Article
Medicine, General & Internal
Haijun Zhang, Cristina Garcia, Wenzhou Yu, Maria Deloria Knoll, Xiaozhen Lai, Tingting Xu, Rize Jing, Ying Qin, Zundong Yin, Brian Wahl, Hai Fang
Summary: The study evaluated the cost-effectiveness of including Hib vaccine in China's national immunization program at national and provincial levels. Including Hib vaccine was projected to significantly reduce the burden of Hib disease nationally. Nationally, Hib vaccine was cost-effective compared to GDP per capita, and it was also cost-effective in 15 of the 31 provinces.
Article
Health Care Sciences & Services
Xiaozhen Lai, Brian Wahl, Wenzhou Yu, Tingting Xu, Haijun Zhang, Cristina Garcia, Ying Qin, Yan Guo, Zundong Yin, Maria Deloria Knoll, Hai Fang
Summary: The study estimated childhood mortality and morbidity attributable to pneumococcus and Hib in China from 2010 to 2017. It found that while there was a decrease in deaths and cases, the burden still varied significantly by region and province.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2022)
Article
Multidisciplinary Sciences
Nadia A. Kadry, Eric A. Porsch, Hao Shen, Joseph W. St Geme
Summary: NTHi is a common cause of respiratory tract disease and preventing colonization is a strategy to prevent disease. Immunization with HMW1 and HMW2 can protect against colonization by both parent NTHi strain and heterologous strains expressing distinct HMW1 and HMW2 proteins. The protection against heterologous strains is IL-17A dependent.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Sara E. Oliver, Amy B. Rubis, Heidi M. Soeters, Arthur Reingold, Meghan Barnes, Susan Petit, Monica M. Farley, Lee H. Harrison, Kathy Como-Sabetti, Sarah A. Khanlian, Rachel Wester, Ann Thomas, William Schaffner, Henju Marjuki, Xin Wang, Susan Hariri
Summary: This study evaluated the epidemiology of NTHi disease in the US, including among pregnant women, infants, and PWH. Results showed that NTHi causes substantial invasive disease, especially among older adults, pregnant/postpartum women, and neonates. Enhanced surveillance and targeted interventions are needed to prevent perinatal NTHi infections.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Janet R. Gilsdorf
Summary: Hib vaccines are crucial in preventing serious infections in children, with conjugated vaccines offering enhanced immunogenicity and prolonged protection. Global incidence of Hib infections has significantly decreased due to widespread vaccination efforts.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Microbiology
M. P. E. Slack, A. W. Cripps, K. Grimwood, G. A. Mackenzie, G. M. Ulanova
Summary: Hib used to be a common cause of bacterial infections in children, but with the widespread use of vaccines, its incidence has decreased. However, other capsulated serotypes are now causing more invasive infections in various regions. Surveillance and prevention efforts need to be strengthened to address this emerging trend.
CLINICAL MICROBIOLOGY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Zilai Liu, Koji Hosomi, Atsushi Shimoyama, Ken Yoshii, Xiao Sun, Huangwenxian Lan, Yunru Wang, Haruki Yamaura, Davie Kenneth, Azusa Saika, Takahiro Nagatake, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
Summary: The study showed that Alcaligenes lipid A enhances PRP-specific IgG responses in the presence of T-cell-dependent antigens without excessive inflammation, suggesting a potential role of Alcaligenes lipid A as an adjuvant activity for thymus-independent antigens.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Jose Goncalo Marques, Florbela Maria Inacio Cunha, Maria Paula Bajanca-Lavado
Summary: This study aimed to characterize the Hib-VF cases in Portugal in a 12-year period and trying to identify the possible associated risk factors. The study found that despite the majority of children being vaccinated against Hib, severe Hib-ID cases still occur. There has been an increase in the number of VF cases in recent years, but no clear predisposing factors were identified.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Infectious Diseases
Anneke Steens, Kamelia R. Stanoeva, Mirjam J. Knol, Rob Mariman, Hester E. de Melker, Nina M. van Sorge
Summary: While the incidence of most respiratory-transmitted diseases decreased during the COVID-19 pandemic, there was an increase in invasive disease caused by Haemophilus influenzae b (Hib) in the Netherlands, affecting both vaccinated and unvaccinated age groups. The vaccine effectiveness against Hib invasive disease remained unchanged, with a high effectiveness rate exceeding 90%. Various factors contributing to this rise in invasive disease were discussed.
Article
Microbiology
Lisa R. McTaggart, Kirby Cronin, Chi Yon Seo, Sarah Wilson, Samir N. Patel, Julianne Kus
Summary: This study reports the epidemiology and antimicrobial susceptibility of invasive H. influenzae in Ontario, Canada from 2014 to 2018, finding an increasing trend in the incidence of invasive disease primarily driven by NTHi. Hib incidence remained low, consistent with widespread vaccination. Serotype-dependent trends in antimicrobial susceptibility were observed, emphasizing the importance of monitoring all serotypes and NTHi in H. influenzae.
MICROBIOLOGY SPECTRUM
(2021)
Article
Microbiology
Stephen C. Watts, Louise M. Judd, Rosemary Carzino, Sarath Ranganathan, Kathryn E. Holt
Summary: Respiratory infection during childhood is a key risk factor in early cystic fibrosis lung disease progression. Haemophilus influenzae and Haemophilus parainfluenzae are commonly isolated from the lungs of children with CF, with a high frequency of colonization and antimicrobial resistance. The genetic basis for AMR in these bacteria was identified, and Haemophilus parainfluenzae had a higher prevalence of acquired AMR genes than H. influenzae.
Article
Microbiology
Aoife S. Reilly, Martha McElligott, Conor Mac Dermott Casement, Richard J. Drew
Summary: Since the introduction of Haemophilus influenzae (Hi) serotype b (Hib) vaccination, there has been an increase in the incidence rate of non-Hib serotypes, specifically Hi serotype f (Hif). A systematic review shows that the global incidence rate of Hif infection is increasing, with invasive infections commonly presenting as pneumonia, septicaemia, and meningitis. Genetic analysis reveals that Hif is relatively clonal, belonging mostly to clonal complex 124, and is currently susceptible to ampicillin.
JOURNAL OF MEDICAL MICROBIOLOGY
(2022)
Article
Infectious Diseases
Eva Hong, Aude Terrade, Melanie Denizon, Myriam Aouiti-Trabelsi, Michael Falguieres, Muhamed-Kheir Taha, Ala-Eddine Deghmane
Summary: The Hib conjugate vaccine in France was simplified to a 2+1 scheme in 2013, but in the years following, there was an increase in the number of Hib invasive infections and cases of vaccine failure. Children in the 3+1 group had significantly higher anti-PRP IgG concentrations and a higher proportion reached the 1 μg/ml threshold compared to the 2+1 group.
BMC INFECTIOUS DISEASES
(2021)
Article
Chemistry, Analytical
Arezoo Saadati, Houman Kholafazad Kordasht, Maryam Ehsani, Mohammad Hasanzadeh, Farzad Seidi, Nasrin Shadjou
Summary: The study utilized pDNA and cDNA in electrochemical biosensors to monitor Haemophilus Influenzae, developing a flexible sensor based on paper with good selectivity and sensitivity, suitable for clinical analysis and medical applications.
MICROCHEMICAL JOURNAL
(2021)
Article
Economics
Eli Liebman, Emily C. Lawler, Abe Dunn, David B. Ridley
Summary: This study investigates the impact of a long-term shortage of the pediatric Haemophilus Influenzae Type B (Hib) vaccine on vaccination rates and healthcare. The findings suggest that the shortage led to a decrease in the uptake of both primary and booster doses of the vaccine, with long-term implications for catch-up vaccination.
JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Gastroenterology & Hepatology
H. Y. Choi, Y. Kim, H. Cho, B. H. Kim, M. Ki
JOURNAL OF VIRAL HEPATITIS
(2018)
Article
Gastroenterology & Hepatology
Byung-Woo Kim, Chang-Mo Oh, Hwa Young Choi, Joong-Won Park, Hyunsoon Cho, Moran Ki
Article
Gastroenterology & Hepatology
Kyung-Ah Kim, Wankyo Chung, Hwa Young Choi, Moran Ki, Eun Sun Jang, Sook-Hyang Jeong
LIVER INTERNATIONAL
(2019)
Article
Gastroenterology & Hepatology
Ju Young Jung, Jae-Jun Shim, Sung Keun Park, Jae-Hong Ryoo, Joong-Myung Choi, In-Hwan Oh, Kyu-Won Jung, Hyunsoon Cho, Moran Ki, Young-Joo Won, Chang-Mo Oh
HEPATOLOGY INTERNATIONAL
(2019)
Article
Medicine, General & Internal
Sung-Eun Kim, Eun Sun Jang, Moran Ki, Geum-Youn Gwak, Kyung-Ah Kim, Gi-Ae Kim, Do Young Kim, Dong Joon Kim, Man Woo Kim, Yun Soo Kim, Young Seok Kim, In Hee Kim, Chang Wook Kim, Ho Dong Kim, Hyung Joon Kim, Neung Hwa Park, Soon Koo Baik, Jeong Ill Suh, Byung-Cheol Song, Il Han Song, Jong Eun Yeon, Byung Seok Lee, Youn Jae Lee, Young Kul Jung, Woo Jin Chung, Sung Bum Cho, Eun-Young Cho, Hyun Chin Cho, Gab Jin Cheon, Hee Bok Chae, DaeHee Choi, Sung-Kyu Choi, Hwa Young Choi, Won Young Tak, Jeong Heo, Sook-Hyang Jeong
JOURNAL OF KOREAN MEDICAL SCIENCE
(2018)
Article
Gastroenterology & Hepatology
Wankyo Chung, Kyung-Ah Kim, Eun Sun Jang, Moran Ki, Hwa Young Choi, Sook-Hyang Jeong
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Infectious Diseases
Jin-Kyoung Oh, Hwa Young Choi, Minji Han, Jae-Kwan Lee, Kyung-Jin Min, Moran Ki
SEXUALLY TRANSMITTED INFECTIONS
(2019)
Article
Multidisciplinary Sciences
Seongmin Jo, JinKwan Hong, Sang-Eun Lee, Moran Ki, Bo Youl Choi, Minki Sung
ROYAL SOCIETY OPEN SCIENCE
(2019)
Article
Nursing
Heeyoung Lee, Eun Young Lee, Brian Greene, Young-jeon Shin
ASIAN NURSING RESEARCH
(2019)
Article
Gastroenterology & Hepatology
Joon Yeul Nam, Eun Sun Jang, Young Seok Kim, Youn Jae Lee, In Hee Kim, Sung Bum Cho, Han Chu Lee, Si Hyun, Moran Ki, Hwa Young Choi, Eun Young Lee, Sook-Hyang Jeong
Article
Multidisciplinary Sciences
Sibylle Bernard-Stoecklin, Birgit Nikolay, Abdullah Assiri, Abdul Aziz Bin Saeed, Peter Karim Ben Embarek, Hassan El Bushra, Moran Ki, Mamunur Rahman Malik, Arnaud Fontanet, Simon Cauchemez, Maria D. Van Kerkhove
SCIENTIFIC REPORTS
(2019)
Article
Gastroenterology & Hepatology
Dahye Baik, Byung-Woo Kim, Jin-Kyoung Oh, Kyung-Ah Kim, Moran Ki
JOURNAL OF VIRAL HEPATITIS
(2020)
Article
Oncology
Yoon Park, Tae-Jin Kim, Chang-Sun Hwang, Chi Heum Cho, Dae Hoon Jeong, Seok Ju Seong, Jae-Kwan Lee, Sooyoung Hur, Mee-Kyung Kee, Jaehyun Seong, Moran Ki
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)
Article
Medicine, General & Internal
Eunji Choi, Yoon Young Lee, Mina Suh, Eun Young Lee, Tran Thi Xuan Mai, Moran Ki, Tin-Kyoung Oh, Hyunsoon Cho, Boyoung Park, Jae Kwan Jun, Yeol Kim, Kui Son Choi
YONSEI MEDICAL JOURNAL
(2018)
Article
Public, Environmental & Occupational Health
Yeong-Jun Song, Jeong-Sun Yang, Hee Jung Yoon, Hae-Sung Nam, Soon Young Lee, Hae-Kwan Cheong, Woo-Jung Park, Sung Han Park, Bo Youl Choi, Sung Soon Kim, Moran Ki
EPIDEMIOLOGY AND HEALTH
(2018)