Review
Biochemistry & Molecular Biology
Wei-Cheng Fang, Cheng-Che E. Lan
Summary: Diabetes mellitus is a significant factor in chronic wounds and non-traumatic amputation, with increasing prevalence and cases worldwide. Keratinocytes, as the outermost layer of the epidermis, play a crucial role in wound healing. However, a high glucose environment disrupts the physiological functions of keratinocytes, leading to prolonged inflammation, impaired proliferation and migration of keratinocytes, and impaired angiogenesis. Understanding the molecular mechanisms responsible for keratinocyte dysfunction in high glucose environments can aid in the development of effective and safe therapeutic approaches for promoting diabetic wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Seigo Usuki, Noriko Tamura, Tomohiro Tamura, Kohei Yuyama, Daisuke Mikami, Katsuyuki Mukai, Yasuyuki Igarashi
Summary: Konjac ceramide (kCer) has effects on cell migration and differentiation in HaCaT keratinocytes, mediated by cascade crosstalk between Nrp1 and histamine-GPCR pathways.
Article
Pharmacology & Pharmacy
Weimin Yu, Gang Xu, Hui Chen, Li Xiao, Gang Liu, Pingping Hu, Siqi Li, Vivi Kasim, Chunyu Zeng, Xiaoyong Tong
Summary: Pulmonary hypertension (PH) is a life-threatening disease characterized by pulmonary vascular remodeling and hyperproliferation of pulmonary artery smooth muscle cells (PASMCs). This study identifies the impact of C674 oxidative inactivation on pulmonary vascular remodeling and PH development, highlighting the importance of C674 in maintaining pulmonary vascular homeostasis by restricting PASMC proliferation. The IRE1 alpha/XBP1s pathway and SERCA2 may serve as potential targets for PH therapy.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Tingzeng Wang, Okkyung Rho, Fernando Eguiarte-Solomon, John DiGiovanni
Summary: Twist1 plays a key role in the development and progression of cSCC by regulating epithelial-mesenchymal transition, stemness, and the balance of keratinocyte proliferation and differentiation. It represents a potential target for prevention and treatment of cSCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Biochemistry & Molecular Biology
Pu Xia, Da-Hua Liu, Dan Wang, Gui-Min Wen, Zhen-Ying Zhao
Summary: Excessive drinking is a major cause of liver cancer, and ALDH2 gene deficiency is associated with increased risk of HCC. This study analyzed the expression levels of ALDH2 and SLC3A2 in liver cancer tissues and confirmed the inhibitory role of ALDH2 and the opposite effect of SLC3A2 in HCC. The main finding was that ALDH2 inhibited BSG expression through the TGF-β1 pathway, indirectly suppressing SLC3A2 expression and sphingolipid metabolism in HCC cells. Therefore, SLC3A2 is a novel target for HCC treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Giorgia Cardinali, Enrica Flori, Arianna Mastrofrancesco, Sarah Mosca, Monica Ottaviani, Maria Lucia Dell'Anna, Mauro Truglio, Antonella Vento, Marco Zaccarini, Christos C. Zouboulis, Mauro Picardo
Summary: Studies have found that the synthetic AhR ligands NPD-0614-13 and NPD-0614-24 show potential in inhibiting inflammatory skin diseases such as psoriasis and atopic dermatitis, with beneficial effects observed in human skin models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Pengpeng Zhang, Shengbin Pei, Zeitian Gong, Yanlong Feng, Xiao Zhang, Fang Yang, Wei Wang
Summary: In this study, 11 genes related to sphingolipid metabolism were identified and a risk model containing these genes was established for lung adenocarcinoma (LUAD). Patients were divided into high- and low-risk groups based on the risk values, and the high-risk group had a worse prognosis. The low-risk group showed more immune cell infiltration and higher expression of immune checkpoints, indicating a potential benefit from immunotherapy. Additionally, it was found that CACYBP may enhance the proliferative, invasive, and migratory abilities of LUAD cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Liang Ou, Ao Zhang, Yuxing Cheng, Ying Chen
Summary: The cGAS-STING signal pathway is an important innate immune signal pathway that plays a role in regulating cancer, autoimmune and inflammatory diseases, microbial and parasitic infectious diseases, as well as bridging innate immunity and adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Elena Levantini, Giorgia Maroni, Marzia Del Re, Daniel G. Tenen
Summary: EGFR plays an important role in maintaining epithelial tissues, but when its signaling is altered, it becomes a major regulator of epithelial transformation and is one of the most studied tyrosine kinase receptors involved in neoplasia worldwide. EGFR-targeted therapies have revolutionized cancer treatment, but the dream of turning solid tumors into chronic diseases remains unfulfilled.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Richa Garg, Sanjana Kumariya, Roshan Katekar, Saurabh Verma, Umesh K. Goand, Jiaur R. Gayen
Summary: Metabolic Syndrome is a multifactorial disease associated with increased risk of cardiovascular disorders, type 2 diabetes mellitus, fatty liver disease, etc., with stress kinase activation potentially playing a crucial role in regulating whole-body metabolism.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
Yi Ding, Qin Chen
Summary: Spinal cord injury (SCI) is a common disabling spinal injury, and the mTOR signaling pathway plays a crucial role in the pathological process. Chinese herbal medicine has been shown to promote nerve repair after SCI by inhibiting the mTOR pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
MargheritaSA Cortini, Andrea Armirotti, Marta Columbaro, Dario Livio Longo, Gemma Di Pompo, Elena Cannas, Alessandra Maresca, Costantino Errani, Alessandra Longhi, Alberto Righi, Valerio Carelli, Nicola Baldini, Sofia Avnet
Summary: This study identified a novel lipid signaling pathway selectively activated in acid-induced metastatic osteosarcoma cells, and demonstrated the impairment of tumor growth by targeting this pathway with FTY720 in combination with a low-serine/glycine diet. The high circulating levels of S1P in osteosarcoma patients suggest its potential as a biomarker.
Review
Biochemistry & Molecular Biology
Sarah Koushyar, Valerie S. Meniel, Toby J. Phesse, Helen B. Pearson
Summary: Aberrant activation of the Wnt pathway is closely related to tumor formation, progression, and therapeutic resistance in prostate cancer. Targeting the Wnt pathway for prostate cancer treatment has shown potential efficacy. However, the functional consequences of activating the Wnt pathway during different stages of prostate cancer progression are still unclear. Preclinical research on targeting Wnt signaling in the treatment of prostate cancer is crucial for identifying effective treatment strategies and improving patient care.
Review
Pharmacology & Pharmacy
Zhengyao Cai, Suxin Yuan, Xingzhao Luan, Jian Feng, Li Deng, Yumei Zuo, Jiafu Li
Summary: This review summarizes the role of pyroptosis and the inflammasome in the development of diabetic cardiomyopathy (DCM) and discusses potential anti-DCM strategies targeting this pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Lulin Ma, Wenjing Zhao, Shiqian Huang, Feng Xu, Yafeng Wang, Daling Deng, Tianhao Zhang, Shaofang Shu, Xiangdong Chen
Summary: Pain, an important problem in medicine and public health, has significant research significance. Opioids are currently the main drugs used to relieve pain, but their use is limited due to obvious side effects. Therefore, there is an urgent need to develop new drugs for pain relief. Multiple studies have shown that the IGF/IGF-1R pathway plays a crucial role in the occurrence and development of pain. This review summarizes and discusses the therapeutic potential of the IGF/IGF-1R signal pathway for pain. It also highlights the regulation of pain by IGF/IGF-1R through actions on neuronal excitability, neuroinflammation, glial cells, apoptosis, and more. However, further research is still needed to fully understand the mechanisms of pain occurrence and development. In conclusion, while more in-depth studies are required, these findings suggest that the IGF/IGF-1R signal pathway holds promise as a therapeutic target for pain.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Zhiqiang Cheng, Alfred Li, Chia-Ling Tu, Christian Santa Maria, Nicholas Szeto, Amanda Herberger, Tsui-Hua Chen, Fuqing Song, Jiali Wang, Xiaodong Liu, Dolores M. Shoback, Wenhan Chang
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Gastroenterology & Hepatology
Nazih L. Nakhoul, Chia-Ling Tu, Karen L. Brown, M. Toriqul Islam, Anna G. Hodges, Solange M. Abdulnour-Nakhoul
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2020)
Review
Dermatology
Yuval Ramot, Marta Bertolini, Maria Boboljova, Yoshikazu Uchida, Ralf Paus
EXPERIMENTAL DERMATOLOGY
(2020)
Review
Dermatology
M. B. Lousada, T. Lachnit, J. Edelkamp, T. Rouillee, D. Ajdic, Y. Uchida, A. Di Nardo, T. C. G. Bosch, R. Paus
Summary: Human hair follicles carry complex microbial communities that differ from the skin surface microbiota, likely due to the moist, less acidic, and relatively protected environment of the HF. Understanding the human HF microbiome and its potential functions in physiological and pathological conditions, such as folliculitis and acne, can provide novel insights into the management of hair diseases. The regulation of antimicrobial peptides, impact on cytokine release, and potential effects on hair growth are key areas of research in exploring the relationship between the HF microbiome and hair health.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Cell Biology
Jeonghyun Lee, Kyong-Oh Shin, Yesol Kim, Jaewon Cho, Hyung W. Lim, Sung-Il Yoon, Geun-Shik Lee, Hyun-Jeong Ko, Pyeung-Hyeun Kim, Yoshikazu Uchida, Kyungho Park, Seung Goo Kang
Article
Dermatology
Anna Celli, Chia-Ling Tu, Elise Lee, Daniel D. Bikle, Theodora M. Mauro
Summary: Reduced expression of CaSR leads to impaired Ca2+ signal propagation in aged keratinocytes, with higher baseline cytosolic Ca2+ concentrations and lower capacitive Ca2+ entry in aged cells. Treatment with a CaSR agonist can normalize Ca2+ propagation and E-cadherin organization, suggesting a potential therapeutic approach by restoring CaSR function in aging skin cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Shota Sakai, Asami Makino, Akihito Nishi, Takeshi Ichikawa, Tadashi Yamashita, Makoto Taniguchi, Yoshihiro Tokudome, Yoshio Hirabayashi, Masashi Akiyama, Debra Crumrine, Yoshikazu Uchida, Peter M. Elias, Tetsuya Tsuchida, Sumiko Hamanaka
Summary: The absence of epidermal SM synthase 2 leads to ichthyotic phenotype in mice, which gradually normalizes over time. Additionally, the study highlights that nonlethal gene abnormalities can result in skin phenotype abnormalities.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2021)
Review
Dermatology
Yoshikazu Uchida, Kyungho Park
Summary: Ceramides play crucial roles in forming the epidermal permeability barrier and regulating cellular functions, with implications in various skin diseases. Dysregulation of ceramide metabolism is associated with disease pathogenesis, highlighting their therapeutic potential in treating skin disorders.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2021)
Article
Neurosciences
Kyong-Oh Shin, Debra A. Crumrine, Sungeun Kim, Yerin Lee, Bogyeong Kim, Katrina Abuabara, Chaehyeong Park, Yoshikazu Uchida, Joan S. Wakefield, Jason M. Meyer, Sekyoo Jeong, Byeong Deog Park, Kyungho Park, Peter M. Elias
Summary: Autism, a childhood behavioral disorder, is associated with atopic dermatitis in approximately 10% of cases. Studies with the valproic acid mouse model of ASD reveal AD-like changes in skin and brain tissues, suggesting a shared susceptibility to neurotoxicity and epidermal toxicity between the two disorders. High levels of cytokines and mast cells in skin and brain indicate a potential link between AD severity and ASD prevalence.
Article
Biochemistry & Molecular Biology
Kyong-Oh Shin, Sungeun Kim, Byeong Deog Park, Yoshikazu Uchida, Kyungho Park
Summary: Studies have shown that the analog of endocannabinoid, PS, can stimulate the generation of ceramides in inflamed skin cells. This increase in specific ceramide species as well as total ceramide content is mediated by the endocannabinoid receptor CB1, enhancing the function of the epidermal permeability barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kyong-Oh Shin, Yoshikazu Uchida, Kyungho Park
Summary: Both intrinsic and extrinsic factors, such as an individual's body clock and air pollutants, accelerate premature aging. This study demonstrates that diesel particulate extract (DPE) increases cell senescence and activates matrix metalloprotease (MMP)-1 and MMP-3, leading to collagen degradation in human dermal fibroblasts. DPE activates NADPH oxidase and increases ceramide production, which in turn activates the arachidonate cascade and promotes MMP activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kyong-Oh Shin, Hisashi Mihara, Kenya Ishida, Yoshikazu Uchida, Kyungho Park
Summary: This study investigates the biological effects of exogenous NP and NDS, widely used as topical ceramide agents, on cultured human keratinocytes. NDS serves as a precursor for diverse ceramide species required for the permeability barrier and enhances differentiation and innate immunity, while NP does not have the same effects.
Article
Chemistry, Medicinal
Kyong-Oh Shin, Sungeun Kim, Bokyung Kim, Hye-Yoon Park, Eunhee Jung, Garyun Kim, Donghee Kim, Hwang Eui Cho, Yoshikazu Uchida, Kyungho Park
Summary: Air pollutants, such as diesel particulate matter (DPM), contribute to the development of diseases. However, extracts from the Korean weed Euphorbia supina Rafin (ESR) have been found to protect keratinocytes from DPM-induced apoptosis by inhibiting NOX activation.
Article
Dermatology
Masaki Yoshida, Kyong-Oh Shin, Sora Muraoka, Yerim Choi, Jae-Ho Park, Soo-Hyun Park, Jin-Taek Hwang, Kyungho Park, Yoshikazu Uchida
Summary: The effects of external stress on the epidermal environment and conditions can influence dermal conditions, but how these changes occur and affect the skin layers is not fully understood.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Chia-Ling Tu, Wenhan Chang, Julie A. Sosa, James Koh
Summary: In this study, it was found that parathyroid tumors from vitamin D-deficient PHPT patients are intrinsically different from those of vitamin D-replete patients. Vitamin D deficiency is associated with increased parathyroid oxyphil cell content and expression of electron transport chain and oxidative phosphorylation pathway components. Oxyphil cells may be derived from chief cells and their increased abundance may be induced by low vitamin D status.
