Article
Biochemistry & Molecular Biology
Chuang Zhang, Yuanyuan Tian, Ao Yang, Weihua Tan, Xiaoqing Liu, Wenchao Yang
Summary: This study revealed the anti-tumor effect of propolis on human cutaneous squamous cell carcinoma (CSCC) A431 cells and investigated its potential mechanism. The results showed that propolis ethanol extract inhibited A431 cell proliferation by regulating multiple signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Simon Mylius Rasmussen, Thomas Nielsen, Sofie Hody, Henrik Hager, Lars Peter Schousboe
Summary: This study introduces a video processing algorithm designed to identify cancer suspicious skin areas, based on remote photoplethysmography signal differences between squamous cell carcinoma and healthy skin. The research shows significant temporal signal changes in cancer areas versus healthy areas, providing valuable insights for further investigation on detailed disease boundary recognition.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Jiao Qu, Qitai Zhao, Li Yang, Yu Ping, Kai Zhang, Qingyang Lei, Fengsen Liu, Yi Zhang
Summary: ESCC is the main pathological subtype of esophageal cancer with high incidence and mortality. Immune and stromal cells in the tumor microenvironment play a significant role in ESCC development. Through analyzing DEGs and functional annotations, this study revealed that C3AR1 may induce an immunosuppressive microenvironment by influencing macrophage polarization, suggesting C3AR1 as a potential target for immunotherapy in ESCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xin Li, Shuang Zhao, Xiaohui Bian, Lining Zhang, Lixia Lu, Shiyao Pei, Liang Dong, Wensheng Shi, Lingjuan Huang, Xiyuan Zhang, Mingliang Chen, Xiang Chen, Mingzhu Yin
Summary: Our study investigates the changes in tumor microenvironment (TME) between primary and recurrent cutaneous squamous cell carcinoma (cSCC) using single-cell RNA sequencing (scRNA-seq). We identified an immunosuppressed microenvironment in recurrent cSCC, with T cell exclusion and enrichment of SPP1+ tumor-associated macrophages (TAMs). CD8+ T cells showed exhaustion and low inflammatory features, while SPP1+ TAMs displayed pro-tumor characteristics. Different subgroups of SPP1+ TAMs exhibited distinct functions. A subset of tumor-specific keratinocytes (TSKs) showed significant epithelial-mesenchymal transition (EMT) features, possibly due to their interaction with IL7R+ cancer-associated fibroblasts (CAFs). We also found that the growth factor/cytokine Midkine (MDK) played a role in different cell-cell interactions in cSCC with different staging.
Article
Multidisciplinary Sciences
Amit Mittal, Mike Wang, Aurobind Vidyarthi, Diana Yanez, Gabriela Pizzurro, Durga Thakral, Erin Tracy, Oscar R. Colegio
Summary: This study investigates the therapeutic potential of transcutaneous arginase inhibition in cSCC, requiring a competent immune microenvironment for tumor growth inhibition using this method. The results support further examination of transcutaneous arginase inhibition as a therapeutic modality for cSCC, showing synergistic co-inhibition of tumor growth.
SCIENTIFIC REPORTS
(2021)
Article
Mathematical & Computational Biology
Jiahua Xing, Muzi Chen, Yan Han
Summary: This study investigates the interactions between tumor microenvironment and cSCC, and identifies four core genes that play a crucial role in the pathogenesis of this disease. Moreover, the core genes are found to be closely associated with immune regulatory genes, suggesting new strategies for cSCC prevention and treatment.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Gautam Adhikary, Erica L. Heipertz, Maja Preradovic, Xi Chen, Wen Xu, John J. Newland, Navjot Kaur, Mohan C. Vemuri, Richard L. Eckert
Summary: Cutaneous squamous cell carcinoma (CSCC) is a common cancer caused by ultraviolet irradiation. Surgical excision can remove CSCC lesions, but a percentage of these cancers reappear as therapy-resistant tumors. This study investigates the potential of ex vivo expanded human NK cells to suppress CSCC cell cancer phenotype and reduce tumor growth.
MOLECULAR CARCINOGENESIS
(2023)
Article
Chemistry, Multidisciplinary
Chia-Lin Chen, Juan Carlos Hernandez, Dinesh Babu Uthaya Kumar, Tatsuya Machida, Stanley M. Tahara, Anthony El-Khoueiry, Meng Li, Vasu Punj, Suresh Kumar Swaminathan, Ameya Kirtane, Yibu Chen, Jayanth Panyam, Keigo Machida
Summary: The improvement of drug selectivity, toxicity, and reduced recurrence of tumors from tumor-initiating stem-like cells is essential for effective cancer therapy. Through high-throughput screens, a combination of histone deacetylase (HDAC) inhibitor(s) and all-trans retinoic acid (ATRA) has been found to effectively inhibit TIC growth. This combined treatment reduces Toll-like receptors (TLR) and stemness genes, leading to loss of self-renewal property of TICs.
Article
Biochemistry & Molecular Biology
Sofia Ali Syed, Muhammad Asif Qureshi, Saeed Khan, Rajesh Kumar, Iqbal A. Muhammad Khyani, Bilal Ahmed Khan, Jawad Safdar
Summary: Oral squamous cell carcinomas are a major healthcare burden in Asian countries, especially in Pakistan. Treatment options are limited, making it essential to investigate the inflammatory environment of OSCC and explore immunotherapeutic approaches. This study focuses on innate lymphoid cells and associated cytokines in OSCC, providing new insights into the molecular circuitry and tumor niche for the development of novel diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Na Li, Jiahong Wang, Xianquan Zhan
Summary: This study identified two reliable immune-related gene signature models that were significantly associated with prognosis and tumor microenvironment cell infiltration in LUAD and LUSC, respectively. Evaluation of these models could help predict response to immunotherapy and guide immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Kylee J. B. Kus, Fadi Murad, Timothy D. Smile, Michael Chang, Sepideh Ashrafzadeh, Guohai Zhou, Evelyn O. Ilori, Shlomo A. Koyfman, Allison T. Vidimos, Chrysalyne D. Schmults, Emily S. Ruiz
Summary: Lymphovascular invasion (LVI) has a significant impact on tumor outcomes in cutaneous squamous cell carcinoma, with LVI-positive tumors showing higher rates of metastasis and death within 5 years.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Cheng-Gang Qiu, Bin Shen, Xiao-Qi Sun
Summary: This study aimed to identify significant genes associated with cutaneous squamous cell carcinoma (CSCC) initiation and development. The results revealed that MYBL2 and TK1 were the most significant biomarkers associated with CSCC initiation and progression, and they may act as promising therapeutic targets for accurate diagnosis and treatment of CSCC.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Medicine, General & Internal
Che-Yuan Hsu, Teruki Yanagi, Hideyuki Ujiie
Summary: TRIM proteins, including TRIM29, are essential in a variety of cell processes and have been linked to functions such as DNA binding, carcinogenesis, DNA damage signaling, and radioresistance. In particular, TRIM29 plays a significant role in regulating keratin distribution and is involved in cutaneous squamous cell carcinoma.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Chester Lai, George Coltart, Andrew Shapanis, Conor Healy, Ahmad Alabdulkareem, Sara Selvendran, Jeffrey Theaker, Matthew Sommerlad, Matthew Rose-Zerilli, Aymen Al-Shamkhani, Eugene Healy
Summary: The study identified a significant presence of CD8+CD103+ TRMs in cutaneous squamous cell carcinomas, with their expression in the tumor being associated with poorer clinical outcomes for patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Physiology
Keigo Machida
Summary: This article reviews the links between HCV-associated HCC and TICs, discussing how HCV promotes the genesis of TICs and the development of HCC, and how this process can be utilized as a novel therapeutic target for HCC treatment. Additionally, it introduces the ten hall marks of TIC oncogenesis and HCC development as targets for novel therapeutic modalities.
FRONTIERS IN PHYSIOLOGY
(2022)