Article
Biochemistry & Molecular Biology
Yung-Tsung Kao, Chih-Ching Yen, Hueng-Chuen Fan, Jen-Kun Chen, Ming-Shan Chen, Ying-Wei Lan, Shang-Hsun Yang, Chuan-Mu Chen
Summary: This study investigated the use of human amniotic fluid mesenchymal stromal cells (hAFMSCs) through in utero transplantation (IUT) as a potential treatment for hemophilia A. The results showed that the transplanted human cells fused with the recipient liver and produced human FVIII protein. This approach significantly improved the coagulation issues in FVIII knockout mice with hemophilia A.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Mohamed A. Ghoneim, Mahmoud M. Gabr, Ayman F. Refaie, Sawsan M. El-Halawani, Mohga M. Al-issawi, Batoul L. Elbassiouny, Mai A. Abd El Kader, Amani M. Ismail, Mona F. Zidan, Mary S. Karras, Raghda W. Magar, Sherry M. Khater, Sylvia A. Ashamallah, Mahmoud M. Zakaria, Malgorzata Kloc
Summary: This study investigated allogenic immune responses following the transplantation of insulin-producing cells (IPCs) differentiated from human adipose tissue-derived stem cells (hAT-MSCs) into humanized mice. The results showed that the engrafted cells were not affected by allogenic immune response, suggesting potential for cell therapy for insulin-dependent diabetes without immunosuppression or encapsulation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Oncology
Alexander Yakobson, Ashraf Abu Jama, Omar Abu Saleh, Regina Michlin, Walid Shalata
Summary: This study focused on the use of cemiplimab and pembrolizumab in elderly and immunocompromised patients with advanced or metastatic cSCC. The results showed that these two drugs were effective and had acceptable safety profiles for this patient population.
Article
Biochemistry & Molecular Biology
Olga Kovaleva, Polina Podlesnaya, Madina Rashidova, Daria Samoilova, Anatoly Petrenko, Valeria Mochalnikova, Vladimir Kataev, Yuri Khlopko, Andrey Plotnikov, Alexei Gratchev
Summary: Esophageal cancer, especially squamous cell carcinoma, shows significant correlations between microbiome composition and tumor infiltrating phenotypes. Specific types of tumors have higher bacterial burdens, with different microbial components associated with disease prognosis.
Article
Immunology
Rajeev K. Tyagi, Justin Jacobse, Jing Li, Margret M. Allaman, Kevin L. Otipoby, Erik R. Sampson, Keith T. Wilson, Jeremy A. Goettel
Summary: Regulatory T cells play a crucial role in maintaining immune homeostasis in the intestine, and dysfunction of T-reg cells is linked to various inflammatory and autoimmune disorders. Treatment with low-dose IL-2 may be a promising therapeutic strategy for inflammatory conditions, but its effectiveness in treating IBD is still uncertain.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Yusuke Amano, Atsushi Kihara, Masayo Hasegawa, Tamaki Miura, Daisuke Matsubara, Noriyoshi Fukushima, Hiroshi Nishino, Yoshiyuki Mori, Toshiro Niki
Summary: In this study, the clinicopathological and prognostic significance of stromal patterns (SP) in oral squamous cell carcinoma (OSCC) were explored. The study found that the SP category was significantly associated with various clinicopathological factors and was also a prognostic predictor for relapse-free survival (RFS) and overall survival (OS) in OSCC.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Qiusheng Shan, Kiyofumi Takabatake, Haruka Omori, Hotaka Kawai, May Wathone Oo, Keisuke Nakano, Soichiro Ibaragi, Akira Sasaki, Hitoshi Nagatsuka
Summary: The study demonstrates that both VSCC-SCs and SCC-SCs may promote the progression of OSCC, with SCC-SCs showing a more prominent effect, indicating a potential regulatory mechanism for OSCC progression.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhiwei Liu, Ruibing Su, Anil Ahsan, Chencai Liu, Xiaoqi Liao, Dongping Tian, Min Su
Summary: Squamous esophageal carcinoma is a common pathological type of esophageal carcinoma worldwide, with genomic instability observed during its development. This study suggests that DNA mutations caused by early DNA damage may serve as an indicator for ultra-early screening of esophageal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Morgan T. Walcheck, Kristina A. Matkowskyj, Anne Turco, Simon Blaine-Sauer, Manabu Nukaya, Jessica Noel, Oline K. Ronnekleiv, Sean M. Ronnekleiv-Kelly
Summary: Female sex hormones play a crucial role in the development of anal squamous cell carcinoma (SCC), while male sex hormones may not be involved. Castrated male KC mice showed no anal tumor formation, in contrast to the high incidence of anal SCC in female KC mice. Exogenous administration of estrogen rescued tumor development in ovariectomized female KC mice, highlighting the estrogen-mediated pathogenesis of anal SCC.
Article
Microbiology
Christoph Schifflers, Samantha Zottnick, Jonas D. Foerster, Sebastian Kruse, Ruwen Yang, Hendrik Wiethoff, Matthias Bozza, Karin Hoppe-Seyler, Mathias Heikenwaelder, Richard P. Harbottle, Carine Michiels, Angelika B. Riemer
Summary: This study presents the development of a new tumor model that mimics the characteristics and response of HPV patients, which is suitable for studying HPV16-specific therapeutic vaccines and immunotherapies.
Article
Biochemistry & Molecular Biology
Alexander Ruehle, Marie Lies, Maren Strack, Ramon Lopez Perez, Birgit Bieber, Andreas R. Thomsen, Peter Bronsert, Peter E. Huber, Jochen Hess, Andreas Knopf, Patrick Wuchter, Anca-Ligia Grosu, Nils H. Nicolay
Summary: This study investigated the influence of mesenchymal stromal cells (MSCs) on the radiosensitivity of head-and-neck squamous cell carcinoma (HNSCC). The results showed that MSCs did not exert radioprotective effects on HNSCCs and can be safely used for radiotherapy-related issues in HNSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Gulce Sari, Jingting Zhu, Charuta Ambardekar, Xin Yin, Andre Boonstra, Zongdi Feng, Thomas Vanwolleghem
Summary: ORF3 plays a crucial role in HEV release and persistent infection, as its absence significantly decreases HEV replication and virion release. Our findings provide a rationale for targeting ORF3 as a treatment strategy for HEV infection.
JOURNAL OF VIROLOGY
(2021)
Article
Chemistry, Medicinal
Yuanyuan Zhang, Xiaodan Shi, Xiaomeng Xie, Kyle Vaughn Laster, Mengjun Pang, Kangdong Liu, Joonsung Hwang, Dong Joon Kim
Summary: Harmaline, a naturally occurring beta-carboline alkaloid, has been found to attenuate ESCC growth by directly targeting mTOR, inducing cell-cycle arrest and inhibiting cell proliferation. Its potential as an mTOR inhibitor for treating ESCC is promising.
PHYTOTHERAPY RESEARCH
(2021)
Article
Oncology
Afshan Shams, Ayaz Ahmed, Ajmal Khan, Shariqa Khawaja, Najeeb Ur Rehman, Asma Saleem Qazi, Adnan Khan, Sami Bawazeer, Syed Abid Ali, Ahmed Al-Harrasi
Summary: Oral squamous cell carcinoma (OSCC) is a prevalent cancer, especially in Asian countries. In this study, two natural compounds, costunolide (CE) and aloe emodin (AE), were found to have potential anticancer effects against OSCC cells. These compounds inhibited cancer cell growth at low doses and induced apoptosis, while showing no toxicity to normal cells. They also regulated gene expression to promote apoptosis and inhibit metastasis. These compounds have the potential to be promising anticancer candidates.
Article
Medicine, Research & Experimental
Kou Kayamori, Ken-ichi Katsube, Hideaki Hirai, Hiroyuki Harada, Tohru Ikeda
Summary: This study found that cancer-associated fibroblasts (CAFs) activate Wnt signaling to promote tumor progression in oral squamous cell carcinoma (OSCC). CAFs stimulate OSCC cells to express WNT7A, which is associated with tumor depth and prognosis. Furthermore, WNT7A downregulates CLDN1 expression through the activation of AKT signaling, promoting OSCC cell migration.
LABORATORY INVESTIGATION
(2023)