Review
Dermatology
L. Nussbaum, Y. L. Chen, G. S. Ogg
Summary: Psoriasis is a chronic inflammatory disease with a strong genetic component that can be triggered by environmental factors. Tregs play a fundamental role in immune homeostasis and contribute to the prevention of autoimmune disease by suppressing immune responses, but their functional regulation remains unclear in the context of psoriasis.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Evelyn Kelemen, Eva Adam, Stella Marta Sagi, Aniko Goblos, Lajos Kemeny, Zsuzsanna Bata-Csorgo, Marta Szell, Judit Danis
Summary: Psoriasis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Increased levels of free nucleic acids in psoriatic skin are associated with IL-23 expression. The study reveals that free nucleic acids regulate IL-23 mRNA expression in epithelial keratinocytes through TLR3 receptor and specific signaling pathways, contributing to the development of an inflammatory milieu favorable for psoriatic symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Afnan AL Doghmi, Bence Pal Barta, Abigel Egyed-Kolumban, Benita Onhausz, Szilvia Kiss, Janos Balazs, Zita Szalai, Maria Bagyanszki, Nikolett Bodi
Summary: The study aimed to evaluate the effects of chronic hyperglycemia and insulin treatment on the pro-inflammatory cytokine interleukin 1 beta (IL1 beta) in enteric neuroinflammation. The results showed that IL1 beta expression was significantly increased in diabetic patients, whereas insulin treatment could prevent this upregulation. These findings suggest that insulin plays an important regulatory role in IL1 beta expression in different myenteric neuronal subpopulations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Bong-Woo Lee, Su-Jin Moon
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects individuals with psoriasis, arthritis, and enthesitis. Inflammatory cytokines, such as TNF-α, IL-23, and IL-17, play a crucial role in the onset and progression of PsA by attracting inflammatory cells to the joint tissues and causing cartilage and bone deterioration. Blocking these cytokines has shown significant clinical benefits, and further research is being conducted to explore other potential therapeutic targets for PsA treatment. This review discusses the current understanding of the role of inflammatory cytokines in PsA pathogenesis and the clinical implications of targeting these cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Deqiao Qin, Ling Ma, Li Qin
Summary: The skin acts as the largest protective barrier organ in the human body, safeguarding internal structures against the harmful environment. Abnormalities in the epidermal cornification process can result in skin barrier dysfunction. The epidermal differentiation complex (EDC) is responsible for epithelial tissue development and the properties of the stratum corneum. While psoriasis is characterized by abnormal terminal differentiation of keratinocytes, the relationship between EDC and psoriasis occurrence remains unclear.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Cell Biology
Yen-You Lin, Chih-Yuan Ko, Shan-Chi Liu, Yu-Han Wang, Chin-Jung Hsu, Chun-Hao Tsai, Tsung-Ju Wu, Chih-Hsin Tang
Summary: The study showed a negative correlation between miR-144-3p and IL-1 beta expression in OA, with transfection of miR-144-3p mimic downregulating IL-1 beta levels and blocking related signaling pathways. Administration of miR-144-3p mimic effectively ameliorated OA progression in a rat model, indicating miR-144-3p as a potential therapeutic target for OA.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biology
Dong Hyun Kim, Hee Young Kim, Sunjung Cho, Su-Jin Yoo, Won-Ju Kim, Hye Ran Yeon, Kyungho Choi, Je-Min Choi, Seong Wook Kang, Won-Woo Lee
Summary: The study demonstrates the crucial role of IL-1RII receptor in regulating IL-17 responses, affecting the functionality of CD4(+) T cells by limiting IL-1 beta responsiveness.
Article
Gastroenterology & Hepatology
Gavin W. Sewell, Arthur Kaser
Summary: The cytokine interleukin-23 (IL-23), mainly produced by macrophages and dendritic cells in response to microbial stimulation, plays a critical role in chronic intestinal inflammation. IL-23 has been found to be associated with disease protection through genetic variations, and therapeutic targeting of the shared p40 subunit of IL-12/IL-23 has shown success in treating inflammatory bowel disease (IBD). Recent phase 2 studies have shown promise in targeting the specific p19 subunit of IL-23. However, the exact pathways downstream of IL-23 in mucosal inflammation in the gut are still debated.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Biochemistry & Molecular Biology
Ya Zhou, Ning Li, Xin Fan, Meiyi Xu, Beinan Wang
Summary: Studies have indicated that T cells responding to streptococcal antigens in the skin are involved in the pathogenesis of psoriasis. In this study, the impact of intranasal streptococcal infection on psoriasis was investigated using a mouse model. The results showed that streptococcal infection induced a persistent Th17 response and exacerbated psoriatic skin lesions. These findings provide evidence that streptococcal infection contributes to the development of psoriasis by activating specific T cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Dermatology
Trinidad Montero-Vilchez, Miguel Soler-Gongora, Antonio Martinez-Lopez, Fernandez-Gonzalez Ana, Agustin Buendia-Eisman, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: Psoriatic patients have impaired epidermal barrier function compared to healthy controls, but phototherapy can improve this function, particularly by increasing stratum corneum hydration on psoriatic plaques.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2021)
Article
Immunology
Junfeng Zhang, Yunsheng Zhang, Zhiya Yang, Dalei Cheng, Hui Zhang, Li Wei, Chen Liu, Fenglian Yan, Chunxia Li, Guanjun Dong, Changying Wang, Dongmei Shi, Huabao Xiong
Summary: Although psoriasis is characterized as a T cell-mediated inflammatory disease, the role of myeloid cells in the development of psoriasis is not fully understood. This study found that the expression of the anti-inflammatory cytokine interleukin-35 (IL-35) was increased in patients with psoriasis, along with an increase in myeloid-derived suppressor cells (MDSCs). IL-35 reduced the number of MDSCs and ameliorated psoriasis. IL-35 also reduced the expression of inducible nitric oxide synthase in MDSCs. Overall, IL-35 may play a critical role in regulating iNOS-expressing MDSCs in psoriasis, suggesting IL-35 as a potential therapeutic strategy for psoriasis and other cutaneous inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Obstetrics & Gynecology
Ezekiel Musa, Mushi Matjila, Naomi S. Levitt
Summary: Kisspeptin plays a significant role in gestational diabetes mellitus by stimulating insulin secretion, reducing insulin resistance, and regulating appetite and glucose homeostasis.
REPRODUCTIVE SCIENCES
(2022)
Article
Immunology
David Achudhan, Shan-Chi Liu, Yen-You Lin, Chien-Chung Huang, Chun-Hao Tsai, Chih-Yuan Ko, I-Ping Chiang, Yueh-Hsiung Kuo, Chih-Hsin Tang
Summary: The study demonstrates that Antcin K, a compound isolated from Antrodia cinnamomea, shows anti-inflammatory effects by inhibiting proinflammatory cytokine production in human rheumatoid synovial fibroblasts. This indicates the potential of Antcin K in treating rheumatoid arthritis by reducing inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medicine, General & Internal
Rossella Palma, Annamaria Pronio, Mario Romeo, Flavia Scognamiglio, Lorenzo Ventriglia, Vittorio Maria Ormando, Antonietta Lamazza, Stefano Pontone, Alessandro Federico, Marcello Dallio
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely associated with extrahepatic components of metabolic syndrome, suggesting a systemic metabolic-related disorder based on genetic, nutritional, and environmental factors. Insulin resistance plays a crucial role and leads to insulin sensitivity disruption in the liver and adipose tissue. Additionally, nutrition, genetic/epigenetic factors, and gut microbiota are also implicated in the relationship between NAFLD and insulin resistance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Geriatrics & Gerontology
Dan Li, Le-Tian Huang, Cheng-pu Zhang, Qiang Li, Jia-He Wang
Summary: This review summarizes the role of platelet-derived growth factors (PDGFs) and platelet-derived growth factor receptors (PDGFRs) in the occurrence and development of Parkinson's disease (PD). The mechanisms by which PDGFs/PDGFRs affect PD include oxidative stress, mitochondrial function, protein folding and aggregation, Ca2+ homeostasis, and cell neuroinflammation. Clinical applications and prospects, especially in genetic treatment, are also discussed. However, contradictory effects of PDGFs within the central nervous system (CNS), such as neuroprotection and disruption of the blood-brain barrier (BBB), are highlighted.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Dermatology
R. Stalder, N. Brembilla, C. Conrad, N. Yawalkar, A. Navarini, Wh Boehncke, G. Kaya
Summary: Using specific biomarkers and cell markers to analyze different types of ND can help differentiate between them, aiding in the diagnosis and treatment of these diseases in clinical practice.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Isabel Haferland, Chantal M. Wallenwein, Tanja Ickelsheimer, Sandra Diehl, Matthias G. Wacker, Susanne Schiffmann, Claudia Buerger, Roland Kaufmann, Anke Koenig, Andreas Pinter
Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Rifampicin treatment can reduce the expression of TLR2 and inhibit the production of pro-inflammatory cytokines.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Rheumatology
Philip J. Mease, Iain B. McInnes, Lai-Shan Tam, Raji Rajalingam, Steve Peterson, Fareen Hassan, Soumya D. Chakravarty, Christine Contre, Alison Armstrong, Wolf-Henning Boehncke, Christopher Ritchlin
Summary: The objective of this study was to update the network meta-analysis (NMA) comparing guselkumab with other targeted therapies for PsA. The results showed that guselkumab demonstrated better skin efficacy than most other PsA treatments and had comparable ACR responses to most agents.
Article
Rheumatology
Proton Rahman, Wolf-Henning Boehncke, Philip J. Mease, Alice B. Gottlieb, Iain B. McInnes, May Shawi, Yanli Wang, Shihong Sheng, Alexa P. Kollmeier, Elke Theander, Jenny Yu, Evan Leibowitz, A. Marilise Marrache, Laura C. Coates
Summary: The safety of guselkumab (GUS) in patients with psoriatic arthritis (PsA) was assessed in both TNFi-naive and TNFi-experienced patients through the end of the studies, up to 2 years. The results showed that the safety profile of GUS remained favorable in both patient groups, without any notable differences.
JOURNAL OF RHEUMATOLOGY
(2023)
Review
Cell & Tissue Engineering
Nicolo C. Brembilla, Hubert Vuagnat, Wolf-Henning Boehncke, Karl-Heinz Krause, Olivier Preynat-Seauve
Summary: Chronic wounds have a significant impact on quality of life and healthcare costs. Adipose-derived stromal cells (ASC) have emerged as a promising therapy for chronic wounds. Studies have shown the clinical efficacy of ASC-based therapies in treating chronic wounds.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Dermatology
Jan Koren, Jo L. W. Lambert, Simon F. F. Thomsen, Helen McAteer, Gabriella Fabbrocini, Valeria Corazza, Denis Jullien, Matthias Augustin, Richard B. B. Warren, Menno A. A. de Rie, Elizabeth Lazaridou, Lluis Puig, Loic Guillevin, Marius Grosser, Wolf-Henning Boehncke
Summary: By combining the perspectives of patients, clinicians, and payors, we identified multiple themes to improve the standard of care for patients with psoriasis. Through a Delphi process, consensus was reached on these themes and a set of practical 'Calls to Action' were proposed. Improving healthcare systems, patient access, quality-of-life measures, relevance and reach of guidelines, and patient education were all recognized as important factors.
DERMATOLOGY AND THERAPY
(2023)
Article
Rheumatology
Alen Zabotti, Gabriele De Marco, Laure Gossec, Xenofon Baraliakos, Daniel Aletaha, Annamaria Iagnocco, Paolo Gisondi, Peter Balint, Heidi Bertheussen, Wolf-Henning Boehncke, Nemanja S. Damjanov, Maarten de Wit, Enzo Errichetti, Helena Marzo-Ortega, Mikhail Protopopov, Lluis Puig, Ruben Queiro, Piero Ruscitti, Laura Savage, Georg Schett, Stefan Siebert, Tanja A. Stamm, Paul Studenic, Ilaria Tinazzi, Filip E. Van den Bosch, Annette van der Helm-van Mil, Abdulla Watad, Josef S. Smolen, Dennis G. McGonagle
Summary: This study proposes EULAR guidelines for the early diagnosis of psoriatic arthritis (PsA) by conducting research on multiple patients. It also establishes standardized operating procedures for clinical practice and trials, providing guidance and consensus in the field of prevention and interception of PsA for psoriasis patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Dermatology
Raphael Andre, Wolf-Henning Boehncke, Emmanuel Laffitte
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
A. Gonzalez-Cantero, W. H. Boehncke, J. De Sutter, J. L. Zamorano, J. Lambert, L. Puig
Summary: This study aims to provide dermatologists with a tool to systematize the treatment of dyslipidemia in psoriasis and aid in decision-making. The study resulted in a list of concepts and recommendations for managing cardiovascular risk and using statin therapy in moderate-severe psoriasis patients. The application of these recommendations will help dermatologists manage patients' dyslipidemia and reduce their cardiovascular risk.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Immunology
Nicolo Costantino Brembilla, Wolf-Henning Boehncke
Summary: Psoriasis is a common chronic inflammatory skin disease, and TH17 lymphocytes are believed to be the central effector cells. However, recent research has shown that the simple linear pathogenetic model may not fully explain the disease. Other IL-17 homologues and IL-23 independent cells also play a role in psoriasis. This review will summarize the current knowledge about IL-17A and its homologues in relation to skin inflammation and psoriasis, and propose a more comprehensive pathogenetic model.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nicolo Costantino Brembilla, Ali Modarressi, Dominik Andre-Levigne, Estelle Brioudes, Florian Lanza, Hubert Vuagnat, Stephane Durual, Laurine Marger, Wolf-Henning Boehncke, Karl-Heinz Krause, Olivier Preynat-Seauve
Summary: This study evaluates the influence of a gelatin sponge on adipose-derived stromal cells (ASC). The results show that the gelatin sponge strongly influences the transcriptome of ASC and acted as a concentrator and reservoir of the regenerative ASC secretome. The gelatin sponge also increased angiogenesis in vivo and promoted wound healing.
Article
Multidisciplinary Sciences
Maria S. Shutova, Julia Borowczyk, Barbara Russo, Sihem Sellami, Justyna Drukala, Michal Wolnicki, Nicolo C. Brembilla, Gurkan Kaya, Andrei I. Ivanov, Wolf-Henning Boehncke
Summary: Abnormal mechanotransduction and compromised epithelial barrier function are observed in various human pathologies, including inflammatory skin disorders. This study investigates the cytoskeletal mechanisms involved in the regulation of inflammatory responses in the epidermis. The results suggest that inflammation up-regulates the Rho-myosin II pathway and disrupts adherens junctions, leading to YAP nuclear entry. The disruption of adherens junctions, increased paracellular permeability, and YAP nuclear translocation are regulated by ROCK2 independently of myosin II activation. The inhibitor KD025 demonstrates the effects of ROCK2 on the inflammatory response in the epidermis through cytoskeletal and transcription-dependent mechanisms.
Article
Rheumatology
Christopher T. Ritchlin, Atul Deodhar, Wolf-Henning Boehncke, Enrique R. Soriano, Alexa P. Kollmeier, Xie L. Xu, Federico Zazzetti, May Shawi, Yusang Jiang, Shihong Sheng, Philip S. Helliwell
Summary: This study evaluated the efficacy and safety of guselkumab, an interleukin-23p19-subunit inhibitor, in patients with active psoriatic arthritis (PsA) who had previously used a tumor necrosis factor inhibitor (TNFi). The results showed that guselkumab provided sustained improvements across multiple domains in both TNFi-naive and TNFi-experienced patients with active PsA, and TNFi-naive patients were more likely to achieve treatment goals related to physical function and pain.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Dermatology
Magdalena Jahn, Victoria Lang, Sandra Diehl, Robin Back, Roland Kaufmann, Torsten Fauth, Claudia Buerger
Summary: Dermatological research relies on suitable models that accurately reflect the in vivo situation. This study validated engineered immortalized cell lines created from primary human keratinocytes as model systems to study epidermal function. The cell lines exhibited growth and differentiation behavior similar to primary keratinocytes in both 2D and 3D culture systems, and were able to reconstitute a functional epidermal barrier in a 3D epidermal model.
EXPERIMENTAL DERMATOLOGY
(2023)
Meeting Abstract
Physiology
M. G. Rotordam, A. Horvath, T. Fauth, C. Buerger, D. -D. Scheub, O. Rauh, N. Fertig, A. Obergrussberger