期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 37, 期 1, 页码 205-213出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/147323000903700125
关键词
ORAL ADSORBENT; AST-120; CHRONIC RENAL FAILURE; RECIPROCAL SERUM CREATININE; LONG-TERM USE
The oral adsorbent AST-120 has been widely used in Japan to delay the initiation of dialysis therapy in patients with chronic renal failure. This study evaluated the long-term effects of AST-120 in patients with chronic renal failure who had not previously undergone dialysis. One hundred out-patients were prospectively enrolled and prescribed 6 g/day oral AST-120 for >= 1 year. The clinical effectiveness of AST-120 was evaluated by comparing changes in the slope of the reciprocal serum creatinine-time plot (1/sCr slope) before and after AST-120 administration. The 1/sCr slope improved significantly after ! 1 year of AST-120 treatment and greatest improvement was observed in patients with the longest AST-120 administration period (> 30 months). The results suggest that long-term treatment with AST-120 may be beneficial for chronic renal failure patients in the pre-dialysis stage.
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