Article
Multidisciplinary Sciences
Kentaro Hyodo, Hironori Masuko, Hisayuki Oshima, Rie Shigemasa, Haruna Kitazawa, Jun Kanazawa, Hiroaki Iijima, Hiroichi Ishikawa, Takahide Kodama, Akihiro Nomura, Katsunori Kagohashi, Hiroaki Satoh, Takefumi Saito, Tohru Sakamoto, Nobuyuki Hizawa
Summary: This study aimed to investigate the exacerbation-prone phenotypes beyond disease labels in asthma and COPD using shared risk factors and to examine the role of the IL4RA gene polymorphism related to type 2 inflammation. The results showed common exacerbation-prone endotypes in chronic inflammatory airway diseases, supporting the use of a treatable traits approach for prevention.
Article
Geriatrics & Gerontology
Karin J. C. Sanders, Roel Wierts, Wouter D. Marken Lichtenbelt, Judith Vos-Geelen, Guy Plasqui, Marco C. J. M. Kelders, Vera B. Schrauwen-Hinderling, Jan Bucerius, Anne-Marie C. Dingemans, Felix M. Mottaghy, Annemie M. W. J. Schols
Summary: There is no correlation between basal metabolic rate (BMR), total daily energy expenditure (TDEE), and brown adipose tissue (BAT) activity in patients with chronic obstructive pulmonary disease (COPD). Additionally, BAT activity and gene expression levels of brown adipocyte or beige markers are comparable between COPD patients and controls.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Alvise Casara, Graziella Turato, Marta Marin-Oto, Umberto Semenzato, Davide Biondini, Mariaenrica Tine, Nicol Bernardinello, Elisabetta Cocconcelli, Pablo Cubero, Elisabetta Balestro, Paolo Spagnolo, Jose M. Marin, Manuel G. Cosio, Marina Saetta, Erica Bazzan
Summary: Chronic bronchitis (CB) significantly affects symptoms, quality of life, and survival in smokers without COPD, with 27% of noCOPD smokers having CB. CB does not impact FEV1 decline in noCOPD but does significantly in COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Xiaoyan Gai, Chenglin Guo, Linlin Zhang, Lijiao Zhang, Mairipaiti Abulikemu, Juan Wang, Qingtao Zhou, Yahong Chen, Yongchang Sun, Chun Chang
Summary: The study found that during acute exacerbation of chronic obstructive pulmonary disease (AECOPD), specific glycerophospholipids were significantly reduced in expression. These glycerophospholipids were able to predict the acute exacerbation and recovery stages, particularly in the non-eosinophilic subtype. Abnormalities in glycerophospholipid metabolism may be associated with the onset of AECOPD.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Z. Lahmar, E. Ahmed, A. Fort, I. Vachier, A. Bourdin, A. Bergougnoux
Summary: COPD is a chronic airway disease that affects millions of people worldwide and is ranked as the third leading cause of death. Genetic susceptibility, environmental factors, and the combined effects of these factors play important roles in the development of COPD. The Hedgehog signaling pathway and its inhibitor HHIP are potential targets for therapeutic interventions in COPD.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Microbiology
Yehudis Rosenwasser, Irene Berger, Zvi G. Loewy
Summary: This article discusses the pharmacotherapeutic approaches for COPD exacerbation, including antimicrobials, bronchodilators, and anti-inflammatory drugs, as well as the connection between the oral cavity and the lungs.
Review
Microbiology
Bryn Short, Stephen Carson, Anna-Claire Devlin, James A. Reihill, Anne Crilly, William MacKay, Gordon Ramage, Craig Williams, Fionnuala T. Lundy, Lorcan P. McGarvey, Keith D. Thornbury, S. Lorraine Martin
Summary: Haemophilus influenzae is a common cause of bacterial infection in the lungs of COPD patients, leading to acute exacerbations. Its ability to adhere to host epithelial cells, form biofilms, and persist through immune evasion and antibiotic tolerance plays a crucial role in the pathogenesis of COPD.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hamad Ghaleb Dailah
Summary: Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), and antioxidants can be used for its treatment.
Review
Respiratory System
Mairi MacLeod, Alberto Papi, Marco Contoli, Bianca Beghe, Bartolome R. Celli, Jadwiga A. Wedzicha, Leonardo M. Fabbri
Summary: Exacerbations in COPD significantly impact disease progression, comorbidities, wellbeing, and mortality. They represent a major socioeconomic burden. Current definitions of exacerbations focus on worsening respiratory symptoms, but other factors can also contribute. Objective measurements like blood counts and C-reactive protein should be used to improve accuracy in diagnosis. Acute management includes interventions like corticosteroids, antibiotics, and non-invasive ventilation. Long-term prevention strategies, such as inhaled therapy and tailored approaches based on clinical phenotypes, are needed to better manage exacerbations.
Article
Respiratory System
Komarla Sundararaja Lokesh, Sindaghatta Krishnarao Chaya, Biligere Siddaiah Jayaraj, Attahalli Shivanarayanprasad Praveena, Murali Krishna, Purnima Madhivanan, Padukudru Anand Mahesh
Summary: In a rural population in South India exposed to sunlight regularly, low Vitamin D levels were associated with COPD and exacerbations of COPD. The study found that COPD patients were more likely to be Vitamin D deficient compared to controls, and Vitamin D deficient COPD patients had a higher risk of exacerbations.
CLINICAL RESPIRATORY JOURNAL
(2021)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Health Care Sciences & Services
Elias Saad, Basheer Maamoun, Assy Nimer
Summary: This study aims to investigate the relationship between red blood cell distribution width (RDW) and the severity of acute exacerbation of chronic obstructive pulmonary disease (COPD). The results showed that different complete blood count (CBC) parameters, such as hemoglobin level, mean corpuscular volume (MCV), mean platelet volume (MPV), and RDW, are correlated with the severity of COPD exacerbation. Furthermore, there is a positive correlation between RDW and C-reactive protein (CRP) levels.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Rohan Karkra, Chaya Sindaghatta Krishnarao, Jayaraj Biligere Siddaiah, Mahesh Padukudru Anand
Summary: COPD is a common and serious condition with significant global impact. Quick and affordable investigations are needed to predict mortality in patients with acute exacerbations, especially in low resource settings.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Yifei Duan, Siyi Zhou, Jianmiao Wang
Summary: Our previous studies have shown that BRD4 is increased in the lungs of stable COPD patients and is involved in inflammatory responses. In this study, we investigated the role of BRD4 in viral exacerbations of COPD.
RESPIRATORY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jun Watanabe, Kazuhiko Kotani, Alejandro Gugliucci
Summary: Overall, patients with COPD had lower PON1 activity, indicating impaired PON1-related antioxidant defense in COPD. Further studies are needed.
