Review
Virology
Nura A. Mohamed, Haissam Abou-Saleh, Hana A. Mohamed, Mohammad A. Al-Ghouti, Sergio Crovella, Luisa Zupin
Summary: Infectious diseases have a global impact and require innovative approaches to prevent and treat viral infections. The development of nanoparticles shows promise in addressing these challenges.
News Item
Geosciences, Multidisciplinary
Audrey Gaudel
Summary: For decades, efforts to mitigate ozone pollution have relied on two chemical regimes. However, a recent global modeling analysis has revealed a third regime involving aerosols that could help concurrently control both ozone and particulate pollution.
Review
Immunology
Hyun Jee Han, Chinekwu Nwagwu, Obumneme Anyim, Chinedu Ekweremadu, San Kim
Summary: COVID-19 is associated with cancer, with cancer patients showing worsened symptoms and higher mortality when infected. Vaccines offer a promising solution to reduce the impact of the virus on cancer patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Mechanics
Alberto F. Rius-Vidales, M. Kotsonis
Summary: The study found that a forward-facing step has an impact on the development of stationary crossflow instability, causing abrupt changes in vortex trajectories and amplification effects. Different step heights affect the stability of the primary stationary mode and its harmonics to varying degrees. In the case of shorter step heights, velocity fluctuations eventually decrease below the level of the configuration without a step.
JOURNAL OF FLUID MECHANICS
(2021)
Editorial Material
Cell Biology
Patrick A. Lewis
Summary: A phase 1 clinical trial for kinase inhibitors targeting LRRK2 lays the groundwork for evaluating the effectiveness of LRRK2 kinase inhibitors in Parkinson's disease.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Immunology
Marco Antonio Cabrera Gonzalez, Ana Alice Maia Goncalves, Jennifer Ottino, Jaqueline Costa Leite, Lucilene Aparecida Resende, Otoni Alves Melo-Junior, Patricia Silveira, Mariana Santos Cardoso, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Renato Lima Santos, Tatiane Furtado de Carvalho, Giani Martins Garcia, Paulo Ricardo de Oliveira Paes, Alexsandro Sobreira Galdino, Miguel Angel Chavez-Fumagalli, Marilia Martins Melo, Denise Silveira-Lemos, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Vanessa Carla Furtado Mosqueira, Rodolfo Cordeiro Giunchetti
Summary: Visceral leishmaniasis (VL) is a fatal disease caused by Leishmania infantum, and dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) is important in controlling human and CVL infections by reducing L. infantum infection. This study evaluated the potential of two polymeric nanoformulations loaded with Leishmania amazonensis antigens as a VL vaccine using golden hamsters as a model. The results showed that the vaccines had no adverse reactions and significantly reduced the parasitic load in the liver and spleen. These vaccines may be promising candidates for a VL vaccine.
Review
Pharmacology & Pharmacy
Pranav Kumar Prabhakar, Navneet Khurana, Manish Vyas, Vikas Sharma, Gaber El-Saber Batiha, Harpreet Kaur, Jashanpreet Singh, Deepak Kumar, Neha Sharma, Ajeet Kaushik, Raj Kumar
Summary: Coronavirus, belonging to the coronaviridae family, has caused various diseases such as SARS-CoV-2, MERS-CoV-2, and COVID-19. In response to the COVID-19 pandemic, nanotechnology-based vaccines have been developed to aid in the detection, diagnosis, and treatment of the disease.
Article
Biochemical Research Methods
Roland Wohlgemuth, Tomasz Twardowski, Alfredo Aguilar
Summary: Continuous, inspiring and interconnected step-by-step changes in thought and understanding, knowhow, actions and behavior have played a crucial role in transitioning from one age to the next in human history. However, it is important for us to continue on the journey to address the challenges by going beyond descriptive work and finding solutions through novel and inspiring steps. Such efforts are further supported by the global acceptance of the concept of bioeconomy, which has created momentum in more than 50 countries and offers great opportunities for mobilizing stakeholders towards sustainable economic growth under planetary boundary conditions.
Review
Pharmacology & Pharmacy
Carina Peres, Ana Matos, Liane I. F. Moura, Rita C. Acurcio, Barbara Carreira, Sabina Pozzi, Daniella Vaskovich-Koubi, Ron Kleiner, Ronit Satchi-Fainaro, Helena F. Florindo
Summary: Targeted immunotherapies have revolutionized cancer treatment, but tumor heterogeneity and immunosuppression mechanisms have hindered the success of cancer vaccines. Nanotechnology offers promising solutions, but the selection of appropriate preclinical models is crucial.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Editorial Material
Neurosciences
Hugo G. Marques, Pedro L. Castelhanito, Megan R. Carey
Summary: A recent study has identified a mechanistic pathway by which norepinephrine alters cerebellar Purkinje output to trigger attacks in a mouse model of EA2, and a pharmacological intervention that effectively reduces them.
TRENDS IN NEUROSCIENCES
(2022)
Editorial Material
Medicine, General & Internal
Brian S. Barnett, Peter R. Chai, Joji Suzuki
Summary: Although fentanyl is the main driver of the opioid crisis in the U.S., the healthcare system has struggled to adapt toxicology screening practices to address this issue.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Shrey Sindhwani, Warren C. W. Chan
Summary: Nanomedicine has been a significant research focus in the last thirty years, with researchers developing methods to synthesize and characterize nanomaterials. The current focus is on translating nanotechnologies to benefit patients and addressing the challenges of clinical translation. Building partnerships between engineers and clinicians to create a feedback loop between bench and bedside is crucial for advancing fundamental studies and addressing clinical challenges in this field.
JOURNAL OF INTERNAL MEDICINE
(2021)
Review
Chemistry, Physical
Nawamin Sa-nguanmoo, Katawut Namdee, Mattaka Khongkow, Uracha Ruktanonchai, YongXiang Zhao, Xing-Jie Liang
Summary: Vaccination is the most effective way to prevent COVID-19, and nanotechnology plays an important role in vaccine design by enhancing antigen presentation and immunogenicity.
Editorial Material
Chemistry, Multidisciplinary
Guido Zichittella, Amedeo Ceruti, Gonzalo Guillen-Gosalbez, Javier Perez-Ramirez
Summary: This article introduces the educational background and research interests of Guido Zichittella, Amedeo Ceruti, Gonzalo Guillen-Gosalbez, and Javier Perez-Ramirez.
Review
Biochemistry & Molecular Biology
Ali Nazarizadeh, Alexander H. Staudacher, Nicole L. Wittwer, Tyron Turnbull, Michael P. Brown, Ivan Kempson
Summary: Aluminium compounds are commonly used as adjuvants in vaccines due to their improved tolerability. Recent studies have shown that moving from microparticles to nanoparticles can modify the immune responses induced by aluminium-based adjuvants. This review compares the adjuvant properties of aluminium nanoparticles and microparticles in the context of infectious disease vaccines and cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
