期刊
JOURNAL OF KOREAN MEDICAL SCIENCE
卷 23, 期 5, 页码 776-780出版社
KOREAN ACAD MEDICAL SCIENCES
DOI: 10.3346/jkms.2008.23.5.776
关键词
Mitochondrial Uncoupling Protein; Polymorphism, Genetic; Blood Pressure; Association
资金
- Ministry of Science and Technology of Korea [M1052701000005N-270100000]
- Rural Development Administration of Korea [20070-301034031]
Recent studies have provided some clues with regard to the relationship existing between uncoupling protein 1 (UCP1) and blood pressure in animal experiments. In an attempt to determine the genetic polymorphisms that are associated with blood pressure in humans, we have analyzed genetic polymorphisms in UCP1 gene. In this study, we assessed the association between UCP1 genotypes and systolic blood pressure (SBP) and diastolic blood pressure (DBP), in a population comprised of 832 Korean female subjects, using a general linear model, which was adjusted for age and body mass index (BMI). Among 4 genetic polymorphisms and the haplotypes constructed from them, haplotype3 of UCP1, UCP1-ht3[GAGA], evidenced significant associations with SBP (p=0.005) and DBP (p=0.013). However, this haplotype was not significantly associated with obesity phenotypes, including BMI or fat mass (p > 0.05), thereby suggesting that its association with blood pressure was independent of obesity phenotypes.
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