with fluorine-18.
Review
Chemistry, Organic
Zhu Yuan, Chen Leyuan, Hou Wenbin, Li Yiliang
Summary: Fluorine-18 is widely used in positron emission tomography radiopharmaceuticals, with nucleophilic F-18 fluoride being a common labeling reagent. Fluorine substitution can impact pharmacokinetic parameters, and arenes and heteroarenes are commonly used candidates for F-18 labeling.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongxiang Tang, Ling Xiao, Chijun Deng, Haoyue Zhu, Xiaomei Gao, Jian Li, Zhiquan Yang, Dingyang Liu, Li Feng, Shuo Hu
Summary: This study investigated the patterns of metabolic abnormalities using [F-18]FDG PET in MTLE patients with different pathologic types. It was found that MTLE patients with isolated gliosis had the worst prognosis and exhibited significant hypometabolism in the insula. Therefore, hypometabolic regions should be prioritized for presurgical evaluation of MTLE patients rather than focusing solely on metabolic uptake values.
EUROPEAN RADIOLOGY
(2023)
Article
Medicine, General & Internal
Haejun Lee, Kyung-Hoon Hwang, Kwang An Kwon
Summary: Background: Colon and rectal cancers are among the top five cancers worldwide. Early detection is crucial for effective treatment. FDG PET parameters can assess malignant lesions in the colon.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Medicine, Research & Experimental
Sureya Nijiati, Fantian Zeng, Cuicui Zuo, Qianyu Zhang, Chao Du, Changrong Shi, Jinhao Gao, Zijian Zhou
Summary: In this study, a PET/F-19 MRI dual-modal imaging probe was developed for the monitoring of ferroptosis-induced acute kidney injury. The probe can be converted and retained in ferroptotic cells and tissues, enabling early diagnosis and mechanistic investigation.
MOLECULAR PHARMACEUTICS
(2023)
