Article
Multidisciplinary Sciences
Matias Blomqvist, Ilmari Koskinen, Eliisa Loyttyniemi, Tuomas Mirtti, Peter J. Bostrom, Pekka Taimen
Summary: In bladder cancer patients, the stem cell markers ALDH1, SOX2, and SSEA-4 show little prognostic or predictive value, with weak or negative cytoplasmic SOX2 staining being associated with lymphovascular invasion and cancer-specific survival but not significantly.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Fei Liao, Jing Zhang, Yangyang Hu, Alireza Hassani Najafabadi, James J. Moon, Max S. Wicha, Bashir Kaspo, Joel Whitfield, Alfred E. Chang, Qiao Li
Summary: This study demonstrates the potential of targeting ALDH(high) CSCs using antigenic peptides derived from ALDH, and the enhanced efficacy achieved by combining the vaccine with anti-PD-L1 treatment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Zhiping Feng, Marisa E. Hom, Thomas E. Bearrood, Zachary C. Rosenthal, Daniel Fernandez, Alison E. Ondrus, Yuchao Gu, Aaron K. McCormick, Madeline G. Tomaske, Cody R. Marshall, Toni Kline, Che-Hong Chen, Daria Mochly-Rosen, Calvin J. Kuo, James K. Chen
Summary: Aldehyde dehydrogenases (ALDHs) are potential cancer drug targets, specifically certain isoforms essential for the survival of stem-like tumor cells. Selective inhibitors of ALDH1B1 have been identified, an enzyme essential for promoting colorectal and pancreatic cancer. Bicyclic imidazoliums and guanidines that target the ALDH1B1 active site have been described, with comparable molecular interactions and potencies. These inhibitors effectively suppress ALDH1B1 function in cells, with guanidines avoiding off-target mitochondrial toxicity observed with imidazoliums. A lead isoform-selective guanidinyl antagonist of ALDHs demonstrates proteome-wide target specificity and selectively hinders the growth of colon cancer spheroids and organoids. The ALDH1B1-dependent transcriptome, involving genes regulating mitochondrial metabolism and ribosomal function, has been elucidated through genetic and chemical perturbations. The importance of ALDH1B1 in colorectal cancer is supported, offering molecular probes for ALDH1B1 studies and potential leads for targeted therapies.
NATURE CHEMICAL BIOLOGY
(2022)
Article
Cell Biology
Wenhao Yao, Xu Qian, Sebastian Ochsenreither, Ferrone Soldano, Albert B. DeLeo, Holger Sudhoff, Felix Oppel, Andreas Kuppig, Konrad Klinghammer, Andreas M. Kaufmann, Andreas E. Albers
Summary: DSF and DSF/Cu2+ inhibited cell proliferation in HNSCC, enhanced sensitivity to cisplatin and IR, and increased radio-chemo sensitivity by inducing apoptosis and ROS activity.
Review
Genetics & Heredity
Eric Gyan, William K. B. A. Owiredu, Linda Ahenkorah Fondjo, Andrew M. Jackson, Andrew R. Green, Ganiyu A. Rahman
Summary: Breast cancer stem cells exhibit racial variations in expression patterns and clinical features, with CD44+/CD24-/low being associated with TNBC/Basal like phenotype across all races. ALDH1, the most studied breast CSC marker, is linked to poor clinicopathological features. Further research is needed to better understand the racial differences in breast cancer stem cells.
Article
Pathology
Gustavo Alcantara da Trindade, Leorik Pereira da Silva, Pedro Paulo de Andrade Santos, Leao Pereira Pinto, Lelia Batista de Souza
Summary: The presence and distribution of stem cells in epithelial odontogenic cysts and tumors were analyzed based on the expression of ALDH1. The study found higher expression of stem cells in odontogenic cysts compared to odontogenic tumors. The expression of ALDH1 may be associated with clinicopathological features and prognosis of these lesions.
HEAD & NECK PATHOLOGY
(2022)
Article
Oncology
Mariana Lopez Flores, Emiliano Honrado Franco, Luis Felipe Sanchez Cousido, Carlos Minguito-Carazo, Oscar Sanz Guadarrama, Laura Lopez Gonzalez, Maria Eva Vallejo Pascual, Antonio Jose Molina de la Torre, Andres Garcia Palomo, Ana Lopez Gonzalez
Summary: The study found that the expression of ALDH1A1 in breast cancer is related to tumor-infiltrating lymphocytes, PD-L1 expression, and treatment response, which may have a significant impact on the treatment and prognosis of breast cancer.
Article
Oncology
Lauren MacDonagh, Rhyla Mae Santiago, Steven G. Gray, Eamon Breen, Sinead Cuffe, Stephen P. Finn, Kenneth J. O'Byrne, Martin P. Barr
Summary: Despite advances in personalized medicine and immune checkpoints in lung cancer treatment, non-small cell lung cancer remains a leading cause of cancer-related deaths worldwide. Drug resistance is a key factor in the relapse of lung cancer patients due to the unlimited renewal capacity of residual cancer stem cells during chemotherapy. This study suggests that targeting the retinoic acid signaling cascade may be a novel strategy in treating subsets of CSCs in cisplatin resistant lung tumors.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Xiufen Zhuang, Guilan Shi, Xiao Hu, Huiru Wang, Wen Sun, Yanhong Wu
Summary: This study aimed to propose a potential strategy for breast cancer by studying the effects of T cells and interferon-gamma on breast cancer stem cells. The results showed that CD8(+) T cells and interferon-gamma can decrease the number of breast cancer stem cells.
CHINESE MEDICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Ethan Read, Jarod Milford, Jiechun Zhu, Lingyun Wu, Marc Bilodeau, Guangdong Yang
Summary: Disulfiram and hydrogen sulfide can sensitize liver cancer cells by inhibiting ALDH activity, and H2S can also inhibit the adhesion of liver cancer stem cells. The combination of DSF and H2S shows potential in inhibiting cancer cell growth and tumor development by targeting ALDH.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mariana Nunes, Francisca Pacheco, Ricardo Coelho, Dina Leitao, Sara Ricardo, Leonor David
Summary: Overexpression of MSLN in ovarian carcinomas does not affect the expression of cancer stem cell markers, indicating that MSLN is not involved in driving the cancer stem cell phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Masahiro Matsuki, Ryuta Inoue, Aiko Murai, Terufumi Kubo, Shinichi Hashimoto, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Sachiyo Nishida, Toshiaki Tanaka, Hiroshi Kitamura, Naoya Masumori, Yoshihiko Hirohashi, Toshihiko Torigoe
Summary: In urothelial carcinoma (UC), NRG1 plays a crucial role in tumor stem cells through signaling with ERBB receptors. This study found that NRG1-beta 1 is essential for the proliferation of UC CSC/CIC, although its downstream targets remain elusive.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Martha B. Alvarez-Elizondo, Daphne Weihs
Summary: In this study, the invasiveness of CD44(+)ALDH(+) cancer stem-like cells (CSCs) was investigated using a rapid mechanobiology-based assay. It was found that CD44(+)ALDH(+) cells showed higher invasiveness and migratory capacity, suggesting their potential role in disease progression and as prognostic markers for recurrence and metastasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Hitomi Motomura, Shoma Tamori, Masa-Aki Yatani, Ayano Namiki, Chotaro Onaga, Ayaka Ozaki, Ryoko Takasawa, Yasunari Mano, Tsugumichi Sato, Yasushi Hara, Keiko Sato, Yuyun Xiong, Yohsuke Harada, Takehisa Hanawa, Sei-Ichi Tanuma, Kazunori Sasaki, Shigeo Ohno, Kazunori Akimoto
Summary: The study showed that GLO 1 and PKC lambda play important roles in the survival of ALDH1-positive breast cancer stem cells, and may serve as potential therapeutic targets for the treatment of ALDH1-positive breast cancer stem cells.
ANTICANCER RESEARCH
(2021)
Article
Cell Biology
Yan Li, Juan Wang, Fang Wang, Wenyu Chen, Chengzhen Gao, Jianhua Wang
Summary: In epithelial ovarian cancer, decreased expression of RNF144A is associated with poor patient survival, while knockout of RNF144A enhances CSC properties and overexpression of RNF144A inhibits EOC cells from acquiring stem cell properties. By ubiquitinating degradation of LIN28B, RNF144A suppresses stem cell properties and tumor growth in EOC cells.
CELL BIOLOGY AND TOXICOLOGY
(2022)
