Article
Nutrition & Dietetics
Peng He, Mi Zhang, Meng Zhao, Mengyao Zhang, Benxu Ma, Hongyu Lv, Yantao Han, Dingtao Wu, Zhangfeng Zhong, Wenwen Zhao
Summary: In this study, a novel polysaccharide, Chuanminshen violaceumis polysaccharide (CVP), was isolated from the root of Chuanminshen violaceum. The protective effect of CVP against myocardial ischemia-reperfusion injury was confirmed, and it was found to inhibit ferroptosis to ameliorate the injury.
FRONTIERS IN NUTRITION
(2022)
Review
Cell Biology
Shuangyu Lv, Xiaotian Li, Shizhen Zhao, Huiyang Liu, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury refers to the changes in functional and structural changes during blood flow recovery after ischemia. Myocardial I/R injury, aggravated by sudden blood circulation disorder, is still not fully understood despite numerous studies. Hydrogen sulfide (H2S) has shown potential in improving myocardial I/R injury, but the underlying signal pathways remain unclear, warranting further research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yan-Cheng Shen, Yan-Jhih Shen, Wen-Sen Lee, Michael Yu-Chih Chen, Wei-Chia Tu, Kun-Ta Yang
Summary: The experiment results suggest that the core structure of 2-APB is the combination of two benzene rings with a boron atom, which can generate phenolic compounds through reaction with H2O2, thereby reducing oxidative stress and injury induced by I/R in rat heart.
Article
Immunology
Liang Wen, Qing-Hui Yang, Xiao-Lei Ma, Ting Li, Sa Xiao, Chao-Feng Sun
Summary: The study demonstrates that inhibition of TNFAIP1 plays a crucial role in ameliorating myocardial I/R injury by reducing cardiomyocyte apoptosis, oxidative stress, and inflammatory response via activation of the Nrf2 signaling pathway. knockdown of TNFAIP1 potentiates Nrf2 signaling through the modulation of the Akt/GSK-3 beta pathway, highlighting TNFAIP1 as a potential therapeutic target for myocardial I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Weijie Xie, Xinyue Wang, Tianbao Xiao, Yibo Cao, Yumei Wu, Dongsheng Yang, Song Zhang
Summary: Ginseng Rb1 has significant neuroprotective effects on cerebral ischemic injury, with mechanisms involving antioxidant, anti-inflammatory, and antiapoptotic activities, as well as inhibition of excitotoxicity and Ca2(+) influx, preservation of blood-brain barrier integrity, and maintenance of energy metabolism. As a result, GRb1 has the potential to be a candidate drug for treating ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Haiyun Guo, Ze Fan, Shiquan Wang, Lina Ma, Jin Wang, Doutong Yu, Zhen Zhang, Lin Wu, Zhengwu Peng, Wenming Liu, Wugang Hou, Yanhui Cai
Summary: The mobilization of astrocytic glycogen inhibits A1-like astrocytes and enhances A2-like astrocytes during reperfusion, leading to reduced reactive oxygen species levels and increased production of NADPH and glutathione. This neuroprotection is mediated through ROS-mediated NF-kappa B inhibition and STAT3 activation, presenting a promising metabolic target for brain reperfusion injury in ischemic stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Samuel M. Law, Jie J. Zheng
Summary: Wnt signaling pathways play a significant role in various diseases. β-catenin is central to the canonical Wnt signaling pathway. CHIR-99021, a GSK-3β inhibitor, is widely used for studying this pathway. However, caution is needed when using CHIR-99021 at certain concentrations.
Article
Pharmacology & Pharmacy
Haixia Qin, Siyuan Li, Zhenbing Liu
Summary: The study revealed that Shexiang Baoxin Pill (SBP) has a protective effect on myocardial ischemia/reperfusion injury in patients with STEMI, improving cardiac function and decreasing myocardial infarction area.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Chantal Eickelmann, Helmut Raphael Lieder, Sharaf-Eldin Shehada, Matthias Thielmann, Gerd Heusch, Petra Kleinbongard
Summary: Mitochondrial function is critical for myocardial ischemia-reperfusion injury and cardioprotection. Measuring mitochondrial function in permeabilized cardiac tissue can reflect mitochondrial dysfunction following ischemia-reperfusion.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cell Biology
Chengliang Li, Jiajia Hao, Huichang Qiu, Hong Xin
Summary: This study found that up-regulation of CaMKK2 provides a therapeutic benefit in MI/R injury by enhancing the activation of the Nrf2 pathway through regulation of the AMPK/AKT/GSK-3β pathway. This suggests CaMKK2 as a new molecular target for the treatment of MI/R injury.
INFLAMMATION RESEARCH
(2023)
Article
Immunology
Sumei Liang, Juanping Han, Weiping Cheng, Xiaoan Chen
Summary: This study investigated the potential role and mechanism of CTRP6 in myocardial ischemia-reperfusion (I/R) injury through in vitro and in vivo experiments. CTRP6 expression was downregulated in hypoxia/reoxygenation (H/R)-treated cardiomyocytes. CTRP6 overexpression alleviated apoptosis, oxidative stress, and inflammation in H/R-treated cardiomyocytes, and ameliorated myocardial injury in mice with myocardial I/R injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Hui-Hui Guo, Xin-Yue Jing, Hui Chen, Hou-Xi Xu, Bing-Mei Zhu
Summary: Electroacupuncture pretreatment (EAP) was found to have a protective effect against myocardial I/R injury, reducing infarct size and cardiomyocyte apoptosis rate, and this effect may be related to the STAT5 signaling pathway.
FRONTIERS IN MEDICINE
(2021)
Article
Biology
Jyh-Gang Leu, Chien-Mei Wang, Chao-Yi Chen, Yi-Feng Yang, Chin-Yu Shih, Jiun-Tsai Lin, Han-Min Chen, Yao-Jen Liang
Summary: The study demonstrated that adenine effectively prevented hypoxia-reoxygenation-induced cell death in cardiomyoblasts, reduced reactive oxygen species production, and decreased apoptosis. Adenine also exhibited antioxidant properties and protected mitochondria in damaged cells.
Article
Chemistry, Medicinal
Xueyang Jiang, Junting Zhou, Yang Wang, Xin Liu, Kaiying Xu, Jian Xu, Feng Feng, Haopeng Sun
Summary: A series of heterobifunctional small molecule PROTACs based on CRBN were designed and synthesized to effectively degrade GSK-3β protein and protect against cell death, showing potential for further investigation in the biological function of GSK-3β protein and its association with diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Fangping Xiao, Lei Wang, Meng Liu, Mingyue Chen, Hao He, Zhiqiang Jia, Lai Zhang, Yaqing Yang, Qianfan Hu, Mei Hong, Hanwen Zhang
Summary: In this study, the therapeutic role of SAC/VAL in regulating the GSK3β/NF-κB signaling pathway to suppress the inflammatory response and apoptosis was reported. SAC/VAL was found to reduce infarct size, improve ventricular function, and reverse pathological ventricular remodeling in I/R injury.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Oncology
Zhaohai Pan, Chuanjun Qu, Ying Chen, Xiaoyu Chen, Xiaona Liu, Wenjin Hao, Wenjuan Xu, Lei Ye, Peng Lu, Defang Li, Qiusheng Zheng
Article
Pharmacology & Pharmacy
Boxue Ren, Lei Ye, Jianwei Gong, Huanhuan Ren, Yangfang Ding, Xiaoyu Chen, Xiaona Liu, Peng Lu, Fei Wei, Wenjuan Xu, Qiusheng Zheng, Defang Li
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Endocrinology & Metabolism
Li Liu, Dan Wang, Yao Qin, Maolei Xu, Ling Zhou, Wenjuan Xu, Xiaona Liu, Lei Ye, Shijun Yue, Qiusheng Zheng, Defang Li
FRONTIERS IN ENDOCRINOLOGY
(2019)
Article
Cell Biology
Minjing Li, Jinliang Chen, Xiaofei Yu, Sen Xu, Defang Li, Qiusheng Zheng, Yancun Yin
Article
Oncology
Xiao-Yu Chen, Ying Chen, Chuan-Jun Qu, Zhao-Hai Pan, Yao Qin, Xin Zhang, Wen-Jing Liu, De-Fang Li, Qiusheng Zheng
Article
Biochemistry & Molecular Biology
Xin Zhang, Yao Qin, Zhaohai Pan, Minjing Li, Xiaona Liu, Xiaoyu Chen, Guiwu Qu, Ling Zhou, Maolei Xu, Qiusheng Zheng, Defang Li
Article
Oncology
Zhaohai Pan, Xin Zhang, Pengfei Yu, Xiaoyu Chen, Peng Lu, Minjing Li, Xiaona Liu, Zhipeng Li, Fei Wei, Kejun Wang, Qiusheng Zheng, Defang Li
FRONTIERS IN ONCOLOGY
(2019)
Article
Medicine, Research & Experimental
Zhaohai Pan, Yongchuan Luo, Yuan Xia, Xin Zhang, Yao Qin, Wenjing Liu, Minjing Li, Xiaona Liu, Qiusheng Zheng, Defang Li
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Cell Biology
Yangfang Ding, Qi Xie, Wenjing Liu, Zhaohai Pan, Xinmei Fan, Xiaoyu Chen, Mingkai Li, Wei Zhao, Defang Li, Qiusheng Zheng
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Oncology
Lingling Si, Xinyan Yan, Yan Wang, Boxue Ren, Huanhuan Ren, Yangfang Ding, Qiusheng Zheng, Defang Li, Ying Liu
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Xue Hu, Zihui Yang, Wenjing Liu, Zhaohai Pan, Xin Zhang, Minjing Li, Xiaona Liu, Qiusheng Zheng, Defang Li
FRONTIERS IN ONCOLOGY
(2020)
Article
Medicine, Research & Experimental
Zhaohai Pan, Jiaojiao Fan, Qi Xie, Xin Zhang, Wen Zhang, Qing Ren, Minjing Li, Qiusheng Zheng, Jun Lu, Defang Li
Summary: TBPoS-2OH exhibits significant photocytoxicity and can effectively increase apoptotic rates in melanoma cells. By elevating intracellular ROS levels and activating the mitochondrial apoptosis pathway, TBPoS-2OH shows anticancer effects on A375 and B16 cells.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Medicinal
Yuzhi Wang, Zhaohai Pan, Xiao-Lan Cheng, Kai Zhang, Xin Zhang, Yao Qin, Jiaojiao Fan, Ting Yan, Tao Han, Kwok Keung Shiu, Sam Chun-Kit Hau, Nai-Ki Mak, Daniel W. J. Kwong, Xiaona Liu, Minjing Li, Guowei Deng, Qiusheng Zheng, Jun Lu, Defang Li
Summary: The novel porphycene-based photosensitizers TBPoS-OH and TBPoS-2OH demonstrate potent photo-cytotoxicity with a LD50 in the nM range under both normoxic and hypoxic conditions. TBPoS-OH shows fast-cellular uptake, localization in lysosomes, and subsequent induction of cell apoptosis via the lysosomal-mitochondrial pathway. Additionally, TBPoS-OH exhibits no obvious immunogenicity and toxicity in vivo.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Wenjing Liu, Yang Liu, Zhaohai Pan, Xin Zhang, Yao Qin, Xiaojie Chen, Minjing Li, Xiaoyu Chen, Qiusheng Zheng, Xiaona Liu, Defang Li
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Zoology
Xiaojie Ding, Xiling Sun, Zuien Wang, Qiusheng Zheng, Xiaofei Yu, Wenjin Hao, Kejun Wang, Wenjuan Xu, Zhengping Dong
PAKISTAN JOURNAL OF ZOOLOGY
(2019)