Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Stefanie May, Claas Ulrich, Eggert Stockfleth, Juergen Eberle
Summary: The study found that celecoxib has strong anti-proliferative effects on cutaneous squamous cell carcinoma (cSCC) by inducing high levels of apoptosis through combination with agonistic CD95 antibody or TNF-related apoptosis-inducing ligand (TRAIL). The drug can also enhance therapeutic effectiveness by activating proapoptotic proteins, reducing anti-apoptotic factors, and increasing levels of reactive oxygen species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Uly Sumarni, Ulrich Reidel, Juergen Eberle
Summary: The study found that PEP005 can induce apoptosis in some CTCL cell lines, but is ineffective in others. This suggests a potential therapeutic strategy for CTCL involving PEP005, particularly in cells where apoptosis is induced.
Article
Oncology
Weixia Liu, Ying Yang, Jing Wang, Shanshan Wu, Zhi Chen
Summary: Cellular c-FLIP prevents apoptosis mediated by death receptor by inhibiting caspase-8 activation. The study shows that triptolide (TPL) accelerates TNF-alpha-induced apoptosis in hepatocellular carcinoma cells by reducing FLIPS protein levels.
Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Peter Langer, Claas Ulrich, Juergen Eberle
Summary: This study investigated the efficacy of three indirubin derivatives in four cSCC cell lines, showing significant effects on cell proliferation, viability, and apoptosis. The mechanisms of action involved induction of reactive oxygen species and activation of various apoptotic pathways, highlighting the importance of ROS in antitumor effects of indirubins.
Article
Biochemistry & Molecular Biology
Zhi-Qiang Bai, Xiaofang Ma, Bin Liu, Tao Huang, Kaifeng Hu
Summary: This study provides a structural basis for understanding the interaction between c-FLIP and procaspase-8 and the molecular mechanisms of c-FLIP in regulating cell death.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Jun Dai, Jing-Jing Hu, Xiaoqi Dong, Biao Chen, Xiyuan Dong, Rui Liu, Fan Xia, Xiaoding Lou
Summary: A new strategy involving GCP/miR-140 nanoparticles is developed to activate Cathepsin B in tumor cells and release anti-PD-L1 substances, while miR-140 targets PD-L1 mRNA and photodynamic therapy triggers immune cell attack on tumor cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Yang Cao, Ying He, Litao Yang, Zhou Luan
Summary: Studies have shown that CR-31 treatment can counter the resistance to TRAIL in GBC cells, increase sensitivity to apoptosis, and may serve as a novel therapeutic strategy.
Article
Cell Biology
Rocio Mora-Molina, Daniela Stoehr, Markus Rehm, Abelardo Lopez-Rivas
Summary: Protein misfolding or unfolding and the resulting endoplasmic reticulum stress commonly occur in highly proliferative tumors. The role of caspase-8 inhibitor cFLIP in regulating the balance between apoptosis and survival in colon cancer cells undergoing ER stress has been investigated. Maintaining high cFLIP levels during ER stress can inhibit caspase-8 activation and apoptosis, while cFLIP knockdown accelerates caspase-8 activation and apoptosis during ER stress. The resistance of multicellular tumor spheroids to ER stress-induced apoptosis correlates with sustained cFLIP(L) expression.
CELL DEATH & DISEASE
(2022)
Article
Biology
Xiaoying Lou, Kexin Li, Benheng Qian, Yiling Li, Donghong Zhang, Wei Cui
Summary: A pan-cancer analysis reveals the importance of pyroptosis in tumor development, prognosis, and immunotherapy. Pyroptosis is associated with tumor immunity, as evident from the elevated expression of pyroptosis-associated genes in high-immune-activity tumors. Furthermore, pyroptosis directly influences the expression of immune checkpoint molecules and cytokines. Pyroptosis score can serve as a potential independent prognostic indicator and help predict the effectiveness of anti-PD-1 immunotherapy.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chiara Musiu, Simone Caligola, Alessandra Fiore, Alessia Lamolinara, Cristina Frusteri, Francesco Domenico Del Pizzo, Francesco De Sanctis, Stefania Cane, Annalisa Adamo, Francesca Hofer, Roza Maria Barouni, Andrea Grilli, Serena Zilio, Paolo Serafini, Evelina Tacconelli, Katia Donadello, Leonardo Gottin, Enrico Polati, Domenico Girelli, Ildo Polidoro, Piera Amelia Iezzi, Domenico Angelucci, Andrea Capece, Ying Chen, Zheng-Li Shi, Peter J. Murray, Marco Chilosi, Ido Amit, Silvio Bicciato, Manuela Iezzi, Vincenzo Bronte, Stefano Ugel
Summary: Research has shown that FLIP can control cytokine release syndrome (CRS) by activating a STAT3-dependent inflammatory program. Expression of a viral FLIP homolog in myeloid cells can trigger a fatal inflammatory syndrome in mice, characterized by increased cytokine output, lymphopenia, lung injury, and multiple organ dysfunctions. Targeting the STAT3 pathway may help alleviate inflammation, immune disorders, and organ failures associated with CRS.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Medicine, General & Internal
Nishant Thakur, Kwang Yeol Paik, Gyoyeon Hwang, Yosep Chong
Summary: The study evaluated the expression and prognostic significance of immune checkpoint and EMT markers in periampullary cancers (PAC). It was found that high PD-L1 expression was significantly related to better overall survival (OS) and disease-free survival (DFS), while PD-L1 and PD-L2 were significantly related to EMT markers.
Article
Multidisciplinary Sciences
Aihua Li, Weibiao Cao
Summary: This study found that carnosol decreases cell proliferation and increases caspase-3 protein expression in esophageal adenocarcinoma cells. It is suggested that carnosol's effect may be mediated by the overproduction of reactive oxygen species (ROS) and the downregulation of SODD. Carnosol shows potential as a treatment for esophageal adenocarcinoma.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Shuo Zhang, Zhen Chen, Puyu Shi, Songqing Fan, Yong He, Qiming Wang, Yixiang Li, Suresh S. Ramalingam, Taofeek K. Owonikoko, Shi-Yong Sun
Summary: The study revealed that EGFR inhibitors such as osimertinib can decrease DR4 levels in EGFR mutant NSCLC cells, inducing apoptosis. However, this modulation is lost in resistant cells. Increased DR4 levels were found in cell lines with acquired osimertinib resistance and NSCLC tissues relapsed from EGFR-targeted therapy.
Article
Chemistry, Medicinal
Jaemyun Kim, Seungwon Ji, Jin-Young Lee, Jean Lorquin, Barbora Orlikova-Boyer, Claudia Cerella, Aloran Mazumder, Florian Muller, Mario Dicato, Olivier Detournay, Marc Diederich
Summary: Palytoxin can induce cancer cell death at low picomolar concentrations without toxicity to normal cells. The mechanism involves downregulation of antiapoptotic proteins and upregulation of proteasomal enzymatic activity. Protein phosphatase 2A plays a critical role in the induction of apoptosis by palytoxin. Palytoxin also shows strong inhibitory effects on leukemia and tumor formation in vivo.
Review
Physiology
Laurel A. Grisanti
Summary: Cardiovascular disease is a leading cause of death globally. Cardiomyocyte death, which occurs in heart damage and stress, contributes to cardiac dysfunction and further damages the heart. Apoptosis, a regulated form of cell death, can occur through intrinsic or extrinsic pathways. The poorly characterized TNF-related ligand TRAIL and its receptors have been found to play a role in cardiac pathology. This article aims to provide an overview of the current understanding of TRAIL and its receptors in normal and pathological conditions in the heart.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tatsuo Serikawa, Juergen Eberle, Jens Kurreck
Review
Biotechnology & Applied Microbiology
Guy Ungerechts, Christine E. Engeland, Christian J. Buchholz, Juergen Eberle, Henry Fechner, Karsten Geletneky, Per Sonne Holm, Florian Kreppel, Florian Kuehnel, Karl Sebastian Lang, Mathias F. Leber, Antonio Marchini, Markus Moehler, Michael D. Muehlebach, Jean Rommelaere, Christoph Springfeld, Ulrich M. Lauer, Dirk M. Nettelbeck
HUMAN GENE THERAPY
(2017)
Article
Biochemistry & Molecular Biology
Veselina Zhivkova, Felix Kiecker, Peter Langer, Juergen Eberle
MOLECULAR CARCINOGENESIS
(2019)
Article
Biochemistry & Molecular Biology
Marwa Y. Soltan, Uly Sumarni, Chalid Assaf, Peter Langer, Ulrich Reidel, Juergen Eberle
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Oncology
Juergen Eberle
Article
Cell Biology
Tarek Hazzan, Juergen Eberle, Margitta Worm, Magda Babina
Article
Biochemistry & Molecular Biology
Zina Sarif, Beatrice Tolksdorf, Henry Fechner, Juergen Eberle
MOLECULAR CARCINOGENESIS
(2020)
Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Stefanie May, Claas Ulrich, Eggert Stockfleth, Juergen Eberle
Summary: The study found that celecoxib has strong anti-proliferative effects on cutaneous squamous cell carcinoma (cSCC) by inducing high levels of apoptosis through combination with agonistic CD95 antibody or TNF-related apoptosis-inducing ligand (TRAIL). The drug can also enhance therapeutic effectiveness by activating proapoptotic proteins, reducing anti-apoptotic factors, and increasing levels of reactive oxygen species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Beatrice Tolksdorf, Sina Zarif, Juergen Eberle, Ahmet Hazini, Babette Dieringer, Franziska Jonsson, Florian Kreppel, Jens Kurreck, Henry Fechner
Summary: Silencing of Mcl-1 can overcome TRAIL resistance in melanoma cells and enhance the cytotoxicity of TRAIL-expressing adenovirus. The increase of apoptosis induced by Mcl-1 silencing is the main mechanism for this effect, which occurs in both TRAIL-sensitive and TRAIL-resistant melanoma cells.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Review
Virology
Dirk M. Nettelbeck, Mathias F. Leber, Jennifer Altomonte, Assia Angelova, Julia Beil, Susanne Berchtold, Maike Delic, Juergen Eberle, Anja Ehrhardt, Christine E. Engeland, Henry Fechner, Karsten Geletneky, Katrin Goepfert, Per Sonne Holm, Stefan Kochanek, Florian Kreppel, Lea Krutzke, Florian Kuehnel, Karl Sebastian Lang, Antonio Marchini, Markus Moehler, Michael D. Muehlebach, Ulrike Naumann, Roman Nawroth, Jurg Nueesch, Jean Rommelaere, Ulrich M. Lauer, Guy Ungerechts
Summary: Virotherapy research in Germany focuses on developing and engineering oncolytic viruses for killing cancer cells directly and indirectly through immune responses and therapeutic protein delivery. Clinical trials explore the safety and efficacy of various virotherapeutics in combination therapies, aiming to implement effective treatments in oncology.
Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Peter Langer, Claas Ulrich, Juergen Eberle
Summary: This study investigated the efficacy of three indirubin derivatives in four cSCC cell lines, showing significant effects on cell proliferation, viability, and apoptosis. The mechanisms of action involved induction of reactive oxygen species and activation of various apoptotic pathways, highlighting the importance of ROS in antitumor effects of indirubins.
Article
Biochemistry & Molecular Biology
Jiaqi Zhu, Bernd Gillissen, Dieu Linh Dang Tran, Stefanie May, Claas Ulrich, Eggert Stockfleth, Juergen Eberle
Summary: Sinecatechins obtained from green tea extract can inhibit cell proliferation and viability of cutaneous squamous cell carcinoma cells, potentially used for the treatment of actinic keratosis. The mechanism may be related to an imbalance of reactive oxygen species levels.
Article
Biochemistry & Molecular Biology
Uly Sumarni, Jiaqi Zhu, Tobias Sinnberg, Juergen Eberle
Summary: Long-term curative treatment of cutaneous T-cell lymphomas remains a challenge. The overexpression of antiapoptotic protein Mcl-1 is related to therapy resistance. The Mcl-1 inhibitor S63845 can induce apoptosis in CTCL cell lines, showing high sensitivity in some cell lines and complete resistance in others. Bcl-w expression may serve as a suitable marker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhe Peng, Bernhard Gillissen, Antje Richter, Tobias Sinnberg, Max S. Schlaak, Juergen Eberle
Summary: Targeting MAP kinase pathways through BRAF inhibitors has shown promise in treating BRAF-mutated melanoma. However, this approach is ineffective for BRAF-WT melanoma, and relapse often occurs after initial regression. Inhibiting MAP kinase pathways downstream at ERK1/2 or targeting antiapoptotic Bcl-2 proteins like Mcl-1 may provide alternative strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Georgios Kokolakis, Robert Sabat, Sabine Kruger-Krasagakis, Jurgen Eberle
Summary: TNF alpha has opposing effects on apoptosis in malignant and normal human keratinocytes, promoting apoptosis in malignant cells while protecting normal cells from apoptosis. These findings have important clinical implications for patients treated with TNF alpha inhibitors.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2021)