Article
Anatomy & Morphology
Ozlem Ucer, Nevin Kocaman
Summary: In this study, the researchers found that Suprabasin protein is increased in expression in squamous cell carcinoma (SCC) and decreases with increasing grade. They also observed no expression of Suprabasin in basal cell carcinoma (BCC). Therefore, Suprabasin can be used as a biomarker to differentiate SCC from BCC.
Review
Medicine, General & Internal
Loredana Ungureanu, Ioana Cosgarea, Simona Senila, Alina Vasilovici
Summary: Basal cell carcinoma is a common cancer in white people, with dermoscopy playing a vital role in early diagnosis and management of the disease. Dermoscopy can aid in differentiation of histological subtypes, assessment of surgical margins, and detection of residual disease post non-ablative therapies.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Edyta Wojtys, Kajetan Kielbowski, Michal Kunc, Seweryn Adam Skrzyniarz, Piotr Lisowski, Rafal Becht, Paulina Zukowska, Konrad Ptaszynski, Janusz Wojcik
Summary: Basal cell carcinoma (BCC) is the most common skin cancer, but metastasizing BCC (MBCC) is rare, occurring in approximately 0.0028% to 0.55% of BCC patients. We report two cases of pulmonary MBCC. The first case is a 72-year-old male with multiple recurrences who underwent surgical resection and adjuvant radiotherapy. Immunohistochemistry showed the expression of Ber-EP4, CK5/6, p63, EMA (focal), BCL-2, and CD10 in neoplastic cells, while they were negative for CK7, CK20, S100, estrogen and progesterone receptors, and TTF-1. The second case is a 64-year-old female treated with vismodegib. Clinicopathological features and differential diagnoses are described.
Article
Biotechnology & Applied Microbiology
Feng Li, Ren Niu, ShaoLin Gao, FangChao Zhao, Zefang Dong, Hao Zhang, Shujun Li
Summary: Our study revealed that LINC00662 promotes angiogenesis through the regulation of the miR-195-5p/VEGFA axis in ESCC cell-derived extracellular vesicles (EVs).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Taku Kimura, Ken-ichiro Sakata, Jun Sato, Chisato Ouchi, Noritaka Ohga, Aya Yanagawa-Matsuda, Kyoko Hida, Yoshimasa Kitagawa
Summary: Metastatic basal cell carcinoma poses challenges in current treatment and requires consideration of treatment history and pathohistological features in posttreatment planning.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Medicine, Research & Experimental
Domenico Ribatti, Roberto Tamma, Tiziana Annese, Enrico Crivellato
Summary: Mast cells play important roles in human skin cancers, being involved in inflammatory processes, allergic reactions, and host responses to parasitic and bacterial infectious diseases.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Review
Cell Biology
Melanie V. Brady, Flora M. Vaccarino
Summary: Human neurodevelopment has historically been complex to decipher, but utilizing organoid systems provides a unique opportunity to model human development and disease, shedding light on the intricacies of neural biology.
Article
Biochemistry & Molecular Biology
Jun Wan, Hongji Dai, Xiaoli Zhang, Sheng Liu, Yuan Lin, Ally-Khan Somani, Jingwu Xie, Jiali Han
Summary: The majority of non-melanoma skin cancer cases are basal cell carcinoma and squamous cell carcinoma which originate from keratinocytes. The incidence of keratinocyte carcinomas in the US is over 5 million per year, three times higher than all other types of cancer combined. Research has shown significant variations in gene expression in these tumors, with novel findings including up-regulation of zinc finger encoding genes in human BCC and a novel link between hedgehog signaling, Wnt signaling, and the cilium.
Article
Physics, Applied
Po-Chien Chien, Chao-Yu Chen, Yun-Chien Cheng, Takehiko Sato, Rui-Zhe Zhang
Summary: This study investigated the effects of atmospheric-pressure cold plasma-generated short-lived species, long-lived species, and electric fields on skin cancer cells and normal cells. The short-lived species showed significant inhibition of skin cancer cells' viability and induction of apoptosis, while the long-lived species and electric fields did not have significant effects on either normal or cancer cells. The study verified that short-lived species in plasma have a greater inhibitory effect on skin cancer cells compared to normal cells.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Oncology
Yuying Liu, Tianzhen Zhang, Haizeng Zhang, Jiping Li, Nannan Zhou, Roland Fiskesund, Junwei Chen, Jiadi Lv, Jingwei Ma, Huafeng Zhang, Ke Tang, Feiran Cheng, Yabo Zhou, Xiaohui Zhang, Ning Wang, Bo Huang
Summary: Biomechanics is a fundamental characteristic of cells, and tumor-repopulating cells evade CD8(+) cytolytic T-cell killing through a mechanical softness mechanism. This reveals a mechanics-mediated tumor immune evasion strategy that impedes perforin pore formation at the immune synapse site.
Review
Dermatology
Louis J. Born, Amor Khachemoune
Summary: Basal cell carcinosarcoma (BCCS) is a rare malignant skin tumor composed of epithelial and mesenchymal components. It is often underdiagnosed and primarily affects elderly individuals in sun-exposed areas. Diagnosis is made through histology using H&E staining, and additional immunohistochemical markers are proposed to address the unreliable phenotypic appearance. Treatment involves excision of the tumor, primarily with Mohs surgery, and is usually curative. Continued efforts in characterizing this complex neoplasm are crucial for accurate diagnosis and treatment options, particularly for metastatic disease.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Review
Oncology
Santina Conte, Sarah Ghezelbash, Bonika Nallanathan, Philippe Lefrancois
Summary: This review explores various features of morpheaform BCC and highlights its poorer prognosis.
Article
Dermatology
J. Weis, C. Grote, M. Weichenthal, A. Hauschild
Summary: This case study discusses the treatment experience of a 78-year-old female patient with skin cancer. The patient underwent systemic treatment with cemiplimab and sonidegib, achieving significant therapeutic efficacy.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Jonas A. Adalsteinsson, Sonal Muzumdar, Reid Waldman, Chaoran Hu, Rong Wu, Desiree Ratner, Jonathan Ungar, Jonathan I. Silverberg, Gudridur H. Olafsdottir, Arni Kjalar Kristjansson, Laufey Tryggvadottir, Jon Gunnlaugur Jonasson
Summary: The study found that a cumulative dose of hydrochlorothiazide above 37,500 mg was associated with an increased risk of invasive SCC. Users of hydrochlorothiazide also had a higher risk of SCCis and BCC.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Paulo Muller Ramos, Alessandra Anzai, Bruna Duque-Estrada, Debora Cadore Farias, Daniel Fernandes Melo, Fabiane Mulinari-Brenner, Giselle Martins Pinto, Leonardo Spagnol Abraham, Leopoldo Duailibe Nogueira Santos, Rodrigo Pirmez, Helio Amante Miot
Summary: The study found that high cumulative exposure to HCTZ is associated with an increased risk of keratinocyte carcinoma, particularly invasive SCC. Users of HCTZ also had an increased risk of SCCis and BCC. However, the study also pointed out limitations in adjusting for all potential factors.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Hematology
Chunhua Song, Zheng Ge, Yali Ding, Bi-Hua Tan, Dhimant Desai, Krishne Gowda, Shantu Amin, Raghavendra Gowda, Gavin P. Robertson, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Zafer Gurel, Soumya Iyer, Pavan Kumar Dhanyamraju, Meixian Xiang, Yuka Imamura Kawasawa, Nathalia M. Cury, Jose Andres Yunes, Mary McGrath, Joe Schramm, Ruijun Su, Yiping Yang, Zhijun Zhao, Xiaoguang Lyu, Markus Muschen, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat
Article
Biochemistry & Molecular Biology
Vikash Singh, Chethana P. Gowda, Vishal Singh, Ashwinkumar S. Ganapathy, Dipti M. Karamchandani, Melanie A. Eshelman, Gregory S. Yochum, Prashant Nighot, Vladimir S. Spiegelman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Tithi Roy, Samuel T. Boateng, Sergette Banang-Mbeumi, Pankaj K. Singh, Pratik Basnet, Roxane-Cherille N. Chamcheu, Federico Ladu, Isabel Chauvin, Vladimir S. Spiegelman, Ronald A. Hill, Konstantin G. Kousoulas, Bolni Marius Nagalo, Anthony L. Walker, Jean Fotie, Siva Murru, Mario Sechi, Jean Christopher Chamcheu
Summary: Novel flavonol-based derivatives targeting skin cancers were synthesized and characterized, showing significant inhibitory effects on human skin cancer cell lines. These compounds were found to induce apoptosis of cancer cells by regulating key molecular targets, presenting promising therapeutic potential for melanoma and non-melanoma skin cancers.
BIOORGANIC CHEMISTRY
(2021)
Article
Oncology
Zheng Ge, Chunhua Song, Yali Ding, Bi-Hua Tan, Dhimant Desai, Arati Sharma, Raghavendra Gowda, Feng Yue, Suming Huang, Vladimir Spiegelman, Jonathon L. Payne, Mark E. Reeves, Soumya Iyer, Pavan Kumar Dhanyamraju, Yuka Imamura, Daniel Bogush, Yevgeniya Bamme, Yiping Yang, Mario Soliman, Shriya Kane, Elanora Dovat, Joseph Schramm, Tommy Hu, Mary McGrath, Zissis C. Chroneos, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat
Summary: IKAROS functions as a transcriptional repressor of MTOR gene in treating HR B-ALL, which can be enhanced by the CK2 inhibitor CX-4945. The combining of CX-4945 with rapamycin shows novel synergistic therapeutic effects in reducing MTOR expression and treating Hispanic/Latino children with HR B-ALL. Dual targeting of oncogene transcription along with oncoprotein inhibition could provide a precision medicine approach for hematological malignancies.
Article
Oncology
Jason M. Biegel, Mayura Dhamdhere, Shuang Gao, Chethana P. Gowda, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Summary: The gain at chromosome 17q21 in neuroblastoma is associated with poor prognosis regardless of MYCN amplification status. Down-regulation of IGF2BP1 activity suppresses neuroblastoma cell growth, and combining IGF2BP1 inhibition with chemotherapeutics or CDK inhibitors has a synergistic effect on suppressing neuroblastoma cell proliferation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Christa N. Grant, Carson A. Wills, Xiaoming Liu, Vladimir S. Spiegelman, Hong-Gang Wang
Summary: In this study, researchers developed a mouse model to study neuroblastoma in different tumor sites. The results showed that tumors developed at the same rate in the thoracic cavity and adrenal gland, but the physiological tolerance for large tumors was lower in the thoracic group.
Article
Biochemistry & Molecular Biology
Nadav Wallis, Froma Oberman, Khriesto Shurrush, Nicolas Germain, Gila Greenwald, Tehila Gershon, Talia Pearl, Giancarlo Abis, Vikash Singh, Amandeep Singh, Arun K. Sharma, Haim M. Barr, Andres Ramos, Vladimir S. Spiegelman, Joel K. Yisraeli
Summary: The study identified a small molecule that inhibits the binding of Igf2bp1 to Kras RNA, leading to reduction in levels of Kras and other Igf2bp1 mRNA targets, inhibition of Kras protein and downstream signaling, and potential improvement in the prognosis of Igf2bp1-expressing tumors, such as lung cancer.
Article
Oncology
Xiaoming Liu, Carson A. Wills, Longgui Chen, Jiawen Zhang, Yuanjun Zhao, Mi Zhou, Jeffrey M. Sundstrom, Todd Schell, Vladimir S. Spiegelman, Megan M. Young, Hong-Gang Wang
Summary: This study investigated the role of neuroblastoma-derived small extracellular vesicles (sEVs) in promoting resistance to anti-GD2 monoclonal antibody therapy and the potential of tipifarnib in sensitizing tumors to the antibody treatment. The results showed that sEVs attenuated the efficacy of the antibody and modulated the tumor microenvironment and immune cell infiltration. Additionally, tipifarnib enhanced the antibody's effectiveness against tumor growth and prevented the immunosuppressive effects of sEVs.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Kondaiah Palsa, Stephanie L. Baringer, Ganesh Shenoy, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
Summary: Iron is vital for brain development and function. This study investigated the role of exosomes in transporting iron across the blood-brain barrier endothelial cells (BBBECs). The results showed that iron activity in the exosome fraction was higher than in the supernatant fraction. The release of exosomes containing iron was regulated by the iron concentration in the endothelial cells and was independent of hepcidin regulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Mayura R. Dhamdhere, Chethana P. Gowda, Vikash Singh, Zhenqiu Liu, Nicholas Carruthers, Christa N. Grant, Arati Sharma, Sinisa Dovat, Jeffrey M. Sundstrom, Hong-Gang Wang, Vladimir S. Spiegelman
Summary: Neuroblastoma (NB) is a highly metastatic cancer that causes a high number of cancer-related deaths in pediatric patients. Up to 50% of NB cases show a partial chromosomal gain at locus 17q21-ter, which is associated with poor survival. This study investigates the role of the proto-oncogene IGF2BP1, located at 17q locus, in promoting NB metastasis and its regulation of small extracellular vesicles (EVs). The study identifies SEMA3A and SHMT2 as novel targets of IGF2BP1 and reveals the mechanisms by which IGF2BP1 contributes to NB metastasis through regulating protein levels in NB-EVs. The findings suggest the clinical significance of IGF2BP1-SEMA3A/SHMT2 axis in NB metastasis.
Article
Cell Biology
Stephanie L. Baringer, Kondaiah Palsa, Vladimir S. Spiegelman, Ian A. Simpson, James R. Connor
Summary: Using cell culture techniques, this study investigates the mechanism by which apo- and holo-Tf influence iron release from endothelial cells. It is found that holo-Tf induces ferroportin internalization, while apo-Tf directly interacts with hephaestin. Only pathophysiological levels of hepcidin disrupt the interaction between holo-Tf and ferroportin. These findings provide a molecular mechanism for the regulation of iron release.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Nicole Betson, Mohammed Hajahmed, Tsige Gebretsadek, Kenneth Ndebele, H. Anwar Ahmad, Paul B. Tchounwou, Vladimir S. Spiegelman, Felicite K. Noubissi
Summary: Inhibition of IGF2BP1 may enhance the sensitivity of CRC cells to chemotherapy and reduce their resistance and migratory capability.
Article
Oncology
Zhenqiu Liu, Vladimir S. Spiegelman, Hong-Gang Wang
Summary: The study identified key RBPs and ncRNAs that regulate upregulated genes in high-risk adult and pediatric AMLs, highlighting the genetic differences between adult and childhood AMLs. The regulatory networks constructed provide insights into molecular mechanisms underlying high-risk AMLs and may contribute to the development of novel therapeutic strategies based on RBPs and ncRNAs.
Article
Multidisciplinary Sciences
Tithi Roy, Samuel T. Boateng, Sergette Banang-Mbeumi, Pankaj K. Singh, Pratik Basnet, Roxane-Cherille N. Chamcheu, Federico Ladu, Isabel Chauvin, Vladimir S. Spiegelman, Ronald A. Hill, Konstantin G. Kousoulas, Bolni Marius Nagalo, Anthony L. Walker, Jean Fotie, Siva Murru, Mario Sechi, Jean Christopher Chamcheu
Summary: This study identifies a panel of novel fisetin analogs that may be developed as potential therapeutic agents for melanoma and non-melanoma skin cancers, providing in-depth biological characterization data to support further research and experimental screening.
Article
Oncology
Irina A. Elcheva, Vladimir S. Spiegelman
Summary: RNA-binding proteins are crucial in cellular physiology, particularly in cancer where they support the expression of cancer-relevant mRNA transcripts. Targeting these proteins with small molecules and understanding the multilevel composition of gene expression regulation could lead to potential therapies for acute and chronic leukemia.