Article
Genetics & Heredity
Agata Leonska-Duniec, Katarzyna Switala, Ildus I. Ahmetov, Craig Pickering, Myosotis Massidda, Maciej Buryta, Andrzej Mastalerz, Ewelina Maculewicz
Summary: The study investigated the impact of the FABP2 Ala54Thr polymorphism on body mass, body composition measurements, and energy metabolism parameters in young, nonobese Caucasian women. While the polymorphism may help identify women at risk for overweight and obesity, no interaction was found between physical activity and the Ala54Thr polymorphism on the examined parameters.
Article
Biochemistry & Molecular Biology
Junting Xie, Xiaoning Hou, Wanshi He, Jie Xiao, Yong Cao, Xiaojuan Liu
Summary: Although the specific action site and signal pathway of astaxanthin in weight loss remain unclear, this study used Caenorhabditis elegans to shed light on its efficacy and specific action sites. The supplementation of 60 μM astaxanthin significantly reduced fat deposition and triglyceride levels and prevented obesity caused by excessive energy accumulation. These effects were induced by sbp-1/mdt-15 and insulin/insulin-like growth factor pathways, and co-regulated the down-regulation of specific sites fat-6 and fat-7.
Article
Biochemistry & Molecular Biology
Prince K. K. Akowuah, Carolina Lema, Rolando E. E. Rumbaut, Alan R. R. Burns
Summary: Feeding mice with a high-fat/sucrose diet causes loss of corneal nerve function and impairs corneal wound healing. Changing to a low fat/sugar diet with enrichments in complex carbohydrates mitigates the reduction in nerve function, but its effect on corneal wound healing needs further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Tengteng Ji, Bing Fang, Fang Wu, Yaqiong Liu, Le Cheng, Yixuan Li, Ran Wang, Longjiao Zhu
Summary: The number of obese people is increasing worldwide due to high-fat diets causing excess energy intake. A 12-week dietary intervention study on high-fat diet-induced obese mice showed that changing the diet significantly reduced weight gain and subcutaneous adipose tissue weight. Diet change also affected lipolysis, lipogenesis, and the proportion of adipocyte stem cells in different fat tissues.
Article
Food Science & Technology
Yang Yang, Shenhan Ge, Qingyan Chen, Shaoling Lin, Shaoxiao Zeng, Bee K. Tan, Jiamiao Hu
Summary: Chlorella unsaturated fatty acids (C.UFAs), rich in linoleic acid, have been found to have antiobesity effects by reducing body weight gain, improving blood glucose and lipid profile. The mechanisms may involve down-regulation of lipogenic genes and up-regulation of lipolytic gene, as well as activation of the AMPK signaling pathway.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Mingming Li, Yang Xiao, Lianggui Xiao, Yu Li, Mengting Jia, Yu Sun, Tingli Pan, Lei Zhou, Yixing Li
Summary: With improvements in living standards, obesity has become an increasingly serious health issue. This study found that epigoitrin (EP) from Radix isatidis has significant potential in preventing and treating obesity. EP reduced fat accumulation, promoted glucose uptake and glycogen storage, increased energy production, and improved lipid and glucose metabolism disorders.
Article
Endocrinology & Metabolism
Vanessa M. Lima, Jianming Liu, Bruna B. Brandao, Caroline A. Lino, Camila S. Balbino Silva, Marcio A. C. Ribeiro, Tiago E. Oliveira, Caroline C. Real, Daniele de Paula Faria, Carly Cederquist, Zhan-Peng Huang, Xiaoyun Hu, Maria Luiza Barreto-Chaves, Julio C. B. Ferreira, William T. Festuccia, Marcelo A. Mori, C. Ronald Kahn, Da-Zhi Wang, Gabriela P. Diniz
Summary: miR-22 plays a role in white, beige, and brown adipocyte differentiation. Deletion of miR-22 reduces white adipocyte differentiation, increases BAT activity, and enhances resistance in HFD-fed mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Biochemistry & Molecular Biology
Dena Nuwaylati, Basmah Eldakhakhny, Abdulhadi Bima, Hussein Sakr, Ayman Elsamanoudy
Summary: Insulin resistance plays a role in the pathogenesis of many diseases, and the ketogenic diet has been proven as an effective treatment for various insulin resistance-related disorders. However, the safety of the ketogenic diet is still debatable, and attention should be given to the opportunities and challenges associated with its implementation.
Article
Nutrition & Dietetics
Yu Wang, Xuyang Gao, Xiaoyou Chen, Qiang Li, Xinrui Li, Junxing Zhao
Summary: Sea buckthorn powder intake has a preventive effect on high-fat diet-induced obesity, reducing body weight, fat mass, and circulating lipid levels, and improving insulin sensitivity. Additionally, it alleviates hepatic steatosis and lipid accumulation, exhibits anti-inflammatory capacity in white adipose tissue, promotes thermogenesis in brown adipose tissue, and induces beige adipocyte formation.
Review
Physiology
Minjeong Kim, Brynn H. Voy
Summary: Modern broiler chickens accumulate more adipose tissue than is necessary due to selection for rapid growth, which can compromise well-being and waste feed. Studies show that diet rich in Omega-3 polyunsaturated fatty acids (n-3 PUFA) can inhibit fat accretion by influencing adipose tissue growth and metabolism. Efforts to reduce fat accretion in broilers by enriching the diet in n-3 PUFA have shown promising results.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Woongjae Yoo, Jacob K. Zieba, Nora J. Foegeding, Teresa P. Torres, Catherine D. Shelton, Nicolas G. Shealy, Austin J. Byndloss, Stephanie A. Cevallos, Erik Gertz, Connor R. Tiffany, Julia D. Thomas, Yael Litvak, Henry Nguyen, Erin E. Olsan, Brian J. Bennett, Jeffrey C. Rathmell, Amy S. Major, Andreas J. Baumler, Mariana X. Byndloss
Summary: It was found that chronic exposure to a high-fat diet can increase levels of circulating trimethlamine N-oxide, a potentially harmful metabolite generated by gut microbiota.
Article
Nutrition & Dietetics
Yu Ra Lee, Hye-Bin Lee, Mi-Jin Oh, Yoonsook Kim, Ho-Young Park
Summary: This study found that thyme extract can alleviate obesity and gut derangements caused by a high-fat diet. It can reduce weight gain and body fat percentage, regulate serum biomarkers associated with obesity, and improve intestinal barrier function and colon shortening. Additionally, thyme extract can alter the levels of metabolites.
Article
Food Science & Technology
Wei Song, Chen Song, Li Li, Tianyi Wang, Jinhong Hu, Lina Zhu, Tianli Yue
Summary: The study found that three Lactobacillus strains have inhibitory effects on obesity induced by high-fat diet, reducing weight gain and adipose accumulation, while also improving hepatic steatosis. These probiotics also regulated serum lipid levels and adipocytokines, and altered the diversity of gut microbiota.
JOURNAL OF FOOD SCIENCE
(2021)
Review
Endocrinology & Metabolism
Ludovica Verde, Stefania Luca, Simona Cernea, Cem Sulu, Volkan Demirhan Yumuk, Trond Geir Jenssen, Silvia Savastano, Gerardo Sarno, Annamaria Colao, Luigi Barrea, Giovanna Muscogiuri
Summary: The purpose of this review is to summarize the current evidence on the role of obesity in the development and progression of chronic kidney disease and the current evidence on nutritional, pharmacological, and surgical strategies for the management of individuals with obesity and chronic kidney disease. Obesity can harm the kidney through direct pathways and systemic complications, leading to glomerular hyperfiltration, proteinuria, and impaired glomerular filtration rate. Various weight loss strategies exist, but there are no clinical practice guidelines for managing obesity and chronic kidney disease.
CURRENT OBESITY REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Tingwei Wang, Yongli Ye, Jian Ji, Shuang Zhang, Xingxing Yang, Jiayuan Xu, Jia-Sheng Wang, Zhiyuan Chen, Bangen Xia, Hongfang Shen, Ruowei Xia, Wenqin Shi, Xiulan Sun
Summary: Astilbin consumption has significant anti-obesity and anti-inflammatory effects in high-fat diet mice. It improves gut microbial dysbiosis, enhances intestinal carbohydrate and lipid metabolism, and protects the integrity of the intestinal barrier. Astilbin is a potential prebiotic for the prevention of gut-liver axis damage and metabolic disruption in obese individuals.
Article
Biotechnology & Applied Microbiology
Daniel de Luis, David Primo, Olatz Izaola, Rocio Aller
Summary: The gene expression in peripheral blood of obese patients was modified after weight loss through a Mediterranean diet, with changes observed in 634 genes related to the endocrine system and nutritional diseases.
Article
Nutrition & Dietetics
Daniel Luis, Rocio Aller, Olatz Izaola, David Primo
Summary: In this study, the T allele of the rs10401670 RETN gene polymorphism showed a significant association with improved response in insulin resistance, triglycerides, and C-reactive protein compared to non T allele carriers after weight loss with a high-fat hypocaloric diet and a Mediterranean diet.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Nutrition & Dietetics
David Primo, Javier Garcia Rioja, Olatz Izaola, Carlos del Rio San Cristobal, Ruben Pinero Teno, Daniel de Luis Roman
Summary: Prescribing physical exercise through an online platform can improve anthropometric parameters, cardiovascular risk factors, and quality of life in sedentary obese patients.
NUTRICION HOSPITALARIA
(2022)
Review
Nutrition & Dietetics
Ricardo Usategui-Martin, Daniel-Antonio De Luis-Roman, Jose Maria Fernandez-Gomez, Marta Ruiz-Mambrilla, Jose-Luis Perez-Castrillon
Summary: This study evaluated the impact of polymorphisms in the vitamin D receptor gene on the response to vitamin D supplementation through a systematic review and meta-analysis. The results suggest that the TaqI and FokI polymorphisms may play a role in modulating the response to vitamin D supplementation.
Article
Endocrinology & Metabolism
Rebeca Jimenez-Sahagun, Emilia Gomez Hoyos, Gonzalo Diaz Soto, Maria de la O. Nieto de la Marca, Marta Sanchez Ibanez, Sofia del Amo Simon, Beatriz Torres Torres, Juan Jose Lopez Gomez, Esther Delgado Garcia, Ana Ortola Buigues, Daniel de Luis Roman
Summary: Flash glucose monitoring (FGM) combined with a structured educational program can improve the quality of life and patient satisfaction in patients with type 1 diabetes (DM1). However, there was no significant improvement in other glycemic control parameters, except for the improvement in HbA1c and reduction in the number of hypoglycemic events.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2022)
Article
Biotechnology & Applied Microbiology
Daniel de Luis, Olatz Izaola, David Primo, Rocio Aller
Summary: This study demonstrated a significant improvement in serum omentin-1 levels after weight loss with both high-fat hypocaloric diets, with Diet M showing a higher improvement compared to Diet P.
Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Katia Benito-Sendin Plaar, Olatz Izaola-Jauregui, David Primo-Martin, Emilia Gomez-Hoyos, Beatriz Torres-Torres, Daniel A. De Luis-Roman
Summary: This study compared the value of muscle ultrasonography with techniques such as anthropometry and impedanciometry in diagnosing malnutrition in patients with oncological pathology. The results showed that muscle ultrasonography correlates with body composition measurement techniques.
Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Nutrition & Dietetics
Daniel de Luis Roman, David Primo, Olatz Izaola, Rocio Aller
Summary: This study investigated the role of the genetic variant rs662799 of the APOA5 gene in metabolic changes after a 9-month consumption of a low-calorie Mediterranean pattern diet. The results showed that non-C allele carriers experienced a decrease in triglyceride, insulin, and HOMA-IR levels, while no such effect was observed in C allele carriers.
Article
Endocrinology & Metabolism
Carla Noemi Tafur Sanchez, Miguel Dura Gil, Andrea Aleman Dominguez del Rio, Celia Maria Hernandez Perez, Natalia Mora Cuadrado, Sara Gomez de la Cuesta, David Primo Martin, Daniel de Luis Roman, Rocio Aller de la Fuente
Summary: This study evaluated the diagnostic accuracy of non-invasive methods based on clinical and analytical data in the diagnosis of metabolic hepatic steatosis, compared to liver biopsy. The results showed that non-invasive steatosis indices were more sensitive, while fibrosis indices were more specific. HFS had the highest sensitivity and negative predictive value in diabetic patients.
ENDOCRINOLOGIA DIABETES Y NUTRICION
(2022)
Article
Endocrinology & Metabolism
David Primo, Olatz Izaola, Daniel A. de Luis
Summary: This study found that the TyG index is more powerful for predicting metabolic syndrome than HOMA-IR in Caucasian obese subjects.
ANNALS OF NUTRITION AND METABOLISM
(2023)
Article
Surgery
Daniel Antonio de Luis, Olatz Izaola, David Primo, Juan Jose Lopez, David Pacheco
Summary: This study aimed to evaluate the effects of the rs9939609 genetic variant on weight loss and metabolic parameters after sleeve gastrectomy. The results showed that non-A allele carriers had better improvement in weight, waist circumference, and insulin levels after surgery, and had a lower percentage of participants with diabetes.
SURGERY FOR OBESITY AND RELATED DISEASES
(2023)
Article
Endocrinology & Metabolism
David Primo, Olatz Izaola, Daniel de Luis
Summary: This study found that the high resistin/uric acid index is associated with metabolic syndrome (MS) and is correlated with glucose levels, insulin levels, and insulin resistance (HOMA-IR) in a population of Caucasian females with obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Nutrition & Dietetics
Juan Jose Lopez-Gomez, David Garcia-Beneitez, Rebeca Jimenez-Sahagun, Olatz Izaola-Jauregui, David Primo-Martin, Beatriz Ramos-Bachiller, Emilia Gomez-Hoyos, Esther Delgado-Garcia, Paloma Perez-Lopez, Daniel A. De Luis-Roman
Summary: This study evaluated the relationship between nutritional ultrasound parameters and morphofunctional assessment in patients with disease-related malnutrition and found that the muscle mass and quality parameters determined by nutritional ultrasound were worse in patients with malnutrition and sarcopenia. In addition, there was a correlation between muscle quality parameters and electrical parameters and muscle strength.
Article
Nutrition & Dietetics
Daniel Antonio de Luis, Olatz Izaola, David Primo, Juan Jose Lopez Gomez
Summary: The objective of this study was to evaluate the role of the rs1042714 genetic variant of ADRB2 gene on weight loss, body composition, and metabolic changes in women with obesity. The study found that the G allele of rs1042714 predicts the magnitude of weight loss resulting from a pMR diet, and these adiposity improvements lead to a better improvement of insulin resistance and impaired glucose metabolism in G allele carriers.