Review
Immunology
Samuel J. Connell, Ali Jabbari
Summary: Alopecia areata is an autoimmune disease that causes hair loss. The immune system mistakenly targets hair follicles, resulting in the infiltration of lymphocytes. The mechanisms behind this immune response and the relationships between immune cells and inflammation are not fully understood. Further research into the pathogenesis of Alopecia areata is crucial for the development of targeted therapeutics.
AUTOIMMUNITY REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Ivan Jozic, Jeremy Cheret, Beatriz Abdo Abujamra, Mariya Miteva, Jennifer Gherardini, Ralf Paus
Summary: The irreversible destruction of hair follicles in cicatricial alopecia is caused by apoptosis and pathological epithelial-mesenchymal transition, along with the collapse of bulge immune privilege and interferon-gamma-mediated chronic inflammation. The scaffolding protein Cav1 may play a crucial role in the pathobiology of cicatricial alopecias, with FFA potentially serving as a model disease for elucidating the role of Cav1 in other stem cell- and/or IP collapse-related pathologies. Therapeutic manipulation of Cav1 expression in FFA could potentially inhibit and reverse pathological EMT and bulge IP collapse.
Article
Immunology
Danning Pei, Lirong Chen, Yue Yao, Linxi Zeng, Guoqiang Zhang
Summary: Alopecia areata (AA) is a common non-cicatricial inflammatory hair loss, possibly an autoimmune disease specific to hair follicle organs. Microneedling combined with compound betamethasone treatment shows promising results for children with severe AA who are resistant or intolerant to conventional treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Molly M. M. Wilson, Paul S. S. Danielian, Griffin Salus, Roberta Ferretti, Charles A. A. Whittaker, Jacqueline A. A. Lees
Summary: BMI1 is involved in the self-renewal and proliferation of adult stem cells and tumors, but in cutaneous melanoma, it promotes epithelial-mesenchymal transition and metastasis while having little effect on proliferation or primary tumor growth. Deletion of melanocyte-specific Bmi1 in mice leads to premature hair greying and gradual loss of melanocytes, and depilation accelerates the depletion of melanocyte stem cells, suggesting a protective role of BMI1 against stress in these cells.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Article
Cell & Tissue Engineering
Jung Min Park, Mee Sook Jun, Jung-A. Kim, Nanda Maya Mali, Tsai-Ching Hsi, Areum Cho, Jung Chul Kim, Jun Young Kim, Incheol Seo, Jungmin Kim, Moonkyu Kim, Ji Won Oh
Summary: This study demonstrated that inflammatory factors induce the expression of major histocompatibility complex class I proteins in dermal papilla cells, and the loss of immune privilege of hair follicles can be rescued by treatment with conditioned media from outer root sheath cells. Transcriptomic analyses identified 58 up-regulated genes and 183 down-regulated genes related to MHC class I+ cells.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2022)
Article
Dermatology
Natella Maglakelidze, Ting Gao, Robert P. Feehan, Ryan P. Hobbs
Summary: Alopecia areata (AA) is an autoimmune hair loss disorder that is associated with sequence variation in AIRE. This study reveals the important role of AIRE in AA pathogenesis and suggests that Aire(-/-) mice can serve as a valuable model for studying AA.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Megan A. Palmer, Irundika H. K. Dias, Eleanor Smart, Yvonne Benatzy, Iain S. Haslam
Summary: The importance of cholesterol in hair follicle biology is highlighted by its connection to alopecias and hair growth disorders. ABCA5 defects have been linked to altered keratinocyte cholesterol distribution in individuals with a specific type of congenital hypertrichosis, but the underlying biological mechanism for this hair growth defect remains unknown. This study aimed to investigate the impact of ABCA5 activity on hair follicle keratinocyte behavior and found that ABCA5 plays a role in the intracellular compartmentalization of free cholesterol in primary hair follicle keratinocytes. The loss of ABCA5 could lead to impaired endo-lysosomal cholesterol transport, which may affect pathways known to influence hair growth, highlighting the need for further research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Biochemistry & Molecular Biology
Fabio Rinaldi, Anna Trink, Giorgia Mondadori, Giammaria Giuliani, Daniela Pinto
Summary: This article explores the relationship between menopause and changes in the hair follicle lifecycle, focusing on hormone and metabolic dynamics. Hormonal fluctuations and aging during menopause can affect the hair follicles, leading to thinning, reduction in volume, and changes in hair texture. These changes are primarily caused by a decrease in estrogen levels. However, not all women experience significant hair changes during menopause, and the extent of transformations can vary greatly due to genetic factors, stress, diet, and other elements. Additionally, menopause affects metabolism and blood flow to the hair follicles, affecting the availability of essential nutrients. The article also discusses the role of energy metabolism in the hair follicle lifecycle and the impact of hormones, especially estrogens, on metabolic efficiency. The concept of a possible menopause clinically independent of menopause is introduced, which is related to changes in hair follicle metabolism, highlighting the importance of individual factors such as estrogen receptor responses, genetics, and the microbiota in determining these dynamics.
Article
Biochemistry & Molecular Biology
Susan L. Limbu, Talveen S. Purba, Matthew Harries, Tongyu C. Wikramanayake, Mariya Miteva, Ranjit K. Bhogal, Catherine A. O'Neill, Ralf Paus
Summary: Dandruff is a common scalp condition that can cause psychological distress, and its pathogenesis may involve immune responses and inflammation in the scalp skin microenvironment, particularly in relation to changes in yeast, bacteria, and sebum by-products.
Review
Dermatology
Daniel G. W. Johnston, Brian Kirby, Desmond J. Tobin
Summary: The innate immune system of human skin consists of multi-layered barrier cells and soluble effector molecules charged with maintaining homeostasis and responding to insults and infections. These barrier layers are compromised in skin diseases, with significant advancements in understanding occurring in the research of hidradenitis suppurativa.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Immunology
Shahnawaz D. Jadeja, Desmond J. Tobin
Summary: Alopecia areata is a chronic disorder that causes unpredictable non-scarring hair loss. The exact factors that cause this disease in the hair follicles remain unclear, but changes in immune-competence and immune response to hair follicle-associated antigens are important factors. The identification of the hair follicle antigen(s) responsible for AA onset is challenging but essential for understanding the disease and developing effective treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ecology
Pablo Burraco, Miguel A. Rendon, Carmen Diaz-Paniagua, Ivan Gomez-Mestre
Summary: The study found that sibships with higher plasticity in spadefoot toad larvae exhibited higher antioxidant enzymatic activity in the absence of predator cues, along with higher lipid peroxidation and slightly greater granulocyte-to-lymphocyte ratio. This suggests that maintaining phenotypic plasticity may be linked to energy demanding metabolic processes. Costs associated with producing plastic responses may include oxidative and immunological factors, which could erode individual fitness and constrain the evolution of plasticity. This study provides the first empirical evidence of a physiological cost to maintaining phenotypic plasticity.
Article
Food Science & Technology
Nicholas John Sadgrove
Summary: This article discusses the impact of poor glucose control and high cholesterol on androgenetic alopecia, highlighting the importance of magnesium in hair health. Treatment options for androgenetic alopecia are suggested to include a low cholesterol and low glycemic index diet, improved glucose control, and magnesium supplementation. The narrative also advises against severe caloric restriction for obvious health reasons.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Gongyan Liu, Ce Liu, Yin Zhang, Haitao Sun, Liping Yang, Liya Bai, Shuxia Gao
Summary: The study revealed that skinning rabbits in winter resulted in better fur quality and hair follicle development compared to other seasons, as indicated by skin weight, area, thickness, hair follicle density, and various gene expressions related to growth factors and signaling pathways. Summer skinning had adverse effects on the rabbit coat, fat weight, and gene expressions, indicating a strong seasonal influence on rabbit physiology.
Article
Cell Biology
Keji Yan, Wen Zong, Haibo Du, Xiaoyan Zhai, Rui Ren, Shuang Liu, Wei Xiong, Yanfei Wang, Zhigang Xu
Summary: In this study, it was found that BAIAP2L2 is localized at the tips of inner ear hair cells' stereocilia, and its inactivation leads to degeneration of mechanotransducing stereocilia, resulting in hearing loss. BAIAP2L2 binds to components of the row 2 complex and MET complex, indicating its crucial role in maintaining stereocilia.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Letter
Dermatology
E. Nakamura, Y. Majima, H. Hashizume, Y. Tokura, H. Nakano
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2019)
Letter
Allergy
Reiko Kageyama, Toshiharu Fujiyama, Takahiro Satoh, Yasuhito Keneko, Seiya Kitano, Yoshiki Tokura, Hideo Hashizume
Letter
Dermatology
Hidehiko Miyazawa, Takatoshi Shimauchi, Hideo Hashizume, Yurika Masuda, Masahiro Aoshima, Taisuke Ito, Yoshiki Tokura
JOURNAL OF DERMATOLOGY
(2019)
Article
Allergy
Emiko Noguchi, Masato Akiyama, Akiko Yagami, Tomomitsu Hirota, Yukinori Okada, Zenichiro Kato, Reiko Kishikawa, Yuma Fukutomi, Michihiro Hide, Eishin Morita, Michiko Aihara, Makiko Hiragun, Yuko Chinuki, Takahiro Okabe, Akiko Ito, Atsuko Adachi, Atsushi Fukunaga, Yumiko Kubota, Toshiyuki Aoki, Youko Aoki, Kazue Nishioka, Tetsuya Adachi, Nobuo Kanazawa, Hitoshi Miyazawa, Hiroyuki Sakai, Takehito Kozuka, Hideo Kitamura, Hideo Hashizume, Chiharu Kanegane, Koji Masuda, Kumiya Sugiyama, Reiko Tokuda, Junichi Furuta, Ikkou Higashimoto, Atsuko Kato, Mariko Seishima, Akihiko Tajiri, Atsuko Tomura, Hiroko Taniguchi, Hiroto Kojima, Hidenori Tanaka, Aiko Sakai, Wataru Morii, Masashi Nakamura, Yoichiro Kamatani, Atsushi Takahashi, Michiaki Kubo, Mayumi Tamari, Hirohisa Saito, Kayoko Matsunaga
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2019)
Meeting Abstract
Dermatology
T. Fujiyama, K. Kurihara, T. Umayahara, T. Ito, H. Hashizume, Y. Tokura
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Dermatology
Hideo Hashizume, Riichiro Abe, Hiroaki Azukizawa, Toshiharu Fujiyama, Natsumi Hama, Yoshiko Mizukawa, Eishin Morita, Yukinobu Nakagawa, Saeko Nakajima, Hiroyuki Niihara, Yuichi Teraki, Mikiko Tohyama, Hideaki Watanabe, Yoshiki Tokura
JOURNAL OF DERMATOLOGY
(2020)
Letter
Dermatology
Toshiharu Fujiyama, Takatsune Umayahara, Kazuo Kurihara, Takatoshi Shimauchi, Taisuke Ito, Masahiro Aoshima, Emiko Otobe, Hideo Hashizume, Hiroaki Yagi, Yoshiki Tokura
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Letter
Dermatology
H. Hashizume, Y. Sano, S. Furukawa, S. Imokawa
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Letter
Dermatology
Hideo Hashizume, Toshiharu Fujiyama, Reiko Kageyama, Yasuhito Kaneko, Tomoyuki Sano, Tetsuya Honda
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Hideo Hashizume, Yuto Ishikawa, Sayaka Ajima
Summary: Steroid pulse therapy for drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms carries risks of cytomegalovirus reactivation, persistency, and high mortality, compared to conventional treatment, while showing lower rates of herpesvirus 6 reactivation or type 1 diabetes. This suggests that the administration mode may differentially impact inflammatory responses and associated consequences. Based on the study findings, steroid pulse therapy should be avoided for these severe adverse reactions.
JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
H. Hashizume, S. Ajima, Y. Ishikawa
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Hideo Hashizume, Sayaka Ajima, Yuto Ishikawa
Summary: SARS-CoV-2 vaccination may trigger or worsen IgA vasculitis, particularly in female patients.
JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Hideo Hashizume, Yuto Ishikawa, Sayaka Ajima
JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Sayaka Ajima, Yusuke Sano, Hideo Hashizume
Summary: A case of immediate hypersensitivity induced by ophthalmic administration of quinolones in a 20-year-old female with bacterial conjunctivitis is reported, with skin prick and basophil activation tests suggesting a type Ib reaction associated with Mas-related G-protein coupled receptor X2. This case serves as a caution to be aware of quinolone immediate hypersensitivity caused by topical ophthalmic preparations, which may predict severe hypersensitivity reactions to systemic administration.
JOURNAL OF DERMATOLOGY
(2021)
Letter
Allergy
Yasuhito Kaneko, Seiya Kitano, Takatsune Umayahara, Reiko Kageyama, Hideo Hashizume
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2019)