Article
Cell & Tissue Engineering
Haijian Sun, Shuang Wang, Zheng Yang, Lijie Tian, Xiaoxia Li, Jie Zhou, Baoli Wang
Summary: In this study, the researchers found that CHRDL1 acts as an antagonist of BMPs by binding to them and blocking their interaction with BMP receptors. They revealed that CHRDL1 suppresses osteoblast differentiation while promoting adipocyte differentiation. Mechanistic exploration showed that CHRDL1 stabilizes IGFBP3 and differentially modulates AKT/mTORC1 signaling, thereby regulating the differentiation of osteoblasts and adipocytes.
Article
Biochemistry & Molecular Biology
Eisaku Ogawa, Tomohiro Edamitsu, Hidetaka Ohmori, Kazuyoshi Kohu, Mineo Kurokawa, Hiroshi Kiyonari, Masanobu Satake, Ryuhei Okuyama
Summary: This study reveals the important roles of Runx1 and Runx3 in keratinocyte differentiation, where they directly inhibit the expression of keratin 1 and keratin 10 genes during the differentiation process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Eugene Kopantzev, Liya Kondratyeva, Marina Kopantseva, Kirill Kashkin, Dmitry Gnatenko, Elizaveta Grigorieva, Irina Alekseenko, Dina Safina, Igor Chernov
Summary: SOX9 is upregulated in pancreatic ductal adenocarcinoma and plays a crucial role in tumor phenotypes and development. Downregulating the expression of SOX9 in pancreatic cancer cells leads to cell-line-specific changes in protein markers and affects cell proliferation and apoptosis.
Article
Biochemistry & Molecular Biology
Carlos Fernandez-Pereira, Maria Aranzazu Penedo, Tania Rivera-Baltanas, Rafael Fernandez-Martinez, Saida Ortolano, Jose Manuel Olivares, Roberto Carlos Agis-Balboa
Summary: This study aimed to evaluate whether the alterations in insulin-like growth factor 2 (IGF-2) and IGF binding protein 7 (IGFBP-7) in schizophrenia patients are related to the psychiatric disorder itself or are a result of antipsychotic treatment. The results showed that drug-naive first episode patients had lower levels of IGF-2 compared to controls, but no significant change in IGFBP-7 levels. However, both IGF-2 and IGFBP-7 significantly increased after atypical antipsychotic treatment in these patients. Chronic patients, on the other hand, had higher levels of both proteins compared to controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zimo Zhou, Senxiang Chen, Tong Wu, Yifeng Chen, Yuxiao Cao, Ying Huang, Da Liu
Summary: This study discovered the differential expression of IGF2BP2 in osteoblast proliferation and osteogenic differentiation, and identified the relationship between IGF2BP2-binding RNAs and SRF, a target of IGF2BP2. Inhibition of IGF2BP2 and SRF affected cell growth and osteogenic differentiation. Therefore, IGF2BP2 could serve as a potential biomarker and therapeutic target for osteoporosis and osteogenic differentiation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Mengqi Zhu, Dan Wang, Kexin Zou, Fang Wang, Zechun Zhang, Xinru Song, Cunling Jia, Zehui Wei
Summary: This study analyzed the coordination between IGF1 and FSH in affecting the characteristics of granulosa cells from prehierarchical follicles. The results showed that IGF1 reduced the expression of genes involved in progesterone synthesis, promoted cell proliferation, and inhibited apoptosis.
ANIMAL REPRODUCTION SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Wenxiu Ru, Ao Qi, Xuemei Shen, Binglin Yue, Xiaoyan Zhang, Jian Wang, Hui Cao, Hong Chen
Summary: The study identified circCPE as a regulator in promoting bovine myoblast proliferation and inhibiting apoptosis and differentiation, potentially through a miR138-mediated mechanism. Overexpression of circCPE was shown to attenuate skeletal muscle regeneration in vivo, shedding light on its role in myogenesis.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shaomin Zhi, Jun Li, Xiao Kong, Xuemei Xie, Qiangli Zhang, Guoxiang Fang
Summary: IGF2BP2 plays a crucial role in wound healing by regulating proliferation, migration, and angiogenesis of keratinocytes. Knockdown of IGF2BP2 inhibits these processes in keratinocytes by decreasing the stability of HPSE.
Article
Biochemistry & Molecular Biology
Zongkui Wang, Peng Jiang, Fengjuan Liu, Xi Du, Li Ma, Shengliang Ye, Haijun Cao, Pan Sun, Na Su, Fangzhao Lin, Rong Zhang, Changqing Li
Summary: This study reveals that GDF11 negatively regulates neurogenesis by activating the ALK5-dependent PI3K-Akt signaling pathway in neural stem cells, inhibiting cell proliferation and migration while promoting differentiation and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pa-Fan Hsiao, Yi-Ting Huang, Po-Hsuan Lu, Ling-Ya Chiu, Tzu-Han Weng, Chi-Feng Hung, Nan-Lin Wu
Summary: This study investigates the expression and regulation of TXNIP in psoriasis, as well as its role in skin keratinocyte differentiation and EGFR signaling.
Article
Biochemistry & Molecular Biology
Genxi Zhang, Xinchao Zhang, Kaizhi Zhou, Xuanze Ling, Jin Zhang, Pengfei Wu, Tao Zhang, Kaizhou Xie, Guojun Dai
Summary: This study has revealed the regulatory role of miRNA-10a-5p in the proliferation, differentiation, and apoptosis of chicken myoblasts by targeting the BCL6 gene. The findings highlight the significance of miRNA-10a-5p and BCL6 in skeletal muscle growth, development, and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Jong Won, Rami Lee, Sun-Hye Choi, Ji-Hun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study aimed to elucidate the involvement of EGFRs in gintonin-induced wound repair in HaCaT keratinocytes. Results showed that gintonin increased EGF receptor activation, as well as promoted proliferation and migration in HaCaT cells. Additionally, gintonin stimulated the expression and release of HB-EGF. These findings suggest a close relationship between gintonin's wound-healing effects and the collaboration of EGF receptor activation and HB-EGF release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alekh Paranjapye, Monali NandyMazumdar, James A. Browne, Shih-Hsing Leir, Ann Harris
Summary: This study characterizes the role of KLF5 in controlling essential pathways of epithelial cell identity and function in the human lung. Results show that KLF5 plays a key role in regulating genes involved in cell adhesion and proinflammatory response, highlighting its pivotal role in coordinating epithelial functions relevant to human lung disease.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Mengjin Gao, Xue Li, Zuojun Yang, Shuo Zhao, Xingxing Ling, Jingjing Li, Kai Xing, Xiaolong Qi, Xiangguo Wang, Longfei Xiao, Hemin Ni, Yong Guo, Xihui Sheng
Summary: This study reveals that circHIPK3 regulates skeletal muscle development through the miR-7/TCF12 pathway, providing important insights into the biological mechanisms involved.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Peipei Zhang, Masaki Ishikawa, Andrew Doyle, Takashi Nakamura, Bing He, Yoshihiko Yamada
Summary: Panx3 regulates skin development by modulating the transcription factor Epfn. Panx3(-/-) mice show impaired skin development and delayed hair follicle regeneration, while Panx3 overexpression promotes HaCaT cell differentiation.
SCIENTIFIC REPORTS
(2021)