A facile synthesis of 5,5-dideutero-4-dimethyl(phenyl)silyl-6-undecyl-tetrahydropyran-2-one as a deuterium labeled synthon for (−)-tetrahydrolipstatin and (+)-δ-hexadecanolide

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Method for regio-, chemo- and stereoselective deuterium labeling of sugars based on ruthenium-catalyzed C–H bond activation

(2010) Yuta Fujiwara et al.   CHEMICAL COMMUNICATIONS

Metal-catalysed hydrogen isotope exchange labelling: a brief overview

(2010) William J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

In Vitro and In Vivo Isotope Effects with Hepatitis C Protease Inhibitors: Enhanced Plasma Exposure of Deuterated Telaprevir versus Telaprevir in Rats

(2009) François Maltais et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hydrogen Exchange Rate of Tyrosine Hydroxyl Groups in Proteins As Studied by the Deuterium Isotope Effect on CζChemical Shifts

(2009) Mitsuhiro Takeda et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Big interest in heavy drugs

(2009) Katharine Sanderson   NATURE

Highly Regio- and Enantioselective Organocatalytic Conjugate Addition of Alkyl Methyl Ketones to a β-Silylmethylene Malonate

(2009) Raghunath Chowdhury et al.   ORGANIC LETTERS

Mild and Efficient H/D Exchange of Alkanes Based on CH Activation Catalyzed by Rhodium on Charcoal

(2008) Tomohiro Maegawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION