Article
Biochemistry & Molecular Biology
Brianna Chen, Dylan McCuaig-Walton, Sean Tan, Andrew P. Montgomery, Bryan W. Day, Michael Kassiou, Lenka Munoz, Ariadna Recasens
Summary: The study demonstrates the important role of DYRK1A kinase in regulating the differentiation commitment of glioblastoma stem cells. Inhibiting DYRK1A insulates GSCs from differentiation-inducing signals, promoting differentiation and limiting stemness acquisition through deactivation of CDK5. This novel DYRK1A-CDK5-SOX2 pathway sheds further light on the mechanisms underlying the maintenance of glioblastoma stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Martijn A. J. Koppens, Hayley Davis, Gabriel N. Valbuena, Eoghan J. Mulholland, Nadia Nasreddin, Mathilde Colombe, Agne Antanaviciute, Sujata Biswas, Matthias Friedrich, Lennard Lee, Lai Mun Wang, Viktor H. Koelzer, James E. East, Alison Simmons, Douglas J. Winton, Simon J. Leedham
Summary: The study reveals that BMP signaling inhibits dedifferentiation of intestinal epithelial cells, and attenuation of the BMP pathway through stromal upregulation of Grem1 is essential for adaptive reprogramming in intestinal regeneration. However, the functional impact of this intervention is submaximal, suggesting potential therapeutic pathway manipulation in inflammatory bowel disease.
Article
Engineering, Biomedical
Zhong Li, Shiqi Xiang, Zixuan Lin, Eileen N. Li, Haruyo Yagi, Lauren Yocum, La Li, Katherine K. Bruce, Madalyn R. Fritch, Huanlong Hu, Bing Wang, Peter G. Alexander, Khiam Aik Khor, Rocky S. Tuan, Hang Lin
Summary: This study successfully enhanced the osteogenic capability of hMSCs by incorporating graphene oxide-based nanosheets into GelMA. Both in vitro and in vivo experiments demonstrated the tremendous potential of this technology, providing new possibilities for bone tissue engineering applications.
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Cell Biology
Kui Huang, Shuyu Cai, Ting Fu, Qiang Zhu, Lin Liu, Zhihao Yao, Pengcheng Rao, Xiaorong Lan, Qing Li, Jingang Xiao
Summary: It was found that the expression of Wnt10b RNA in OP-ASCs was significantly lower than that in ASCs. The upregulation of Wnt10b can enhance the osteogenic ability of OP-ASCs and promote bone defect healing.
CELL PROLIFERATION
(2023)
Article
Gastroenterology & Hepatology
Yu-Hsuan Lin, Qiyu Zeng, Yuemeng Jia, Zixi Wang, Lin Li, Meng-Hsiung Hsieh, Qiang Cheng, Chase A. Pagani, Nicholas Livingston, Jeon Lee, Yu Zhang, Tripti Sharma, Daniel J. Siegwart, Dean Yimlamai, Benjamin Levi, Hao Zhu
Summary: Using an in vivo CRISPR screening system, the study identified SPP2 as a secreted factor that negatively regulates liver regeneration. The results provide a method to identify, validate, and characterize secreted factors in vivo.
Article
Cell Biology
Taylor A. Cootes, Nayan D. Bhattacharyya, Susie S. Y. Huang, Lina Daniel, Kim S. Bell-Anderson, Sebastian A. Stifter, Tracy Chew, Samantha M. Solon-Biet, Luis R. Saraiva, Yi Cai, Xinchun Chen, Stephen J. Simpson, Carl G. Feng
Summary: Modulation of individual macronutrients or caloric density can regulate host resistance to infection. This study found that diet composition, independent of macronutrient and energy content, can also affect infection susceptibility, with highly processed food potentially impairing host defense.
Article
Biochemistry & Molecular Biology
Yining Zhang, Yixin Zhao, Zhengsong Xie, Molin Li, Yujiao Liu, Xiaolin Tu
Summary: Our study confirmed that BMP-7 mediates the anabolic actions of Wnt/β-catenin signaling in osteocytes. This provides new evidence for the clinical application of BMP-7-overexpressed osteocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rishi Man Chugh, Hang-Soo Park, Sahar Esfandyari, Amro Elsharoud, Mara Ulin, Ayman Al-Hendy
Summary: The study found that BMP-2 plays a therapeutic role in human PCOS in vitro cell model by suppressing cell proliferation, androgen production, and related gene expression in H295R cells. The BMP-2 secreted by BM-hMSCs is identified as a key factor mediating the beneficial effects of stem cell therapy in PCOS treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Ethan Baratz, Olga Protchenko, Shyamalagauri Jadhav, Deliang Zhang, Pierre-Christian Violet, Samantha Grounds, Minoo Shakoury-Elizeh, Mark Levine, Caroline C. Philpott
Summary: Oral supplementation of vitamin E can reduce liver iron stores in mice by suppressing the iron-and redox-sensing transcription factor Nrf2, leading to enhanced iron efflux through liver FPN. Iron depletion may indirectly enhance the antioxidative effects of vitamin E.
JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Fabien Kawecki, Jessica Jann, Michel Fortin, Francois A. Auger, Nathalie Faucheux, Julie Fradette
Summary: The success of dental implant treatment after tooth extraction can be improved by preserving the alveolar ridge using cell-free biomaterials. The use of a bone-like substitute supplemented with bone morphogenetic protein (BMP) can enhance in vitro osteogenic potential and promote alveolar bone healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Wytrwal, Malgorzata Sekula-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubialka
Summary: This study investigated the covalent binding of recombinant human bone morphogenetic protein-2 and -7 in stem cells and its effects on cell adhesion, migration, and osteogenesis. The presence of both proteins enhanced cell adhesion but limited cell motility, while the presence of single proteins promoted cell migration activity. Additionally, the coexistence of the proteins significantly increased early osteogenic marker expression.
Article
Neurosciences
Nadia Skauli, Ekaterina Savchenko, Ole Petter Ottersen, Laurent Roybon, Mahmood Amiry-Moghaddam
Summary: This study suggests that the canonical BMP-signaling pathway may play a role in regulating the expression of AQP4 and the subcellular compartmentation of the associated DAP complex, thereby impacting the development of neurological conditions.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Polymer Science
Oana Gherasim, Alexandru Mihai Grumezescu, Valentina Grumezescu, Ecaterina Andronescu, Irina Negut, Alexandra Catalina Birca, Bianca Galateanu, Ariana Hudita
Summary: Osteoconductive and osteoinductive coatings are effective strategies for enhancing the integration of metallic implants with bone. Composite materials based on PLA and HAp benefit bone cell development, while the addition of osteogenic proteins contributes to new bone formation. Laser-processed composites show superior ability to promote osteoprogenitor cell adhesion, viability, and proliferation.
Article
Biochemistry & Molecular Biology
Huong Giang Pham, Sulagna Mukherjee, Min Ji Choi, Jong Won Yun
Summary: This study demonstrates the important roles of BMP11 in white and brown adipocytes, showing that silencing of Bmp11 affects the expression of specific genes and reduces the levels of lipolytic protein markers. Moreover, BMP11 induces browning of 3T3-L1 adipocytes by coordinating multiple signaling pathways, including mTORC1-COX2 and p38MAPK-PGC-1 alpha as non-canonical pathways, as well as Smad1/5/8 as a canonical pathway. These results suggest the therapeutic potential of BMP11 for obesity treatment.
CELL BIOCHEMISTRY AND FUNCTION
(2021)