期刊
JOURNAL OF INVESTIGATIVE DERMATOLOGY
卷 133, 期 6, 页码 1462-1465出版社
ELSEVIER SCIENCE INC
DOI: 10.1038/jid.2013.67
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Cancer immune escape is frequently associated with the induction of an inappropriate immune response, i.e., a response that does not inhibit but perhaps even promotes the tumor. Indeed, increased frequencies of tumor-infiltrating regulatory T cells (Tregs) are associated with an impaired prognosis in several cancers. Thus, depletion of Tregs, e. g., by cyclophosphamide, was proposed as a means to boost immune responses to cancer. In the present issue of the Journal, Sevko et al., however, provide evidence that cyclophosphamide exerted the unexpected effect of induction of myeloid-derived suppressor cells.
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