Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Mengting Li, Caiqin Gan, Runan Zhang, Jiahui Wang, Youwei Wang, Weining Zhu, Lan Liu, Jian Shang, Qiu Zhao
Summary: Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disease. TRAF5 deficiency exacerbates colitis, but its role in regulating CD4(+) T cell immune responses in IBD pathogenesis is unclear.
Article
Nanoscience & Nanotechnology
Yee Huang, Li Nan, Chenwen Xiao, Jie Dong, Ke Li, Jvfen Cheng, Quanan Ji, Qiang Wei, Guolian Bao, Yan Liu
Summary: The study successfully developed GAN-OMV, which can stimulate Th1/Th2/Th17 immune responses against Bb and provide a promising strategy for novel vaccine development against the microbial pathogen. GAN-OMV showed a stable core-shell structure and effectively internalized into macrophages through multiple endocytotic pathways, promoting cell proliferation, cytokine secretion, and M1 polarization. Subcutaneous GAN-OMV vaccination significantly enhanced specific antibody production, lymphocyte proliferation, and the production of Th1/Th2/Th17 cytokines.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ritian Lin, Caiyun Ma, Leilei Fang, Chunjin Xu, Cui Zhang, Xiaohan Wu, Wei Wu, Ruixin Zhu, Yingzi Cong, Zhanju Liu
Summary: TOB1 expression is decreased in IBD patients, and overexpression of TOB1 can suppress the differentiation of IBD CD4(+) T cells into Th1/Th17 cells. It inhibits Th1/Th17 cell differentiation through the Smad4/5-ID2 pathway.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Medicine, Research & Experimental
Dominik Sonanini, Christoph M. Griessinger, Barbara F. Schoerg, Philipp Knopf, Klaus Dittmann, Martin Roecken, Bernd J. Pichler, Manfred Kneilling
Summary: The study demonstrated that low-dose TBI can significantly improve the efficacy of CD4+ T cell-based immunotherapies, leading to increased survival of RIP1-Tag2 mice and enhanced infiltration of CD4+ T cells in tumor tissue. This approach may provide a rationale for combining TBI with immunotherapy for cancer treatment in clinical settings.
Article
Ophthalmology
Xiangyu Fan, Jing Zhang, Yiqin Dai, Kun Shan, Jianjiang Xu
Summary: Blocking P2X7R can significantly alleviate corneal allograft rejection and promote graft survival by reducing inflammatory cell infiltration and Th1/Th17 cell frequencies. Research also showed that its effect on promoting immune responses in corneal allograft rejection relies heavily on activation on the NLRP3/caspase-1/IL-1 beta axis.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Immunology
Jongdae Lee, Beatriz Lozano-Ruiz, Fengyuan Mandy Yang, Dengxia Denise Fan, Liya Shen, Jose M. Gonzalez-Navajas
Summary: Immune checkpoint inhibition has become a key aspect of cancer therapy, with CD4(+) T cells playing a crucial role in modulating immune responses against tumors. Different subsets of helper T cells have varying impacts on the clinical response to immune checkpoint therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Robert Krause, Christian M. Warren, Joshua D. Simmons, Peter F. Rebeiro, Fernanda Maruri, Farina Karim, Timothy R. Sterling, John R. Koethe, Al Leslie, Yuri F. van der Heijden
Summary: Patients with stable/increased HbA1c during TB treatment exhibited an increased pro-inflammatory state and elevated T cell activity. These changes were associated with unresolved dysglycemia and may indicate failure to fully resolve infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Sudhanshu Shekhar, Navdeep K. Brar, Fernanda C. Petersen
Summary: Exposure to antibiotics reduces the number of CD4+ and CD8+ T cells, as well as suppresses Th1 and Th17 responses to Streptococcus pneumoniae in neonatal mice.
PEDIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Thamrong Wongchang, Panwadee Pluangnooch, Suradej Hongeng, Adisak Wongkajornsilp, Dean Thumkeo, Kitipong Soontrapa
Summary: Allergic contact dermatitis (ACD) is a type IV hypersensitivity mediated by Th1/Th17 immune response. A novel immunosuppressant, the DYRK1B inhibitor, was found to reduce ear inflammation and inhibit Th1 and Th17 cell differentiation while promoting Treg differentiation. This is potentially a promising novel agent for ACD treatment.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Kuo-Tung Tang, Chi-Chien Lin, Shih-Chao Lin, Jou-Hsuan Wang, Sen-Wei Tsai
Summary: The experiment demonstrated that kurarinone showed significant improvement in symptoms of arthritis in CIA mice, reducing levels of proinflammatory cytokines, inhibiting T cell proliferation and differentiation, and reducing oxidative stress through activating the antioxidant pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sihan Wu, Rui Ma, Yajie Zhong, Zilin Chen, Hongyan Zhou, Minyi Zhou, Waipo Chong, Jun Chen
Summary: IL-27 signaling plays a suppressive role in regulating uveitogenic Th1/Th17 responses in EAU, with deficiency exacerbating ocular inflammation and impairing visual function. It also affects multiple CD4(+) cell subsets, including effector Th1 and Th17 cells, and regulatory Tr1 cells, indicating therapeutic potential in controlling uveitis through enhancing IL-27 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xiao-Di Chen, Jing Xie, Yong Wei, Ji-Feng Yu, Ye Cao, Lu Xiao, Xue-Jing Wu, Cong-Jian Mao, Run-Min Kang, Yong-Gang Ye
Summary: Despite long-term control efforts, hepatic coccidiosis caused by Eimeria stiedai infection remains persistent in rabbits in China. This study provides the first evidence of changes in Th1/Th2/Treg/Th17/Th9/Th21 cells in rabbits infected with E. stiedai, offering insights into immune regulation mechanisms and potential vaccine development.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Qian Zhu, Kahindo P. Muyayalo, Qian-Han Xu, Jing Wang, Huan Wang, Ai-Hua Liao
Summary: This study showed that the use of Prunella vulgaris can improve inflammation and obstetric complications in EAT rats, alleviate autoimmune thyroiditis, and enhance pregnancy outcomes by reducing Th1/Th17 immune responses and promoting Treg cell proliferation.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Immunology
Indumathi Manoharan, Daniel Swafford, Arulkumaran Shanmugam, Nikhil Patel, Puttur D. Prasad, Muthusamy Thangaraju, Santhakumar Manicassamy
Summary: The activation of the TCF4 transcription factor in dendritic cells is critical for controlling the magnitude of inflammatory responses and limiting neuroinflammation. Loss of TCF4 in DCs leads to heightened activation of p38 MAPK and increased levels of proinflammatory cytokines, exacerbating experimental autoimmune encephalomyelitis pathology. Manipulation of the TCF4 pathway in dendritic cells represents a potential therapeutic approach to control autoimmune neuroinflammation.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Marion Rolot, Annette M. Dougall, Justine Javaux, Francois Lallemand, Benedicte Machiels, Philippe Martinive, Laurent Gillet, Benjamin G. Dewals
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Virology
Emeline Goffin, Justine Javaux, Eric Destexhe, Carla D. Pretto, Katherine R. Spindler, Benedicte Machiels, Laurent Gillet
JOURNAL OF VIROLOGY
(2019)
Article
Virology
Sophie Jacobs, Caroline Zeippen, Fanny Wavreil, Laurent Gillet, Thomas Michiels
Article
Immunology
Mickael Dourcy, Celine Maquee, Lorene Dams, Gautier Gilliaux, Justine Javaux, Daniel Desmecht, Matthias Mack, Benjamin G. Dewals, Benedicte Machiels, Laurent Gillet
MUCOSAL IMMUNOLOGY
(2020)
Article
Virology
Melanie Koehler, Martin Delguste, Christian Sieben, Laurent Gillet, David Alsteens
ANNUAL REVIEW OF VIROLOGY, VOL 7, 2020
(2020)
Article
Chemistry, Multidisciplinary
Martin Delguste, Gregoire Le Brun, Florian Cotin, Benedicte Machiels, Laurent Gillet, David Alsteens
Summary: Viruses are highly efficient pathogenic entities that have evolved over millions of years, with some viral proteins still having unclear functions. Through atomic force microscopy experiments, it was discovered that gH/gL is the main actor in binding to cell surface glycosaminoglycans during virus attachment. Fab antibody fragments targeting gH/gL or gp70 show potential as a treatment to prevent virus attachment to cell surfaces.
Article
Microbiology
Justine Defeche, Samira Azarzar, Alyssia Mesdagh, Patricia Dellot, Amandine Tytgat, Fabrice Bureau, Laurent Gillet, Yasmine Belhadj, Sebastien Bontems, Marie-Pierre Hayette, Raphael Schils, Souad Rahmouni, Marie Ernst, Michel Moutschen, Gilles Darcis
Summary: Testing and isolation of COVID-19 patients are crucial in controlling the pandemic, with PCR tests being the gold standard for diagnosis. The study compared the sensitivity of different sample specimens and found that nasopharyngeal swabs were most sensitive, while throat washing showed better performance at later time points.
Article
Biology
Steven Van Vooren, James Grayson, Marc Van Ranst, Elisabeth Dequeker, Lies Laenen, Reile Janssen, Laurent Gillet, Fabrice Bureau, Wouter Coppieters, Nathalie Devos, Benjamin Hengchen, Pierre Wattiau, Sibylle Mehauden, Yvan Verlinden, Kurt Van Baelen, Theresa Pattery, Jean-Pierre Valentin, Kris Janssen, Martine Geraerts, John Smeraglia, Jan Hellemans, Pieter Wytynck, Pieter Mestdagh, Nienke Besbrugge, Rene Hoefer, Friedel Nollet, Jo Vandesompele, Pieter De Smet, John Lebon, Emmanuel Vandewynckele, Steven Verstrepen, Wouter Uten, Arnaud Capron, Hugues Malonne, Jeroen Poels, Emmanuel Andre
Summary: This article presents the rapid establishment of a standardized, multi-site, nation-wide COVID-19 screening program in Belgium and the implementation of a reliable, validated, high-volume workflow to overcome challenges caused by shortages of equipment and reagents.
Article
Biology
M. Arnst, G. Louppe, R. Van Hulle, L. Gillet, F. Bureau, V Denoel
Summary: A hybrid stochastic model is proposed to evaluate the impact of measures such as screening testing on reducing disease transmission in university campuses and surrounding communities. The model incorporates various factors including interaction with the surrounding community, variability of transmission dynamics, participation rate in screening testing, etc.
MATHEMATICAL BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Benoit Petre, Marine Paridans, Nicolas Gillain, Eddy Husson, Anne-Francoise Donneau, Nadia Dardenne, Christophe Breuer, Fabienne Michel, Margaux Dandoy, Fabrice Bureau, Laurent Gillet, Dieudonne Leclercq, Michele Guillaume
Summary: This study aimed to understand the factors that encourage participation and level of engagement of nursing homes staff in a routine saliva testing program for COVID-19. The results showed that perception of the justification of the efforts required for testing and perception of practicability of the procedure were significantly associated with the adoption of the system by the nursing homes directors. Staff support, incentives, and meetings increased the level of engagement in testing.
Article
Virology
Xiang Du, Emeline Goffin, Lucie Gillard, Benedicte Machiels, Laurent Gillet
Summary: Canine Distemper Virus (CDV) is a fatal and highly contagious pathogen. This study explores the use of replicating adenovirus (AdV) as oral vaccine vectors to immunize against CDV in wildlife carnivores. The results demonstrate the feasibility and effectiveness of this approach.
Article
Virology
Julie Frere, Olga Chatzis, Kelly Cremer, Joanna Merckx, Mathilde De Keukeleire, Florence Renard, Nathalie Ribesse, Frederic Minner, Jean Ruelle, Benoit Kabamba, Hector Rodriguez-Villalobos, Bertrand Bearzatto, Marie-Luce Delforge, Coralie Henin, Fabrice Bureau, Laurent Gillet, Annie Robert, Dimitri Van der Linden
Summary: This prospective study conducted in Belgian French-speaking schools examined the role of asymptomatic children and school staff in the spread of COVID-19. The results showed that asymptomatic positive children remaining at school did not lead to an increase in cases, but the study was carried out during a period of low prevalence.
Article
Environmental Sciences
Gianni Parisi, Veronique Renault, Marie-France Humblet, Nicolas Ochelen, Anh Nguyet Diep, Michele Guillaume, Anne-Francoise Donneau, Fabrice Bureau, Laurent Gillet, Anne-Catherine Lange, Fabienne Michel, Sebastien Fontaine, Claude Saegerman
Summary: This study aimed to assess compliance with COVID-19 prevention measures on campuses and found that the highest compliance was observed during educational activities for mask wearing and physical distancing, while the lowest compliance was observed for physical distancing outside of educational activities and hand sanitization. The study also revealed differences in compliance depending on room types and exam sessions.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Marine Paridans, Justine Monseur, Anne-Francoise Donneau, Nicolas Gillain, Eddy Husson, Dieudonne Leclercq, Christelle Meuris, Gilles Darcis, Michel Moutschen, Claude Saegerman, Laurent Gillet, Fabrice Bureau, Michele Guillaume, Benoit Petre
Summary: This study examines the intentions and decision-making process regarding COVID-19 vaccine boosters among a university population. The findings suggest that a significant percentage of participants changed their minds between their initial intention and final decision. Health literacy and previous intentions regarding the COVID-19 primal vaccination were related to the intentions, while factors such as previous COVID-19 infection, past intentions for primal vaccination, and neutralizing antibody levels influenced the decision not to get vaccinated. These results highlight the importance of personalized approaches to decision-making for individuals.