Article
Oncology
Laura Streit, Sophie Moog, Sylvain Hugel, Marion Rame, Emeline Tanguy, Virginie Andry, Herbert A. Schmid, Laurent Brunaud, Florence Bihain, Claire Nomine-Criqui, Yannick Goumon, Stephanie Lacomme, Sandra Lomazzi, Michel Vix, Didier Mutter, Nicolas Vitale, Stephane Ory, Stephane Gasman
Summary: NETs like pheochromocytoma can cause severe symptoms and life-threatening conditions. Treatment with somatostatin analogues may help inhibit the secretion of catecholamines. The study found that SOM230 could effectively inhibit catecholamine secretion and be considered a potential anti-secretory treatment for patients with pheochromocytoma.
Article
Oncology
Alba Sanjuan-Sanjuan, Emilia Alors-Perez, Marina Sanchez-Frias, Alicia Dean-Ferrer, Manuel D. Gahete, Susana Heredero-Jung, Raul M. Luque
Summary: Oral squamous cell carcinoma (OSCC) poses a significant global health challenge, requiring novel prognostic biomarkers and treatment options. The study found that SST2 may serve as a promising prognostic biomarker for recurrence and metastasis in OSCC, and that different SSA have anti-tumoral effects on OSCC cells. These findings suggest the potential use of SSA as a targeted therapy for OSCC.
Article
Chemistry, Multidisciplinary
Hirofumi Ochiai, Taiji Shimoda, Kazuhiro Fukae, Masatoshi Maeda, Kazuyuki Ishii, Kenta Yoshida, Katsunari Tezuka, Keisuke Tazuru, Hayato Saijo, Hiroaki Asai, Akio Kanatani, Yuji Nishiuchi
Summary: Somatostatin, a growth hormone inhibitory factor, can affect physiological functions through its action on five distinct receptor subtypes. By attaching human complex-type oligosaccharides, we have developed glycosylated somatostatin analogues that have improved metabolic stability and high affinity to all receptor subtypes. These analogues have the potential to be novel therapeutic drugs for somatostatin-related diseases and can provide insights into new indications.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Endocrinology & Metabolism
Federico Gatto, Richard A. Feelders, Peter M. van Koetsveld, Fadime Dogan, Sebastian J. C. M. M. Neggers, Aart-Jan van der Lelij, Jessica Amaru, Diego Ferone, Leo J. Hofland
Summary: Cabergoline (CAB) is an off-label medical therapy for acromegaly, but it is overshadowed by first-generation somatostatin receptor ligands like octreotide (OCT). In this study, OCT was found to be slightly more effective than CAB in inhibiting growth hormone (GH) secretion in vitro. Additionally, the response to CAB treatment was shown to be better in GH/prolactin (PRL) co-secreting tumors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Sumei Ren, Xiaodong Wang, Jun Song, Guangyi Jin
Summary: A series of novel ibrutinib analogues were synthesized and evaluated for their proliferation inhibitory activities against various B lymphoma cell lines and solid tumor cells. The compound YL7 showed strong antiproliferative activity in all cell lines, with particularly impressive efficacy in B16 cells. Mechanistic studies revealed that YL7 inhibited proliferation and migration, induced cell cycle arrest, apoptosis, and autophagy in B16 cells, demonstrating potential as an anti-melanoma treatment.
BIOORGANIC CHEMISTRY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chayenne H. A. M. Veerman, Hinke Siebinga, Daphne M. V. de Vries-Huizing, Margot E. T. Tesselaar, Jeroen J. M. A. Hendrikx, Marcel P. M. Stokkel, Else A. Aalbersberg
Summary: According to guidelines, long-acting somatostatin analogues (LA-SSAs) should be discontinued prior to peptide receptor radionuclide therapy (PRRT). This study aimed to determine the effect of continued use of LA-SSAs during PRRT on the uptake of [Lu-177]Lu-HA-DOTATATE. The results showed that long-acting octreotide and lanreotide do not interfere with the uptake of [Lu-177]Lu-HA-DOTATATE in tumor lesions, but significantly decrease uptake in healthy liver parenchyma and spleen tissue.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Wenjun Zheng, Yong Li, Zheng Su, Jian Zhang, Fen Shi, Weiqiang Liang
Summary: The study revealed that EIF3H is upregulated in malignant melanoma and correlated with tumor stage and risk of lymphatic metastasis. Silencing EIF3H in MM cells significantly suppresses cell proliferation, promotes cell apoptosis, induces cell cycle arrest, and restrains cell motility. The effects of EIF3H knockdown were also verified in mice xenograft model, showing slower tumor growth and smaller tumor volume.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Paola Matarrese, Sonia Maccari, Barbara Ascione, Rosa Vona, Vanessa Vezzi, Tonino Stati, Maria Cristina Gro, Giuseppe Marano, Caterina Ambrosio, Paola Molinari
Summary: This study found that beta-AR stimulation affects the proliferative activity of B16F10 cells by regulating cAMP levels. Additionally, alpha 2-AR agonists can inhibit cell proliferation, which is disrupted by the inhibitory effect of beta-AR agonists on alpha 2-AR. These findings suggest that the crosstalk between beta-AR and alpha 2-AR signaling pathways plays an important role in regulating melanoma proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xinxin Zhou, Jiayuan He, Qingyuan Wang, Teng Ma
Summary: The study revealed that miR-128-3p acts as a tumor suppressor in malignant melanoma cells by inhibiting proliferation, migration, invasion, and inducing apoptosis. The oncogene neurotrophin receptor 3 (NTRK3) was found to be up-regulated in MM cells, enhancing their malignant behaviors. The interaction between miR-128-3p and NTRK3 genes modulate the malignant behavior of MM, suggesting potential new therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tibor Hajdu, Patrik Kovacs, Emese Zsigrai, Roland Takacs, Judit Vago, Sinyoung Cho, Laszlo Sasi-Szabo, Daniel Becsky, Aniko Keller-Pinter, Gabriella Emri, Kalman Racz, Dora Reglodi, Roza Zakany, Tamas Juhasz
Summary: The study confirms the expression of PACAP receptors in melanocytes and melanoma cells, demonstrating that PACAP can inhibit proliferation and migration of melanoma cells, making it a potential target in melanoma progression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Boukje T. Bootsma, Victor D. Plat, Tim van de Brug, Daitlin E. Huisman, M. Botti, Peter B. van den Boezem, Bert A. Bonsing, Koop Bosscha, Cornelis H. C. Dejong, Bas Groot-Koerkamp, Jeroen Hagendoorn, Erwin van der Harst, Ignace H. de Hingh, Vincent E. de Meijer, Misha D. Luyer, Vincent B. Nieuwenhuijs, Bobby K. Pranger, Hjalmar C. van Santvoort, Jan H. Wijsman, Barbara M. Zonderhuis, Geert Kazemier, Marc G. Besselink, Freek Daams
Summary: This study investigated the effect of different somatostatin analogues (SA) protocols on the incidence of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy. The study found that the use of lanreotide in all patients undergoing pancreatoduodenectomy may have a protective effect on POPF development, and protocols for high-risk patients might be favorable as well. However, further studies are needed to confirm these findings.
Article
Endocrinology & Metabolism
Rosaria M. Ruggeri, Irene Aini, Stefano Gay, Erika Maria Grossrubatscher, Camilla Mancini, Maria Grazia Tarsitano, Virginia Zamponi, Andrea M. Isidori, Annamaria Colao, Antongiulio Faggiano
Summary: With the increasing incidence of neuroendocrine tumors, interest in gender-driven management has grown. However, current studies have not shown substantial differences between males and females in the efficacy and toxicity of SSTR-targeted therapies.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Oncology
Zhaozhou Ren, Feifei Ni, Tao Zhang, Xiangnan Yuan, Jianjun Li, Wan'an Xiao
Summary: NLE1 is elevated in melanoma and its expression level is correlated with lymphatic metastasis and tumor stage. Knockdown of NLE1 inhibits proliferation, enhances apoptotic sensitivity, and hinders migration of melanoma cells, suggesting its potential as a novel target for molecular therapy.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Endocrinology & Metabolism
E. Vitali, E. Palagano, M. L. Schiavone, G. Mantovani, C. Sobacchi, G. Mazziotti, A. Lania
Summary: This study provides the first evidence of the direct action of OCT on osteoblasts, which may have clinically relevant implications for the management of skeletal health in subjects with acromegaly and metastatic NETs.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Oncology
Sebastian Gulde, Tobias Wiedemann, Mathias Schillmaier, Isabel Valenca, Amelie Lupp, Katja Steiger, Hsi-Yu Yen, Stephen Baeuerle, Johannes Notni, Raul Luque, Herbert Schmid, Stefan Schulz, Donna P. Ankerst, Franz Schilling, Natalia S. Pellegata
Summary: There is currently a lack of effective medical therapy for residual/recurrent nonfunctioning pituitary tumors (NFPTs). Pasireotide may be an effective treatment, especially for female NFPTs patients. Female NFPTs patients have higher levels of Sstr3 expression, which may also be present in human NFPTs patients.
Letter
Dermatology
A. Alturo-Pons, F. Alamon-Reig, V. Sanmartin Novell, F. Vilardell, R. M. Marti
ACTAS DERMO-SIFILIOGRAFICAS
(2023)
Letter
Dermatology
Elena Canal-Garcia, Xavier Soria, Felip Vilardell, Rosa M. Marti
ANAIS BRASILEIROS DE DERMATOLOGIA
(2023)
Article
Oncology
James E. Barrett, Allison Jones, Iona Evans, Chiara Herzog, Daniel Reisel, Adeola Olaitan, Tim Mould, Nicola MacDonald, Konstantinos Doufekas, Claire Newton, Emma J. Crosbie, Line Bjorge, Nicoletta Colombo, Lukas Dostalek, Laura Costas, Paula Peremiquel-Trillas, Jordi Ponce, Xavier Matias-Guiu, Michal Zikan, David Cibula, Jiangrong Wang, Karin Sundstroem, Joakim Dillner, Martin Widschwendter
Summary: To reduce the morbidity caused by aggressive treatment for advanced endometrial cancer, it is necessary to identify women at risk and detect the cancer earlier. A new test called WID-EC based on DNA methylation was developed and validated in different sets of samples, showing promising results in identifying women with or at risk of endometrial cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Isabel C. Lopez-Mejia, Jordi Pijuan, Raul Navaridas, Maria Santacana, Sonia Gatius, Ana Velasco, Gerard Castella, Anais Panosa, Elisa Cabiscol, Miquel Pinyol, Laura Coll, Nuria Bonifaci, Laura Plata Pena, August Vidal, Alberto Villanueva, Eloi Gari, David Llobet-Navas, Lluis Fajas, Xavier Matias-Guiu, Andree Yeramian
Summary: Uterine serous carcinoma (USC) is a highly metastatic and fatal form of endometrial cancer (EC). This study identified focal adhesion kinase (FAK) as a highly activated tyrosine kinase in USC and showed that targeting FAK can inhibit cell growth and reduce migration in USC cell lines. The study also revealed that oxidative stress is increased in USC tumors compared to endometrioid endometrial carcinoma (EEC), and ROS-mediated FAK activation plays a role in cell migration and poor prognosis in USC.
MOLECULAR ONCOLOGY
(2023)
Article
Cell Biology
Yaiza Jung-Garcia, Oscar Maiques, Joanne Monger, Irene Rodriguez-Hernandez, Bruce Fanshawe, Marie-Charlotte Domart, Matthew J. Renshaw, Rosa M. Marti, Xavier Matias-Guiu, Lucy M. Collinson, Victoria Sanz-Moreno, Jeremy G. Carlton
Summary: Metastasis involves cancer cells spreading from the primary tumor to other sites. Researchers discovered increased expression of the protein LAP1 in metastatic melanoma cells, primary melanoma tumors, and metastases. They found that a shorter isoform of LAP1, LAP1C, supports constrained cell migration and invasion by allowing a weaker coupling between the nuclear envelope and the nuclear lamina. This suggests that LAP1 contributes to melanoma aggressiveness.
NATURE CELL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Laura Devis-Jauregui, August Vidal, Laura Plata-Pena, Maria Santacana, Sandra Garcia-Mulero, Nuria Bonifaci, Eulalia Noguera-Delgado, Nuria Ruiz, Marta Gil, Eduard Dorca, Francisco J. Llobet, Laura Coll-Iglesias, Katja Gassner, Maria Martinez-Iniesta, Ruth Rodriguez-Barrueco, Marc Barahona, Lola Marti, Francesc Vinals, Jordi Ponce, Rebeca Sanz-Pamplona, Josep M. Piulats, Ana Vivancos, Xavier Matias-Guiu, Alberto Villanueva, David Llobet-Navas
Summary: To address the clinical management challenges in endometrial cancer (EC), researchers have generated a collection of patient-derived orthoxenograft (PDOX) mouse models, which provide a valuable tool for studying and developing precision medicine in EC.
Letter
Dermatology
A. Alturo-Pons, F. Alamon-Reig, V. Sanmartin Novell, F. Vilardell, R. M. Marti
ACTAS DERMO-SIFILIOGRAFICAS
(2023)
Article
Multidisciplinary Sciences
Eva Crosas-Molist, Vittoria Graziani, Oscar Maiques, Pahini Pandya, Joanne Monger, Remi Samain, Samantha L. George, Saba Malik, Jerrine Salise, Valle Morales, Adrien Le Guennec, R. Andrew Atkinson, Rosa M. Marti, Xavier Matias-Guiu, Guillaume Charras, Maria R. Conte, Alberto Elosegui-Artola, Mark Holt, Victoria Sanz-Moreno
Summary: Cell migration is controlled by AMP-activated protein kinase (AMPK) acting as an adhesion sensing molecular hub. High AMPK activity in low adhering migratory cells induces mitochondrial fission and amoeboid migration. Reducing adhesion or activating AMPK promotes efficient rounded-amoeboid migration. This study reveals how mitochondrial dynamics and AMPK contribute to cell migration.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Marike S. Lombaers, Karlijn M. C. Cornel, Nicole C. M. Visser, Johan Bulten, Heidi V. N. Kuesters-Vandevelde, Frederic Amant, Dorry Boll, Peter Bronsert, Eva Colas, Peggy M. A. J. Geomini, Antonio Gil-Moreno, Dennis van Hamont, Jutta Huvila, Camilla A. Krakstad, Arjan A. Kraayenbrink, Martin Koskas, Gemma Mancebo, Xavier Matias-Guiu, Huy M. Ngo, Brenda M. Pijlman, Maria Caroline Vos, Vit Weinberger, Marc P. L. M. W. Snijders, Sebastiaan W. S. van Koeverden, Ingfrid S. Haldorsen, Casper Reijnen, Johanna M. A. Pijnenborg
Summary: Patients with high-grade uterine cancer have a higher risk of cancer spreading to the lymph nodes compared to patients with low-grade uterine cancer. CA125, a marker detectable in blood, is associated with increased tumor spread. This study aimed to assess the predictive value of CA125 for uterine cancer spread and survival and the additional value of CT scan in high-grade uterine cancer. The findings showed that elevated CA125 was associated with advanced stage, lymph node metastasis, and a worse prognosis in high-grade uterine cancer.
Article
Biochemistry & Molecular Biology
Eva Parisi, Ivan Hidalgo, Robert Montal, Ona Pallise, Jordi Tarragona, Anabel Sorolla, Anna Novell, Kyra Campbell, Maria Alba Sorolla, Andreu Casali, Antonieta Salud
Summary: In this study, a genetic screen identified 13 new genes that modified circulating tumor cell numbers in a whole animal CRC model. Evaluation of candidate genes at the gene expression level in both internal and independent human CRC cohorts revealed that low expression of PLA2G12A correlated with poor clinical outcomes. Further analysis showed that low expression of PLA2G12A was enriched in epithelial-mesenchymal transition signatures. Functional validation using colon cancer cell lines demonstrated that PLA2G12A deficiency increased cell proliferation, migration, and invasion. Overall, this study identifies PLA2G12A as a prognostic biomarker for early-stage CRC and provides evidence for its role in tumor growth and dissemination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Raul Navaridas, Maria Vidal-Sabanes, Anna Ruiz-Mitjana, Gisela Altes, Aida Perramon-Guell, Andree Yeramian, Joaquim Egea, Mario Encinas, Sonia Gatius, Xavier Matias-Guiu, Xavier Dolcet
Summary: Simultaneous deletion of Pten and p53 in endometrial epithelial cells is sufficient to trigger epithelial-to-mesenchymal transition, leading to the development of metastatic uterine carcinosarcomas.
Review
Oncology
Mariona Pont, Marta Marques, Maria Alba Sorolla, Eva Parisi, Izaskun Urdanibia, Serafin Morales, Antonieta Salud, Anabel Sorolla
Summary: CRISPR technology has revolutionized cancer research, particularly in the field of breast cancer and triple negative breast cancer (TNBC). It allows scientists to model these diseases more effectively, discover unknown genes involved in cancer progression, improve early and sensitive diagnosis, and explore more selective and efficient treatments. Scientists are currently exploring different methods to optimize the distribution of CRISPR components in tumors. However, CRISPR technology also has limitations and future directions for improvement.
Article
Oncology
Jonathan S. Berek, Xavier Matias-Guiu, Carien Creutzberg, Christina Fotopoulou, David Gaffney, Sean Kehoe, Kristina Lindemann, David Mutch, Endometrial Canc Staging Subcomm, FIGO Womens Canc Comm
Summary: Since the 2009 update of the FIGO staging system, there have been significant advances in understanding the pathologic and molecular features of endometrial cancer. The new staging system aims to better define prognostic groups and create substages to guide more appropriate treatment.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)