Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tian Jiang, Yi Zhang, Fang Dai, Chao Liu, Honglin Hu, Qiu Zhang
Summary: This study aimed to explore the role of non-invasive detection of advanced glycation end products (AGEs) in the early screening of diabetes mellitus (DM) in the Chinese community and investigate the moderating effect of body mass index (BMI) and metabolic indexes. The results indicate that in Chinese participants with high AGE accumulation, priority should be given to the quality of metabolic-related indicators such as BMI, TG, and TC to effectively reduce fasting blood glucose levels.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Endocrinology & Metabolism
Elaf Al-Saoudi, Marie M. B. Christensen, Peter Nawroth, Thomas Fleming, Eva E. E. Hommel, Marit E. E. Jorgensen, Jesper Fleischer, Christian S. S. Hansen
Summary: In young adults with type 1 diabetes, increased levels of AGEs involving different metabolic pathways were associated with several measures of CAN and DSPN, suggesting that AGEs may play a diverse role in the pathogeneses of diabetic neuropathy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Raphael S. Pinto, Guilherme S. Ferreira, Gina Camillo R. Silvestre, Monique de Fatima M. Santana, Valeria S. Nunes, Lucas Ledesma, Paula R. Pinto, Sayonara Ivana S. de Assis, Ubiratan F. Machado, Erasmo S. da Silva, Marisa Passarelli
Summary: Advanced glycation end products (AGEs) are independently associated with cardiovascular disease (CVD) and soluble RAGE (sRAGE) alleviates the harmful effects of AGE in atherogenesis. This study examined the correlation between plasma AGEs and sRAGE with cholesterol, oxysterols, and markers of cholesterol synthesis and absorption in atherosclerotic plaques. The results showed that symptomatic subjects had increased cholesterol and oxysterol levels in plaques compared to asymptomatic individuals. Plasma AGEs and sRAGE were correlated with sterol accumulation in plaques, while sRAGE was inversely correlated with AGEs, oxysterols, and markers of cholesterol synthesis and absorption. These findings suggest that plasma AGEs and sRAGE can predict sterol accumulation in atherosclerotic lesions.
DIABETES & VASCULAR DISEASE RESEARCH
(2022)
Review
Chemistry, Medicinal
Amna Parveen, Razia Sultana, Seung Min Lee, Tae Hun Kim, Sun Yeou Kim
Summary: Research shows that advanced glycation end products play a crucial role in diabetes and its related complications, while natural products rich in bioactive constituents can control and prevent these diseases through various signaling cascades.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Medicine, General & Internal
Mitra Nadali, Lovisa Lyngfelt, Malin C. Erlandsson, Sofia Toyra Silfversward, Karin M. E. Andersson, Maria Bokarewa, Rille Pullerits
Summary: The study suggests that low sRAGE is a marker of metabolic failure developed during chronic inflammation in rheumatoid arthritis (RA) patients. It emphasizes the importance of monitoring metabolic health in female RA patients for timely prevention of cardiovascular disease (CVD). Low sRAGE is associated with higher estimation of CVD risk and metabolic events, especially in patients younger than 50 years old.
FRONTIERS IN MEDICINE
(2021)
Review
Cell Biology
Qian Yu, Guo-hong Qiao, Min Wang, Li Yu, Yaoxiang Sun, Hui Shi, Tie-liang Ma
Summary: Diabetic foot ulcer poses a worldwide challenge in clinical medicine due to the ineffective traditional treatments. Researching the pathogenesis and molecular mechanisms of stem cell therapy for diabetic foot is of great importance in maximizing the repair properties of stem cells. Additionally, effective application modalities are crucial for improving stem cell survival and viability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Neda Emami, AliReza Alizadeh, Arezoo Maleki-Hajiagha, Alireza Dizavi, Samira Vesali, Ashraf Moini
Summary: This study found no significant differences in the levels of serum sRAGE and FF sRAGE between Iranian women with and without PCOS. However, BMI and dietary intake of AGEs had more significant effects on sRAGE concentration in Iranian women.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Chemistry, Analytical
Natalia Arteaga-Marrero, Abian Hernandez, Enrique Villa, Sara Gonzalez-Perez, Carlos Luque, Juan Ruiz-Alzola
Summary: Thermography technology provides non-invasive foot temperature measurements for diabetic patients, aiding in early detection and reducing complications. Various segmentation methods were evaluated, with the U-Net approach showing robustness and optimal performance.
Article
Medicine, General & Internal
Andrei Ardelean, Diana-Federica Balta, Carmen Neamtu, Adriana Andreea Neamtu, Mihai Rosu, Luminita Pilat, Silviu Moldovan, Cristi Tarta, Bogdan Totolici
Summary: Strategies have been researched and implemented to reduce the number of people with diabetic foot ulcers (DFUs). Accurate assessment of DFU severity is a challenge for resource allocation and treatment choice. This study focused on assessing pentraxin-3 as a biomarker for infected DFUs (IDFUs) and evaluating other markers such as white blood cells, C-reactive protein, erythrocyte sedimentation rate, and procalcitonin for identifying IDFUs.
Article
Biochemistry & Molecular Biology
Govigerel Bayarsaikhan, Delger Bayarsaikhan, Pyung Chun Oh, Woong Chol Kang, Bonghee Lee
Summary: Researchers investigated the utility of AGEs as prognostic biomarkers for AMI and found that CUPRAC-reactive AGEs exhibit various patterns of changes in serum samples of AMI patients.
Article
Chemistry, Multidisciplinary
Hwan June Kang, Suneel Kumar, Arielle D'Elia, Biraja Dash, Vikas Nanda, Henry C. Hsia, Martin L. Yarmush, Francois Berthiaume
Summary: The combination of AGEs and RAGE triggers pro-inflammatory signals that inhibit the proliferative phase of skin wound healing. A new coacervate system has been developed to reverse AGE-mediated changes, accelerate diabetic wound healing, and provide a potential therapeutic approach.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Endocrinology & Metabolism
Lin Mao, Ruili Yin, Longyan Yang, Dong Zhao
Summary: Atherosclerosis is a chronic inflammatory disease caused by factors like hyperglycemia, dyslipidemia, AGEs, inflammation, and insulin resistance. AGEs play a significant role in the pathogenesis of AS by affecting the function of VSMCs, contributing to the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2022)