期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 134, 期 2, 页码 345-350出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2013.298
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资金
- UK Food Standards Agency (FSA) [T07051]
- Medical Research Council (MRC)
- UK National Institute for Health Research (NIHR)
- NIHR [NIHRCS/01/2008/009]
- Wellcome Trust [092530/Z/10/Z, 090066/B/09/Z, 098439/Z/12/Z]
- MRC [MC_G1001205, G0700314] Funding Source: UKRI
- Asthma UK [MRC-AsthmaUKCentre] Funding Source: researchfish
- Medical Research Council [G1000758, G0700314, MC_G1001205, G1000758B] Funding Source: researchfish
- National Institute for Health Research [CS/08/08/09] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [CS/08/08/09] Funding Source: National Institutes of Health Research (NIHR)
Filaggrin (FLG) loss-of-function skin barrier gene mutations are associated with atopic dermatitis (AD) and transepidermal water loss (TEWL). We investigated whether FLG mutation inheritance, skin barrier impairment, and AD also predispose to allergic sensitization to foods. Six hundred and nineteen exclusively breastfed infants were recruited at 3 months of age and examined for AD and disease severity (SCORing Atopic Dermatitis (SCORAD)), and screened for the common FLG mutations. TEWL was measured on unaffected forearm skin. In addition, skin prick testing was performed to six study foods (cow's milk, egg, cod, wheat, sesame, and peanut). Children with AD were significantly more likely to be sensitized (adjusted odds ratio (OR) = 6.18, 95% confidence interval (Cl): 2.94-12.98, P<0.001), but this effect was independent of FLG mutation carriage, TEWL, and AD phenotype (flexural vs. non-flexural). There was also a strong association between food sensitization and AD severity (adjusted ORSCORAD<20 = 3.91, 95% CI: 1.70-9.00, P = 0.001 vs. adjusted ORSCORAD >= 20 = 25.60, 95% CI: 9.03-72.57, P<0.001). Equally, there was a positive association between AD and sensitization with individual foods (adjusted ORegg = 9.48, 95% CI: 3.77-23.83, P<0.001; adjusted ORcow's (milk) = 9.11, 95% CI : 2.27-36.59, P = 0.002; adjusted ORpeanut = 4.09, 95% CI : 1.00-16.76, P = 0.05). AD is the main skin-related risk factor for food sensitization in young infants. In exclusively breastfed children, this suggests that allergic sensitization to foods can be mediated by cutaneous antigen-presenting cells.
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