Genetics of congenital and drug-induced long QT syndromes: current evidence and future research perspectives

Evaluating Pathogenicity of Rare Variants From Dilated Cardiomyopathy in the Exome Era

(2012) Nadine Norton et al.   Circulation-Cardiovascular Genetics

Combined assessment of sex- and mutation-specific information for risk stratification in type 1 long QT syndrome

(2012) Jason Costa et al.   HEART RHYTHM

In Silico Cardiac Risk Assessment in Patients With Long QT Syndrome

(2012) Ryan Hoefen et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia

(2012) Yalda Jamshidi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exome sequencing and the genetic basis of complex traits

(2012) Adam Kiezun et al.   NATURE GENETICS

Genetic Testing of Inherited Arrhythmias

(2012) Carlo Napolitano   PEDIATRIC CARDIOLOGY

Using Genome-Wide Association Studies to Identify Genes Important in Serious Adverse Drug Reactions

(2011) Ann K. Daly   Annual Review of Pharmacology and Toxicology

Genetic Testing for Potentially Lethal, Highly Treatable Inherited Cardiomyopathies/Channelopathies in Clinical Practice

(2011) David J. Tester et al.   CIRCULATION

Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Long QT Syndrome: Is Personalized Medicine Ready for Prime Time?

(2011) Silvia G. Priori   CIRCULATION RESEARCH

Cardiomyocytes Obtained From Induced Pluripotent Stem Cells With Long-QT Syndrome 3 Recapitulate Typical Disease-Specific Features In Vitro

(2011) Daniela Malan et al.   CIRCULATION RESEARCH

Pharmacogenomics: Application to the Management of Cardiovascular Disease

(2011) J A Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Opportunities for Use of Human iPS Cells in Predictive Toxicology

(2011) B D Anson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome

(2011) Dimitry Migdalovich et al.   HEART RHYTHM

Personalized medicine and the genotype–phenotype dilemma

(2011) Dan M. Roden   JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome

(2011) Masayuki Yazawa et al.   NATURE

Modelling the long QT syndrome with induced pluripotent stem cells

(2011) Ilanit Itzhaki et al.   NATURE

Pharmacological and non-pharmacological management of the congenital long QT syndrome: The rationale

(2011) Peter J. Schwartz   PHARMACOLOGY & THERAPEUTICS

Use of Mutant-Specific Ion Channel Characteristics for Risk Stratification of Long QT Syndrome Patients

(2011) C. Jons et al.   Science Translational Medicine

Ionic Channels as Targets for Drug Design: A Review on Computational Methods

(2011) Gregorio Fernández-Ballester et al.   Pharmaceutics

Identification of a Kir3.4 Mutation in Congenital Long QT Syndrome

(2010) Yanzong Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Challenges of sequencing human genomes

(2010) D. C. Koboldt et al.   BRIEFINGS IN BIOINFORMATICS

Drug-induced hERG Block and Long QT Syndrome

(2010) Harry J. Witchel   Cardiovascular Therapeutics

Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen

(2010) David S. Peal et al.   CIRCULATION

Unexpected allelic heterogeneity and spectrum of mutations in Fowler syndrome revealed by next-generation exome sequencing

(2010) Emilie Lalonde et al.   HUMAN MUTATION

Novel genomic techniques open new avenues in the analysis of monogenic disorders

(2010) Gregor Kuhlenbäumer et al.   HUMAN MUTATION

Polymorphisms in the NOS1APGene Modulate QT Interval Duration and Risk of Arrhythmias in the Long QT Syndrome

(2010) Marta Tomás et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

(2010) Sarah B Ng et al.   NATURE GENETICS

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

Patient-Specific Induced Pluripotent Stem-Cell Models for Long-QT Syndrome

(2010) Alessandra Moretti et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug-Induced Long QT Syndrome

(2010) P. Kannankeril et al.   PHARMACOLOGICAL REVIEWS

Analysis of Genetic Inheritance in a Family Quartet by Whole-Genome Sequencing

(2010) J. C. Roach et al.   SCIENCE

NOS1AP Is a Genetic Modifier of the Long-QT Syndrome

(2009) Lia Crotti et al.   CIRCULATION

Genotype-Phenotype Aspects of Type 2 Long QT Syndrome

(2009) Wataru Shimizu et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Exome sequencing identifies the cause of a mendelian disorder

(2009) Sarah B Ng et al.   NATURE GENETICS

Common variants at ten loci modulate the QT interval duration in the QTSCD Study

(2009) Arne Pfeufer et al.   NATURE GENETICS

Common variants at ten loci influence QT interval duration in the QTGEN Study

(2009) Christopher Newton-Cheh et al.   NATURE GENETICS

Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation

(2009) Charlotte van Noord et al.   Pharmacogenetics and Genomics

Repolarization Reserve

(2008) Dan M. Roden   CIRCULATION

Clinical Impact of Genetic Studies in Lethal Inherited Cardiac Arrhythmias

(2008) Wataru Shimizu   CIRCULATION JOURNAL

Therapeutic Strategies for Long-QT Syndrome

(2008) Yanfei Ruan et al.   Circulation-Arrhythmia and Electrophysiology

Long QT Syndrome

(2008) Ilan Goldenberg et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Whole genome association study identifies polymorphisms associated with QT prolongation during iloperidone treatment of schizophrenia

(2008) S Volpi et al.   MOLECULAR PSYCHIATRY

Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

(2008) K. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA