Article
Immunology
Dora E. Corzo-Leon, Donna M. MacCallum, Carol A. Munro
Summary: Malassezia species are important members of the normal mycobiota, colonizing sebum-rich skin regions and causing various infections. The study observed differences in skin responses to Malassezia sympodialis under oily and non-oily skin conditions, affecting the expression of immune-related genes and protein levels in the tissue.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lin Hou, Wei Wang, Mei-Kun Wang, Xue-Song Song
Summary: This study reports a multifunctional composite wound dressing loaded with chitosan-binding bFGF and antimicrobial peptides. The dressing exhibited excellent antibacterial activity, effectively inhibiting the growth of bacteria, and accelerated wound healing. Cell experiments and animal experiments demonstrated the positive effects of the composite dressing on cell growth and tissue repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Brittany Woodby, Erika Pambianchi, Francesca Ferrara, Jean-Philippe Therrien, Alessandra Pecorelli, Nicolo' Messano, Mary Ann Lila, Giuseppe Valacchi
Summary: Exposure to O3 is reported to affect AMP levels in the skin, playing a role in skin inflammatory conditions, indicating a possible defensive strategy against pollution-associated skin conditions.
Article
Biochemistry & Molecular Biology
Michal Ostrowka, Anna Duda-Madej, Filip Pietluch, Pawel Mackiewicz, Przemyslaw Gagat
Summary: Lactoferrin, an iron-binding glycoprotein, has multiple functions including antimicrobial, antiviral, antifungal, anticancer, antioxidant, and immunomodulatory activities. This study generated three novel human lactoferrin fragments, which were predicted to have antimicrobial activity. However, none of the new fragments showed antimicrobial properties, except for hLF 1-11, which was lethal against Pseudomonas aeruginosa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Anna Ramata-Stunda, Martins Boroduskis, Elza Kaktina, Liene Patetko, Uldis Kalnenieks, Zane Lasa, Marta Rubina, Inese Strazdina, Gints Kalnins, Reinis Rutkis
Summary: Skin and soft tissue infections (SSTIs) and acne are common skin conditions. Antibiotic resistance in pathogens causing SSTIs and acne is increasing, making treatment challenging. This study designed and compared six new antimicrobial peptides (AMPs) with existing ones. RP556 showed broad-spectrum antibacterial activity without cytotoxicity or hemolysis and stimulated IL-10 production. Four new AMPs showed specific activity against Cutibacterium acne below cytotoxic or hemolytic concentrations.
Article
Immunology
Alexander Humberg, Lisa Neuenburg, Hannah Boeckel, Mats Ingmar Fortmann, Christoph Haertel, Egbert Herting, Heilwig Hinrichs, Franziska Rademacher, Juergen Harder
Summary: This study examined the expression of antimicrobial peptides (AMPs) in the skin of preterm infants and found that the expression of AMPs was decreased in preterm infants compared to term infants. Preterm infants with infections or inflammation had higher concentrations of AMPs. These findings are significant for understanding the susceptibility to infection in preterm infants and developing new prevention strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Igor S. D. Costa, Tiago Junot, Fernanda L. Silva, Wanessa Felix, Jose L. Cardozo Fh, Antonio F. Pereira de Araujo, Constanca Pais do Amaral, Sonia Goncalves, Nuno C. Santos, Jose R. S. A. Leite, Carlos Bloch Jr, Guilherme D. Brand
Summary: The existence of antimicrobial encrypted fragments in human proteins has been demonstrated, and algorithms have been developed to identify these segments on a large scale. These fragments are typically cationic and amphiphilic segments that exert antimicrobial activity by disrupting membranes. The study found that about 2% of all human proteins contain these segments, with a higher prevalence in transmembrane and peripheral membrane proteins. These segments have conservation scores similar to other residues with similar solvent accessibility.
Review
Biochemistry & Molecular Biology
Piotr Brzoza, Urszula Godlewska, Arkadiusz Borek, Agnieszka Morytko, Aneta Zegar, Patrycja Kwiecinska, Brian A. Zabel, Artur Osyczka, Mateusz Kwitniewski, Joanna Cichy
Summary: This review focuses on exploring cysteine-based redox active antimicrobial proteins/peptides in the skin and intestine, discussing the causal links between different redox environments of these barrier tissues and the ability of AMPs to control cutaneous and intestinal microbes, and highlighting how bacteria can influence the bactericidal potential of redox-sensitive AMPs through intrinsic mechanisms.
Article
Biophysics
Emanuelle D. Freitas, Rogerio A. Rataglioli, Josephine Oshodi, Marisa M. Beppu
Summary: The coronavirus pandemic has highlighted the importance of bioactive materials in mitigating viral infections. Bioinspired antimicrobial peptides (AMPs) have emerged as suitable building blocks for antimicrobial coatings due to their versatile design and environmentally friendly features. This review discusses the advances and opportunities in using AMPs to create virucidal coatings, including the fundamental characteristics of peptide structure, advances in coating medical devices, and the role of different materials in designing antiviral coatings.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Marija Petkovic, Michelle Vang Mouritzen, Biljana Mojsoska, Havard Jenssen
Summary: Cutaneous wound healing is a crucial biological process, with chronic wounds often arising from persistent inflammatory conditions caused by factors such as autoimmune diseases. Host defense peptides play a significant role in modulating immune skin function and offer potential for inspiring topical treatments for chronic wounds.
Article
Chemistry, Multidisciplinary
Marco Campanile, Rosario Oliva, Pompea Del Vecchio, Roland Winter, Luigi Petraccone
Summary: LL-III, a natural anticancer peptide, has been found to bind to G-quadruplex structures with high affinity, which are known to be important targets in anticancer treatment.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Gabriel Goncalves de Freitas, Joao Martins Barbosa, Carlos Jose Correia de Santana, Ana Carolina Martins Magalhaes, Keven Wender Rodrigues Macedo, Jessica Oliveira de Souza, Jessica Schneider de Castro, Isadora Alves de Vasconcelos, Amanda Araujo Souza, Sonia Maria de Freitas, Sonia Nair Bao, Samuel Ribeiro Costa, Guilherme Dotto Brand, Ian de Meira Chaves, Vivian Vasconcelos Costa, Wagner Fontes, Osmindo Rodrigues Pires Junior, Mariana S. Castro
Summary: In recent years, the number of multidrug-resistant pathogenic microorganisms has been increasing due to inappropriate use of commercial antibiotics. The spread of antimicrobial resistance is a serious global public health problem, leading to the need for new antimicrobial drugs. Antimicrobial peptides, particularly those derived from anurans' skin glands, are a promising alternative. This study isolated two novel antimicrobial peptides, Raniseptins-3 and -6, from Boana raniceps skin secretion and evaluated their structural and biological properties.
Review
Dermatology
Franziska Rademacher, Regine Glaser, Jurgen Harder
Summary: The skin microbiota plays a crucial role in maintaining skin homeostasis, and dysbiosis may lead to cutaneous inflammation. Antimicrobial peptides (AMPs) may influence the microbiota by controlling their growth. A fine-tuned and well-balanced interplay between AMPs and the microbiota on the skin surface may be crucial for skin health.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Fisheries
Louise A. Rollins-Smith
Summary: Antimicrobial peptides (AMPs) are produced by various organisms for defense purposes, from simple bacteria to complex mammals. Some amphibian families have developed a highly sophisticated defensive strategy by storing AMPs in specialized granular glands in their skin. These glands, controlled by the sympathetic nervous system, release AMPs to cleanse wounds and aid in healing. This article reviews the nature and diversity of amphibian AMPs, their production regulation, and presents evidence supporting their important role in protecting amphibian skin. Despite the progress made in understanding amphibian AMPs, there are still gaps in our knowledge of peptide synthesis, storage, and functions.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Microbiology
David Huang, Despina Dobbins, Parviz Ghahramani, Ian Friedland, Jonathan Steckbeck
Summary: This first-in-human study evaluated the safety and pharmacokinetics of PLG0206, a novel engineered cationic antimicrobial peptide, when administered intravenously as a single dose to healthy subjects. The study found that PLG0206 exhibited linear pharmacokinetics, was well tolerated, and had a low incidence of treatment-related adverse events.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
