Article
Endocrinology & Metabolism
Verena Fischer, Deniz Ragipoglu, Johanna Diedrich, Lena Steppe, Anne Dudeck, Konrad Schutze, Miriam Kalbitz, Florian Gebhard, Melanie Haffner-Luntzer, Anita Ignatius
Summary: Mast cells play a critical role in osteoporosis development, with mast cell-deficient mice being protected from ovariectomy-induced bone loss. Mast cells trigger inflammatory responses and regulate osteoblast and osteoclast activities, as well as RANKL levels in the serum, negatively affecting bone fracture healing under estrogen-deficient conditions. Targeting mast cells may offer a therapeutic strategy for improving disturbed bone repair in postmenopausal osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Xing Guo, Kai Zhong, LongFei Zou, Hao Xue, ShuLing Zheng, Jiang Guo, Hui Lv, Ke Duan, DengHua Huang, MeiYun Tan
Summary: This study found that antibiotic treatment leads to dysbiosis of the gut microbiota in mice, which in turn affects bone development and bone density. On the other hand, probiotic treatment promotes fracture healing in osteoporotic mice after dysbiosis, potentially through inhibiting the RAS/RANKL/RANK pathway.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Yihui Chai, Xiang Pu, Yongzhen Wu, Xingzhong Tian, Qian Li, Fanyong Zeng, Jing Wang, Jie Gao, Huaqian Gong, Yunzhi Chen
Summary: The study demonstrated that Astragalus Membranaceus can improve bone density and microstructure, promote osteogenesis, and alleviate osteoporosis in a dose-independent manner in SAMP6 mice. This provides new insight for the treatment of spontaneous senile osteoporosis and serves as a research basis for the application of Astragalus Membranaceus.
Article
Biochemistry & Molecular Biology
Benjamin Thilo Krueger, Lena Steppe, Sabine Vettorazzi, Melanie Haffner-Luntzer, Sooyeon Lee, Ann-Kristin Dorn, Anita Ignatius, Jan Tuckermann, Mubashir Ahmad
Summary: Long-term use of glucocorticoids can lead to glucocorticoid-induced osteoporosis, and current drugs for treating bone loss are expensive or have major side effects. Therefore, finding cost-effective small-molecule inhibitors is necessary. This study found that inhibition of Cdk5 improves glucocorticoid-induced bone loss, but does not reverse compromised fracture healing.
Article
Medicine, Research & Experimental
Kui Huang, Ya-Qiong Sun, Xiao-Feng Chen, Feng Tian, Fan Cheng, Qian-Long Gong, Ke-Bin Liu
Summary: Psoralen extracted from Psoraleacorylifolia promotes bone formation and accelerates fracture healing in osteoporotic animals by increasing BMP-2 and ER-alpha levels, and OPG/RANKL ratio.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Daniel Halloran, Venu Pandit, Connor MacMurray, Victoria Stone, Kailey DeGeorge, Mark Eskander, Denise Root, Sean McTague, Heather Pelkey, Anja Nohe
Summary: This study demonstrates the key role of BMPRIa in CK2.3-mediated osteogenesis and confirms C57BL/6 mice as a reliable model that mimics data obtained from patients with osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Fujiang Wang, Pengfei Tu, Kewu Zeng, Yong Jiang
Summary: The study found that the total glycosides and polysaccharides extracts of Cistanche deserticola can promote osteoblastogenic bone formation and improve bone microstructure damage in SAMP6 mice, and their therapeutic effect on osteoporosis is via activating the Wnt/beta-catenin signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cell Biology
Jessika Appelt, Serafeim Tsitsilonis, Ellen Otto, Denise Jahn, Paul Koehli, Anke Baranowsky, Shan Jiang, Melanie Fuchs, Christian H. Bucher, Georg N. Duda, Karl-Heinz Frosch, Johannes Keller
Summary: Despite the crucial role of osteoclast-to-osteoblast coupling in normal bone turnover, it appears to have limited relevance in bone healing, as shown in the study with CTR-deficient mice. Accelerated bone regeneration was not observed in the CTR-deficient mice, indicating that the specific involvement of the CTR-S1P axis may not significantly impact bone repair.
Article
Food Science & Technology
Shen Wang, Ke Heng, Xingchen Song, Juan Zhai, Huanyu Zhang, Qinghe Geng
Summary: This study suggests that lycopene may have beneficial effects on senile osteoporosis by reducing oxidative stress, cellular senescence, and senescence-associated secretory phenotype (SASP). Lycopene supplementation improves bone mass, microstructure, biomechanical properties, and strength in a senile osteoporosis model. The underlying mechanism may involve the regulation of ROS-accelerated cellular senescence and SASP.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cell & Tissue Engineering
J. Li, R. M. Y. Wong, Y. L. Chung, S. S. Y. Leung, S. K-H Chow, M. Ip, W-H Cheung
Summary: With the increasing aging population, fragility fractures have become one of the most common conditions. This study investigates whether microbiological outcomes and fracture-healing are worse in osteoporotic bone compared to normal bone with fracture-related infection (FRI).
BONE & JOINT RESEARCH
(2022)
Article
Nutrition & Dietetics
Zhengmeng Yang, Lu Feng, Ming Wang, Yucong Li, Shanshan Bai, Xuan Lu, Haixing Wang, Xiaoting Zhang, Yaofeng Wang, Sien Lin, Micky D. Tortorella, Gang Li
Summary: Sesamin has been found to promote osteoporotic fracture healing by activating the BMP2 signaling pathway and enhancing chondrogenesis and angiogenesis activities.
Review
Biochemistry & Molecular Biology
Emerito Carlos Rodriguez-Merchan
Summary: This article reviews recent findings on the molecular mechanisms of bone healing and presents various biological alternatives for treating recalcitrant nonunions, such as using morin, BMP9, and leptin. It also discusses factors that impact bone regeneration, including inhibition of estrogen receptor signaling, smoking-induced inflammatory responses, and delayed fracture healing in diabetic animals due to BMP6 deficiency. The combination of bioceramics and expanded autologous human mesenchymal stem cells from bone marrow is highlighted as a promising alternative for treating nonunions that do not respond well to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Camilla Bergh, Michael Moller, Jan Ekelund, Helena Brisby
Summary: Limited information is available on age-related mortality across fractures in different anatomical regions. This study aimed to investigate mortality rates at 30 days and 1 year post-fracture within four different age groups. The findings showed that older age groups had higher mortality rates, and fractures of the femur and humerus diaphysis were associated with the highest mortality rates. Additionally, pelvic, acetabulum, spine, and tibia fractures had moderately high mortality rates across all age groups.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Dominik Saul, Sundeep Khosla
Summary: More than 2.1 million age-related fractures occur in the United States annually, resulting in a significant socioeconomic burden. Age-related deterioration of bone structure is associated with impaired bone healing, which occurs in four stages: inflammation, angiogenesis and cartilage formation, soft callus development, and remodeling. Impaired fracture healing due to aging is related to detrimental changes at the cellular level, and recent studies show that clearing senescent cells enhances fracture repair.
Article
Nutrition & Dietetics
Aleksey Bychkov, Vyacheslav Koptev, Varvara Zaharova, Polina Reshetnikova, Elena Trofimova, Elena Bychkova, Ekaterina Podgorbunskikh, Oleg Lomovsky
Summary: This study presents findings on the biological action of a supplement containing vitamin D and soluble silicon, which are involved in bone formation and mineralization. The supplement showed the ability to stimulate bone tissue regeneration, accelerate bone cell differentiation, and promote the restoration of bone structure. Additionally, it enhanced calcium absorption and reduced skeletal damage.
