Article
Biology
Maximilian Lenz, Pia Kruse, Amelie Eichler, Jakob Straehle, Juergen Beck, Thomas Deller, Andreas Vlachos
Summary: A defining feature of the brain is its ability for synaptic contacts to adapt structurally and functionally, with atRA being identified as a potent mediator of synaptic plasticity in the adult human cortex. The coordinated structural and functional changes in excitatory synapses observed in cortical slices were accompanied by ultrastructural remodeling of the spine apparatus organelle and required mRNA translation for these synaptic adaptations. The absence of these changes in synaptopodin-deficient mice suggests the importance of this organelle in the process.
Article
Biophysics
Francesca Cuomo, Sara Ceglie, Maria Miguel, Bjorn Lindman, Francesco Lopez
Summary: This study investigated the ability of cationic and anionic liposomes to encapsulate, protect, and deliver ATRA in an in-vitro digestion process, showing that cationic vesicles are preferable for higher bioavailability of ATRA.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Cell Biology
Dong-Hwan Kim, Joonbum Lee, Yeunsu Suh, Jae-Kyun Ko, Kichoon Lee
Summary: This study found that all-trans-retinoic acid (atRA) can induce the transdifferentiation of myoblasts into adipocytes by increasing the expression of Ppar gamma. This discovery provides a new nutrient for enhancing marbling in poultry.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Junning Pu, Daiwen Chen, Gang Tian, Jun He, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Yuheng Luo, Hui Yan, Bing Yu
Summary: This study found that all-trans retinoic acid (ATRA) can attenuate the inflammatory injury caused by transmissible gastroenteritis virus (TGEV) in porcine intestinal epithelial cells. ATRA achieves this protective effect by inhibiting inflammatory response, maintaining epithelial barrier integrity, and suppressing TGEV-mediated activation of the RLRs/NF-kB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Junning Pu, Daiwen Chen, Gang Tian, Jun He, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Yuheng Luo, Hui Yan, Bing Yu
Summary: Transmissible gastroenteritis virus (TGEV) infection can induce apoptosis in pig intestinal epithelial cells, but all-trans retinoic acid (ATRA) can attenuate the damage and apoptosis caused by TGEV by improving antioxidant capacity and inhibiting ROS-mediated signaling pathways.
Article
Immunology
Li Guo, Yan Zhang, Honghong Liu, Qianyu Cheng, Shiyao Yang, Deqin Yang
Summary: ATRA inhibits the migration, proliferation, and osteogenic ability of periodontal ligament stem cells (PDLSCs). This is achieved by promoting the expression of interleukin-1 beta (IL-1 beta) through activating NF-kappa B signaling and NLRP3 inflammasome, which disrupts the osteogenesis and mineralization of PDLSCs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Ophthalmology
Dillon M. Brown, Jianshi Yu, Praveen Kumar, Quinn M. Paulus, Michael A. Kowalski, Jay M. Patel, Maureen A. Kane, C. Ross Ethier, Machelle T. Pardue
Summary: This study investigates the effects of exogenous all-trans retinoic acid (atRA) on myopia development and scleral biomechanics in mice.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Nutrition & Dietetics
King Clyde B. Yabut, Nina Isoherranen
Summary: Cellular retinoic acid binding proteins (CRABP1 and CRABP2) have a high affinity for all-trans-retinoic acid (atRA), and bind to atRA-clearing enzymes and nuclear receptors. This study shows that CRABP1 and CRABP2 also impact atRA metabolism by CYP26A1, suggesting their critical role in modulating atRA concentrations.
Review
Chemistry, Medicinal
Chengyuan Liang, Guaiping Qiao, Yuzhi Liu, Lei Tian, Nan Hui, Juan Li, Yuling Ma, Han Li, Qianqian Zhao, Wenqiang Cao, Hong Liu, Xiaodong Ren
Summary: All-trans-retinoic acid (ATRA) is effective in preventing cancer and treating skin diseases and acute promyelocytic leukaemia (APL) by regulating differentiation-related gene transcription and autophagy through inhibiting mTOR. A total of 68 ATRA analogues show promising antitumour therapeutic potential for further development and research.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Franz Ewendt, Anne Lehmann, Maximilian F. Wodak, Gabriele I. Stangl
Summary: Sclerostin, a protein secreted by osteocytes and skeletal muscles, inhibits bone formation through the Wnt/beta-catenin pathway. This study shows that ATRA and beta-carotene can increase sclerostin synthesis in muscle cells, but the effect of beta-carotene depends on its conversion to a retinoid.
Article
Biophysics
Weinan Li, Hexin Gong, Yuhan Fu, Jialin Sun, Yanhong Wang
Summary: Developing a pH-sensitive prodrug delivery system using nanoparticle carriers shows promising results in inhibiting breast cancer cell growth and releasing drugs at lower pH levels.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biotechnology & Applied Microbiology
Quan Hong, Xue-Dong Li, Peng Xie, Shi-Xin Du
Summary: ATRA suppresses chondrogenesis in rat embryo hindlimb bud mesenchymal cells by inhibiting the expression of HoxD9 and its downstream protein targets, including Sox9 and Col2a1, and may be correlated with inhibition of the Shh-Gli3 signaling pathway.
Article
Cell Biology
Bojjibabu Chidipi, Syed Islamuddin Shah, Michelle Reiser, Manasa Kanithi, Amanda Garces, Byeong J. Cha, Ghanim Ullah, Sami F. Noujaim
Summary: The study found that ATRA can increase DRP1 protein levels and affect mitochondrial structure, leading to mitochondrial remodeling and changes in ultrastructure. Numerical modeling suggests that ATRA promotes mitochondrial fission events.
Review
Biochemistry & Molecular Biology
Geoffrey Brown
Summary: Cancer stem cells are the root cause of cancer, and all-trans retinoic acid (ATRA) signaling plays a crucial role in tissue patterning and development. Dysregulation of ATRA signaling is observed in many cancers. Targeting ATRA synthesis and RAR & gamma; provides promising approaches to eliminate cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Mina M. Tayari, Helena G. Dos Santos, Deukwoo Kwon, Terrence J. Bradley, Amber Thomassen, Charles Chen, Yvonne Dinh, Aymee Perez, Arthur Zelent, Lluis Morey, Luisa Cimmino, Ramin Shiekhattar, Ronan T. Swords, Justin M. Watts
Summary: Clinical trial of ATRA plus TCP in patients with relapsed/refractory AML and MDS showed acceptable safety and improved efficacy in subsets of patients. Gene expression analysis revealed that responders had a more quiescent phenotype while nonresponders exhibited a more proliferative one.
CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Maria Hytti, Eveliina Korhonen, Juha M. T. Hyttinen, Heidi Roehrich, Kai Kaarniranta, Deborah A. Ferrington, Anu Kauppinen
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Biochemistry & Molecular Biology
Eveliina Korhonen, Niina Piippo, Maria Hytti, Juha M. T. Hyttinen, Kai Kaarniranta, Anu Kauppinen
Article
Biochemistry & Molecular Biology
Iswariyaraja Sridevi Gurubaran, Johanna Viiri, Ali Koskela, Juha M. T. Hyttinen, Jussi J. Paterno, Greta Kis, Miklos Antal, Arto Urtti, Anu Kauppinen, Szabolcs Felszeghy, Kai Kaarniranta
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Janusz Blasiak, Ali Koskela, Elzbieta Pawlowska, Mikko Liukkonen, Johanna Ruuth, Elisa Toropainen, Juha M. T. Hyttinen, Johanna Viiri, John E. Eriksson, Heping Xu, Mei Chen, Szabolcs Felszeghy, Kai Kaarniranta
Summary: The common loss of PGC-1 alpha and NFE2L2 genes in aged animals leads to hijacked epithelial-mesenchymal transition, altered RPE morphology, and increased immunoreactivity of senescence markers. These findings suggest that EMT and senescence pathways may intersect in the retinas of dKO mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Juha M. T. Hyttinen, Janusz Blasiak, Szabolcs Felszeghy, Kai Kaarniranta
Summary: Age-related macular degeneration (AMD) is a progressive disease affecting the vision of elderly individuals. The weakening of autophagy clearance has been suggested as an important mechanism in the pathogenesis of AMD, with autophagy-targeting miRNAs potentially playing a crucial role in AMD therapy.
AGEING RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Janusz Blasiak, Juha M. T. Hyttinen, Joanna Szczepanska, Elzbieta Pawlowska, Kai Kaarniranta
Summary: AMD is the leading cause of visual impairment in the aging population, with age and family history as the strongest risk factors. Long non-coding RNAs play a significant role in the pathogenesis of AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Iswariyaraja Sridevi Gurubaran, Hanna Helotera, Stephen Marry, Ali Koskela, Juha M. T. Hyttinen, Jussi J. Paterno, Arto Urtti, Mei Chen, Heping Xu, Anu Kauppinen, Kai Kaarniranta
Summary: The text discusses the current research status, pathological mechanisms, and animal models of age-related macular degeneration (AMD), focusing on the changes of inflammatory markers in a novel AMD model and their potential significance.
Article
Cell Biology
Toni Tamminen, Ali Koskela, Elisa Toropainen, Iswariyaraja Sridevi Gurubaran, Mateusz Winiarczyk, Mikko Liukkonen, Jussi J. Paterno, Petri Lackman, Amir Sadeghi, Johanna Viiri, Juha M. T. Hyttinen, Ari Koskelainen, Kai Kaarniranta
Summary: The study demonstrates the positive effects of natural pinosylvin extract on age-related macular degeneration, preserving significant retinal function and morphology while reducing chronic oxidative stress. Pinosylvin supplementation may lower the risk of AMD onset and slow down its progression.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Oncology
Tero Sievanen, Tia-Marje Korhonen, Tiina Jokela, Maarit Ahtiainen, Laura Lahtinen, Teijo Kuopio, Anna Lepisto, Elina Sillanpaa, Jukka-Pekka Mecklin, Toni T. Seppala, Eija K. Laakkonen
Summary: Circulating microRNAs (c-miRs) play a significant role in cancer development and LS genetic variation. They have the potential to be used for early cancer detection and LS risk stratification.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Pharmacology & Pharmacy
Juha Hyttinen, Janusz Blasiak, Pasi Tavi, Kai Kaarniranta
Summary: AMD is a leading cause of sight loss in the elderly, with most patients lacking treatment options. Targeting PGC-1 alpha may offer a potential therapy, through drug interventions and epigenetic approaches to enhance its expression. This approach could potentially be applied to other disorders associated with disturbances in the mitochondria-antioxidant response-autophagy axis.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2021)
Article
Cell Biology
Sundus F. Shalabi, Masaru Miyano, Rosalyn W. Sayaman, Jennifer C. Lopez, Tiina A. Jokela, Michael E. Todhunter, Stefan Hinz, James C. Garbe, Martha R. Stampfer, Kai Kessenbrock, Victoria E. Seewaldt, Mark A. LaBarge
Summary: This study found that histologically normal breast tissue from younger women with germline mutations exhibit hallmarks of accelerated aging, including loss of lineage fidelity in epithelial cells, decreased proportions of basal cells, and failure of differentiation of progenitor cells. High-risk cells are enriched in transcription of genes from the opposite lineage.
Article
Cell & Tissue Engineering
Tiina A. Jokela, Mark A. LaBarge
Summary: Cancer stem cells (CSCs) play a central role in tumor progression and are regulated by signals from the tumor microenvironment. The mechanical properties and extracellular matrix composition of the microenvironment influence CSC growth and survival through integrins and other cell surface receptors. Understanding the signaling that maintains cells in CSC states may guide future therapeutic interventions.
CURRENT STEM CELL REPORTS
(2021)
Article
Genetics & Heredity
Jussi J. Paterno, Ali Koskela, Juha M. T. Hyttinen, Elina Vattulainen, Ewelina Synowiec, Raimo Tuuminen, Cezary Watala, Janusz Blasiak, Kai Kaarniranta
Article
Ophthalmology
Eveliina Korhonen, Jovana Bisevac, Juha M. T. Hyttinen, Niina Piippo, Maria Hytti, Kai Kaarniranta, Goran Petrovski, Anu Kauppinen
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Meeting Abstract
Oncology
Tiina A. Jokela, Dustin Schones, Mark A. LaBarge