Article
Biochemistry & Molecular Biology
C. A. Miguel, M. V. Noya-Riobo, G. L. Mazzone, M. J. Villar, M. F. Coronel
Summary: Secondary damage is a key factor in promoting cell death, neurodegeneration, and functional deficits following acute central nervous system insults. Resveratrol, a natural compound found in grape skin and red wine, has shown potential neuroprotective effects by modulating multiple pathways involved in antioxidant, anti-inflammatory, and anti-apoptotic processes.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Agnieszka Gegotek, Elzbieta Skrzydlewska
Summary: This review highlights the importance of ascorbate as a strong antioxidant and its various mechanisms of action. It also emphasizes the interaction of ascorbate with other antioxidants and its role in promoting antioxidant proteins and transcription factors.
Article
Medicine, Research & Experimental
Bassem Refaat, Mohamed El-Boshy
Summary: This study is the first to link NF-kappa B, TGF-beta, Nrf2, AMPK, and AKT with SFZ-induced nephrotoxicity. In addition, this is the first report to reveal antioxidative and anti-inflammatory effects for BCP against SFZ-associated nephropathy.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Review
Nutrition & Dietetics
Tianli Zhang, Hiroyasu Tsutsuki, Katushiko Ono, Takaaki Akaike, Tomohiro Sawa
Summary: Cysteine persulfide and polysulfides, sulfur-containing derivatives of cysteine, play diverse roles in biological processes including biosynthesis, signal transduction regulation, and cellular redox balance maintenance, suggesting their potential therapeutic implications in immune responses and oxidative stress protection.
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Jelica Grujic-Milanovic, Vesna Jacevic, Zoran Miloradovic, Djurdjica Jovovic, Ivica Milosavljevic, Sladjan D. Milanovic, Nevena Mihailovic-Stanojevic
Summary: Resveratrol significantly reduces blood pressure in hypertensive animals, improves cardiac tissue morphology, decreases the presence of TGF-beta and Bax in cardiac myocytes, and suppresses lipid peroxidation, indicating its potential in preventing hypertrophic and apoptotic consequences induced by high blood pressure, especially in malignant hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Veterinary Sciences
Amany M. Ramez, Ehab Kotb Elmahallawy, Gehad E. Elshopakey, Amira A. Saleh, Samar M. Moustafa, Ashraf Al-Brakati, Walied Abdo, Dina M. M. El-Shewehy
Summary: The combined treatment with Spirulina platensis and matcha green tea showed effective therapeutic effects in Schistosoma mansoni-infected mice. It reduced liver damage, enhanced antioxidant capacity, suppressed inflammatory response, and improved tissue structure. Further research is recommended to explore the mechanisms of this combined treatment for developing novel therapies against the disease.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Tiantian Meng, Dingfu Xiao, Arowolo Muhammed, Juying Deng, Liang Chen, Jianhua He
Summary: Resveratrol, a natural phytoalexin polyphenol, demonstrates antioxidant, anti-inflammatory, and anti-carcinogenic properties, with the ability to modulate inflammatory responses and exhibit immunomodulatory function both in vivo and in vitro.
Review
Pharmacology & Pharmacy
Supat Chupradit, Dmitry Bokov, Mohammad Yassin Zamanian, Mahsa Heidari, Elham Hakimizadeh
Summary: The liver is a vital organ in the body, and resveratrol (RES) exhibits pharmacological activities that can treat various liver diseases by reducing inflammation, inducing apoptosis, and reducing oxidative stress.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hernan Speisky, Maria Fernanda Arias-Sante, Jocelyn Fuentes
Summary: Recent research challenges the belief that the oxidation of flavonoids would result in a loss of their antioxidant properties. It has been found that the oxidation of quercetin and its analogue kaempferol leads to the formation of metabolites with significantly higher antioxidant potency than the precursors. The amplification of antioxidant properties is even greater for kaempferol, with a 100-fold increase compared to quercetin.
Article
Nutrition & Dietetics
Cuicui Wang, In-Jeong Kim, Hye-Rim Seong, Chan Ho Noh, Sangryong Park, Tae Myoung Kim, Heon Sang Jeong, Ka Young Kim, Seung Tae Kim, Hyun-Gyun Yuk, Sang-Chul Kwon, Ehn-Kyoung Choi, Yun-Bae Kim
Summary: This study analyzed the polyphenol content and antioxidative activity of rosebud extracts from 24 newly crossbred Korean roses, and found that Pretty Velvet rosebud extract (PVRE) contains high polyphenols and exhibits in vitro antioxidative and anti-inflammatory activities. PVRE shows dual (steroid- and NSAID-like) anti-inflammatory activities by blocking both the iNOS-NO and COX-2-PG pathways, and could be a potential candidate as an anti-inflammatory material for diverse tissue injuries.
Article
Immunology
Fatma Gonca Kocanci, Azize Yasemin Goksu
Summary: Microglial cells are crucial for the normal development and functioning of neurons in the central nervous system. They play a key role in maintaining brain homeostasis by monitoring the microenvironment for signs of injury or stress. This study investigated the potential of the FDA-approved calcineurin inhibitor Tacrolimus (FK506) to modulate microglial activation and reduce inflammation and oxidative stress. The findings suggest that FK506 could be a promising therapeutic agent for neurodegenerative diseases.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Namiko Kawamura, Goro Katsuura, Nobuko Yamada-Goto, Riho Nakama, Yuki Kambe, Atsuro Miyata, Tomoyuki Furuyashiki, Shuh Narumiya, Yoshihiro Ogawa, Akio Inui
Summary: Fractalkine-CX3CR1 signaling induces anorexigenic actions via activation of the BDNF-TrkB pathway and suppresses HFD-induced hypothalamic inflammation in mice.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Yao-Tseng Wen, Ching-Wen Huang, Chih-Peng Liu, Chih-Hung Chen, Chia-Mu Tu, Chrong-Shiong Hwang, Yi-Hsun Chen, Wan-Ru Chen, Keh-Liang Lin, Yu-Chieh Ho, Ta-Ching Chen, Rong-Kung Tsai
Summary: The study showed that treatment with E212 can increase the superoxide dismutase activity of the retina, reduce reactive oxygen species produced by RGCs, prevent disruption of the blood-retinal barrier, improve visual function and RGC density, and decrease RGC apoptosis and macrophage infiltration.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Agricultural Engineering
Guoyong Xie, Shuyi Jin, Hongting Li, Mingkun Ai, Feng Han, Yiqun Dai, Wei Tao, Yan Zhu, Yucheng Zhao, Minjian Qin
Summary: This study compared the chemical constituents and biological activities of wild and cultivated Corydalis saxicola, finding that wild samples had higher total alkaloid content, stronger anti-inflammatory and anti-proliferative activities, while cultivated samples showed better antioxidant activities. The research provides reference for the further development and utilization of this medicinal plant.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Biochemistry & Molecular Biology
Mari Numata, Dennis R. Voelker
Summary: Pulmonary surfactant, a mixture of lipids and proteins, has anti-inflammatory effects and can prevent viral replication by regulating Toll-like receptors and blocking interactions between viruses and host cells. Components like phosphatidylglycerol and phosphatidylinositol show potential as prophylaxis and treatment for respiratory viral infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)