MicroRNA in Osteoarthritis

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes

(2010) Nahid Akhtar et al.   ARTHRITIS AND RHEUMATISM

miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression

(2010) Sang Yun Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

New molecular targets for the treatment of osteoarthritis

(2010) Maria José Alcaraz et al.   BIOCHEMICAL PHARMACOLOGY

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Type II Collagen Expression Is Regulated by Tissue-specific miR-675 in Human Articular Chondrocytes

(2010) Katarzyna A. Dudek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Methylation Mediated by a MicroRNA Pathway

(2010) Liang Wu et al.   MOLECULAR CELL

Recent Developments in Patent Anti-Cancer Agents Targeting the Matrix Metalloproteinases (MMPs)

(2010) Xun Li et al.   Recent Patents on Anti-Cancer Drug Discovery

Silencing microRNA-34a inhibits chondrocyte apoptosis in a rat osteoarthritis model in vitro

(2010) M. M. Abouheif et al.   RHEUMATOLOGY

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

(2009) Shigeru Miyaki et al.   ARTHRITIS AND RHEUMATISM

Profiling microRNA expression in bovine articular cartilage and implications for mechanotransduction

(2009) Walter Dunn et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Expression of MicroRNA-146a in osteoarthritis cartilage

(2009) Keiichiro Yamasaki et al.   ARTHRITIS AND RHEUMATISM

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

(2009) Ginette Tardif et al.   BMC MUSCULOSKELETAL DISORDERS

Regulation of chondrocytic phenotype by micro RNA 18a: Involvement ofCcn2/Ctgfas a major target gene

(2009) Toshihiro Ohgawara et al.   FEBS LETTERS

Structural and Inhibition Analysis Reveals the Mechanism of Selectivity of a Series of Aggrecanase Inhibitors

(2009) Micky D. Tortorella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many roads to maturity: microRNA biogenesis pathways and their regulation

(2009) Julia Winter et al.   NATURE CELL BIOLOGY

Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals

(2009) F. Bazzoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2)

(2008) Adam M. Gilbert et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

miRiad Roles for the miR-17-92 Cluster in Development and Disease

(2008) Joshua T. Mendell   CELL

Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage

(2008) Marco A. da Silva et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Let Me Count the Ways: Mechanisms of Gene Regulation by miRNAs and siRNAs

(2008) Ligang Wu et al.   MOLECULAR CELL

The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13

(2008) S.W. Jones et al.   OSTEOARTHRITIS AND CARTILAGE

Integrative MicroRNA and Proteomic Approaches Identify Novel Osteoarthritis Genes and Their Collaborative Metabolic and Inflammatory Networks

(2008) Dimitrios Iliopoulos et al.   PLoS One

Dicer-dependent pathways regulate chondrocyte proliferation and differentiation

(2008) T. Kobayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA