Article
Orthopedics
Yuan Wang, Yexin Wang, Da Liang, Hongtao Hu, Guangwei Li, Xiaoguang Meng, Bing Zhu, Wei Zhong
Summary: The polymorphisms of the MIR31 host gene (MIR31HG) are associated with the risk of steroid-induced osteonecrosis of the femoral head (SONFH) in the Chinese Han population. Specifically, the rs10965059 polymorphism is correlated with a reduced risk of SONFH in individuals over 40 years old, male populations, and those with bilateral SONFH.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Immunology
Shuyuan Liu, Nannan Liu, Hui Wang, Xinwen Zhang, Yufeng Yao, Shuqiong Zhang, Li Shi
Summary: The study found an association between CCR5 promoter polymorphisms and pulmonary TB and TB progression in the Chinese Han population.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mingming Li, Yuhan Zhang, Aopeng Zhang, He Cai, Rui Zhang, Ran Cheng, Tao Hu
Summary: This study found that single gene polymorphisms in A20 and IL-10 genes were not associated with the risk of periodontitis. NF-kappa B1 gene polymorphism indirectly affects susceptibility to periodontitis. The combined effect of anti-inflammatory gene polymorphisms (A20 and IL-10) correlated with the decreased risk of periodontitis.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Medicine, General & Internal
Peng Huang, Yu-Qing Hou, Jing-Jing Wu, Yi-Di Wang, Xiang-Yu Ye, Feng Zang, Rong-Bin Yu, Sheng Yang
Summary: This study showed a significant association between TNFRSF11 rs9525641 and HCV chronicity, especially among individuals older than 50 years, females, and those with ALT <40 U/L and AST < 40 U/L.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Qianbo Cui, Jing Li, Jing Wang
Summary: The study found no association between the polymorphisms of TNF-alpha gene loci rs1799964, rs1800630, and rs769178 and allergic rhinitis (AR). However, the GT and GT+TT genotypes of rs769178 were found to increase the risk of AR compared to GG, and haplotypes C-G-A-T and C-G-C-T were associated with an increased risk of AR, while the C-G-C-G haplotype decreased the risk. Stratified and crossover analyses revealed significant associations between certain factors and the risk of AR.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Yi Han, Yongshuo Zhang, Shousheng Liu, Guangxia Chen, Linlin Cao, Yongning Xin
Summary: LDLR rs1433099 polymorphism is not significantly associated with the risk of NAFLD, CVD, or NAFLD combined with CVD in the Chinese population. Carriers of the T allele of LDLR rs1433099 may have higher alkaline phosphatase and gamma-glutamyl transpeptidase levels in the CVD group.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Genetics & Heredity
Baoping Hu, Yuhe Wang, Zhongtao Wang, Xue He, Li Wang, Dongya Yuan, Yongjun He, Tianbo Jin, Shumei He
Summary: By studying the northwest Chinese Han population, this research identified the relationships between polymorphisms in or near the SLC11A1 gene and age- and sex-specific tuberculosis risk.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Jie Wei, Huan Zhang, Xiaoya Ma, Yujie Li, Wenqian Zhou, Jinping Guo, Tianbo Jin, Mingjun Hu
Summary: This study investigated the association between single nucleotide polymorphisms (SNPs) of the OR51E1 gene and glioma susceptibility in the Chinese Han population. The results showed that polymorphisms rs10768148, rs7102992, and rs10500608 were associated with glioma risk in the overall sample. Stratified analyses based on gender and age revealed specific SNP-glioma associations. Additionally, synergistic and redundant relationships between certain SNPs were identified. Overall, this study provides a basis for assessing glioma risk-associated variants in the Chinese Han population.
Article
Clinical Neurology
Dong Guan, Yichun Ji, Xiaoyun Lu, Weiyi Feng, Wenbing Ma
Summary: Genetic variation in the MTHFR gene may contribute to the development of cerebral infarction. This study aimed to analyze the effect of MTHFR gene polymorphism on serum lipid and homocysteine levels among Chinese Han population with cerebral infarction. Results showed that the TT genotype and T allele frequencies were significantly higher among CI patients, and CT/TT carriers had higher homocysteine levels and lower HDL-C and ApoA-I levels.
FRONTIERS IN NEUROLOGY
(2023)
Article
Virology
Yinan Yao, Yan Shen, Haifeng Shao, Yuchang Liu, Yan Ji, Guoming Du, Xiangyu Ye, Peng Huang, Haiming Chen
Summary: RLRs, specifically the DDX58 rs3824456, DHX58 rs2074160, and IFIH1 rs2111485 SNPs, may be predictive markers for spontaneous clearance of HBV in the Chinese Han population.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Endocrinology & Metabolism
Xiaoya Zheng, Jiani Ma, Jian Long, Qiang Wei, Wei Ren
Summary: This study explored the association between genetic polymorphisms of HIF1 alpha and obesity as well as obesity-related cytokines in the Han Chinese population. The results suggest that the C allele of rs2301104 may be a protective mutation against obesity, and the CC/CG genotypes of rs2301104 could be protective genotypes of obesity. Furthermore, subjects with CC/CG genotypes of rs2301104 had lower levels of IL-6, TNF-alpha, IL-1 beta, IL-8, and IL-10 than those with GG genotypes.
ACTA DIABETOLOGICA
(2023)
Article
Endocrinology & Metabolism
Wei Liu, Xin Wang, JianFei Chen, Fan Zeng, Jun Xiong
Summary: This study found a significant correlation between MIR31HG variants and the risk of alcoholic ONFH among Chinese Han males. These findings provide new insights into the prevention and diagnosis of alcoholic ONFH involving MIR31HG.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Clinical Neurology
Ji-Lan Han, Yao-Xian Yue, Xiang Gao, Yan-Chen Xie, Hong-Jun Hao, Hong-Yan Li, Xiao-Long Yu, Jie Li, Rui-Sheng Duan, Hai-Feng Li
Summary: In a case-control study, the association between VDR gene polymorphism and susceptibility/severity of MG patients was investigated. There were no significant differences in allele and genotype frequencies between MG patients and healthy controls, as well as between different MG subgroups. However, significant differences were found in the frequencies of alleles and genotypes in rs731236 between adult non-thymoma AChRAb negative MG subgroup and the control group, as well as the adult non-thymoma AChRAb positive MG group in the comprehensive classification analysis. Further confirmation is needed to establish the possible association in the Chinese Han population.
FRONTIERS IN NEUROLOGY
(2021)
Article
Genetics & Heredity
Nan Li, Hangyu Shi, Pengfei Hou, Lu Gao, Yongqiang Shi, Weiyang Mi, Gang Zhang, Ning Wang, Wei Dai, Lin Wei, Tianbo Jin, Yongzhi Shi, Shiwen Guo
Summary: The study revealed the negative role of ARRDC3 polymorphisms in glioma risk, and found that the effect of candidate SNPs in ARRDC3 on susceptibility to glioma depended on the age, gender, and histology of patients.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2022)
Article
Immunology
Juan Zhang, Ming-gui Wang, Jian-Qing He
Summary: This study reveals the association between ALOX5 gene polymorphism and susceptibility to multisystemic tuberculosis in the Chinese Han population.
MICROBIAL PATHOGENESIS
(2023)
