Article
Immunology
Manupati Srikanth, Mahaboobkhan Rasool
Summary: Research shows that 3, 3'-diindolylmethane (DIM) can be used to treat psoriasis by blocking the action of interleukin (IL) 17A, reducing symptoms and inhibiting the expression of pathogenic mediators in psoriatic keratinocytes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Eirini Giannoudaki, Anna M. Stefanska, Hazel Lawler, Gemma Leon, Yasmina E. Hernandez Santana, Najma Hassan, Shane E. Russell, Rachel Horan, Cheryl Sweeney, Roger S. Preston, Alberto Mantovani, Cecilia Garlanda, Padraic G. Fallon, Patrick T. Walsh
Summary: The study demonstrates that SIGIRR is downregulated in psoriatic lesions, correlating with increased IL-36 family cytokines, and acts as a negative regulator of IL-36 responses in the skin through dendritic cells and keratinocytes. Blocking IL-36R signaling alleviates psoriasiform inflammation in Sigirr(-/-) mice.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Marina Luise Viola Azevedo, Aline Cristina Zanchettin, Caroline Busatta Vaz de Paula, Jarbas da Silva Motta Junior, Mineia Alessandra Scaranello Malaquias, Sonia Mara Raboni, Plinio Cezar Neto, Rafaela Chiuco Zeni, Amanda Prokopenko, Nicolas Henrique Borges, Thiago Mateus Godoy, Ana Paula Kubaski Benevides, Daiane Gavlik de Souza, Cristina Pellegrino Baena, Cleber Machado-Souza, Lucia de Noronha
Summary: By comparing post-mortem lung samples from patients who died of severe COVID-19 and H1N1pdm09 infection, it was found that the H1N1 group showed an increase in tissue expression of IL-8/IL-17A and a higher number of neutrophils. There was no significant difference in the distribution of genotype frequencies in the IL17A gene between the two groups. However, in SNP rs3819025 (G/A), the G allele may be considered a risk allele in patients who died from COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Pascale Zwicky, Florian Ingelfinger, Bruno Marcel Silva de Melo, Fiorella Ruchti, Stefanie Scharli, Nicole Puertas, Mirjam Lutz, Truong San Phan, Thomas M. Kundig, Mitchell P. Levesque, Julia-Tatjana Maul, Christoph Schlapbach, Salome LeibundGut-Landmann, Sarah Mundt, Burkhard Becher
Summary: Psoriasis is a chronic inflammatory skin disorder caused by dysregulated cytokine signaling. Research shows that IL-12 signaling blocks the hyperproliferation of keratinocytes, maintains skin barrier integrity, and reduces disease-driving immune circuits. IL-23p19 inhibitors demonstrate superior efficacy in patients with psoriasis, potentially due to the unperceived role of IL-12 in maintaining skin epithelial cell homeostasis.
SCIENCE IMMUNOLOGY
(2021)
Article
Dermatology
Yanyun Jiang, Siyao Lu, Yuhsien Lai, Liangchun Wang
Summary: This study investigated the role of topical Entinostat in psoriasis therapy. The results showed that this medication significantly improved psoriatic inflammation and inhibited the expression of inflammatory genes.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2023)
Article
Immunology
Stephen J. Gaudino, Huakang Huang, Makheni Jean-Pierre, Preet Joshi, Michael Beaupre, Cody Kempen, Hoi Tong Wong, Pawan Kumar
Summary: The study investigates the role of intestinal IL-17RA signaling in mediating systemic metabolic functions under prolonged high-fat diet conditions. It shows that IL-17RA-driven changes in microbiota composition regulate systemic glucose metabolism, emphasizing the importance of intestinal IL-17RA signaling in high-fat diet-mediated systemic glucose and lipid metabolism.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Developmental Biology
Fang Guo, Yongpei He, Yixian Fan, Zhenzhen Du, Huanhuan Sun, Zuohua Feng, Guimei Zhang, Ting Xiong
Summary: Evidence suggests that neutrophils modulated by G-CSF and IL-6 through the STAT3 pathway may promote the establishment of early endometriosis by altering the expression levels of angiogenesis-related genes such as Mmp9, Bv8, and Trail.
MOLECULAR HUMAN REPRODUCTION
(2021)
Article
Pharmacology & Pharmacy
Kohei Morimoto, Mai Ouchi, Taisuke Kitano, Ryota Eguchi, Ken-ichi Otsuguro
Summary: Dopamine promotes IL-6 expression and process formation in astrocytes via D1-like receptors and beta-adrenoceptors, and this regulation is bidirectional, with the effects of D1-like receptors and beta-adrenoceptors negatively regulated by D2-like receptors and alpha(2)-adrenoceptors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Dermatology
Zhenrui Shi, Xuesong Wu, Chun-Yi Wu, Satya P. Singh, Timothy Law, Daisuke Yamada, Mindy Huynh, William Liakos, Guiyan Yang, Joshua M. Farber, Yu-Jui Yvonne Wan, Samuel T. Hwang
Summary: Bile acids can improve psoriasiform dermatitis through multiple mechanisms, including direct inhibition of IL-17A production and blockade of CCL20-mediated trafficking. These findings support the potential use of bile acids in the treatment of psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Cell Biology
Yanfei Hong, Zhulang Chu, Jingwei Kong, Qiuyi Li, Na Li, Liting Liu, Tong Wu, Jiajing Liu, Dongyu Ge, Jie Li, Guiying Peng
Summary: Recent studies have revealed that IL-17A plays a detrimental role in exacerbating intestinal immune injury caused by asthma, by facilitating neutrophil trafficking. These findings provide insights into exploring new potential biomarkers for treating asthma.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Alexander O. O. Mann, Bola S. S. Hanna, Andres R. Munoz-Rojas, Inga Sandrock, Immo Prinz, Christophe Benoist, Diane Mathis
Summary: The accumulation and function of γδT cells during skeletal muscle regeneration after acute injury are microbiota-dependent, providing a new perspective for the treatment of muscle pathologies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Cell Biology
Ines Alves, Beatriz Santos-Pereira, Noelia de la Cruz, Ana Campar, Vanda Pinto, Pedro M. Rodrigues, Marco Araujo, Sofia Santos, Javier Ramos-Soriano, Carlos Vasconcelos, Roberto Silva, Nuno Afonso, Filipe Mira, Cristina C. Barrias, Nuno L. Alves, Javier Rojo, Lelita Santos, Antonio Marinho, Salome S. Pinho
Summary: Autoimmune diseases, such as systemic lupus erythematosus (SLE), are life-threatening disorders that progressively cause disability. This study found that the presence of microbial-associated mannose structures on the kidney surface triggers a pathogenic autoimmune response mediated by IL-17a, induced by DC-SIGN-expressing gamma 6 T cells. Mice lacking Mgat5, which have more mannose structures in the kidney, displayed spontaneous development of lupus with increased infiltration of gamma 6 T cells. N-acetylglucosamine supplementation inhibited gamma 6 T cell infiltration and controlled disease development, highlighting glycometabolic reprogramming as a potential therapeutic strategy for autoimmune diseases.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Hao Tang, Shida Zhu, Kai Chen, Shujie Yuan, Junzu Hu, Hongkai Wang
Summary: This study aimed to clarify the mechanism of low concentration IL-17A promoting osteoclastogenesis by regulating autophagic activity. The results showed that IL-17A can enhance autophagy and promote osteoclast differentiation, suggesting it as a potential therapeutic target for cancer-related bone resorption.
Article
Immunology
Rodolfo Soria-Castro, Angel R. Alfaro-Doblado, Gloria Rodriguez-Lopez, Marcia Campillo-Navarro, Yatsiri G. Meneses-Preza, Adrian Galan-Salinas, Violeta Alvarez-Jimenez, Juan C. Yam-Puc, Rosario Munguia-Fuentes, Adriana Dominguez-Flores, Sergio Estrada-Parra, Sonia M. Perez-Tapia, Alma D. Chavez-Blanco, Rommel Chacon-Salinas
Summary: The study found that MC infected with L.m were able to clear the bacterial load and responded by degranulating and producing various cytokines. TLR2 was shown to mediate some MC activation pathways during L.m infection, particularly those related to IL-6 and IL-13 production. Interestingly, p38 activation depended on TLR2, but not ERK or NF-kappa B activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Saeideh Sadat Shobeiri, MohammadAli Rezaee, Safoora Pordel, Navideh Haghnnavaz, Mohammadreza Dashti, Malihe Moghadam, Mojtaba Sankian
Summary: The therapeutic effects of M2 and M7 anti-IL17A ssDNA aptamers were evaluated in an IMQ-induced psoriasis mouse model. The application of aptamers significantly improved psoriatic lesions and decreased the expression levels of inflammatory factors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Ophthalmology
Julia Stingl, Sol A. Ban, Markus Nagler, Irene Schmidtmann, Philipp S. Wild, Karl J. Lackner, Thomas Muenzel, Manfred E. Beutel, Norbert Pfeiffer, Alexander K. Schuster
Summary: The study found that the refractive error in phakic eyes changes with age, with a myopic shift at the age of 35-44 and a hyperopic shift at the age of 45-64. This shift decreases with higher age. Smoking is associated with a hyperopic shift, while female sex and myopic baseline SE are associated with a myopic shift. Educational level and occupation were not linked to a change in refractive error at the age of 35-74.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Natalie Arnold, Iris M. Hermanns, Andreas Schulz, Omar Hahad, Volker H. Schmitt, Marina Panova-Noeva, Juergen H. Prochaska, Harald Binder, Norbert Pfeiffer, Manfred Beutel, Karl J. Lackner, Thomas Muenzel, Philipp S. Wild
Summary: This study investigates the predictive ability of direct plasma renin and aldosterone concentrations as well as their ratio (aldosterone-to-renin, ARR) for incident hypertension in the general population. The study finds that ARR has a stronger predictive value for incident hypertension than renin or aldosterone alone, especially in obese subjects.
CARDIOVASCULAR RESEARCH
(2023)
Article
Psychology, Clinical
Danieelle Otten, Mareike Ernst, Antonia M. Werner, Ana N. Tibubos, Iris Reiner, Elmar Braehler, Joerg Wiltink, Matthias Michal, Markus Nagler, Philipp S. Wild, Thomas Muenzel, Jochem Koenig, Karl J. Lackner, Norbert Peiffer, Manfred E. Beutel
Summary: This study aimed to predict the occurrence of chronic diseases based on baseline depressive symptoms and to examine the sex-dependent effects. The results showed that baseline depressive symptoms predicted cardiovascular disease, chronic obstructive lung disease, diabetes, and migraine in both men and women, but not cancer. Additional adjustments for metabolic and lifestyle risk factors increased the risk of chronic obstructive lung disease and migraine for each point of depressive symptoms. There were trends suggesting a relevance of depressive symptoms for cardiovascular disease in men and for diabetes in women.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas Muenzel, Omar Hahad, Andreas Daiber, Philip J. Landrigan
Summary: Healthy soil is essential for human health as it supports the growth of crops, provides food, and sustains populations. However, soil pollution poses a great threat to human health, reducing soil's ability to yield food and resulting in contamination and disease. It also causes water pollution and contributes to air, water, and soil pollution, leading to millions of deaths each year.
CARDIOVASCULAR RESEARCH
(2023)
Article
Ophthalmology
Achim Fiess, Michael S. Urschitz, Markus Nagler, Stefan Nickels, Susanne Marx-Gross, Thomas Muenzel, Philipp S. Wild, Manfred E. Beutel, Karl J. Lackner, Norbert Pfeiffer, Alexander K. Schuster
Summary: This study aimed to analyze the long-term effect of low birth weight on corneal aberrations in adulthood. The results indicated that low birth weight is associated with increased spherical aberration, which may affect optical image quality and visual function.
JOURNAL OF OPTOMETRY
(2023)
Article
Respiratory System
Karsten Keller, Volker H. Schmitt, Mir A. Ostad, Thomas Muenzel, Lukas Hobohm, Christine Espinola-Klein
Summary: Pulmonary embolism is a life-threatening acute disease. Risk stratification of hospitalized patients with PE is crucial. The performance of Mansoor's Self-Report Tool for Cardiovascular Risk Assessment in predicting adverse in-hospital events was evaluated.
CLINICAL RESPIRATORY JOURNAL
(2023)
Editorial Material
Medicine, General & Internal
John F. Keaney, Thomas Muenzel
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Immunology
Aikaterini Gatsiou, Simon Tual-Chalot, Matteo Napoli, Almudena Ortega-Gomez, Tommy Regen, Rachit Badolia, Valeriana Cesarini, Claudia Garcia-Gonzalez, Raphael Chevre, Giorgia Ciliberti, Carlos Silvestre-Roig, Maurizio Martini, Jedrzej Hoffmann, Rana Hamouche, Joseph R. Visker, Nikolaos Diakos, Astrid Wietelmann, Domenico Alessandro Silvestris, Georgio Georgiopoulos, Ali Moshfegh, Andre Schneider, Wei Chan, Stefan Guenther, Johanne Backs, Shin Kwak, Craig H. Selzman, Kimon Stamatelopoulos, Stefan Rose-John, Christian Trautwein, Ioakim Spyridopoulos, Thomas Braun, Ari Waisman, Angela Gallo, Stavros G. Drakos, Stefanie Dimmeler, Markus Sperandio, Oliver Soehnlein, Konstantinos Stellos
Summary: RNA editor ADAR2 regulates endothelial responses to IL-6, controlling leukocyte trafficking in inflamed and ischemic tissues. ADAR2 is required for IL-6 trans-signaling and immune cell infiltration through suppressing primary microRNA processing.
Article
Neurosciences
Stephan A. Muller, Merav D. Shmueli, Xiao Feng, Johanna Tushaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Summary: In this study, the researchers identified SEZ6 and gp130/IL6ST as physiological substrates of BACE1 in non-human-primate cerebrospinal fluid. They also found a reduction of gp130 in human CSF from a clinical trial with a BACE inhibitor and in plasma of BACE1-deficient mice. These findings provide insights into the relationship between BACE1 and gp130 in neuronal signaling and survival.
MOLECULAR NEURODEGENERATION
(2023)
Review
Physiology
Andreas Daiber, Marin Kuntic, Matthias Oelze, Omar Hahad, Thomas Muenzel
Summary: Smoking is a major cardiovascular health risk factor, and the decline in tobacco cigarette use is partially offset by the rise in shisha smoking and e-cigarette vaping. E-cigarettes may have less harm than tobacco smoking but can still cause oxidative stress, inflammation, endothelial dysfunction, and cardiovascular problems. Both vaping and smoking have similar detrimental effects on endothelial function due to the overlapping toxic compounds in vapor and tobacco smoke. The belief that e-cigarettes help quit smoking and nicotine addiction may be false. This review emphasizes the adverse health effects of tobacco cigarettes and e-cigarettes, particularly on endothelial function and cardiovascular health.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Virology
Volker H. Schmitt, Lukas Hobohm, Ingo Sagoschen, Visvakanth Sivanathan, Omar Hahad, Christine Espinola-Klein, Thomas Muenzel, Karsten Keller
Summary: A study in Germany found that diabetes mellitus (DM) has a significant impact on the clinical outcome of patients with COVID-19 infection. Compared to non-diabetic patients, COVID-19 patients with DM are more likely to develop pneumonia, acute respiratory distress syndrome, require intensive care, and have a higher mortality rate.
Article
Cardiac & Cardiovascular Systems
Omar Hahad, Donya A. Gilan, Julian Chalabi, Sadeer Al-Kindi, Alexander K. Schuster, Felix Wicke, Matthias Buettner, Oliver Tuescher, Karl J. Lackner, Peter R. Galle, Stavros Konstantinides, Andreas Daiber, Philipp S. Wild, Thomas Muenzel
Summary: This study aims to investigate the association between social disadvantage and cardiovascular burden and mortality. The findings suggest that low socioeconomic status is associated with increased risk of cardiovascular disease and mortality, with education and occupation being stronger predictors compared to household net income.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Immunology
Stefan Rose-John, Brendan J. Jenkins, Christoph Garbers, Jens M. Moll, Juergen Scheller
Summary: This review discusses the discovery of the IL-6 trans-signalling pathway and the development of biologics that specifically inhibit this pathway. Targeting IL-6 trans-signalling can decrease disease-promoting activities of IL-6 without blocking its protective actions.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Neurosciences
Monica M. Santisteban, Samantha Schaeffer, Antoine Anfray, Giuseppe Faraco, David Brea, Gang Wang, Melissa J. Sobanko, Rose Sciortino, Gianfranco Racchumi, Ari Waisman, Laibaik Park, Josef Anrather, Costantino Iadecola
Summary: This study reveals the critical role of meningeal T cells and macrophage IL-17 signaling in the neurovascular and cognitive dysfunction in a mouse model of hypertension.
NATURE NEUROSCIENCE
(2023)
Article
Infectious Diseases
Ornela Velollari, Christian Malte Reinhardt, Maike Knorr, Katharina Schnitzler, Dirk Graafen, Matthias Miederer, Ralph Stephan von Bardeleben, Thomas Muenzel, Kai-Helge Schmidt, Christian Giebels, Hans-Joachim Schaefers, Lukas Hobohm
Summary: This case study presents a patient with prosthesis endocarditis and paraaortic abscess caused by Cutibacterium acnes. The use of diagnostic imaging techniques confirmed the inflammatory process. The patient was treated with intravenous antibiotics and surgical intervention.
INFECTIOUS DISEASE REPORTS
(2023)