期刊
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
卷 54, 期 13, 页码 775-779出版社
WILEY-BLACKWELL
DOI: 10.1002/jlcr.1921
关键词
paichongding; neonicotinoids; radiosynthesis; [14C]nitromethane
资金
- National Basic Research Program of China (973 Program) [2010CB126104]
- National High Technology Research, the Development Program of China (863 Program) [2011AA10A207]
- National Key Technology R&D Program of China [2011BAE06B01]
- Special Fund for Agro-scientific Research in the Public Interest [201103007]
- Shanghai Foundation of Science and Technology [09391911800, 09XD1401300]
- Shanghai Leading Academic Discipline Project [B507]
- Fundamental Research Funds for the Central Universities
Paichongding, a novel neonicotinoids pesticide with excellent insecticidal activity against imidacloprid-resistant brown planthopper, has been sold in the Chinese market as new pesticide. [14C]Paichongding was proposed as a tracer to support the further study to elucidate the metabolism of the commercialized pesticide. This paper describes an efficient synthesis of [14C]paichongding in five radiochemical steps from [14C]nitromethane (1). Then the four diastereoisomers (a, b, c, and d) were separated by preparative chiral HPLC and characterized by HPLC and HPLC-LSC. This methodology could be utilized in the syntheses of other 14C-labeled nitromethylene neonicotinoids derivatives. Copyright (C) 2011 John Wiley & Sons, Ltd.
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