Article
Chemistry, Applied
Jia-Jia Wen, Ming-Zhi Li, Chun-Hua Chen, Tao Hong, Jing-Rui Yang, Xiao-Jun Huang, Fang Geng, Jie-Lun Hu, Shao-Ping Nie
Summary: Tea polyphenol (TP) and epigallocatechin gallate (EGCG) can improve hyperlipidemia and liver fat accumulation by regulating gut microbiota and promoting gut health.
Article
Pharmacology & Pharmacy
Changchao Huan, Weiyin Xu, Bo Ni, Tingting Guo, Haochun Pan, Luyao Jiang, Lin Li, Jingting Yao, Song Gao
Summary: The natural molecule EGCG, found in green tea, is effective against PEDV infection at the cellular level by inhibiting attachment, entry, replication, and assembly processes of the virus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sitan Ye, Haiyong Weng, Lirong Xiang, Liangquan Jia, Jinchai Xu
Summary: This study aimed to develop reliable models for tea polyphenols and EGCG content prediction using FT-NIR spectroscopy combined with machine learning algorithms. Various preprocessing methods and variable selection algorithms were applied to improve the models' efficiency. The results showed that the developed models could accurately predict tea polyphenol and EGCG content, which is beneficial for tea quality control and product development.
Article
Chemistry, Applied
Manzar Alam, Sabeeha Ali, Ghulam Md Ashraf, Anwar L. Bilgrami, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan
Summary: Epigallocatechin 3-gallate (EGCG), a polyphenolic component derived from green tea extract, possesses various biological functions, including anti-cancer and anti-inflammatory properties. It modulates multiple signaling pathways to inhibit tumor growth and induce cell death. EGCG also exhibits antioxidant, anti-angiogenic, and apoptotic effects. Therefore, EGCG shows potential in cancer treatment.
Article
Multidisciplinary Sciences
Seungil Park, Gyeong Han Jeong, Sung Hoon Jee, Tae Hoon Kim, Seong Bong Kim
Summary: This study reported an efficient method for dimerization of EGCG, the major bioactive constituent isolated from tea leaves, using low-temperature plasma. The contribution of ozone in the reaction process was quantified as a major factor, and the mechanism of synthesizing dimers A and B through the generation of ozone and formaldehyde during plasma treatment was investigated.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sana Iram, Safikur Rahman, Shahid Ali, Jihoe Kim
Summary: Epigallocatechin gallate inhibits the activation of plasminogen by binding to tetranectin, showing anticancer effects on CT-26 colon cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Nadine Tritsch, Marc C. Steger, Valerie Segatz, Patrik Blumenthal, Marina Rigling, Steffen Schwarz, Yanyan Zhang, Heike Franke, Dirk W. Lachenmeier
Summary: This article reviews the safety of coffee leaf tea, highlighting caffeine and epigallocatechin gallate (EGCG) as potentially hazardous substances. The caffeine content is comparable to roasted coffee beans, while the EGCG content is typically low. The article suggests a maximum intake of 1-3 cups per day of coffee leaf tea. The conclusion is that coffee leaf tea is not assumed to be risky for consumers.
Article
Biochemistry & Molecular Biology
Jana Adamcakova, Sona Balentova, Romana Barosova, Juliana Hanusrichterova, Pavol Mikolka, Kristian Prso, Juraj Mokry, Zuzana Tatarkova, Dagmar Kalenska, Daniela Mokra
Summary: This study aimed to evaluate the early effects of EGCG on markers of inflammation and lung fibrosis in silicotic rats. The results showed that early treatment with EGCG had the potential to alleviate inflammation and oxidative stress-induced changes, and prevent fibrotic changes in the bronchioles and pulmonary vessels. However, further investigations are needed to elucidate the effects of EGCG in the lung silicosis model and its potential adverse effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Chia-Pei Chen, Tsung-Chen Su, Meei-Ju Yang, Wen-Ting Chen, An-Ci Siao, Ling-Ru Huang, Yen-Yue Lin, Yow-Chii Kuo, Jia-Fang Chung, Ching-Feng Cheng, Hui-Chen Ku, Yung-Hsi Kao
Summary: Green tea epigallocatechin gallate (EGCG) inhibits 3T3-L1 cell growth through the miR-143/MAPK7 pathway, indicating the crucial role of miR-143 in the regulation of fat cell proliferation by EGCG.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jing-hua Zou, Fei Chen, Yi-lin Li, Hao Chen, Tong-ke Sun, Si-meng Du, Jun Zhang
Summary: The objective of this study was to investigate the effect of EGCG on tooth movement and root resorption during orthodontic treatment in rats. The results showed that EGCG reduced the distance of tooth movement and root resorption, decreased the number of TRAP positive cells in the periodontium, and decreased the expression level of RANKL while increasing the expression level of OPG, OCN, and Runx2. The effects were more pronounced in the 100 mg/kg group compared to the 50 mg/kg group.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shih-Chung Huang, Yung-Hsi Kao, Shao-Fu Shih, Min-Chien Tsai, Chin-Sheng Lin, Liv Weichien Chen, Yi-Ping Chuang, Pi-Fen Tsui, Ling-Jun Ho, Jenn-Haung Lai, Sy-Jou Chen
Summary: EGCG can suppress cytokine secretion in activated human primary T cells, likely mediated by AP-1 inactivation through the ERK and JNK pathways.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Jirayu Buatong, Ajay Mittal, Pimonsri Mittraparp-arthorn, Suriya Palamae, Jirakrit Saetang, Soottawat Benjakul
Summary: The antibacterial effect of chitooligosaccharide conjugated with five different polyphenols against Listeria monocytogenes was investigated. Among all the conjugates tested, COS-EGCG showed the highest inhibition toward Listeria monocytogenes, with a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of 1024 μg/mL, respectively. The COS-EGCG conjugate also had a bactericidal effect on the environmental and clinical strains of L. monocytogenes.
Review
Neurosciences
Luiza Fernandes, Thyago R. Cardim-Pires, Debora Foguel, Fernando L. Palhano
Summary: The accumulation of protein aggregates in human tissues is a hallmark of more than 40 diseases called amyloidoses, with seven of them being associated with neurodegenerative processes. EGCG, a natural compound found in green tea, has shown potential in inhibiting protein aggregation, reducing toxicity, and remodeling fibril structures in neurodegenerative diseases such as AD, PD, and HD.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Sze Wan Hung, Yiran Li, Xiaoyan Chen, Kai On Chu, Yiwei Zhao, Yingyu Liu, Xi Guo, Gene Chi-Wai Man, Chi Chiu Wang
Summary: Green tea, with its main component EGCG, shows potential in suppressing reproductive cancers by regulating autophagy and other cellular processes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Analytical
Li Wang, Xin Huang, Huijuan Jing, Xin Ye, Chao Jiang, Jiajia Shao, Chaoyang Ma, Hongxin Wang
Summary: A new method using resin and crystallization was developed to separate and purify EGCG and ECG from green tea polyphenols. After resin purification and crystallization, high purities of EGCG and ECG were achieved, with stable separation efficiency of the resin over multiple cycles.
ANALYTICAL METHODS
(2021)
Article
Gastroenterology & Hepatology
Doohyung Lee, Juri Na, Jihye Ryu, Hye-Jin Kim, Seo Hee Nam, Minkyung Kang, Jae Woo Jung, Mi-Sook Lee, Haeng Eun Song, Jungeun Choi, Gyu-Ho Lee, Tai Young Kim, June-Key Chung, Ki Hun Park, Sung-Hak Kim, Hyunggee Kim, Howon Seo, Pilhan Kim, Hyewon Youn, Jung Weon Lee
Article
Chemistry, Medicinal
Sahng-Wook Hahm, Jieun Park, Se-Yeong Oh, Chul-Won Lee, Kun-Young Park, Hyunggee Kim, Yong-Suk Son
JOURNAL OF MEDICINAL FOOD
(2015)
Article
Biochemistry & Molecular Biology
Jinlong Yin, Gunwoo Park, Tae Hoon Kim, Jun Hee Hong, Youn-Jae Kim, Xiong Jin, Sangjo Kang, Ji-Eun Jung, Jeong-Yub Kim, Hyeongsun Yun, Jeong Eun Lee, Minkyung Kim, Junho Chung, Hyunggee Kim, Ichiro Nakano, Ho-Shin Gwak, Heon Yoo, Byong Chul Yoo, Jong Heon Kim, Eun-Mi Hur, Jeongwu Lee, Seung-Hoon Lee, Myung-Jin Park, Jong Bae Park
Article
Pathology
Min-Suk Song, Young-Hun Cho, Su-Jin Park, Philippe Noriel Q. Pascua, Yun Hee Baek, Hyeok-Il Kwon, Ok-Jun Lee, Byung-Whi Kong, Hyunggee Kim, Eui-Cheol Shin, Chul-Joong Kim, Young Ki Choi
AMERICAN JOURNAL OF PATHOLOGY
(2013)
Review
Chemistry, Medicinal
Jun-Kyum Kim, Hee-Young Jeon, Hyunggee Kim
ARCHIVES OF PHARMACAL RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Xiong Jin, Xun Jin, Ji-Eun Jung, Samuel Beck, Hyunggee Kim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2013)
Article
Engineering, Biomedical
Lina Yoo, Jin-Seung Park, Koo Chul Kwon, Seong-Eun Kim, Xiong Jin, Hyunggee Kim, Jeewon Lee
Article
Oncology
Xun Jin, Xiong Jin, Young-Woo Sohn, Jinlong Yin, Sung-Hak Kim, Kaushal Joshi, Do-Hyun Nam, Ichiro Nakano, Hyunggee Kim
Article
Oncology
Jun-Kyum Kim, Xiong Jin, Young-Woo Sohn, Xun Jin, Hee-Young Jeon, Eun-Jung Kim, Seok Won Ham, Hye-Min Jeon, So-Young Chang, Se-Yeong Oh, Jinlong Yin, Sung-Hak Kim, Jong Bae Park, Ichiro Nakano, Hyunggee Kim
Article
Oncology
Hye-Min Jeon, Sung-Hak Kim, Xun Jin, Jong Bae Park, Se Hoon Kim, Kaushal Joshi, Ichiro Nakano, Hyunggee Kim
Article
Oncology
Se-Yeong Oh, Hyun Jung Kang, Young Sook Kim, Hyunggee Kim, Young Chang Lim
EUROPEAN JOURNAL OF CANCER
(2013)
Article
Biochemistry & Molecular Biology
Jun-Kyum Kim, Seung-Yup Lee, Chang-Won Park, Suk-Hwang Park, Jinlong Yin, Jaebong Kim, Jae-Bong Park, Jae-Yong Lee, Hyunggee Kim, Sung-Chan Kim
MOLECULAR BIOLOGY REPORTS
(2014)
Article
Multidisciplinary Sciences
Seung Ah Choi, Ji Yeoun Lee, Sung Eun Kwon, Kyu-Chang Wang, Ji Hoon Phi, Jung Won Choi, Xiong Jin, Ja Yun Lim, Hyunggee Kim, Seung-Ki Kim
Article
Oncology
Eun-Jung Kim, Sung-Ok Kim, Xiong Jin, Seok Won Ham, Jaebong Kim, Jae-Bong Park, Jae-Yong Lee, Sung-Chan Kim, Hyunggee Kim
Correction
Virology
Jun Han Lee, Sung-Hak Kim, Philippe Noriel Q. Pascua, Min-Suk Song, Yun Hee Baek, Xun Jin, Joong-Kook Choi, Chul-Joong Kim, Hyunggee Kim