Article
Oncology
Won-Gun Yun, Wooil Kwon, Youngmin Han, Hee Ju Sohn, Hyeong Seok Kim, Mirang Lee, Hongbeom Kim, Alexander S. Thomas, Michael D. Kluger, Jin-Young Jang
Summary: Research shows that metastatectomy can significantly improve survival in pancreatic ductal adenocarcinoma (PDAC) patients with isolated lung metastasis compared to those receiving only chemotherapy or supportive treatment. This finding is consistent with external validation. It is recommended to consider multimodal therapy with chemotherapy and surgical treatment for PDAC patients with isolated lung metastasis.
Article
Biotechnology & Applied Microbiology
Ji Li, Wang Jing, Xiaoyang Zhai, Wenxiao Jia, Hui Zhu, Jinming Yu
Summary: This study validates the feasibility of the Lung-molGPA tool in predicting survival of patients with non-small-cell lung cancer, providing evidence for its usefulness in determining treatment strategies and prognosis. Patients in the adenocarcinoma group with higher Lung-molGPA scores had longer median survival times, while a similar trend was observed in the non-adenocarcinoma group.
ONCOTARGETS AND THERAPY
(2021)
Article
Medicine, General & Internal
Wenxia Li, Tongsheng Wang, Yubing Zhu, Haijiao Yu, Ling Ma, Yuhan Ding, Gao Hong, Ding Lei
Summary: This study investigated the clinical characteristics, survival, prognostic factors, and treatment of brain metastasis from colorectal cancer. The researchers found that Karnofsky performance status and treatment modalities were independent prognostic factors, and patients with high Karnofsky performance status and multimodal treatment had improved survival.
Article
Oncology
Oscar Godino, Ignacio Visus, Iago Garreta, Luis Lopez-Obarrio, Lluis Gonzalez-Canas, Juan Jose Sanchez, Mar Marin, Abelardo Montero, Hector Perez, Leyre Asiain, Arturo Navarro-Martin
Summary: The study aims to assess the value of a common clinical language in a multidisciplinary tumour board for spinal metastasis. The results show that using RADES and SINS scores for decision-making can improve survival rates and complication rates in patients with spinal metastasis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Article
Oncology
Miao Wang, Qiuji Wu, Jun Zhang, Guizhen Qin, Tian Yang, Yixin Liu, Xulong Wang, Boyu Zhang, Yongchang Wei
Summary: This study found that the number and sites of extracranial metastasis (ECM) in NSCLC patients with BM have a significant impact on prognosis, with ECM number being an independent prognostic factor. Patients with 0-1 ECM showed better survival, and different ECM organs have varied effects on survival rates.
Article
Medicine, General & Internal
Se-Jun Park, Chang-Hyun Ma, Chong-Suh Lee, Chung-Youb Jeon, Tae-Soo Shin, Jin-Sung Park
Summary: This study analyzed the survival and functional outcome after surgery in spinal metastasis patients with a short life expectancy and compared baseline characteristics based on 3-month survival. A total of 492 surgical cases with a preoperative revised Tokuhashi score <= 8 were reviewed. The median overall survival was 10.6 months. The 2013-2020 period showed a significantly better median survival than the other two periods. Surgery can be considered even in spinal metastasis patients with a short life expectancy, particularly those with a good performance status.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Andras Piffko, Benedikt Asey, Lasse Duehrsen, Inka Ristow, Johannes Salamon, Harriet Wikman, Cecile L. Maire, Katrin Lamszus, Manfred Westphal, Thomas Sauvigny, Malte Mohme
Summary: Non-small cell lung cancer is the leading cause of cancer-related death globally, with an increasing incidence of brain metastases in NSCLC patients. This study identified systemic metastatic load and number of brain metastases as significant factors affecting overall survival in resectable NSCLC patients. Factors such as age, absence of other systemic metastases, and number of brain metastases were found to impact survival outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biology
Yi-Han Huang, Huai-Che Yang, Chi-Lu Chiang, Hsiu-Mei Wu, Yung-Hung Luo, Yong-Sin Hu, Chung-Jung Lin, Wen-Yuh Chung, Cheng-Ying Shiau, Wan-Yuo Guo, Cheng-Chia Lee
Summary: Administering stereotactic radiosurgery to the surgical cavity after surgery can improve local tumor control, but it does not have a significant effect on overall survival.
Review
Oncology
Sophia G. Kisling, Gopalakrishnan Natarajan, Ramesh Pothuraju, Ashu Shah, Surinder K. Batra, Sukhwinder Kaur
Summary: Pancreatic cancer is a highly lethal malignancy with poor prognosis mainly due to metastasis. Global studies utilizing computational methods have identified prognostic and metastatic genes, leading to the development of new treatment modalities.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Surgery
Beichen Ding, Yucong Zhang, Wei Hu, Dongliang Hu, Jianjun Liu, Shanchao Zhao, Fei Wang, Li Xue, Zhanping Xu, Liang Chen
Summary: The study assessed the prognostic factors for patients with prostate sarcomas and found that negative distant metastasis and radical tumor resection were significantly associated with better overall survival. Age, tumor size, symptom duration, and chemo/radiotherapy were not significantly related to survival. There were differences in treatment regimens between Chinese and US patients, with a higher rate of radical surgery in the US cohort leading to better survival outcomes.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yongping Hao, Ting Tang, Jing Ren, Guang Li
Summary: This study retrospectively analyzed the iPFS and OS of patients receiving SRS treatment for brain metastasis (BM), and explored the relationship between various clinical characteristics and patient prognosis. The results showed that the number of BMs ≥5 was a strong predictor for shorter iPFS and OS. For patients with more than 5 BMs, the combination of SRS and WBRT could achieve better local control.
Article
Oncology
Chao Zhang, Jun Wang, Haixiao Wu, Yile Lin, Vladimir P. Chekhonin, Karl Peltzer, Artem V. Bukharov, Andrey D. Kaprin, Xu Guo, Zheng Liu
Summary: This study aimed to evaluate the survival outcome and limb function in cancer patients with proximal limb metastasis. Factors associated with survival outcome and limb function were identified. The study also compared the outcomes of intramedullary nailing and prosthesis surgery in these patients.
Article
Oncology
Tian-Qi Du, Xiang Li, Wei-Si Zhong, Jian-Dong Tian, Yu-Xia Zhao, Dan Liu
Summary: For patients with brain metastasis of lung cancer, SIB-IMRT may be associated with a more favorable prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Viet-Thang Le, Anh Minh Nguyen, Tuan Anh Pham, Phuc Long Nguyen
Summary: This study aimed to evaluate the factors influencing the occurrence of seizures before brain tumor surgery and effective measures for enhancing epilepsy outcomes. The majority of patients diagnosed with glioma were at increased risk of postoperative seizures, especially those with low-grade gliomas and frontotemporal lobe tumors. However, gross total resection of the tumor reduced the incidence of postoperative seizures.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Maria Anna Smolle, Ewald Musser, Marko Bergovec, Joerg Friesenbichler, Christine Linda Wibmer, Lukas Leitner, Michala Skovlund Sorensen, Michael Mork Petersen, Iva Brcic, Joanna Szkandera, Susanne Scheipl, Andreas Leithner
Summary: The current study validates the prognostic accuracy of the 2013-SPRING model for bone metastasis patients treated surgically in an external patient cohort. The model showed clinically relevant performance in predicting patient prognosis, even after stratification for surgical procedure and metastasis location.