期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 134, 期 5, 页码 1295-1304出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2013.500
关键词
-
类别
资金
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [25293224, 24591553, 24591468] Funding Source: KAKEN
Proliferation and differentiation of keratinocytes are normally well balanced, but this balance can be perturbed in wound healing and is dysregulated in pathological conditions such as atopic dermatitis. Epithelial mesenchymal interaction affects this event via the cross-talk of cytokines and growth factors. Periostin, a matricellular protein, has an important role during reepithelialization in wound healing and is critical for hyperproliferation of keratinocytes in atopic dermatitis. Here we investigated how periostin regulates proliferation and differentiation of keratinocytes in the epithelial mesenchymal interactions using a three-dimensional organotypic air liquid interface coculture system. The release of IL-1 alpha from keratinocytes and subsequent IL-6 production from fibroblasts were critical for keratinocyte proliferation and differentiation. Periostin secreted from fibroblasts was required for IL-1 alpha-induced IL-6 production and enhanced IL-6 production by activation of the NF-kappa B pathway synergistically with IL-1 alpha. Thus, the combination of an autocrine loop of periostin and a paracrine loop composed of IL-1 alpha and IL-6 regulates keratinocyte proliferation and differentiation in the epithelial-mesenchymal interactions, and periostin tunes the magnitude of keratinocyte proliferation and differentiation by interacting with the paracrine IL-1 alpha/IL-6 loop.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据