期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 41, 期 4, 页码 1228-1235出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0300060513487631
关键词
Insulin-like growth factor 1; insulin-like growth factor receptor; colorectal polyps; colorectal carcinoma; quantitative real-time RT-PCR; enzyme-linked immunosorbent assay
资金
- Science and Technology Planning Project of Guangdong Province [2009B030801158, 2012B031800097, 2012B031800282]
Objective To investigate the role of insulin-like growth factor (IGF)-1 and its receptor (IGF1R) in the formation and development of colorectal carcinoma. Methods Colorectal tissue and matching serum samples were collected from patients with adenomatous polyps or carcinoma and healthy control subjects. IGF1R mRNA levels were determined via quantitative real-time reverse transcription-polymerase chain reaction. Serum IGF1 was quantified using enzyme-linked immunosorbent assay. Results Serum IGF1 concentrations and mucosal IGF1R mRNA levels were significantly higher in patients with adenomatous polyps (n=24) or carcinoma (n=13) compared with healthy control subjects (n=13). There was a significant positive correlation between serum IGF1 and mucosal IGF1R mRNA in patients with adenomatous polyps. Conclusions High circulating IGF1 concentrations and mucosal IGF1R expression may play important roles in both the formation and development of colorectal carcinoma. IGF1 and its receptor may be activated before carcinogenesis, and may promote the growth and malignant transformation of adenomatous polyps. IGF1 and IGF1R may be useful biomarkers for evaluating the stage and risk of carcinogenesis.
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