期刊
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
卷 37, 期 6, 页码 1831-1841出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/147323000903700619
关键词
HEART FAILURE; ELDERLY PEOPLE; N-3 FATTY ACIDS; INFLAMMATORY MARKERS; N-TERMINAL PRO-BRAIN NATRIURETIC PEPTIDE
资金
- Shanghai Rising-Star Programme [08QA14055]
- Shanghai Pujiang Programme [PJ[2007]00182]
Several previous studies have suggested that n-3 polyunsaturated fatty acids (n-3 PUFA) can exert favourable effects in patients with heart failure, but the mechanisms involved are not fully understood. This study was designed to investigate the effects of n-3 PUFA on circulating inflammatory markers and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with heart failure. Seventy-six patients with heart failure were randomly assigned to receive 2 g/day of n-3 PUFA or placebo for 3 months. Treatment with n-3 PUFA significantly decreased plasma levels of tumour necrosis factor, interleukin-6, intercellular adhesion molecule I and NT- proBNP. Left ventricular ejection fraction showed a small, non-significant improvement. High-sensitivity C-reactive protein levels decreased significantly in smokers after n-3 PUFA treatment. Thus, n-3 PUFA can reduce levels of plasma inflammatory markers and NT-proBNP as biomarkers of risk stratification in patients with heart failure. n-3 PUFA may offer a novel therapy for heart failure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据